An analytical solution was presented to the unsaturated soil with a finite thickness under confinement in the lateral direction and sinusoidal cyclic loading in the vertical direction based on Fredlund's one-dimen...An analytical solution was presented to the unsaturated soil with a finite thickness under confinement in the lateral direction and sinusoidal cyclic loading in the vertical direction based on Fredlund's one-dimensional consolidation equation for unsaturated soil. The transfer relationship between the state vectors at the top surface and any depth was gained by applying the Laplace transform and Cayley-Hamilton mathematical methods to the governing equations of water and air, Darcy's law and Fick's law. The excess pore-air and pore-water pressures and settlement in the Laplace-transformed domain were obtained by using the Laplace transform with the initial and boundary conditions. The analytical solutions of the excess pore-air and pore-water pressures at any depth and settlement were obtained in the time domain by performing the inverse Laplace transforms. A typical example illustrates the consolidation characteristics of unsaturated soil under sinusoidal loading from analytical results. Finally, comparisons between the analytical solutions and results of the numerical method indicate that the analytical solution is correct.展开更多
The transient response of an unlimited cylindrical cavity buried in the infinite elastic soil subjected to an anti-plane impact load along the cavern axis direction was studied.Using Laplace transform combining with c...The transient response of an unlimited cylindrical cavity buried in the infinite elastic soil subjected to an anti-plane impact load along the cavern axis direction was studied.Using Laplace transform combining with contour integral of the Laplace inverse transform specifically,the general analytical expressions of the soil displacement and stress are obtained in the time domain,respectively.And the numerical solutions of the problem computed by analytical expressions are presented.In the time domain,the dynamic responses of the infinite elastic soil are analyzed,and the calculation results are compared with those from numerical inversion proposed by Durbin and the static results.One observes good agreement between analytical and numerical inversion results,lending the further support to the method presented.Finally,some valuable shear wave propagation laws are gained: the displacement of the soil remains zero before the wave arrival,and after the shear wave arrival,the stress and the displacement at this point increase abruptly,then reduce and tend to the static value gradually at last.The wave attenuates along the radial,therefore the farther the wave is from the source,the smaller the stress and the displacement are,and the stress and the displacement are just functions of the radial distance from the axis.展开更多
Objective To investigate the effects of captopril on cardiac function and levels of energy-rich phosphates in pressure overload induced left ventricular hypertrophy rats. Methods One hundred and twenty SD rats were ra...Objective To investigate the effects of captopril on cardiac function and levels of energy-rich phosphates in pressure overload induced left ventricular hypertrophy rats. Methods One hundred and twenty SD rats were randomly divided into three groups: sham operation group (SH group, n=40),coarctation of abdominal aorta group (CAA group, n=40) and captopril treatment lmg~ 100g1 ~ d-1) group (CAP group, n=40). Left ventricular end-diastolic pressure (LVEDP), left venh-icular mass index (LVMI), levels of energy-rich phosphates and morphological changes of the myocardial mitochondria were compared at the 62 and 82 week after operation. Results At 62 week, in CAA group, LVMI and LVEDP were increased and _ dp/dtmax was decreased, while ATP and ADP were decreased and AMP was increased (P〈0.01). These changes were much obvious at 8th week (P〈0.01). Compared with those of CAA group, the parameters of heart function and energy-rich phosphates (ATP, ADP, AMP, TAN) in CAP group were improved significantly(P〈0.01) at the 6th and 8th week. In CAP group, the parameters of heart function and energy-rich phosphates (ADP, AMP, TAN) were much better at 8~ week than those at 6th week. The morphological change of mitochondria was less in CAP group than that in CAA group. Conclusion Captopril significantly improves myocardial energy metabolism in pressure overload rats and protects the function of myocardial mitochondria展开更多
基金Project(2010G016-B)supported by Science and Technology Research and Development of China
文摘An analytical solution was presented to the unsaturated soil with a finite thickness under confinement in the lateral direction and sinusoidal cyclic loading in the vertical direction based on Fredlund's one-dimensional consolidation equation for unsaturated soil. The transfer relationship between the state vectors at the top surface and any depth was gained by applying the Laplace transform and Cayley-Hamilton mathematical methods to the governing equations of water and air, Darcy's law and Fick's law. The excess pore-air and pore-water pressures and settlement in the Laplace-transformed domain were obtained by using the Laplace transform with the initial and boundary conditions. The analytical solutions of the excess pore-air and pore-water pressures at any depth and settlement were obtained in the time domain by performing the inverse Laplace transforms. A typical example illustrates the consolidation characteristics of unsaturated soil under sinusoidal loading from analytical results. Finally, comparisons between the analytical solutions and results of the numerical method indicate that the analytical solution is correct.
文摘The transient response of an unlimited cylindrical cavity buried in the infinite elastic soil subjected to an anti-plane impact load along the cavern axis direction was studied.Using Laplace transform combining with contour integral of the Laplace inverse transform specifically,the general analytical expressions of the soil displacement and stress are obtained in the time domain,respectively.And the numerical solutions of the problem computed by analytical expressions are presented.In the time domain,the dynamic responses of the infinite elastic soil are analyzed,and the calculation results are compared with those from numerical inversion proposed by Durbin and the static results.One observes good agreement between analytical and numerical inversion results,lending the further support to the method presented.Finally,some valuable shear wave propagation laws are gained: the displacement of the soil remains zero before the wave arrival,and after the shear wave arrival,the stress and the displacement at this point increase abruptly,then reduce and tend to the static value gradually at last.The wave attenuates along the radial,therefore the farther the wave is from the source,the smaller the stress and the displacement are,and the stress and the displacement are just functions of the radial distance from the axis.
基金Corresponding author: Dr. Cao Xuebin, MD, Department of Cardiology, 252 Hospital of Chinese PLA, Baoding 071000,Hebei Province,China Email: cxb252@yahoo.com.cn. This study was supported by the National Natural Science Foundation of China (30873398), Research Project of "Eleventh Five-year Plan" for Medical Science Development of PLA(2006MA064) and the Research Project of Hebei Province (06276012D- 114).
文摘Objective To investigate the effects of captopril on cardiac function and levels of energy-rich phosphates in pressure overload induced left ventricular hypertrophy rats. Methods One hundred and twenty SD rats were randomly divided into three groups: sham operation group (SH group, n=40),coarctation of abdominal aorta group (CAA group, n=40) and captopril treatment lmg~ 100g1 ~ d-1) group (CAP group, n=40). Left ventricular end-diastolic pressure (LVEDP), left venh-icular mass index (LVMI), levels of energy-rich phosphates and morphological changes of the myocardial mitochondria were compared at the 62 and 82 week after operation. Results At 62 week, in CAA group, LVMI and LVEDP were increased and _ dp/dtmax was decreased, while ATP and ADP were decreased and AMP was increased (P〈0.01). These changes were much obvious at 8th week (P〈0.01). Compared with those of CAA group, the parameters of heart function and energy-rich phosphates (ATP, ADP, AMP, TAN) in CAP group were improved significantly(P〈0.01) at the 6th and 8th week. In CAP group, the parameters of heart function and energy-rich phosphates (ADP, AMP, TAN) were much better at 8~ week than those at 6th week. The morphological change of mitochondria was less in CAP group than that in CAA group. Conclusion Captopril significantly improves myocardial energy metabolism in pressure overload rats and protects the function of myocardial mitochondria