The effect of cimetidine on the elimination of praziquantel(PQT)in rats was studied. The results showed that cimetidine 100 mg/kg,ip 2 reduced the clearances of intravenous and oral PQT by 60 and 69 percent respective...The effect of cimetidine on the elimination of praziquantel(PQT)in rats was studied. The results showed that cimetidine 100 mg/kg,ip 2 reduced the clearances of intravenous and oral PQT by 60 and 69 percent respectively.Cimetidine also markedly reduced liver blood flow of rats(a reduction of 58%)and inhibited PQT metabolism in hepatic microsomes of rats(an inhibition of 55%). The reduction in clearance of intravenous PQT could be attributed to the result of cimetidine lowering liver blood flow,whereas the reduction in clearance of oral PQT might be related mainly to the inhibition of cimetidine on the activity of hepatic drug-metabolizing enzymes.展开更多
The results of experimental works aimed on finding the optimal composition of concretes containing alternative materials as mineral additives for assurance their high resistance to chemical aggressive attack are prese...The results of experimental works aimed on finding the optimal composition of concretes containing alternative materials as mineral additives for assurance their high resistance to chemical aggressive attack are presented in the paper. 4 kinds of additives （blast furnace slag, fly ash, non-treated and treated serpentinite waste） and 4 kinds of aggressive environments （distilled water, HCI, MgSO4 and NaOH） representing the concrete corrosive processes was checked within experimental process. The open laboratory curing was used as a reference environment. Moreover, the amounts of additives were varied, so 16 various recipes were checked on the whole. The resistance of samples was tested in the terms of flexural strength, compressive strength and evaluation of decrease/increase of strengths after long time （28 months） exposition in monitored aggressive media. Based on obtained results, it is possible for each of aggressive environments recommend the most promising recipe from various points of view, in accordance with user＇s priorities. From the percentage increase of 28-day compressive strengths point of view, there are： for HCI action - recipe with 20% of non treated serpentinite waste with plasticizer application, for MgSO4 action - recipe with 20% of blast furnace slag without plasticizer application and for NaOH action - recipe with 10% of non treated serpentinite waste without plasticizer application. Application of alternative materials as partial substitution of cement appears to be beneficial for achievement the resistance to aggressive chemical actions. With the keeping or enhancement of technical parameters it extra represents both the environmental and economic benefit.展开更多
文摘The effect of cimetidine on the elimination of praziquantel(PQT)in rats was studied. The results showed that cimetidine 100 mg/kg,ip 2 reduced the clearances of intravenous and oral PQT by 60 and 69 percent respectively.Cimetidine also markedly reduced liver blood flow of rats(a reduction of 58%)and inhibited PQT metabolism in hepatic microsomes of rats(an inhibition of 55%). The reduction in clearance of intravenous PQT could be attributed to the result of cimetidine lowering liver blood flow,whereas the reduction in clearance of oral PQT might be related mainly to the inhibition of cimetidine on the activity of hepatic drug-metabolizing enzymes.
文摘The results of experimental works aimed on finding the optimal composition of concretes containing alternative materials as mineral additives for assurance their high resistance to chemical aggressive attack are presented in the paper. 4 kinds of additives （blast furnace slag, fly ash, non-treated and treated serpentinite waste） and 4 kinds of aggressive environments （distilled water, HCI, MgSO4 and NaOH） representing the concrete corrosive processes was checked within experimental process. The open laboratory curing was used as a reference environment. Moreover, the amounts of additives were varied, so 16 various recipes were checked on the whole. The resistance of samples was tested in the terms of flexural strength, compressive strength and evaluation of decrease/increase of strengths after long time （28 months） exposition in monitored aggressive media. Based on obtained results, it is possible for each of aggressive environments recommend the most promising recipe from various points of view, in accordance with user＇s priorities. From the percentage increase of 28-day compressive strengths point of view, there are： for HCI action - recipe with 20% of non treated serpentinite waste with plasticizer application, for MgSO4 action - recipe with 20% of blast furnace slag without plasticizer application and for NaOH action - recipe with 10% of non treated serpentinite waste without plasticizer application. Application of alternative materials as partial substitution of cement appears to be beneficial for achievement the resistance to aggressive chemical actions. With the keeping or enhancement of technical parameters it extra represents both the environmental and economic benefit.
