目的 探讨经颅多普勒发泡试验(contrast-enhanced transcranial Doppler,c-TCD)在月经相关偏头痛(menstrualr elat ed mi gr ai ne,MRM)筛查中的临床价值。方法 选择2021年1月-2022年7月在福建医科大学第三临床医学院福州市第二医院治疗...目的 探讨经颅多普勒发泡试验(contrast-enhanced transcranial Doppler,c-TCD)在月经相关偏头痛(menstrualr elat ed mi gr ai ne,MRM)筛查中的临床价值。方法 选择2021年1月-2022年7月在福建医科大学第三临床医学院福州市第二医院治疗的60例月经相关性偏头痛患者为病例组,60例匹配的非经期偏头痛患者为对照组,收集所有患者的临床信息和c-TCD检测的结果。使用单因素分析比较各组之间临床数据的差异,分析c-TCD与月经性相关偏头痛相关性并行χ^(2)检验。结果 病例组的c-TCD阳性(76.7%)明显高于对照组(50.0%),差异有统计学意义(P=0.002);按c-TCD检测微气泡信号数量分级的分布差异也有统计学意义(P=0.005);组间比较时,所有其他临床数据差异无统计学意义(P>0.05)。结论 发泡试验阳性水平可能与MRM发生相关,筛查MRM的c-TCD具有较高的临床价值。展开更多
Objective: Pregnancy-induced hypertension with proteinuria (preeclampsia- PE) is linked to increased vascular reactivity, increased vasoconstrictors, endothelial damage and platelet hyperaggregation, which are also ty...Objective: Pregnancy-induced hypertension with proteinuria (preeclampsia- PE) is linked to increased vascular reactivity, increased vasoconstrictors, endothelial damage and platelet hyperaggregation, which are also typical features of migraine patients. Thus, we investigated the association between headache and PE. Methods: In a case-control study, we evaluated the occurrence of primary headache forms in 75 women with a recent history of PE. Seventy-five controls were selected from women having uneventful pregnancy at term. Both groups were matched for age and parity. Subjects’ headache history was evaluated by using an ad hoc structured questionnaire. The International Headache Society criteria for primary headaches were applied to diagnose the specific form of headache. Results: In PE cases, gestational age at parturition was 34.2 ± 3.8 weeks and birthweight was 1820 ± 746 g, whereas in controls they were 39.3± 1.5 weeks and 3365 ± 437 g, respectively (P < 0.01). Sixty-six (44% ) subjects suffered from headache. Headache was significantly more frequent in PE (47/75) than in controls (19/75), OR 4.95 (95% CI, 2.47- 9.92). Migraine without aura was more frequently present in cases than in controls while episodic tension-type headache was equally distributed among groups. Fifty-two patients met the criteria of severe PE. The number of patients suffering from headache was significantly higher in severe patients (39 cases, 75% ) than in those with moderate PE (8 cases, 34.8% ), OR = 5.63 (95% CI, 1.97- 16.03). With respect to controls, PE patients reported a more frequent onset at menarche, more menstrually related attacks and an increased rate of improvement during pregnancy. Conclusion: This study shows that there is a strong association between migraine history and PE development, namely with the severe form of PE.展开更多
文摘目的 探讨经颅多普勒发泡试验(contrast-enhanced transcranial Doppler,c-TCD)在月经相关偏头痛(menstrualr elat ed mi gr ai ne,MRM)筛查中的临床价值。方法 选择2021年1月-2022年7月在福建医科大学第三临床医学院福州市第二医院治疗的60例月经相关性偏头痛患者为病例组,60例匹配的非经期偏头痛患者为对照组,收集所有患者的临床信息和c-TCD检测的结果。使用单因素分析比较各组之间临床数据的差异,分析c-TCD与月经性相关偏头痛相关性并行χ^(2)检验。结果 病例组的c-TCD阳性(76.7%)明显高于对照组(50.0%),差异有统计学意义(P=0.002);按c-TCD检测微气泡信号数量分级的分布差异也有统计学意义(P=0.005);组间比较时,所有其他临床数据差异无统计学意义(P>0.05)。结论 发泡试验阳性水平可能与MRM发生相关,筛查MRM的c-TCD具有较高的临床价值。
文摘Objective: Pregnancy-induced hypertension with proteinuria (preeclampsia- PE) is linked to increased vascular reactivity, increased vasoconstrictors, endothelial damage and platelet hyperaggregation, which are also typical features of migraine patients. Thus, we investigated the association between headache and PE. Methods: In a case-control study, we evaluated the occurrence of primary headache forms in 75 women with a recent history of PE. Seventy-five controls were selected from women having uneventful pregnancy at term. Both groups were matched for age and parity. Subjects’ headache history was evaluated by using an ad hoc structured questionnaire. The International Headache Society criteria for primary headaches were applied to diagnose the specific form of headache. Results: In PE cases, gestational age at parturition was 34.2 ± 3.8 weeks and birthweight was 1820 ± 746 g, whereas in controls they were 39.3± 1.5 weeks and 3365 ± 437 g, respectively (P < 0.01). Sixty-six (44% ) subjects suffered from headache. Headache was significantly more frequent in PE (47/75) than in controls (19/75), OR 4.95 (95% CI, 2.47- 9.92). Migraine without aura was more frequently present in cases than in controls while episodic tension-type headache was equally distributed among groups. Fifty-two patients met the criteria of severe PE. The number of patients suffering from headache was significantly higher in severe patients (39 cases, 75% ) than in those with moderate PE (8 cases, 34.8% ), OR = 5.63 (95% CI, 1.97- 16.03). With respect to controls, PE patients reported a more frequent onset at menarche, more menstrually related attacks and an increased rate of improvement during pregnancy. Conclusion: This study shows that there is a strong association between migraine history and PE development, namely with the severe form of PE.
