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Optimal Control for Age Distribution and Weighted Size Competitive Species in a Polluted Environment
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作者 WANG Zhanping 《应用数学》 北大核心 2024年第4期1014-1026,共13页
In the paper,we study an optimal control for a system representing a competitive species model with fertility and mortality depending on a weighted size in a polluted environment.A fixed point theorem is applied to ob... In the paper,we study an optimal control for a system representing a competitive species model with fertility and mortality depending on a weighted size in a polluted environment.A fixed point theorem is applied to obtain the existence and uniqueness exhibited by a non-negative solution of above mentioned model.A maximum principle helps to carefully verify the existence of the optimal control policy,and tangent-normal cone techniques help to obtain the optimal condition specific to control issue. 展开更多
关键词 Optimal control Competitive species POLLUTION Maximum principle
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Synergistic effect of pinellia total alkaloids and uncaria total alkaloids on anticonvulsant action in mice and rats 被引量:11
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作者 成银霞 王明正 +5 位作者 陈靖京 杨蓉 何欣嘏 马永刚 杨李华 张明升 《Journal of Chinese Pharmaceutical Sciences》 CAS 2007年第2期139-145,共7页
Aim To investigate the synergistic effect of the combination of pinellia total alkaloid (PTA) and uncaria total alkaloid (UTA), and explore the mechanism of anticonvulsant action. Methods Anticonvulsant and toxic ... Aim To investigate the synergistic effect of the combination of pinellia total alkaloid (PTA) and uncaria total alkaloid (UTA), and explore the mechanism of anticonvulsant action. Methods Anticonvulsant and toxic effect profiles of combinations of PTA with UTA, alone and at three fixed ratios of 1:4, 1 :1, 4:1, were evaluated in maximal electroshock (MES)-induced seizures and acute toxicity test in mice. Respective ED50 and LD50 were calculated with Bliss's method. Their synergistic effect were evaluated by isobolographic analysis and allowed the determination of benefit indices (BI) for respective combinations. The model of convulsive rats kindled by penicillin topically injected into cortex was used to investigated the content of Glu, Asp, Gly and GABA in hippocampus using high performance liquid chromatography (HPLC). Results Combinations of PTA and UTA at the ratio of 4:1 were synergistic in MES test and antagonistic in acute toxicity test, showing the best profile for combinations of PTA with UTA. In contrast, the ratios of 1 :4 and 1 : 1, despite synergistic in MES test, were additive in acute toxicity test. The 4:1 combination and two drugs alone significantly decreased Glu level and increased GABA level in the hippocampus, but the GABA level in the 4:1 combination group was higher than that in the two drugs alone groups. They did not have significant influence on the levels of ASp and Gly. Conclusion Combinations of PTA and UTA at 4:1 ratio demonstrated synergistic effect in anticonvulsant action and antagonistic effect in toxicity. The anticonvulsant mechanism might be related to decreasing the excitability of Glutamatergic neurons and increasing the inhibition of GABAergic neurons. 展开更多
关键词 Pinellia total alkaloids Uncaria total alkaloids Synergistic effect Anticonvulsant action Isobolographic analysis Maximal electroshock Penicillin kindling NEUROTRANSMITTERS
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Effects of parameters of asphalt concrete surfacing on mechanical property of paving layer 被引量:6
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作者 钱振东 黄卫 《Journal of Southeast University(English Edition)》 EI CAS 2003年第1期79-82,共4页
The important parameters that influence the mechanical property of the pavinglayer on an orthotropic steel bridge deck are the paving layer thickness and modulus of the asphaltconcrete surfacing. Three important indic... The important parameters that influence the mechanical property of the pavinglayer on an orthotropic steel bridge deck are the paving layer thickness and modulus of the asphaltconcrete surfacing. Three important indices that control the typical failures of the paving layerare the maximum tensile stress of paving layer, the maximum shear stress between the steel deck andthe paving layer, and the maximum deflection on the paving surface. In this paper, the analyticalmodel of paving systems on orthotropic steel bridge deck is established, and the finite elementmethod is adopted to study the stress and strain of paving system. With the variation of asphaltconcrete modulus in high or low temperature season, the influences of paving layer thickness onthree control indices are researched. The results provide a theoretical basis for the determinationof thickness of the paving layer on the steel bridge deck. 展开更多
关键词 paving layer othotropic steel deck stress strain surface deflection finite element
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Development of the artificial seabed technology and implementation pretrial well in the South China Sea 被引量:3
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作者 郭永峰 纪少君 唐长全 《Journal of Marine Science and Application》 2009年第3期246-251,共6页
This paper introduces the recent highly significant activity of China Oilfield Services Ltd. (COSL) in the South China Sea, where COSL conducted pretrial drilling in June of 2008. The paper discusses some key resear... This paper introduces the recent highly significant activity of China Oilfield Services Ltd. (COSL) in the South China Sea, where COSL conducted pretrial drilling in June of 2008. The paper discusses some key research and new practices which led to the fabrication of related equipment which was evaluated in the trial. The market for deepwater drilling in the world has grown over the past 10 years but there are few drilling vessels or platforms suitable for drilling in deepwater or super deepwater. China needs equipment capable of deepwater drilling operations. COSL has some semisubmersible platforms, but they are only considered suitable for operations in water depths less than 475 m. An enabling technology, referred to as an artificial seabed, has been under development by COSL since 2004, and it applies the research results and experiences of many experts in deepwater drilling. COSL hopes this technology will allow drilling to depths of approximately 1 000-1 500m with its current platforms. The paper presents research progress and improvements in fabrication and necessary upgrades to equipment for extending deepwater drilling. The pretrial well was executed at a water depth of nearly 500m. COSL will drill the trial well around 2009 at the same location in the South China Sea. 展开更多
关键词 deep water artificial buoyancy seabed model test maximum loading forces pretrial well
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AUTOMATIC MULTILEVEL THRESHOLDING METHOD BASED ON MAXIMUM ENTROPY 被引量:2
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作者 曹力 史忠科 郑家伟 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2005年第4期335-338,共4页
In the multilevel thresholding segmentation of the image, the classification number is always given by the supervisor. To solve this problem, a fast multilevel thresholding algorithm considering both the threshold val... In the multilevel thresholding segmentation of the image, the classification number is always given by the supervisor. To solve this problem, a fast multilevel thresholding algorithm considering both the threshold value and the classification number is proposed based on the maximum entropy, and the self-adaptive criterion of the classification number is given. The algorithm can obtain thresholds and automatically decide the classification number. Experimental results show that the algorithm is effective. 展开更多
关键词 multilevel thresholding maximum entropy classification number nonparametric method
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Formability determination of AZ31B tube for IHPF process at elevated temperature 被引量:2
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作者 林艳丽 何祝斌 +1 位作者 苑世剑 吴佳 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2011年第4期851-856,共6页
Ring hoop tension test and tube bulging test were carried out at elevated temperatures up to 480 ℃to evaluate the formability of AZ31B extruded tube for internal high pressure forming (IHPF) process. The total elon... Ring hoop tension test and tube bulging test were carried out at elevated temperatures up to 480 ℃to evaluate the formability of AZ31B extruded tube for internal high pressure forming (IHPF) process. The total elongation along hoop direction and the maximum expansion ratio (MER) of the tube were obtained. The fracture surface after bursting was also analyzed. The results show that the total elongation along hoop direction and the MER value have a similar changing tendency as the testing temperature increases, which is quite different from the total elongation along axial direction. Both the total elongation along hoop direction and the MER value increase to a peak value at about 160 ℃. After that, they begin to decrease quickly until a certain rebounding temperature is reached. From the rebounding temperature, they begin to increase rapidly again. Burnt structure appears on the fracture surface when tested at temperatures higher than 420 ℃. Therefore, the forming temperature of the tested tube should be lower than 420 ℃, even though bigger formability can be achieved at higher temperature. 展开更多
关键词 AZ31B tube FORMABILITY HYDROFORMING tube bulging test maximum expansion ratio
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Accelerating SAGE algorithm in PET image reconstruction by rescaled block-iterative method 被引量:1
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作者 朱宏擎 舒华忠 +1 位作者 周健 罗立民 《Journal of Southeast University(English Edition)》 EI CAS 2005年第2期207-210,共4页
A new method to accelerate the convergent rate of the space-alternatinggeneralized expectation-maximization (SAGE) algorithm is proposed. The new rescaled block-iterativeSAGE (RBI-SAGE) algorithm combines the RBI algo... A new method to accelerate the convergent rate of the space-alternatinggeneralized expectation-maximization (SAGE) algorithm is proposed. The new rescaled block-iterativeSAGE (RBI-SAGE) algorithm combines the RBI algorithm with the SAGE algorithm for PET imagereconstruction. In the new approach, the projection data is partitioned into disjoint blocks; eachiteration step involves only one of these blocks. SAGE updates the parameters sequentially in eachblock. In experiments, the RBI-SAGE algorithm and classical SAGE algorithm are compared in theapplication on positron emission tomography (PET) image reconstruction. Simulation results show thatRBI-SAGE has better performance than SAGE in both convergence and image quality. 展开更多
关键词 positron emission tomography space-alternating generalizedexpectation-maximization image reconstruction rescaled block-iterative maximum likelihood
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Using a linear array to estimate the velocity of underwater moving targets 被引量:2
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作者 严光洪 陈志菲 孙进才 《Journal of Marine Science and Application》 2009年第4期343-347,共5页
A new method uses a linear array that takes advantage of underwater physical sound fields to estimate the velocity of an underwater moving target. The mathematical model was established by considering the geometric re... A new method uses a linear array that takes advantage of underwater physical sound fields to estimate the velocity of an underwater moving target. The mathematical model was established by considering the geometric relationship between the moving target installed with only two transducers to radiate sound of different frequencies and the linear array. In addition, deterministic maximum likelihood and signal phase matching algorithms were introduced to effectively find the directions of arrival (DOAs) of the sound sources of the two transducers installed on the target. Factors causing velocity measurement errors were considered. To track the target, a linear array with a compass, a pressure transducer, a signal conditioner and a digital recorder was configured. Relevant requirements for the array parameters were derived. The simulation showed that a 16-element array with an aperture of less than lm can measure velocity with relative error of no more', than 4% when including typical system errors. Anechoic pool and reservoir experiments confirmed these results. 展开更多
关键词 underwater velocity measurement linear array direction of arrival (DOA) deterministicmaximum likelihood signal phase matching
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Novel operating theatre scheduling method based on estimation of distribution algorithm 被引量:3
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作者 周炳海 殷萌 《Journal of Southeast University(English Edition)》 EI CAS 2016年第1期112-118,共7页
In order to improve the efficiency of operating rooms,reduce the costs for hospitals and improve the level of service qualities, a scheduling method was developed based on an estimation of distribution algorithm( EDA... In order to improve the efficiency of operating rooms,reduce the costs for hospitals and improve the level of service qualities, a scheduling method was developed based on an estimation of distribution algorithm( EDA). First, a scheduling problem domain is described. Based on assignment constraints and resource capacity constraints, the mathematical programming models are set up with an objective function to minimize the system makespan. On the basis of the descriptions mentioned above, a solution policy of generating feasible scheduling solutions is established. Combined with the specific constraints of operating theatres, the EDA-based algorithm is put forward to solve scheduling problems. Finally, simulation experiments are designed to evaluate the scheduling method. The orthogonal table is chosen to determine the parameters in the proposed method. Then the genetic algorithm and the particle swarm optimization algorithm are chosen for comparison with the EDA-based algorithm, and the results indicate that the proposed method can decrease the makespan of the surgical system regardless of the size of operations. Moreover, the computation time of the EDA-based algorithm is only approximately 5 s when solving the large scale problems, which means that the proposed algorithm is suitable for carrying out an on-line scheduling optimization of the patients. 展开更多
关键词 operating theatre scheduling estimation of distribution algorithm MAKESPAN
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EFFECTIVE IMAGE SEGMENTATION FRAMEWORK FOR GAUSSIAN MIXTURE MODEL INCORPORATING LOCAL INFORMATION 被引量:3
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作者 蔡维玲 丁军娣 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2008年第4期266-274,共9页
A new two-step framework is proposed for image segmentation. In the first step, the gray-value distribution of the given image is reshaped to have larger inter-class variance and less intra-class variance. In the sec-... A new two-step framework is proposed for image segmentation. In the first step, the gray-value distribution of the given image is reshaped to have larger inter-class variance and less intra-class variance. In the sec- ond step, the discriminant-based methods or clustering-based methods are performed on the reformed distribution. It is focused on the typical clustering methods-Gaussian mixture model (GMM) and its variant to demonstrate the feasibility of the framework. Due to the independence of the first step in its second step, it can be integrated into the pixel-based and the histogram-based methods to improve their segmentation quality. The experiments on artificial and real images show that the framework can achieve effective and robust segmentation results. 展开更多
关键词 pattern recognition image processing image segmentation Gaussian mixture model (GMM) expectation maximization (EM)
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Solar Energy Resource Characteristics of Photovoltaic Power Station in Shandong Province 被引量:2
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作者 薛德强 王新 王新堂 《Agricultural Science & Technology》 CAS 2013年第4期666-671,共6页
[Objective] The aim was to analyze characters of solar energy in photo- voltaic power stations in Shandong Province. [Method] The models of total solar radiation and scattered radiation were determined, and solar ener... [Objective] The aim was to analyze characters of solar energy in photo- voltaic power stations in Shandong Province. [Method] The models of total solar radiation and scattered radiation were determined, and solar energy resources in pho-tovoltaic power stations were evaluated based on illumination in horizontal plane and cloud data in 123 counties or cities and observed information in Jinan, Fushan and Juxian in 1988-2008. [Result] Solar energy in northern regions in Shandong proved most abundant, which is suitable for photovoltaic power generation; the optimal angle of tilt of photovoltaic array was at 35°, decreasing by 2°-3° compared with local latitude. Total solar radiation received by the slope with optimal angle of tilt exceeded 1 600 kw.h/(m2.a), increasing by 16% compared with horizontal planes. The maximal irradiance concluded by WRF in different regions tended to be volatile in 1 020-1 060 W/m2. [Conclusion] The research provides references for construction of photovoltaic power stations in Shandong Province. 展开更多
关键词 Shandong Province Solar energy resource Photovoltaic power stations Optimum tilt angle WRF(weather research and forecasting model) Maximal daily irradiance
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In_(0.53)Ga_(0.47)As/In_(0.52)Al_(0.48)As HEMTs with f_(max) of 183GHz 被引量:1
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作者 刘亮 张海英 +7 位作者 尹军舰 李潇 杨浩 徐静波 宋雨竹 张健 牛洁斌 刘训春 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2007年第12期1860-1863,共4页
By epitaxial layer structure design and key fabrication process optimization,a lattice-matched InP-based In0.53Ga0.47 As-In0.52Al0.48As HEMT with an ultra high maximum oscillation frequency (fmax) of 183GHz was fab-... By epitaxial layer structure design and key fabrication process optimization,a lattice-matched InP-based In0.53Ga0.47 As-In0.52Al0.48As HEMT with an ultra high maximum oscillation frequency (fmax) of 183GHz was fab- ricated. The fmax is the highest value for HEMTs in China. Also, the devices are reported, including the device structure, the fabrication process, and the DC and RF performances. 展开更多
关键词 maximum oscillation frequency/power-gain cutoff frequency high electron mobility transistor InGaAs/InAIAs INP
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A min-max optimization approach for weight determination in analytic hierarchy process 被引量:10
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作者 孙璐 《Journal of Southeast University(English Edition)》 EI CAS 2012年第2期245-250,共6页
A min-max optimization method is proposed as a new approach to deal with the weight determination problem in the context of the analytic hierarchy process. The priority is obtained through minimizing the maximal absol... A min-max optimization method is proposed as a new approach to deal with the weight determination problem in the context of the analytic hierarchy process. The priority is obtained through minimizing the maximal absolute difference between the weight vector obtained from each column and the ideal weight vector. By transformation, the. constrained min- max optimization problem is converted to a linear programming problem, which can be solved using either the simplex method or the interior method. The Karush-Kuhn- Tucker condition is also analytically provided. These control thresholds provide a straightforward indication of inconsistency of the pairwise comparison matrix. Numerical computations for several case studies are conducted to compare the performance of the proposed method with three existing methods. This observation illustrates that the min-max method controls maximum deviation and gives more weight to non- dominate factors. 展开更多
关键词 analytic hierarchy process rain-max optimization WEIGHT linear programming
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Application of Maximum Probability Approach to the Fault Diagnosis of a Servo System 被引量:3
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作者 马东升 胡佑德 戴凤智 《Journal of Beijing Institute of Technology》 EI CAS 2002年第1期29-32,共4页
In an actual control system, it is often difficult to find out where the faults are if only based on the outside fault phenomena, acquired frequently from a fault system. So the fault diagnosis by outside fault phenom... In an actual control system, it is often difficult to find out where the faults are if only based on the outside fault phenomena, acquired frequently from a fault system. So the fault diagnosis by outside fault phenomena is considered. Based on the theory of fuzzy recognition and fault diagnosis, this method only depends on experience and statistical data to set up fuzzy query relationship between the outside phenomena (fault characters) and the fault sources (fault patterns). From this relationship the most probable fault sources can be obtained, to attain the goal of quick diagnosis. Based on the above approach, the standard fuzzy relationship matrix is stored in the computer as a system database. And experiment data are given to show the fault diagnosis results. The important parameters can be on line sampled and analyzed, and when faults occur, faults can be found, the alarm is given and the controller output is regulated. 展开更多
关键词 maximum probability approach fault diagnosis fault tree servo system
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Propulsive performance and flow field characteristics of a 2-D flexible fin with variations in the location of its pitching axis 被引量:1
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作者 王志东 丛文超 张晓庆 《Journal of Marine Science and Application》 2009年第4期298-304,共7页
The thrust coefficients and propulsive efficiency of a two-dimensional flexible fin with heaving and pitching motion were computed using FLUENT. The effect of different locations of the pitching axis on propulsive per... The thrust coefficients and propulsive efficiency of a two-dimensional flexible fin with heaving and pitching motion were computed using FLUENT. The effect of different locations of the pitching axis on propulsive performance was examined using three deflexion modes which are respectively, modified Bose mode, cantilever beam with uniformly distributed load and cantilever beam with non-uniformly distributed load. The results show that maximum thrust can be achieved with the pitching axis at the trailing edge, but the highest propulsive efficiency can be achieved with the pitching axis either 1/3 of the chord length from the leading edge in modified Bose mode, or 2/3 of the chord length from the leading edge in cantilever beam mode. At the same time, the effects of the Strouhal number and maximal attack angle on the hydrodynamics performance of the flexible fin were analyzed. Parameter interval of the maximum thrust coefficient and the highest propulsive efficiency were gained. If the Strouhal number is low, high propulsive efficiency can be achieved at low αmax , and vice versa. 展开更多
关键词 flexible fin pitching axis Strouhal number maximal attack angle propulsive performance
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OFDM blind channel estimation based on polynomial models 被引量:1
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作者 方承志 都思丹 薛卫 《Journal of Southeast University(English Edition)》 EI CAS 2007年第2期162-167,共6页
A two-dimensional (2-D) polynomial regression model is set up to approximate the time-frequency response of slowly time-varying orthogonal frequency-division multiplexing (OFDM) systems. With this model the estima... A two-dimensional (2-D) polynomial regression model is set up to approximate the time-frequency response of slowly time-varying orthogonal frequency-division multiplexing (OFDM) systems. With this model the estimation of the OFDM time-frequency response is turned into the optimization of some time-invariant model parameters. A new algorithm based on the expectation-maximization (EM) method is proposed to obtain the maximum-likelihood (ML) estimation of the polynomial model parameters over the 2-D observed data. At the same time, in order to reduce the complexity and avoid the computation instability, a novel recursive approach (RPEMTO) is given to calculate the values of the parameters. It is further shown that this 2-D polynomial EM-based algorithm for time-varying OFDM (PEMTO) can be simplified mathematically to handle the one-dimensional sequential estimation. Simulations illustrate that the proposed algorithms achieve a lower bit error rate (BER) than other blind algorithms. 展开更多
关键词 orthogonal frequency-division multiplexing EXPECTATION-MAXIMIZATION polynomial model RECURSIVE
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Effects of Climatic Factors on Tree-ring Maximum Latewood Density of Picea schrenkiana in Xinjiang, China 被引量:1
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作者 孙宇 王丽丽 尹红 《Agricultural Science & Technology》 CAS 2016年第6期1479-1487,共9页
Based on two tree-ring maximum latewood density (MXD) chronologies of Picea schrenkiana from the Manas River Basin, Xinjiang, the response characteristics of MXD to climate variation was discussed. Correlation analy... Based on two tree-ring maximum latewood density (MXD) chronologies of Picea schrenkiana from the Manas River Basin, Xinjiang, the response characteristics of MXD to climate variation was discussed. Correlation analysis between MXD chronologies and instrumental records from Shihezi meteorological station showed that each chronology was significantly and positively correlated with the maximum monthly average temperature in July-August, and especially, the regional chronology (RC) was the most highly correlated variable (r=0.54, P〈0.001). Afterwards, the maximum average temperature in July-August was reconstructed using RC. Comparison among reconstructed temperature, observed values, and the drought index (Is) confirmed that precipitation would affect MXD when the absolute value of Is is greater than 1.5σ (|Is| 〉 2.5 during 1953-2008) or near to 1.5a over a 2-3 year period. The response characteristics are related to the semiarid climate of the study area. In dry years, lack of precipitation would limit the thickening of latewood cell walls and, as a result, impact MXD. Therefore, compared with relatively humid regions, the response of tree-ring MXD to air temperature similarly would be influenced by extreme moisture conditions in semiarid areas, and MXD, as a temperature proxy, should be used prudently on a limited scale. 展开更多
关键词 Picea schrenkiana Tree ring Maximum latewood density Air temperature PRECIPITATION
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Gaussian mixture model clustering with completed likelihood minimum message length criterion 被引量:1
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作者 曾洪 卢伟 宋爱国 《Journal of Southeast University(English Edition)》 EI CAS 2013年第1期43-47,共5页
An improved Gaussian mixture model (GMM)- based clustering method is proposed for the difficult case where the true distribution of data is against the assumed GMM. First, an improved model selection criterion, the ... An improved Gaussian mixture model (GMM)- based clustering method is proposed for the difficult case where the true distribution of data is against the assumed GMM. First, an improved model selection criterion, the completed likelihood minimum message length criterion, is derived. It can measure both the goodness-of-fit of the candidate GMM to the data and the goodness-of-partition of the data. Secondly, by utilizing the proposed criterion as the clustering objective function, an improved expectation- maximization (EM) algorithm is developed, which can avoid poor local optimal solutions compared to the standard EM algorithm for estimating the model parameters. The experimental results demonstrate that the proposed method can rectify the over-fitting tendency of representative GMM-based clustering approaches and can robustly provide more accurate clustering results. 展开更多
关键词 Gaussian mixture model non-Gaussian distribution model selection expectation-maximization algorithm completed likelihood minimum message length criterion
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Lower bound on BER performance for maximal ratio combining with weighting errors 被引量:1
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作者 盛彬 尤肖虎 《Journal of Southeast University(English Edition)》 EI CAS 2005年第4期379-384,共6页
The theoretical lower bounds on mean squared channel estimation errors for typical fading channels are presented by the infinite-length and non-causal Wiener filter and the exact closed-form expressions of the lower b... The theoretical lower bounds on mean squared channel estimation errors for typical fading channels are presented by the infinite-length and non-causal Wiener filter and the exact closed-form expressions of the lower bounds for different channel Doppler spectra are derived. Based on the obtained lower bounds on mean squared channel estimation errors, the limits on bit error rate (BER) for maximal ratio combining (MRC) with Gaussian distributed weighting errors on independent and identically distributed (i. i. d) fading channels are presented. Numerical results show that the BER performances of ideal MRC are the lower bounds on the BER performances of non-ideal MRC and deteriorate as the maximum Doppler frequency increases or the SNR of channel estimate decreases. 展开更多
关键词 lower bound bit error rate minimum mean-square error channel estimation maximal ratio combining
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Acute Toxicity Test of Chinese Herbal Compound Tongmai Tangyanming Capsule 被引量:1
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作者 周训蓉 李平 屈相玲 《Agricultural Science & Technology》 CAS 2016年第10期2332-2333,2433,共3页
[Objective] This study was conducted to determine the safe dose of Tongmai Tangyanming capsule in clinic by evaluating its acute toxicity, so as to ensure clinical medication safety. [Method] The test was designed acc... [Objective] This study was conducted to determine the safe dose of Tongmai Tangyanming capsule in clinic by evaluating its acute toxicity, so as to ensure clinical medication safety. [Method] The test was designed according to "Technique Requirements of Research of New Chinese Medicine" and "Guide for Research of New Chinese Medicine", mice were intragastrically administrated with Tongmai Tangyanming capsule at a maximum concentration and a maximum volume, and the acute toxic response of mice was observed, so as to determine medi- na lethal dose (LDso) and maximum administration dosage of Tongmai Tangyanming capsule. [Result] The LD^o could not be detected in the test, and the maximum administration dosage of mouse was calculated to be 112.104 g of dried herbs/(kg.d), equivalent to 260 times of clinical dose of adult. [Conclusion] Chinese herbal compound Tongmai Tangyanming capsule has low acute toxicity, and its clinical dose is safe and reliable. 展开更多
关键词 Tongmai Tangyanming capsule Acute toxicity test Median lethal dose Maximum administration dosage
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