AIM: To evaluate the effects of prucalopride on intestinal prokinetic activity in fast rats and to provide experimental basis for clinical treatrnent of gastrointestinal motility diseases.METHODS: Gastrointestinal pro...AIM: To evaluate the effects of prucalopride on intestinal prokinetic activity in fast rats and to provide experimental basis for clinical treatrnent of gastrointestinal motility diseases.METHODS: Gastrointestinal propulsion rate was measured by the migration rate of activated charcoal, which reflexes gastrointestinal motility function. 120 Spraque-Dawley rats were randomly divided into four groups and received an intravenous injection of physiological saline (served as control), prucalopdde 1 mg/kg, prucalopride 2 mg/kg and cisapride 1 mg/kg,respectively. The gastrointestinal propulsion rate was measured 1, 2 or 4 hours after intravenous injection of the drugs.RESULTS: Significant accelerations of gastrointestinal propulsion rate in prucalopride 1 mg/kg and 2 mg/kg groups were found compared with control group at 2 and 4 hours (83.2%±5.5%, 81.7%±8.5% vs70.5%±9.2%, P＜0.01;91.2%±2.2%, 91.3%±3.9% vs86.8%±2.6%, P＜0.01).The gastrointestinal propulsion rates at 1, 2 or 4 hours were faster in prucalopride 1 mg/kg and 2 mg/kg groups than in cisapride group (84.0%±11.7%, 77.1%±11.9% vs 66.3%±13.6%, P＜0.01, P＜0.05; 83.2%±5.5%, 81.7%±8.5% vs75.4%±5.9 %, P＜0.01, P＜0.05; 91.2%±2.2%,91.3%±3.9% vs 88.6%±3.5%,P＜0.05, P＜0.05). No difference of gastrointestinal propulsion rate was found between prucalopride 1 mg/kg group and prucalopride 2 mg/kg group (P＞0.05).CONCLUSION: Prucalopride accelerates intestinal motility in fast rats, and has no dose dependent effect.展开更多
文摘AIM: To evaluate the effects of prucalopride on intestinal prokinetic activity in fast rats and to provide experimental basis for clinical treatrnent of gastrointestinal motility diseases.METHODS: Gastrointestinal propulsion rate was measured by the migration rate of activated charcoal, which reflexes gastrointestinal motility function. 120 Spraque-Dawley rats were randomly divided into four groups and received an intravenous injection of physiological saline (served as control), prucalopdde 1 mg/kg, prucalopride 2 mg/kg and cisapride 1 mg/kg,respectively. The gastrointestinal propulsion rate was measured 1, 2 or 4 hours after intravenous injection of the drugs.RESULTS: Significant accelerations of gastrointestinal propulsion rate in prucalopride 1 mg/kg and 2 mg/kg groups were found compared with control group at 2 and 4 hours (83.2%±5.5%, 81.7%±8.5% vs70.5%±9.2%, P＜0.01;91.2%±2.2%, 91.3%±3.9% vs86.8%±2.6%, P＜0.01).The gastrointestinal propulsion rates at 1, 2 or 4 hours were faster in prucalopride 1 mg/kg and 2 mg/kg groups than in cisapride group (84.0%±11.7%, 77.1%±11.9% vs 66.3%±13.6%, P＜0.01, P＜0.05; 83.2%±5.5%, 81.7%±8.5% vs75.4%±5.9 %, P＜0.01, P＜0.05; 91.2%±2.2%,91.3%±3.9% vs 88.6%±3.5%,P＜0.05, P＜0.05). No difference of gastrointestinal propulsion rate was found between prucalopride 1 mg/kg group and prucalopride 2 mg/kg group (P＞0.05).CONCLUSION: Prucalopride accelerates intestinal motility in fast rats, and has no dose dependent effect.
