Background/Aims: Therapeutic options for hepatitis C nonresponder patients are limited. Methods: We initiated an open-label pilot study to investigate the efficacy of CIFN plus ribavirin on viral kinetics, sustained v...Background/Aims: Therapeutic options for hepatitis C nonresponder patients are limited. Methods: We initiated an open-label pilot study to investigate the efficacy of CIFN plus ribavirin on viral kinetics, sustained virological response (SVR), and histological response in hepatitis C non-responder patients. Seventy-seven patients were enrolled to receive CIFN given daily in combination with 1000/1200 mg ribavirin. An 8 week induction-dosing regimen of 18 μ g CIFN, followed by 9 μ g for 40 weeks was compared to 9 μ g CIFN for 48 weeks. 90% of patients were infected with HCV-genotype 1. Results: Overall, 82% of the patients demonstrated an early virological response, 65% had an end-of-treatment response, and the SVR was 30% . Interferon/ribavirin non-responders demonstrated a SVR of 22% . Induction-dosing resulted in a greater first-phase HCV-RNA decay that, however, did not translate to better SVRs, presumably due to more dose modifications. High ALT, younger age, and second-phase viral kinetics were associated with SVR. Only sustained responders and relapse patients showed an improved liver histology. Conclusions: Daily dosing of CIFN plus ribavirin may be a promising concept for selected non-responder patients before considering therapies which are anti-viral but not curative. However,motivation and compliance are requisites and a CIFN induction is not required.展开更多
丙型肝炎是由丙型肝炎病毒(Hepatitis C vi-rus,HCV)引起的一种主要经血液传播的传染病,呈世界性流行,全球流行率平均为3%,感染丙型肝炎病毒20年后,肝硬化的年发生率为10%~15%,一旦发展为肝硬化,每年肝癌的发生率为1%~7%[1]。2009年...丙型肝炎是由丙型肝炎病毒(Hepatitis C vi-rus,HCV)引起的一种主要经血液传播的传染病,呈世界性流行,全球流行率平均为3%,感染丙型肝炎病毒20年后,肝硬化的年发生率为10%~15%,一旦发展为肝硬化,每年肝癌的发生率为1%~7%[1]。2009年4月我院收治了49例慢性丙型肝炎(Chronic hepatitis C,CHC)患者,展开更多
文摘Background/Aims: Therapeutic options for hepatitis C nonresponder patients are limited. Methods: We initiated an open-label pilot study to investigate the efficacy of CIFN plus ribavirin on viral kinetics, sustained virological response (SVR), and histological response in hepatitis C non-responder patients. Seventy-seven patients were enrolled to receive CIFN given daily in combination with 1000/1200 mg ribavirin. An 8 week induction-dosing regimen of 18 μ g CIFN, followed by 9 μ g for 40 weeks was compared to 9 μ g CIFN for 48 weeks. 90% of patients were infected with HCV-genotype 1. Results: Overall, 82% of the patients demonstrated an early virological response, 65% had an end-of-treatment response, and the SVR was 30% . Interferon/ribavirin non-responders demonstrated a SVR of 22% . Induction-dosing resulted in a greater first-phase HCV-RNA decay that, however, did not translate to better SVRs, presumably due to more dose modifications. High ALT, younger age, and second-phase viral kinetics were associated with SVR. Only sustained responders and relapse patients showed an improved liver histology. Conclusions: Daily dosing of CIFN plus ribavirin may be a promising concept for selected non-responder patients before considering therapies which are anti-viral but not curative. However,motivation and compliance are requisites and a CIFN induction is not required.
文摘丙型肝炎是由丙型肝炎病毒(Hepatitis C vi-rus,HCV)引起的一种主要经血液传播的传染病,呈世界性流行,全球流行率平均为3%,感染丙型肝炎病毒20年后,肝硬化的年发生率为10%~15%,一旦发展为肝硬化,每年肝癌的发生率为1%~7%[1]。2009年4月我院收治了49例慢性丙型肝炎(Chronic hepatitis C,CHC)患者,