成人非对称性近屈曲部疹2例

报告2例成人非对称性近屈曲部疹。例1.女,21岁。2周前右大腿内侧近腹股沟处及腘窝出现红斑、丘疹。皮肤科检查:右大腿内侧和右腘窝见红斑、斑丘疹,皮损中心融合成片,10d后皮损自行消退。例2.女,28岁。因右胁部、胸部红斑及丘疹伴瘙痒4 d就诊。皮肤科检查:右侧胁部、胸腹部散在直径2～5 mm的红斑、丘疹。左侧躯干仅见零散分布互不融合的红斑、丘疹。2周后皮损自愈。2例患者均诊断为非对称性近屈曲部疹。

胡部即西凉乐考——兼论以西凉为中心的中西乐舞交融

中晚唐时期,教坊四部乐之一的胡部,实即西凉乐。其渊源主要为龟兹乐,后经南北朝时期的不断中国化,与以鼓乐为主的龟兹乐拉开了距离,逐渐形成了以管弦为主的演奏风格,并在太常、教坊皆有演奏。在太常演出者,自开元时起,因与道调、法曲合奏,三者逐渐融合,隶属“法曲部”;在教坊演出者,以西凉乐、大曲新声为主,名“胡部”。

曙光初露中西部

关丁如何缩小我国地区间发忣差距的问题,一直是党和政府十分关切的问题之一。中共中央在关于制定“九五”计划和2010年远景目标的建议中,用了较大篇幅强调逐步缩小地区发展差距、促进地区经济协调发展的重要性,并把促进中西部地区发展提到了战略高度。此举意味着我国中西部地区今后将获得更多的支持和帮助。

李渔小说创作的虚构意识

在清代白话短篇小说作家中,李渔无疑是佼佼者。创作实践姑置之勿论,仅仅就其在小说创作中渗透着明确的虚构意识这一点而言,就足以使人刮目相看了.这种明确的虚构意识体现在两个方面:一是力求突破题材的继承性,避免“事有所本”;二是力求突破真人真事的局限,追求远胜于“真境”的“幻境”。

Seismic performance of double-skin steel-concrete composite box piers: Part Ⅱ—Nonlinear finite element analysis

An accurate finite element （ FE） model was constructed to examine the hysteretic behavior of double-skin steel-concrete composite box （ DSCB） piers for further understanding the seismic performance of DSCB piers; where the local buckling behavior of steel tubes, the confinement of the in-filled concrete and the interface action between steel tube and in-filled concrete were considered. The accuracy of the proposed FE model was verified by the bidirectional cyclic loading test results. Based on the validated FE model, the effects of some key parameters, such as section width to steel thickness ratio, slenderness ratio, aspect ratio and axial load ratio on the hysteretic behavior of DSCB piers were investigated. Finally, the skeleton curve model of DSCB piers was proposed. The numerical simulation results reveal that the peak strength and elastic stiffness decrease with the increase of the section width to steel thickness ratio. Moreover, the increase of the slenderness ratio may result in a significant reduction in the peak strength and elastic stiffness while the ultimate displacement increases. The proposed skeleton curve model can be taken as a reference for seismic performance analyses of the DSCB piers.

Blow-up of Solution for a Nonlinear Hyperbolic Equation

In this paper, the existence and uniqueness of the local generalized solution of the initial boundary value problem for a nonlinear hyperbolic equation are proved by the contraction mapping principle and the sufficient conditions of blow_up of the solution in finite time are given.

Global buckling behavior of submarine unburied pipelines under thermal stress

Buckling of submarine pipelines under thermal stress is one of the most important problems to be considered in pipeline design. And pipeline with initial imperfections will easily undergo failure due to global buckling under thermal stress and internal pressure. Therefore, it is vitally important to study the global buckling of the submarine pipeline with initial imperfections. On the basis of the characteristics of the initial imperfections, the global lateral buckling of submarine pipelines was analyzed. Based on the deduced analytical solutions for the global lateral buckling, effects of temperature difference and properties of foundation soil on pipeline buckling were analyzed. The results show that the snap buckling is predominantly governed by the amplitude value of initial imperfection; the triggering temperature difference of Mode I for pipelines with initial imperfections is higher than that of Mode I1; a pipeline with a larger friction coefficient is safer than that with a smaller one; pipelines with larger initial imperfections are safer than those with smaller ones.

Posterior Selective Thoracic Fusion in Adolescent Idiopathic Scoliosis Patients:a Comparison of All Pedicle Screws versus Hybrid Instrumentation

Objective To analyze the influence of segmental pedicle screws versus hybrid instrumentation on the correction results in adolescent idiopathic scoliosis patients undergoing posterior selective thoracic fusion. Methods By reviewing the medical records and roentgenograms of adolescent idiopathic scoliosis patients who underwent selective thoracic fusion from February 2000 to January 2007 in our hospital, the patients were divided into 2 groups according to different instrumentation fashions： Group A was hook-screw-rod （hybrid） internal fixation type, Group B was screw-rod （all pedicle screws） internal fixation type, and the screws were used in every segment on the concave side of the thoracic curve. The parameters of the scoliosis were measured and the correction results were analyzed. Results Totally, 48 patients （7 males, 41 females） were included, with an average age of 14.4 years old and a mean follow-up time of 12.3 months. Thirty and 18 patients were assigned to group A and group B, respectively. The mean preoperative coronal Cobb angles of the thoracic curve were 48.8° and 47.4°, respectively. After surgery, they were corrected to 13.7° and 6.8°, respectively. At final follow-up, they were 17.0° and 9.5°, with an average correction rate of 64.6% and 79.0%, respectively, and the correction rate of group B was significantly higher than that of group A （P=0.003）. The mean preoperative coronal Cobb angles of the lumbar curve were 32.6° and 35.2°, respectively. After surgery, they were corrected to 8.6° and 8.3°, respectively. At final follow-up, they were 10.3° and 11.1°, with an average correction rate of 66.8% and 69.9%, respectively, and the correction rate of group B was significantly higher than that of group A （P=0.003）. The correction loss of the thoracic curve and lumbar curve in the 2 groups were 3.1° and 1.8°, 2.4° and 2.4°, respectively. No significant difference was noted （both P〉0.05）. The decompensation rate at final follow-up in these 2 groups were 4% （1/25） and 7.1% （1/14） respectively, with no significant difference （P〉0.05）.

An Efficient Approach to Pulmonary Vessels Extraction Based on Curve Evolution

Pulmonary vessels extraction is a challenging task in clinical medicine. Many pulmonary diseases are accompanied by the changes of vessel diameters. The vessels and their branches, which exhibit much variability, are most important in performing diagnosis and planning the follow-up therapies. In this paper, we propose an efficient approach to pulmonary vessels extraction based on the curve evolution. This approach models the vessels as monotonically marching front under the speed field integrating both the region and the edge information where a new region speed function is designed and integrated with the edge based speed function. Due to the region based speed term, the front could even propagate in small narrow vessel branches. To further improve the segmentation results, a multi-initial fast marching algorithm is developed to fast implement the numerical solution, which may avoid the monotonically marching front leaking out of the weak boundary too earlier and also reduce the computational cost. The validity of our approach is demonstrated by CT pulmonary vessels extraction. Experiments show that the segmentation results by our approach, especially on the narrow thin vessel branches extraction, are more precise than that of the existing method.

Mechanical model for controlling floor heave in deep roadways with U-shaped steel closed support

Open U-shaped steel arch supports are commonly used in large-section static-pressure roadways in coal mines that are more than 900 m deep;however,it is very difficult to control floor heave of roadways.In this paper,a U-shaped steel closed support with an inverted U-shaped steel arch in the floor is proposed as a method for improving the support effect of the surrounding rock during the process of floor heaving.This research established a mechanical model for the U-shaped steel closed support,and determined the reaction forces at the connection of a camber angle.Using the limit load method calculated the critical buckling load of the inverted U-shaped steel arch,and use of a strength check method tested the strength of the U-shaped steel material.A numerical simulation was conducted using the finite difference software FLAC3 D.The simulation results show that the U-shaped steel closed support is able to control the floor heave of roadways,which is successfully used in the West 11-2 development roadway of the Zhuji Mine in the Huainan mining area in China.The cumulative floor heave over two years was less than50 mm.

Serum type Ⅳ collagen level is predictive for esophageal varices in patients with severe alcoholic disease

AIM： To determine factors predictive for esophagea varices in severe alcoholic disease （SAD）. METHODS： Abdominal ultrasonography （US） was performed on 444 patients suffering from alcoholism. Forty-four patients found to have splenomegaly and/ or withering of the right liver lobe were defined as those with SAD. SAD patients were examined by upper gastrointestinal （UGI） endoscopy for the presence of esophageal varices. The existence of esophageal varices was then related to clinical variables. RESULTS： Twenty-five patients （56.8%） had esophageal varices. A univariate analysis revealed a significant difference in age and type Ⅳ collagen levels between patients with and without esophageal varices. A logistic regression analysis identified type Ⅳ collagen as the only independent variable predictive for esophageal varices （P = 0.017）. The area under the curve （AUC） for type Ⅳ collagen as determined by the receiver operating characteristic （ROC） for predicting esophageal varices was 0.78. CONCLUSION： This study suggests that the level of type Ⅳ collagen has a high diagnostic accuracy for the detection of esophageal varices in SAD.

Immuno-oncology combinations： raising the tail of the survival curve

There have been exponential gains in immuno-oncology in recent times through the development of immune checkpoint inhibitors. Already approved by the U.S. Food and Drug Administration for advanced melanoma and non-small cell lung cancer,immune checkpoint inhibitors also appears to have significant antitumor activity in multiple other tumor types. An exciting component of immunotherapy is the durability of antitumor responses observed, with some patients achieving disease control for many years. Nevertheless, not all patients benefit, and efforts should thus now focus on improving the efficacy of immunotherapy through the use of combination approaches and predictive biomarkers of response and resistance. There are multiple potential rational combinations using an immunotherapy backbone, including existing treatments such as radiotherapy, chemotherapy or molecularly targeted agents, as well as other immunotherapeutics. The aim of such antitumor strategies will be to raise the tail on the survival curve by increasing the number of long term survivors, while managing any additive or synergistic toxicities that may arise with immunotherapy combinations. Rational trial designs based on a clear understanding of tumor biology and drug pharmacology remain paramount. This article reviews the biology underpinning immuno-oncology, discusses existing and novel immunotherapeutic combinations currently in development, the challenges of predictive biomarkers of response and resistance and the impact of immuno-oncology on early phase clinical trial design.

COMPARISON OF PATIENT-CONTROLLED ANALGESIA WITH TRAMADOL VS MORPHINE IN PATIENTS UNDERGOING ABDOMINAL GYNECOLOGICAL SURGERY

Objective.To c ompare the analgesic efficacy and adverse effects of patient-controlled analges iawith tramadol and with morphine for postoperative middle or severe pain .Methods.Fifty-nine patients,scheduled for elective hysterectomy or hystero myomectomy ,were ran-domly divided into Group Tand Group M.The2drugs were administered intravenously v ia a patient-controlled analgesia device till24h postoperatively.Efficacy wa s assessed by comparing total pain reliefand the sum of pain intensity differencevalues over24h.Results.Statistically significant equival ence of tramadol and morphine was shown by TOTPAR values(15.9±4.4and1 6.4±3.5,respectively)and SPID values(9.2±4.7and9.0±2.0, respectively).Tramadol caused fewer adverse events than morphin e(16.7%and26.7%of patients,respectively).Conclusion.The analgesic efficacy of PCA with tramadol and with morphine were equivalent in the treatme nt of postoperative pain,and tramadol can cause slighter gastrointestinal adve rse effects.

Experimental Analysis on Local Buckling of GFRP?Foam Sandwich Pipe Under Axial Compressive Loading

To find out the local buckling behaviors of glass fiber reinforced plastic(GFRP)-foam sandwich pipe suffering axial loading,a series of quasi-static axial compression tests are carried out in the laboratory.Comparing with the test data,systematic numerical analysis on the local buckling behavior of this sandwich pipe is also conducted,and the buckling failure mechanism is revealed.The influences of the key parameters on bearing capacity of the sandwich structure are discussed.Test and numerical results show that the local buckling failure of the GFRPfoam sandwich pipe is dominated basically by two typical modes,i.e.,the conjoint buckling and the layered buckling.Local buckling at the end,shear failure at the end and interface peeling failure are less efficient than the local buckling failure at the middle height,and ought to be restrained by appropriate structural measures.The local buckling bearing capacity increases linearly with the core density of the sandwich pipe structure.When the core density is relatively high(higher than 0.05 g/cm3),the effect of increasing the core density on improving the bearing efficiency is less on the specimens with a large ratio of the wall thickness to the radius than on those with a small one.Local layered buckling is another failure mode with lower bearing efficiency than the local conjoint buckling,and it can be restrained by increasing the core density to ensure the cooperation of the inner and the outer GFRP surface layer.The bearing capacity of the GFRP-foam sandwich pipe increases with the height-diameter ratio;however,the bearing efficiency decreases with this parameter.

Linear Weingarten spacelike hypersurface in locally symmetric Lorentz space

The rigidity of spacelike hypersurface Mn immersed in locally symmetric space M1n+1 is investigated,where the(normalized)scalar curvature R and mean curvature H of Mn satisfy R=aH+b,and a,b are real constants.First,an estimate of the upper bound of the function L(nH)is given,where L is a second-order differential operator.Then,under the assumption that the square norm of the second fundamental form is bounded by a given positive constant,it is proved that Mn must be either totally umbilical or contain two distinct principle curvatures,one of which is simple.Moreover,a similar result is obtained for complete noncompact spacelike hypersurfaces in locally symmetric Einstein spacetime.Hence,some known rigidity results for hypersurface with constant scalar curvature are extended for the linear Weingarten case.

An Evaluation on the Effects of the Policy of the Great Campaign of Western Development of China in the First 10 Years Based on the Kuznets Regional Inverted-U Theory

In order to reduce the regional differentials or narrow the gap in economic development between eastern and western areas and prevent the intensification of contradictions resulting from the regional inequality during the development process, the government of China launched the Great Campaign of Western Development （GCWD） in 2000. In this paper, we will evaluate the effects of the first 10 years＇ GCWD and use the latest Chinese annual data from 1978 to 2010 to investigate the problem of regional differentials in the development process, evaluate the effects of GCWD policy and test whether there is a regional Kuznets inverted-U curve in the regional development of China. The result shows that there are both good and bad news： the good news is that the inverted U-shaped curve of absolute differential between eastern and western areas finally emerges （the previous studies showed that the inverted-U curve did not appear and the differentials between eastern and western areas became worse） and the bad news is that the differential is in the first half of the inverted U-shaped curve in our choice of time span （1978-2010）, that is, it is still in the situation of deterioration, and the turning better point will emerge in 2025. Although the western areas have benefitted from GCWD, the absolute gap has been still widened. To narrow the gap, the western areas should accelerate the industrial development and the government should adjust the policy and make more efforts to support the development of the industry in the western areas, especially cultivate and support the development of the western characteristic and advantageous industry rather than just supporting the construction of infrastructure in the western areas.

Bending tests and finite element analysis of lipped channels with complex edge stiffeners and web stiffeners

In order to study the bearing capacity and stability behavior of cold-formed steel flexural members with complicated sections,a total of 12 specimens divided into 6 groups were tested,including 3 groups of pure bending tests and non-pure bending tests each.There were three types of sections considered in this investigation,including channels with complex edge stiffeners(called B1-section),Σsection with complex edge stiffeners(called B2-section),and channels with complex edge stiffeners and V-type web stiffeners(called B3-section).Local buckling,distortional buckling and interaction buckling between them were observed in tests.The experimental results indicate that the bending strengths of B2-section specimens were the largest of these three types of specimens under the same conditions.It is found that the bending strength of B2-section specimens was increased by 6.47%for pure bending state and 8.12%for non-pure bending state,compared with that of B1-section specimens.Bending strength of B3-section specimens was almost the same with that of B1-section specimens under pure bending,but a little smaller than that of B1-section under non-pure bending state.It is also shown that B2-section specimens have better plastic deformation behavior than the other two sections.In addition,a non-linear finite element model was presented and verified against tests.The finite element analysis results agree well with experimental bending strength and failure modes.

A dipole wind curl pattern induced by Taiwan Island and its effect on upper stratification in the northeastern South China Sea

Using hydrographic data sampled during four successive late summer-early autumn cruises in 2004-2007, vertical stratification along transects in the lee of Taiwan Island was analyzed to investigate upper ocean responses to orographically induced dipole wind stress curl (WSC). Results indicate that mixed-layer depth (MLD) and its relationship with thermocline depth varied under different local wind forcings. Average MLD along the transects from the 2004 to 2007 cruises were 18.5,30.7,39.2 and 24.5m, respectively. The MLD along the transects deepened remarkably and resulted in thermocline ventilation in 2005 and 2006, whereas ventilation did not occur in 2004 and 2007. Estimates indicate that frictional wind speed was the major factor in MLD variations. To a large degree, the combined effects of frictional wind speed and Ekman pumping are responsible for the spatial pattern of MLD during the cruises.

Concealed fault analysis based on the CT projection matrix

This paper proposes the concept of projection curves based on the theory of CT image reconstruction to probe the internal structure of the working panel prior to formal mining of the working panel.As well as reducing costs,this method provides safe and efficient excavation of the working panel.According to the results of the numerical model and the actual working panel,the new method has been proven to be accurate in detecting the location of the fault that extends into the face.Concealed faults of the internal working panel,as well as the start and end points of the fault,can be detected by this method.Engineering practice has proven that the method is highly reliable,has a highly decisive impact on faults for coal mining,and can be used to guide the safe mining of the working panel.