To evaluate the effect of intrathecal administration of glycine on the minimum alveolar concentration （MAC） of isoflurane in rats. Methods Intrathecal catheters were implanted in 40 adult male rats anesthetized wit...To evaluate the effect of intrathecal administration of glycine on the minimum alveolar concentration （MAC） of isoflurane in rats. Methods Intrathecal catheters were implanted in 40 adult male rats anesthetized with isoflurane. Baseline MAC of isoflurane was measured during the infusion of artificial cerebrospinal fluid （CSF） alone. Subsequently, 10, 40, 80, 160, and 300 mmol/L of glycine dissolved in artificial CSF were infused for two hours at the same rate as under control conditions, and MAC for isoflurane was re-determined. Results Intrathecal administration of glycine produced a significant, dose-dependent decrease in MAC for isoflurane （up to -65.2% ± 16. 2% ）. Conclusions Intrathecal administration of glycine decreases anesthetic requirement. This result supports the idea that glycine receptors may be important to the immobilizing effect of anesthetics that enhance glycine receptor function such as isoflurane.展开更多
An efficient and accurate method for solving the two-dimensional Helmholtz equation in domains exterior to elongated obstacles is developed in this paper.The method is based on the so called transformed field expansio...An efficient and accurate method for solving the two-dimensional Helmholtz equation in domains exterior to elongated obstacles is developed in this paper.The method is based on the so called transformed field expansion(TFE) coupled with a spectral-Galerkin solver for elliptical domain using Mathieu functions.Numerical results are presented to show the accuracy and stability of the proposed method.展开更多
文摘To evaluate the effect of intrathecal administration of glycine on the minimum alveolar concentration （MAC） of isoflurane in rats. Methods Intrathecal catheters were implanted in 40 adult male rats anesthetized with isoflurane. Baseline MAC of isoflurane was measured during the infusion of artificial cerebrospinal fluid （CSF） alone. Subsequently, 10, 40, 80, 160, and 300 mmol/L of glycine dissolved in artificial CSF were infused for two hours at the same rate as under control conditions, and MAC for isoflurane was re-determined. Results Intrathecal administration of glycine produced a significant, dose-dependent decrease in MAC for isoflurane （up to -65.2% ± 16. 2% ）. Conclusions Intrathecal administration of glycine decreases anesthetic requirement. This result supports the idea that glycine receptors may be important to the immobilizing effect of anesthetics that enhance glycine receptor function such as isoflurane.
基金supported in part by NSF grant DMS-0610646supported by AcRF Tier 1 Grant RG58/08+1 种基金Singapore MOE Grant T207B2202Singapore NRF2007IDM-IDM002-010
文摘An efficient and accurate method for solving the two-dimensional Helmholtz equation in domains exterior to elongated obstacles is developed in this paper.The method is based on the so called transformed field expansion(TFE) coupled with a spectral-Galerkin solver for elliptical domain using Mathieu functions.Numerical results are presented to show the accuracy and stability of the proposed method.
