Objective: A series of 4-aryl substituted semicarbazones of levulinic acid (4-oxo pentanoic acid) was designed and synthesized to meet the structural requirements essential for anticonvulsant activity. Methods: All th...Objective: A series of 4-aryl substituted semicarbazones of levulinic acid (4-oxo pentanoic acid) was designed and synthesized to meet the structural requirements essential for anticonvulsant activity. Methods: All the compounds were evaluated for anticonvulsant activity. Anticonvulsant activity was determined after intraperitoneal (i.p.) administration to mice by maximal electroshock (MES) and subcutaneous metrazol (ScMet) induced seizure methods and minimal motor impairment was determined by rotorod test. Results: A majority of the compounds exhibited significant anticonvulsant activity after intraperitoneal administration. In the present study 4-(4'-fluoro phenyl) levulinic acid semicarbazone emerged as the most active molecule, showing broad spectrum of activity with low neurotoxicity. Unsubstituted levulinic acid semicarbazone was found to be inactive in all the screens. Conclusion: The results obtained validate the hypothesis that presence of an aryl group near the semicarbazone moiety is essential for anticonvulsant activity. The results also indicate that the hydrophilic-hydrophobic site can accommodate hydrophilic groups.展开更多
The QUENCH experimental programme at Karlsruhe under severe accident conditions, but while the geometry is still Institute of Technology investigates heat-up and reflooding of a core mainly rod-like. The recent QUENCH...The QUENCH experimental programme at Karlsruhe under severe accident conditions, but while the geometry is still Institute of Technology investigates heat-up and reflooding of a core mainly rod-like. The recent QUENCH-ACM series of experiments, comprising QUENCH-12 （El 10 cladding alloy）, -14 （M5 alloy） and -15 （Zirlo^TM alloy）, together with QUENCH-06 （reference case, Zircaloy-4 alloy） addressed the effect of alternative cladding materials on oxidation and quenching under similar conditions. Superficial inspection of the experimental results reveals only minor differences in the thermal and oxidation response, except for the much larger hydrogen release during reflood in QUENCH-12. Post-test calculations were performed using a version of SCDAP/RELAP5/MOD3.2, modified to represent the QUENCH facility and to invoke alternative oxidation correlations. The calculations agreed rather well with experiments QUENCH-06, -14 and -15, but the significant hydrogen release during reflood in QUENCH-12 was not captured. Closer examination of the experimental results reveals further differences between QUENCH-12 which may be linked to breakaway oxidation of the E110 cladding. The analyses support the heuristic observation that there was no major difference between the influence of Zircaloy-4, M5 or ZirloTM, but the E-110 exhibited a contrasting behaviour with a consequent impact on the reflooding.展开更多
The development of high-performance glucose sensors is an urgent need, especially for diabetes mellitus diagnosis. However, the glucose monitoring is conventionally operated in an invasive finger-prick manner and thei...The development of high-performance glucose sensors is an urgent need, especially for diabetes mellitus diagnosis. However, the glucose monitoring is conventionally operated in an invasive finger-prick manner and their noninvasive alternatives largely suffered from the relatively poor sensitivity, selectivity, and stability, resulted from the lack of robust and efficient catalysts. In this paper, we design a concave shaped nitrogen-doped carbon framework embellished with single Co site catalyst(Co SSC) by selectively controlling the etching rate on different facet of carbon substrate, which is beneficial to the diffusion and contact of analyte. The Co SSC prompts a significant improvement in the sensitivity of the solutiongated graphene transistor(SGGT) devices, with three orders of magnitude better than those of SGGT devices without catalysts. Our findings expand the field of single site catalyst in the application of biosensors, diabetes diagnostics and personalized health-care monitoring.展开更多
In this paper, the choice of the optimal parameters for a relaxation additive Schwarz alternating method in two subregions case is obtained by an algebraic method, which shows that the arithmetic average is the best. ...In this paper, the choice of the optimal parameters for a relaxation additive Schwarz alternating method in two subregions case is obtained by an algebraic method, which shows that the arithmetic average is the best. A counterexample illustrates that the same result is not true for many subregions case. In the last, this technique is applied to demonstrate some well known results ,, simply and intuitively.展开更多
文摘Objective: A series of 4-aryl substituted semicarbazones of levulinic acid (4-oxo pentanoic acid) was designed and synthesized to meet the structural requirements essential for anticonvulsant activity. Methods: All the compounds were evaluated for anticonvulsant activity. Anticonvulsant activity was determined after intraperitoneal (i.p.) administration to mice by maximal electroshock (MES) and subcutaneous metrazol (ScMet) induced seizure methods and minimal motor impairment was determined by rotorod test. Results: A majority of the compounds exhibited significant anticonvulsant activity after intraperitoneal administration. In the present study 4-(4'-fluoro phenyl) levulinic acid semicarbazone emerged as the most active molecule, showing broad spectrum of activity with low neurotoxicity. Unsubstituted levulinic acid semicarbazone was found to be inactive in all the screens. Conclusion: The results obtained validate the hypothesis that presence of an aryl group near the semicarbazone moiety is essential for anticonvulsant activity. The results also indicate that the hydrophilic-hydrophobic site can accommodate hydrophilic groups.
文摘The QUENCH experimental programme at Karlsruhe under severe accident conditions, but while the geometry is still Institute of Technology investigates heat-up and reflooding of a core mainly rod-like. The recent QUENCH-ACM series of experiments, comprising QUENCH-12 （El 10 cladding alloy）, -14 （M5 alloy） and -15 （Zirlo^TM alloy）, together with QUENCH-06 （reference case, Zircaloy-4 alloy） addressed the effect of alternative cladding materials on oxidation and quenching under similar conditions. Superficial inspection of the experimental results reveals only minor differences in the thermal and oxidation response, except for the much larger hydrogen release during reflood in QUENCH-12. Post-test calculations were performed using a version of SCDAP/RELAP5/MOD3.2, modified to represent the QUENCH facility and to invoke alternative oxidation correlations. The calculations agreed rather well with experiments QUENCH-06, -14 and -15, but the significant hydrogen release during reflood in QUENCH-12 was not captured. Closer examination of the experimental results reveals further differences between QUENCH-12 which may be linked to breakaway oxidation of the E110 cladding. The analyses support the heuristic observation that there was no major difference between the influence of Zircaloy-4, M5 or ZirloTM, but the E-110 exhibited a contrasting behaviour with a consequent impact on the reflooding.
基金supported by the Postdoctoral Science Foundation of China (2019M653052)the Fundamental Research Funds for the Central Universities (WK2060120002)+1 种基金the National Key R&D Program of China (2017YFA, 0208300)the National Natural Science Foundation of China (21671180)。
文摘The development of high-performance glucose sensors is an urgent need, especially for diabetes mellitus diagnosis. However, the glucose monitoring is conventionally operated in an invasive finger-prick manner and their noninvasive alternatives largely suffered from the relatively poor sensitivity, selectivity, and stability, resulted from the lack of robust and efficient catalysts. In this paper, we design a concave shaped nitrogen-doped carbon framework embellished with single Co site catalyst(Co SSC) by selectively controlling the etching rate on different facet of carbon substrate, which is beneficial to the diffusion and contact of analyte. The Co SSC prompts a significant improvement in the sensitivity of the solutiongated graphene transistor(SGGT) devices, with three orders of magnitude better than those of SGGT devices without catalysts. Our findings expand the field of single site catalyst in the application of biosensors, diabetes diagnostics and personalized health-care monitoring.
文摘In this paper, the choice of the optimal parameters for a relaxation additive Schwarz alternating method in two subregions case is obtained by an algebraic method, which shows that the arithmetic average is the best. A counterexample illustrates that the same result is not true for many subregions case. In the last, this technique is applied to demonstrate some well known results ,, simply and intuitively.
