The removal of antibiotics from water by clay minerals has become the focus of research due to their strong adsorptive ability. In this study, adsorption of chlortetracycline (CTC) onto rectories was conducted and the...The removal of antibiotics from water by clay minerals has become the focus of research due to their strong adsorptive ability. In this study, adsorption of chlortetracycline (CTC) onto rectories was conducted and the effects of time, concentration, temperature and pH were investigated. Experimental results showed that adsorption equilibrium was reached in 8 h. Based on the Langmuir model, the maximum adsorption capacity of CTC on rectories was 177.7 mg·g 1 at room temperature. By the study on adsorption dynamics, it is found that the kinetic date fit the pseudo-second-order model well. The adsorption of CTC by rectories is endothermic and the free energy is in the range of 10 to 30 kJ·mol 1 . The pH value of solution has significant effects on adsorption and the optimal pH is at acidity (pH 2-6). At concentration of 2500 mg·L 1 , the intercalated CTC produces an interlayer space with a height of 1.38 nm, which is 1.12 nm in raw rectories, suggesting that the adsorption occurs between layers of rectories.展开更多
For measurement of component content in the extraction and separation process of praseodymium/neodymium(Pr/Nd), a soft measurement method was proposed based on modeling of ion color features, which is suitable for fas...For measurement of component content in the extraction and separation process of praseodymium/neodymium(Pr/Nd), a soft measurement method was proposed based on modeling of ion color features, which is suitable for fast estimation of component content in production field. Feature analysis on images of the solution is conducted,which are captured from Pr/Nd extraction/separation field. H/S components in the HSI color space are selected as model inputs, so as to establish the least squares support vector machine(LSSVM) model for Nd(Pr) content,while the model parameters are determined with the GA algorithm. To improve the adaptability of the model,the adaptive iteration algorithm is used to correct parameters of the LSSVM model, on the basis of model correction strategy and new sample data. Using the field data collected from rare earth extraction production, predictive methods for component content and comparisons are given. The results indicate that the proposed method presents good adaptability and high prediction precision, so it is applicable to the fast detection of element content in the rare earth extraction.展开更多
Given that randomized studies testing the long-term impact of antithymocyte globulin(ATG)dosing are scarce,we report the results of an extended follow-up from the original trial.In our prospective,multicenter,randomiz...Given that randomized studies testing the long-term impact of antithymocyte globulin(ATG)dosing are scarce,we report the results of an extended follow-up from the original trial.In our prospective,multicenter,randomized trial,408 leukemia patients 14–65 years of age who underwent haploidentical hematopoietic cell transplantation(haplo-HCT)under our original“Beijing Protocol”were randomly assigned one-to-one to ATG doses of 7.5 mg/kg(n=203,ATG-7.5)or 10 mg/kg(n=205,ATG-10.0)at four sites.Extended follow-up(median 1968 d(range:1300–2710 d)indicated comparable 5-year probabilities of moderate-to-severe chronic graft-versus-host disease(GVHD)(hazard ratio(HR):1.384,95%confidence interval(CI):0.876–2.189,P=0.164),nonrelapse mortality(HR:0.814,95%CI:0.526–1.261,P=0.357),relapse(HR:1.521,95%CI:0.919–2.518,P=0.103),disease-free survival(HR:1.074,95%CI:0.783–1.473,P=0.658),and GVHD-free/relapse-free survival(HR:1.186,95%CI:0.904–1.555,P=0.219)between groups(ATG-7.5 vs.ATG-10.0).The 5-year rate of late effects did not differ significantly.However,the cytomegalovirus/Epstein-Barr virus-related death rate was much higher in the ATG-10.0 cohort than in the ATG-7.5 cohort(9.8%vs.1.5%;P=0.003).In summary,patients undergoing haplo-HCT benefit from 7.5 mg/kg ATG compared to 10.0 mg/kg ATG based on a balance between GVHD and infection control.ATG(7.5 mg/kg)is potentially regarded as the standard regimen in the platform.These results support the optimization of ATG use in the“Beijing Protocol”,especially considering the potential economic advantage in developing countries.展开更多
Land surface process modeling of high and cold area with vegetation cover has not yielded satisfactory results in previous applications. In this study, land surface energy budget is simulated using a land surface mode...Land surface process modeling of high and cold area with vegetation cover has not yielded satisfactory results in previous applications. In this study, land surface energy budget is simulated using a land surface model for the A'rou meadow in the upper-reach area of the Heihe River Basin in the eastern Tibetan Plateau. The model performance is evaluated using the in-situ observations and remotely sensed data. Sensible and soil heat fluxes are overestimated while latent heat flux is underestimated when the default parameter setting is used. By analyzing physical and physiological processes and the sensitivities of key parameters, the inappropriate default setting of optimum growth and inhibition temperatures is identified as an important reason for the bias. The average daytime temperature during the period of fastest vegetation growth(June and July) is adopted as the optimum growth temperature, and the inhibition temperatures were adjusted using the same increment as the optimum temperature based on the temperature acclimation. These adjustments significantly reduced the biases in sensible, latent, and soil heat fluxes.展开更多
基金Supported by the Fundamental Research Funds for the Central Universities (2011YXL056)the National Program of Control and Treatment of Water Pollution (2009ZX07424-002)
文摘The removal of antibiotics from water by clay minerals has become the focus of research due to their strong adsorptive ability. In this study, adsorption of chlortetracycline (CTC) onto rectories was conducted and the effects of time, concentration, temperature and pH were investigated. Experimental results showed that adsorption equilibrium was reached in 8 h. Based on the Langmuir model, the maximum adsorption capacity of CTC on rectories was 177.7 mg·g 1 at room temperature. By the study on adsorption dynamics, it is found that the kinetic date fit the pseudo-second-order model well. The adsorption of CTC by rectories is endothermic and the free energy is in the range of 10 to 30 kJ·mol 1 . The pH value of solution has significant effects on adsorption and the optimal pH is at acidity (pH 2-6). At concentration of 2500 mg·L 1 , the intercalated CTC produces an interlayer space with a height of 1.38 nm, which is 1.12 nm in raw rectories, suggesting that the adsorption occurs between layers of rectories.
基金Supported by the National Natural Science Foundation of China(51174091,61364013,61164013)Earlier Research Project of the State Key Development Program for Basic Research of China(2014CB360502)
文摘For measurement of component content in the extraction and separation process of praseodymium/neodymium(Pr/Nd), a soft measurement method was proposed based on modeling of ion color features, which is suitable for fast estimation of component content in production field. Feature analysis on images of the solution is conducted,which are captured from Pr/Nd extraction/separation field. H/S components in the HSI color space are selected as model inputs, so as to establish the least squares support vector machine(LSSVM) model for Nd(Pr) content,while the model parameters are determined with the GA algorithm. To improve the adaptability of the model,the adaptive iteration algorithm is used to correct parameters of the LSSVM model, on the basis of model correction strategy and new sample data. Using the field data collected from rare earth extraction production, predictive methods for component content and comparisons are given. The results indicate that the proposed method presents good adaptability and high prediction precision, so it is applicable to the fast detection of element content in the rare earth extraction.
基金supported by the National Key Research and Development Program of China(2019YFC0840606)from the Ministry of Science and Technologythe National Natural Science Foundation of China(82070189,81770189,81621001,and 81530046)+1 种基金the Science and Technology Project of Guangdong Province of China(2016B030230003)the Project of Health Collaborative Innovation of Guangzhou City(201704020214)。
文摘Given that randomized studies testing the long-term impact of antithymocyte globulin(ATG)dosing are scarce,we report the results of an extended follow-up from the original trial.In our prospective,multicenter,randomized trial,408 leukemia patients 14–65 years of age who underwent haploidentical hematopoietic cell transplantation(haplo-HCT)under our original“Beijing Protocol”were randomly assigned one-to-one to ATG doses of 7.5 mg/kg(n=203,ATG-7.5)or 10 mg/kg(n=205,ATG-10.0)at four sites.Extended follow-up(median 1968 d(range:1300–2710 d)indicated comparable 5-year probabilities of moderate-to-severe chronic graft-versus-host disease(GVHD)(hazard ratio(HR):1.384,95%confidence interval(CI):0.876–2.189,P=0.164),nonrelapse mortality(HR:0.814,95%CI:0.526–1.261,P=0.357),relapse(HR:1.521,95%CI:0.919–2.518,P=0.103),disease-free survival(HR:1.074,95%CI:0.783–1.473,P=0.658),and GVHD-free/relapse-free survival(HR:1.186,95%CI:0.904–1.555,P=0.219)between groups(ATG-7.5 vs.ATG-10.0).The 5-year rate of late effects did not differ significantly.However,the cytomegalovirus/Epstein-Barr virus-related death rate was much higher in the ATG-10.0 cohort than in the ATG-7.5 cohort(9.8%vs.1.5%;P=0.003).In summary,patients undergoing haplo-HCT benefit from 7.5 mg/kg ATG compared to 10.0 mg/kg ATG based on a balance between GVHD and infection control.ATG(7.5 mg/kg)is potentially regarded as the standard regimen in the platform.These results support the optimization of ATG use in the“Beijing Protocol”,especially considering the potential economic advantage in developing countries.
基金supported by the National Natural Science Foundation of China(Grant Nos.91125002,40971221)FP7 CEOP-AEGI(Coordinated Asia European Long-Term Observing System of the Qinhai Tibet Plateau Hydro-meteorological Processes and the Asian Monsoon System with Ground Satellite Image data and numerical simulation)project
文摘Land surface process modeling of high and cold area with vegetation cover has not yielded satisfactory results in previous applications. In this study, land surface energy budget is simulated using a land surface model for the A'rou meadow in the upper-reach area of the Heihe River Basin in the eastern Tibetan Plateau. The model performance is evaluated using the in-situ observations and remotely sensed data. Sensible and soil heat fluxes are overestimated while latent heat flux is underestimated when the default parameter setting is used. By analyzing physical and physiological processes and the sensitivities of key parameters, the inappropriate default setting of optimum growth and inhibition temperatures is identified as an important reason for the bias. The average daytime temperature during the period of fastest vegetation growth(June and July) is adopted as the optimum growth temperature, and the inhibition temperatures were adjusted using the same increment as the optimum temperature based on the temperature acclimation. These adjustments significantly reduced the biases in sensible, latent, and soil heat fluxes.
