Objective To explore the regulatory effect of fragile X mental retardation protein (FMRP) on the translation of microtubule associated protein 1B (MAP1B). Methods The expressions of MAP1B protein and MAP1B mRNA in...Objective To explore the regulatory effect of fragile X mental retardation protein (FMRP) on the translation of microtubule associated protein 1B (MAP1B). Methods The expressions of MAP1B protein and MAP1B mRNA in the brains of 1-week and 6-week old fragile X mental retardation-1 (FmrI) knockout (KO) mice were investigated by immunohistochemistry, Western blot, and in situ hybridization, with the age-matched wild type mice (WT) as controls. Results The mean optical density (MOD) of MAP1B was significantly decreased in each brain region in KO6W compared with WT6W, whereas in KO1W, this decrease was only found in the hippocampus and cerebellum. MAP1B in 6-week mice was much less than that in 1-week mice of the same genotype. The results of Western blot and in situ hybridization showed that MAP1B protein and MAP1B mRNA were significantly decreased in the hippocampus of both KO1W and KO6W. Conclusion The decreased MAP1B protein and MAP1B mRNA in the Fmrl knockout mice indicate that FMRP may positively regulate the expression of MAP1B.展开更多
An intelligent camera for surface defect inspection is presented which can pre-process the surface image of a rolled strip and pick defective areas out at a spead of 1 600 meters per minute. The camera is made up of a...An intelligent camera for surface defect inspection is presented which can pre-process the surface image of a rolled strip and pick defective areas out at a spead of 1 600 meters per minute. The camera is made up of a high speed line CCD, a 60 Mb/s CCD digitizer with correlated double sampling function, and a field programmable gate array(FPGA), which can quickly distinguish defective areas using a perceptron embedded in FPGA thus the data to be further processed would dramatically be reduced. Some experiments show that the camera can meet high producing speed, and reduce cost and complexity of automation surface inspection systems.展开更多
To track the narrow butt welding seams in container manufacture, a visual tracking system based on smart camera is proposed in this paper. A smart camera is used as the sensor to detect the welding seam. The feature e...To track the narrow butt welding seams in container manufacture, a visual tracking system based on smart camera is proposed in this paper. A smart camera is used as the sensor to detect the welding seam. The feature extraction algorithm is designed with the consideration of the characteristics of the smart caraera, which is used to compute the error between the welding torch and the welding seam. Visual control system based on image is preseated, which employs a programmable controller to control a stepper motor to eliminate the tracking error detected by the smart camera. Experiments are conducted to demonstrate the effectiveness of the vision system.展开更多
The intelligent environment needs Human-Computer Interactive technology (HCI) and a projector projects screen on wall in the intelligent environments. We propose the front-face detection from four captured images re...The intelligent environment needs Human-Computer Interactive technology (HCI) and a projector projects screen on wall in the intelligent environments. We propose the front-face detection from four captured images related to the intelligent room for the deaf. Our proposal purpose is that a deaf user faces wall displaying everywhere. system gets the images from four cameras, and detects the user region from a silhouette image using a different method, detects and cuts a motion body region from a different image, and cuts the vertexchest region from the cut body region image. The system attempts to find front-face using Haar-like feature, and selects a detected front-face image from the vertex-chest region. We estimate the front-face detection of recognition rate, which shows somewhat successfully.展开更多
AIM:To study the incidence and survival rate of stomach cancer(SC)and its associated factors in a high risk population in Chile. METHODS:The population-based cancer registry of Valdivia,included in the International A...AIM:To study the incidence and survival rate of stomach cancer(SC)and its associated factors in a high risk population in Chile. METHODS:The population-based cancer registry of Valdivia,included in the International Agency for Research on Cancer system,covers 356 396 residents of Valdivia Province,Southern Chile.We studied all SC cases entered in this Registry during 1998-2002 (529 cases).Population data came from the Chilean census(2002).Standardized incidence rates per 100 000 inhabitants(SIR)using the world population, cumulative risk of developing cancer before age 75, and rate ratios by sex,age,ethnicity and social factors were estimated.Relative survival(EdererⅡmethod) and age-standardized estimates(Brenner method) were calculated.Specific survival rates(Kaplan-Meier) were measured at 3 and 5 years and survival curves were analyzed with the Logrank and Breslow tests. Survival was studied in relation to demographics, clinical presentation,laboratory results and medical management of the cases.Those variables significantly associated with survival were later included in a Cox multivariate model. RESULTS:Between 1998 and 2002,529 primary gastric cancers occurred in Valdivia(crude incidence rate 29.2 per 100000 inhabitants).Most cases were male(69.0%), residents of urban areas(57.5%)and Hispanic(83.2%), with a low education level(84.5%<8 school years). SC SIR was higher in men than women(40.8 and 14.8 respectively,P<0.001),risk factors were low education RR 4.4(95%CI:2.9-6.8)and 1.6,(95%CI:1.1-2.1) for women and men respectively and Mapuche ethnicity only significant for women(RR 2.2,95%CI:1.2-3.7).Of all cases,76.4%were histologically confirmed,11.5% had a death certificate only(DCO),56.1%were TNM stageⅣ;445 cases(84.1%)were eligible for survival analysis,all completed five years follow-up;42 remained alive,392 died of SC and 11 died from other causes. Specific 5-year survival,excluding cases with DCO,was 10.6%(95%CI:7.7-13.5);5-year relative survival rate was 12.3%(95%CI:9.1-16.1),men 10.9%(95%CI: 7.4-15.2)and women 16.1%(95%CI:9.5-24.5).Fiveyear specific survival was higher for patients aged<55 years(17.3%),with intestinal type of cancer(14.6%), without metastasis(22.2%),tumor size<4 cm(60.0%), without lymphatic invasion(77.1%),only involvement of the mucous membrane(100%).Statistically significant independent prognostic factors were:TNM staging, diffuse type,metastasis,supraclavicular adenopathy, palpable tumor,and hepatitis or ascites. CONCLUSION:Social determinants are the main risk factors for SC,but not for survival.An advanced clinical stage at consultation is the main cause of poor SC survival.展开更多
Mobile applications are being used in a great range of fields and application areas. As a result, many research fields have focused on the study and improvement of such devices. The current Smartphones are the best ex...Mobile applications are being used in a great range of fields and application areas. As a result, many research fields have focused on the study and improvement of such devices. The current Smartphones are the best example of the research and the evolution of these technologies. Moreover, the software design and development is progressively more focused on the user; finding and developing new mobile interaction models. In order to do so, knowing what kind of problems the users could have is vital to enhance a bad interaction design. Unfortunately, a good software quality evaluation takes more time than the companies can invest. The contribution revealed in this work is a new approach to quality testing methodology focused on mobile interactions and their context in use where external capturing tools, such as cameras, are suppressed and the evaluation environments are the same as the user will use the application. By this approach, the interactions can be captured without changing the context and consequently, the data will be more accurate, enabling the evaluation of the quality-in-use in real environments.展开更多
文摘Objective To explore the regulatory effect of fragile X mental retardation protein (FMRP) on the translation of microtubule associated protein 1B (MAP1B). Methods The expressions of MAP1B protein and MAP1B mRNA in the brains of 1-week and 6-week old fragile X mental retardation-1 (FmrI) knockout (KO) mice were investigated by immunohistochemistry, Western blot, and in situ hybridization, with the age-matched wild type mice (WT) as controls. Results The mean optical density (MOD) of MAP1B was significantly decreased in each brain region in KO6W compared with WT6W, whereas in KO1W, this decrease was only found in the hippocampus and cerebellum. MAP1B in 6-week mice was much less than that in 1-week mice of the same genotype. The results of Western blot and in situ hybridization showed that MAP1B protein and MAP1B mRNA were significantly decreased in the hippocampus of both KO1W and KO6W. Conclusion The decreased MAP1B protein and MAP1B mRNA in the Fmrl knockout mice indicate that FMRP may positively regulate the expression of MAP1B.
文摘An intelligent camera for surface defect inspection is presented which can pre-process the surface image of a rolled strip and pick defective areas out at a spead of 1 600 meters per minute. The camera is made up of a high speed line CCD, a 60 Mb/s CCD digitizer with correlated double sampling function, and a field programmable gate array(FPGA), which can quickly distinguish defective areas using a perceptron embedded in FPGA thus the data to be further processed would dramatically be reduced. Some experiments show that the camera can meet high producing speed, and reduce cost and complexity of automation surface inspection systems.
文摘To track the narrow butt welding seams in container manufacture, a visual tracking system based on smart camera is proposed in this paper. A smart camera is used as the sensor to detect the welding seam. The feature extraction algorithm is designed with the consideration of the characteristics of the smart caraera, which is used to compute the error between the welding torch and the welding seam. Visual control system based on image is preseated, which employs a programmable controller to control a stepper motor to eliminate the tracking error detected by the smart camera. Experiments are conducted to demonstrate the effectiveness of the vision system.
基金supported by the Ministry of Knowledge Economy,Korea,the ITRC(Information Technology Research Center)support program(NIA-2009-(C1090-0902-0007))the Contents Technology Research Center support program
文摘The intelligent environment needs Human-Computer Interactive technology (HCI) and a projector projects screen on wall in the intelligent environments. We propose the front-face detection from four captured images related to the intelligent room for the deaf. Our proposal purpose is that a deaf user faces wall displaying everywhere. system gets the images from four cameras, and detects the user region from a silhouette image using a different method, detects and cuts a motion body region from a different image, and cuts the vertexchest region from the cut body region image. The system attempts to find front-face using Haar-like feature, and selects a detected front-face image from the vertex-chest region. We estimate the front-face detection of recognition rate, which shows somewhat successfully.
文摘AIM:To study the incidence and survival rate of stomach cancer(SC)and its associated factors in a high risk population in Chile. METHODS:The population-based cancer registry of Valdivia,included in the International Agency for Research on Cancer system,covers 356 396 residents of Valdivia Province,Southern Chile.We studied all SC cases entered in this Registry during 1998-2002 (529 cases).Population data came from the Chilean census(2002).Standardized incidence rates per 100 000 inhabitants(SIR)using the world population, cumulative risk of developing cancer before age 75, and rate ratios by sex,age,ethnicity and social factors were estimated.Relative survival(EdererⅡmethod) and age-standardized estimates(Brenner method) were calculated.Specific survival rates(Kaplan-Meier) were measured at 3 and 5 years and survival curves were analyzed with the Logrank and Breslow tests. Survival was studied in relation to demographics, clinical presentation,laboratory results and medical management of the cases.Those variables significantly associated with survival were later included in a Cox multivariate model. RESULTS:Between 1998 and 2002,529 primary gastric cancers occurred in Valdivia(crude incidence rate 29.2 per 100000 inhabitants).Most cases were male(69.0%), residents of urban areas(57.5%)and Hispanic(83.2%), with a low education level(84.5%<8 school years). SC SIR was higher in men than women(40.8 and 14.8 respectively,P<0.001),risk factors were low education RR 4.4(95%CI:2.9-6.8)and 1.6,(95%CI:1.1-2.1) for women and men respectively and Mapuche ethnicity only significant for women(RR 2.2,95%CI:1.2-3.7).Of all cases,76.4%were histologically confirmed,11.5% had a death certificate only(DCO),56.1%were TNM stageⅣ;445 cases(84.1%)were eligible for survival analysis,all completed five years follow-up;42 remained alive,392 died of SC and 11 died from other causes. Specific 5-year survival,excluding cases with DCO,was 10.6%(95%CI:7.7-13.5);5-year relative survival rate was 12.3%(95%CI:9.1-16.1),men 10.9%(95%CI: 7.4-15.2)and women 16.1%(95%CI:9.5-24.5).Fiveyear specific survival was higher for patients aged<55 years(17.3%),with intestinal type of cancer(14.6%), without metastasis(22.2%),tumor size<4 cm(60.0%), without lymphatic invasion(77.1%),only involvement of the mucous membrane(100%).Statistically significant independent prognostic factors were:TNM staging, diffuse type,metastasis,supraclavicular adenopathy, palpable tumor,and hepatitis or ascites. CONCLUSION:Social determinants are the main risk factors for SC,but not for survival.An advanced clinical stage at consultation is the main cause of poor SC survival.
文摘Mobile applications are being used in a great range of fields and application areas. As a result, many research fields have focused on the study and improvement of such devices. The current Smartphones are the best example of the research and the evolution of these technologies. Moreover, the software design and development is progressively more focused on the user; finding and developing new mobile interaction models. In order to do so, knowing what kind of problems the users could have is vital to enhance a bad interaction design. Unfortunately, a good software quality evaluation takes more time than the companies can invest. The contribution revealed in this work is a new approach to quality testing methodology focused on mobile interactions and their context in use where external capturing tools, such as cameras, are suppressed and the evaluation environments are the same as the user will use the application. By this approach, the interactions can be captured without changing the context and consequently, the data will be more accurate, enabling the evaluation of the quality-in-use in real environments.