Smart cars are promising application domain for ubiquitous computing. Context-awareness is the key feature of a smart car for safer and easier driving. Despite many industrial innovations and academic progresses have ...Smart cars are promising application domain for ubiquitous computing. Context-awareness is the key feature of a smart car for safer and easier driving. Despite many industrial innovations and academic progresses have been made, we find a lack of fully context-aware smart cars. This study presents a general architecture of smart cars from the viewpoint of context- awareness. A hierarchical context model is proposed for description of the complex driving environment. A smart car prototype including software platform and hardware infrastructures is built to provide the running environment for the context model and applications. Two performance metrics were evaluated: accuracy of the context situation recognition and efficiency of the smart car. The whole response time of context situation recognition is nearly 1.4 s for one person, which is acceptable for non-time critical applications in a smart car.展开更多
In order to deliver and/or release anti-cancer therapeutics at the tumor sites, novel environment-responsive drug delivery systems are designed to specifically respond to tumor microenvironment （such as low pH and hy...In order to deliver and/or release anti-cancer therapeutics at the tumor sites, novel environment-responsive drug delivery systems are designed to specifically respond to tumor microenvironment （such as low pH and hypoxia）. Due to their extraordinary advantages, these environment-responsive drug delivery systems can improve antitumor efficacy, and most importantly, they can decrease toxicity associated with the anti-cancer therapeutics. This review highlights different mechanisms of environmentresponsive drug delivery systems and their applications for targeted cancer therapy.展开更多
基金Project supported by the National Hi-Tech Research and Develop-ment Program (863) of China (Nos. 2006AA01Z198, and2008AA01Z132)the National Natural Science Foundation of China(No. 60533040)the National Science Fund for Distinguished Young Scholars of China (No. 60525202)
文摘Smart cars are promising application domain for ubiquitous computing. Context-awareness is the key feature of a smart car for safer and easier driving. Despite many industrial innovations and academic progresses have been made, we find a lack of fully context-aware smart cars. This study presents a general architecture of smart cars from the viewpoint of context- awareness. A hierarchical context model is proposed for description of the complex driving environment. A smart car prototype including software platform and hardware infrastructures is built to provide the running environment for the context model and applications. Two performance metrics were evaluated: accuracy of the context situation recognition and efficiency of the smart car. The whole response time of context situation recognition is nearly 1.4 s for one person, which is acceptable for non-time critical applications in a smart car.
基金National Basic Research Program of China(Grant No.973 Program,2013CB932500)National Natural Science Foundation of China(Grant No.81273458)Specialized Research Fund for the Doctoral Program of Higher Education(Grant No.20110071130011)
文摘In order to deliver and/or release anti-cancer therapeutics at the tumor sites, novel environment-responsive drug delivery systems are designed to specifically respond to tumor microenvironment （such as low pH and hypoxia）. Due to their extraordinary advantages, these environment-responsive drug delivery systems can improve antitumor efficacy, and most importantly, they can decrease toxicity associated with the anti-cancer therapeutics. This review highlights different mechanisms of environmentresponsive drug delivery systems and their applications for targeted cancer therapy.
