We report the successful treatment of multiple lung metastases after hepatic resection for hepatocellular carcinoma (HCC) with combined docetaxel, cisplatin (CDDP), and enteric-coated tegafur/uracil (UFT-E). A 68-year...We report the successful treatment of multiple lung metastases after hepatic resection for hepatocellular carcinoma (HCC) with combined docetaxel, cisplatin (CDDP), and enteric-coated tegafur/uracil (UFT-E). A 68-year-old man was diagnosed with multiple lung metastases of HCC 7 mo after partial hepatectomy for HCC. Oral UFT-E was given daily and docetaxel and CDDP were given intra-arterially (administered just before the bronchial arteries) every 2 wk via a subcutaneous injection port. One month after starting chemotherapy, levels of tumor marker, protein induced by vitamin K absence(PIVKA--), decreased rapidly,and after a further month, chest X-ray and computed tomography revealed the complete disappearance of multiple liver metastases. Two years after the combined chemotherapy, HCC recurred in the liver and was treated but no pulmonary recurrence occurred. In the absence of a standardized highly effective therapy, this combined chemotherapy with docetaxel, CDDP and UFT-E may be an attractive option for multiple lung metastases of HCC.展开更多
As an oral chemotherapy prodrug,tegafur,can be converted to 5-fluorouracil,which is activated to kill tumor cells mainly by the inhibition of thymidylate synthase.In the present study,we synthesized 20 new tegafur der...As an oral chemotherapy prodrug,tegafur,can be converted to 5-fluorouracil,which is activated to kill tumor cells mainly by the inhibition of thymidylate synthase.In the present study,we synthesized 20 new tegafur derivatives containing amino acid ester groups by substitution,hydrolysis,and condensation.Their structures were confirmed by 1H NMR,13C NMR,and H RMS,and their inhibitory effects on tumor cell growth were studied.The results showed that some of the compounds had good anti-tumor activity.展开更多
Objective：To observe the anesthesia effect of ear acupuncture for in vitro fertilization-embryo transfer （IVF-ET） egg retrieval.Method：All of 160 IVF-ET cases were allocated into a treatment group （120 cases） an...Objective：To observe the anesthesia effect of ear acupuncture for in vitro fertilization-embryo transfer （IVF-ET） egg retrieval.Method：All of 160 IVF-ET cases were allocated into a treatment group （120 cases） and a control group （40 cases）.Ear acupuncture and Pethidine Hydrochloride （Dolantin） were employed respectively to alleviate pain.After that,the anesthesia effects in two groups were compared.Results：There were no significant differences in anesthesia effect and retrieved eggs between the treatment group and the control group （P〉0.05）.Conclusion：Ear acupuncture can obtain similar effects as Pethidine Hydrochloride;however,it is safer and more effective.展开更多
文摘We report the successful treatment of multiple lung metastases after hepatic resection for hepatocellular carcinoma (HCC) with combined docetaxel, cisplatin (CDDP), and enteric-coated tegafur/uracil (UFT-E). A 68-year-old man was diagnosed with multiple lung metastases of HCC 7 mo after partial hepatectomy for HCC. Oral UFT-E was given daily and docetaxel and CDDP were given intra-arterially (administered just before the bronchial arteries) every 2 wk via a subcutaneous injection port. One month after starting chemotherapy, levels of tumor marker, protein induced by vitamin K absence(PIVKA--), decreased rapidly,and after a further month, chest X-ray and computed tomography revealed the complete disappearance of multiple liver metastases. Two years after the combined chemotherapy, HCC recurred in the liver and was treated but no pulmonary recurrence occurred. In the absence of a standardized highly effective therapy, this combined chemotherapy with docetaxel, CDDP and UFT-E may be an attractive option for multiple lung metastases of HCC.
基金Science and Technology Program of Shandong Academy of Medical Sciences(Grant No.2016-5)National Innovation and Entrepreneurship Training Program for College Students(Grant No.201810427013)。
文摘As an oral chemotherapy prodrug,tegafur,can be converted to 5-fluorouracil,which is activated to kill tumor cells mainly by the inhibition of thymidylate synthase.In the present study,we synthesized 20 new tegafur derivatives containing amino acid ester groups by substitution,hydrolysis,and condensation.Their structures were confirmed by 1H NMR,13C NMR,and H RMS,and their inhibitory effects on tumor cell growth were studied.The results showed that some of the compounds had good anti-tumor activity.
文摘Objective：To observe the anesthesia effect of ear acupuncture for in vitro fertilization-embryo transfer （IVF-ET） egg retrieval.Method：All of 160 IVF-ET cases were allocated into a treatment group （120 cases） and a control group （40 cases）.Ear acupuncture and Pethidine Hydrochloride （Dolantin） were employed respectively to alleviate pain.After that,the anesthesia effects in two groups were compared.Results：There were no significant differences in anesthesia effect and retrieved eggs between the treatment group and the control group （P〉0.05）.Conclusion：Ear acupuncture can obtain similar effects as Pethidine Hydrochloride;however,it is safer and more effective.
