AIM： TO investigate the role of Lactobacillus crispatus （L. crispatus） strain China Center for Type Culture Col- lection （CCTCC） M206119 in intestinal inflammation.METHODS： Forty 8-wk-old Balb/c mice （20± ...AIM： TO investigate the role of Lactobacillus crispatus （L. crispatus） strain China Center for Type Culture Col- lection （CCTCC） M206119 in intestinal inflammation.METHODS： Forty 8-wk-old Balb/c mice （20± 2 g） were divided into four groups of 10 mice each. Three groups that had received dextran sulfate sodium （DSS） were administered normal saline, sulfasalazine or CCTCC M206119 strain, and the fourth group received none of these. We assessed the severity of colitis using a disease activity index, measured the colon length and weight, collected stools and mesenteric lymph nodes for bacterial microflora analysis. One centimeter of the proximal colon, middle colon and distal colon were collected and fixed in 10% buffered formalin, dehydrated in ethanol, and embedded in paraffin. Interleukin （IL）- 1β, IL-6 and tumor necrosis factor （TNF）-α expression was detected using reverse transcription polymerase chain reaction. Protective factors zonula occludens （ZO）-1 and β-defensin 2 were detected by immunoblot-ting. The features of CCTCC M206119 strain were identified based on morphology, biochemical profile, and 16S RNA sequencing.RESULTS： DSS-colitis animals treated with CCTCC M206119 had markedly more severe disease, with greater weight loss, diarrhea, fecal bleeding, and shortened colon length. In addition, the CCTCC-M206119- treated group had comparatively higher histologi- cal scores and more neutrophil infiltration than the controls. Expression of protective factors ZO-1 and β-defensin 2 was downregulated due to destruction of the mucosal barrier after CCTCC M206119 strain treatment. An in vitro assay demonstrated that CCTCC M206119 strain increased the nuclear translocation of nuclear factor-κB in epithelial cells. Intestinal proinflam- matory or anti-inflammatory cytokine responses were evaluated. Proinflammatory colonic cytokine （IL-Iβ, IL-6 and TNF-α） levels were clearly increased in CCTCC- M206119-treated animals, whereas anti-inflammatory colonic cytokine （IL-10） level was lowered compared with saline or 5-aminosalicylic-acid-treated DSS-colitis mice. Next, CCTCC M206119 strain was characterized as 1. crispatus by microscopic morphology, biochemical tests and 16S rRNA gene level.CONCLUSION： Not all lactobacilli are beneficial for in- testinal inflammation, and L. crispatus CCTCC M206119 strain is involved in exacerbation of intestinal inflamma- tion in DSS-colitis mice.展开更多
A redundant manipulator that can online clamp pipe was developed to track along a cylinder intersection curve. With an ultrasonic transducer mounted on its end-effector, the manipulator can perform welding seam inspec...A redundant manipulator that can online clamp pipe was developed to track along a cylinder intersection curve. With an ultrasonic transducer mounted on its end-effector, the manipulator can perform welding seam inspection at pipe joint in nuclear industry. An inverse kinematics solution expressed in joint space was solved based on the combination of geometric method and D-H matrix transformation. Expression about joints variables was obtained based on the scanning parameters of pipeline. The analysis method and results can be widely applied for online trajectory planning of intersection curve scanning manipulators.展开更多
A T-Q diagram based on entransy theory is applied to graphically and quantitatively describe the irreversibility of the heat transfer processes.The hot and cold composite curves can be obtained in the T-Q diagram.The ...A T-Q diagram based on entransy theory is applied to graphically and quantitatively describe the irreversibility of the heat transfer processes.The hot and cold composite curves can be obtained in the T-Q diagram.The entransy recovery and entransy dissipation that are affected by temperature differences can be obtained through the shaded area under the composite curves.The method for setting the energy target of the HENs in T-Q diagram based on entransy theory is proposed.A case study of the diesel oil hydrogenation unit is used to illustrate the application of the method.The results show that three different heat transfer temperature differences is 10 K,15 K and 20 K,and the entransy recovery is 5.498×10~7k W·K,5.377×10~7k W·K,5.257×10~7k W·K,respectively.And the entransy transfer efficiency is 92.29%,91.63%,90.99%.Thus,the energy-saving potential of the HENs is obtained by setting the energy target based on the entransy transfer efficiency.展开更多
The operation parameters （vibration, shaft displacement and pressure fluctuation） of No. 1 Francis reversible unit of Baoquan pumped-storage power station were measured on site in the no-load mode at net heads of 51...The operation parameters （vibration, shaft displacement and pressure fluctuation） of No. 1 Francis reversible unit of Baoquan pumped-storage power station were measured on site in the no-load mode at net heads of 518.04, 522.01 and 530.38 m, re- spectively. The rotational speed fluctuations in the no-load mode at three net heads were beyond synchronization requirement with obvious S-shaped characteristic, and misaligned guide vanes （MGV） had to be put into use for synchronization. Further analysis demonstrated that the rotating frequency signal was generally dominant in vibration and shaft displacement mixing signal in the no-load mode, while the frequency domain was wide without an obvious main frequency in pressure fluctuation mixing signal. Besides, the SSTκ-ω turbulence model was adopted to simulate the four quadrant characteristic curves of Baoquan model pump-turbine at three gate openings, and the relative error between simulation results and model test data was within ±6%, indicating that the simulation method in this paper is feasible and S-shaped characteristic of the pump-turbine can be simulated with CFD method.展开更多
We introduce two operator commutators by using different-degree loop algebras of the Lie algebra A1,then under the framework of zero curvature equations we generate two(2+1)-dimensional integrable hierarchies, includi...We introduce two operator commutators by using different-degree loop algebras of the Lie algebra A1,then under the framework of zero curvature equations we generate two(2+1)-dimensional integrable hierarchies, including the(2+1)-dimensional shallow water wave(SWW) hierarchy and the(2+1)-dimensional Kaup–Newell(KN)hierarchy. Through reduction of the(2+1)-dimensional hierarchies, we get a(2+1)-dimensional SWW equation and a(2+1)-dimensional KN equation. Furthermore, we obtain two Darboux transformations of the(2+1)-dimensional SWW equation. Similarly, the Darboux transformations of the(2+1)-dimensional KN equation could be deduced. Finally,with the help of the spatial spectral matrix of SWW hierarchy, we generate a(2+1) heat equation and a(2+1) nonlinear generalized SWW system containing inverse operators with respect to the variables x and y by using a reduction spectral problem from the self-dual Yang–Mills equations.展开更多
We have studied the reversal of magnetisation in Ising ferromagnet by the field having gradient along a particular direction. We employed the Monte Carlo simulation with Metropolis single spin nip algorithm. The avera...We have studied the reversal of magnetisation in Ising ferromagnet by the field having gradient along a particular direction. We employed the Monte Carlo simulation with Metropolis single spin nip algorithm. The average lifetime of the metastable state was observed to increase with the magnitude of the gradient of applied field. In the high gradient regime, the system was observed to show two distinct region of up and down spins. The interface or the domain wall was observed to move as one increases the gradient. The displacement of the mean position of the interface was observed to increase with the gradient as hyperbolic tangent function. The roughness of the interface was observed to decay exponentially as the gradient increases. The number of spin flip per site was observed to show a discontinuity in the vicinity of the domain wall. The amount of the discontinuity was found to diverge with the system size as a power law fashion with an exponent 5/3.展开更多
文摘AIM： TO investigate the role of Lactobacillus crispatus （L. crispatus） strain China Center for Type Culture Col- lection （CCTCC） M206119 in intestinal inflammation.METHODS： Forty 8-wk-old Balb/c mice （20± 2 g） were divided into four groups of 10 mice each. Three groups that had received dextran sulfate sodium （DSS） were administered normal saline, sulfasalazine or CCTCC M206119 strain, and the fourth group received none of these. We assessed the severity of colitis using a disease activity index, measured the colon length and weight, collected stools and mesenteric lymph nodes for bacterial microflora analysis. One centimeter of the proximal colon, middle colon and distal colon were collected and fixed in 10% buffered formalin, dehydrated in ethanol, and embedded in paraffin. Interleukin （IL）- 1β, IL-6 and tumor necrosis factor （TNF）-α expression was detected using reverse transcription polymerase chain reaction. Protective factors zonula occludens （ZO）-1 and β-defensin 2 were detected by immunoblot-ting. The features of CCTCC M206119 strain were identified based on morphology, biochemical profile, and 16S RNA sequencing.RESULTS： DSS-colitis animals treated with CCTCC M206119 had markedly more severe disease, with greater weight loss, diarrhea, fecal bleeding, and shortened colon length. In addition, the CCTCC-M206119- treated group had comparatively higher histologi- cal scores and more neutrophil infiltration than the controls. Expression of protective factors ZO-1 and β-defensin 2 was downregulated due to destruction of the mucosal barrier after CCTCC M206119 strain treatment. An in vitro assay demonstrated that CCTCC M206119 strain increased the nuclear translocation of nuclear factor-κB in epithelial cells. Intestinal proinflam- matory or anti-inflammatory cytokine responses were evaluated. Proinflammatory colonic cytokine （IL-Iβ, IL-6 and TNF-α） levels were clearly increased in CCTCC- M206119-treated animals, whereas anti-inflammatory colonic cytokine （IL-10） level was lowered compared with saline or 5-aminosalicylic-acid-treated DSS-colitis mice. Next, CCTCC M206119 strain was characterized as 1. crispatus by microscopic morphology, biochemical tests and 16S rRNA gene level.CONCLUSION： Not all lactobacilli are beneficial for in- testinal inflammation, and L. crispatus CCTCC M206119 strain is involved in exacerbation of intestinal inflamma- tion in DSS-colitis mice.
基金Foundation Program Conducted by Science&Technology Committee of National Defence ( T0 12 0 0 1A0 0 1)
文摘A redundant manipulator that can online clamp pipe was developed to track along a cylinder intersection curve. With an ultrasonic transducer mounted on its end-effector, the manipulator can perform welding seam inspection at pipe joint in nuclear industry. An inverse kinematics solution expressed in joint space was solved based on the combination of geometric method and D-H matrix transformation. Expression about joints variables was obtained based on the scanning parameters of pipeline. The analysis method and results can be widely applied for online trajectory planning of intersection curve scanning manipulators.
基金Supported by the National Natural Science Foundation of China(21406124)
文摘A T-Q diagram based on entransy theory is applied to graphically and quantitatively describe the irreversibility of the heat transfer processes.The hot and cold composite curves can be obtained in the T-Q diagram.The entransy recovery and entransy dissipation that are affected by temperature differences can be obtained through the shaded area under the composite curves.The method for setting the energy target of the HENs in T-Q diagram based on entransy theory is proposed.A case study of the diesel oil hydrogenation unit is used to illustrate the application of the method.The results show that three different heat transfer temperature differences is 10 K,15 K and 20 K,and the entransy recovery is 5.498×10~7k W·K,5.377×10~7k W·K,5.257×10~7k W·K,respectively.And the entransy transfer efficiency is 92.29%,91.63%,90.99%.Thus,the energy-saving potential of the HENs is obtained by setting the energy target based on the entransy transfer efficiency.
文摘The operation parameters （vibration, shaft displacement and pressure fluctuation） of No. 1 Francis reversible unit of Baoquan pumped-storage power station were measured on site in the no-load mode at net heads of 518.04, 522.01 and 530.38 m, re- spectively. The rotational speed fluctuations in the no-load mode at three net heads were beyond synchronization requirement with obvious S-shaped characteristic, and misaligned guide vanes （MGV） had to be put into use for synchronization. Further analysis demonstrated that the rotating frequency signal was generally dominant in vibration and shaft displacement mixing signal in the no-load mode, while the frequency domain was wide without an obvious main frequency in pressure fluctuation mixing signal. Besides, the SSTκ-ω turbulence model was adopted to simulate the four quadrant characteristic curves of Baoquan model pump-turbine at three gate openings, and the relative error between simulation results and model test data was within ±6%, indicating that the simulation method in this paper is feasible and S-shaped characteristic of the pump-turbine can be simulated with CFD method.
基金Supported by the National Natural Science Foundation of China under Grant No.11371361the Shandong Provincial Natural Science Foundation of China under Grant Nos.ZR2012AQ011,ZR2013AL016,ZR2015EM042+2 种基金National Social Science Foundation of China under Grant No.13BJY026the Development of Science and Technology Project under Grant No.2015NS1048A Project of Shandong Province Higher Educational Science and Technology Program under Grant No.J14LI58
文摘We introduce two operator commutators by using different-degree loop algebras of the Lie algebra A1,then under the framework of zero curvature equations we generate two(2+1)-dimensional integrable hierarchies, including the(2+1)-dimensional shallow water wave(SWW) hierarchy and the(2+1)-dimensional Kaup–Newell(KN)hierarchy. Through reduction of the(2+1)-dimensional hierarchies, we get a(2+1)-dimensional SWW equation and a(2+1)-dimensional KN equation. Furthermore, we obtain two Darboux transformations of the(2+1)-dimensional SWW equation. Similarly, the Darboux transformations of the(2+1)-dimensional KN equation could be deduced. Finally,with the help of the spatial spectral matrix of SWW hierarchy, we generate a(2+1) heat equation and a(2+1) nonlinear generalized SWW system containing inverse operators with respect to the variables x and y by using a reduction spectral problem from the self-dual Yang–Mills equations.
文摘We have studied the reversal of magnetisation in Ising ferromagnet by the field having gradient along a particular direction. We employed the Monte Carlo simulation with Metropolis single spin nip algorithm. The average lifetime of the metastable state was observed to increase with the magnitude of the gradient of applied field. In the high gradient regime, the system was observed to show two distinct region of up and down spins. The interface or the domain wall was observed to move as one increases the gradient. The displacement of the mean position of the interface was observed to increase with the gradient as hyperbolic tangent function. The roughness of the interface was observed to decay exponentially as the gradient increases. The number of spin flip per site was observed to show a discontinuity in the vicinity of the domain wall. The amount of the discontinuity was found to diverge with the system size as a power law fashion with an exponent 5/3.
