Embodiment theories proposed that the comprehension of language involves sensory-motor simulation in the brain.The present study examined the brain response to motor compatibility effect in comprehending action-relate...Embodiment theories proposed that the comprehension of language involves sensory-motor simulation in the brain.The present study examined the brain response to motor compatibility effect in comprehending action-related linguistic materials for participants learning Chinese as a second language(L2).In this study,participants are required to read action-related sentences describing an agent performing two manual actions simultaneously or sequentially by manipulating temporal conjunctions.The sentences with simultaneous actions are marked by Chinese parallel structure一边……一边……(“while”)showing non-congruent motor condition while the sequential action sentences are marked by先……然后……(“after”)showing congruent motor condition.Event-Related Potentials(ERPs)were recorded with the second verb phrase.A larger fronto-central late positivity was observed for the sentences with simultaneous actions rather than the sentences with sequential actions due to body constraints,revealing that late L2 Chinese learners integrate embodied knowledge while processing action-related complex sentence despite demanding more cognitive resources,and longer processing time.展开更多
The recent clinical curative effect and adverse events of docetaxel and capecitabine （DX） of neo- adjuvant chemotherapy in patients with locally advanced breast cancer was discussed. Methods： The data of 72 cases o...The recent clinical curative effect and adverse events of docetaxel and capecitabine （DX） of neo- adjuvant chemotherapy in patients with locally advanced breast cancer was discussed. Methods： The data of 72 cases of neoadjuvant chemotherapy （DX） in locally advanced breast cancer after 4 cycles were retrospectively analyzed. Docetaxel 75 mg/m^2 by infusion 1 h on dl, capecitabine 2000 mg/m^2 by oral for twice daily on d1-14, 21 days was a cycle. Results： All 72 patients were assessed for efficacy and adverse events. The total effective rate was 80.5% （58/72）, including pathological complete response （pCR） was 7 （9.7%）, clinical complete remission （cCR） was 15（20.8%）, clinical partial response （PR） was 43 （59.7%）, stable disease （SD） was 8 （11.1%） and progressive disease （PD） was 6 （8.3%）. The main adverse events were gastrointestinal reactions and bone marrow suppression. The 3 to 4 degrees of adverse reactions including granulocytopenia in 7 patients （20.6%）, hand-foot syndrome in 6 patients （15.2%）. Conclusion： The DX regimen provide a favorable efficacy and safety profile in patients with locally advanced breast cancer for neoadjuvant chemotherapy.展开更多
文摘Embodiment theories proposed that the comprehension of language involves sensory-motor simulation in the brain.The present study examined the brain response to motor compatibility effect in comprehending action-related linguistic materials for participants learning Chinese as a second language(L2).In this study,participants are required to read action-related sentences describing an agent performing two manual actions simultaneously or sequentially by manipulating temporal conjunctions.The sentences with simultaneous actions are marked by Chinese parallel structure一边……一边……(“while”)showing non-congruent motor condition while the sequential action sentences are marked by先……然后……(“after”)showing congruent motor condition.Event-Related Potentials(ERPs)were recorded with the second verb phrase.A larger fronto-central late positivity was observed for the sentences with simultaneous actions rather than the sentences with sequential actions due to body constraints,revealing that late L2 Chinese learners integrate embodied knowledge while processing action-related complex sentence despite demanding more cognitive resources,and longer processing time.
基金Supported by grants from the Sub-Topics of Major Drug Discovery platform in the Twelfth-Five Year Research Program of China(No.2012ZX09303016-002)the Liaoning Province Science & Technology Development Funds(No.2012225019)
文摘The recent clinical curative effect and adverse events of docetaxel and capecitabine （DX） of neo- adjuvant chemotherapy in patients with locally advanced breast cancer was discussed. Methods： The data of 72 cases of neoadjuvant chemotherapy （DX） in locally advanced breast cancer after 4 cycles were retrospectively analyzed. Docetaxel 75 mg/m^2 by infusion 1 h on dl, capecitabine 2000 mg/m^2 by oral for twice daily on d1-14, 21 days was a cycle. Results： All 72 patients were assessed for efficacy and adverse events. The total effective rate was 80.5% （58/72）, including pathological complete response （pCR） was 7 （9.7%）, clinical complete remission （cCR） was 15（20.8%）, clinical partial response （PR） was 43 （59.7%）, stable disease （SD） was 8 （11.1%） and progressive disease （PD） was 6 （8.3%）. The main adverse events were gastrointestinal reactions and bone marrow suppression. The 3 to 4 degrees of adverse reactions including granulocytopenia in 7 patients （20.6%）, hand-foot syndrome in 6 patients （15.2%）. Conclusion： The DX regimen provide a favorable efficacy and safety profile in patients with locally advanced breast cancer for neoadjuvant chemotherapy.
