目的评估围术期输血指征（POTTS）方案应用于非心脏择期手术的安全性。方法从2012年—2016年按照华西医院提出的《POTTS安全性与有效性试验方案》共纳入1 213名患者的多中心试验中,提取270例非心脏择期手术中输注悬浮红细胞的病例,其中...目的评估围术期输血指征（POTTS）方案应用于非心脏择期手术的安全性。方法从2012年—2016年按照华西医院提出的《POTTS安全性与有效性试验方案》共纳入1 213名患者的多中心试验中,提取270例非心脏择期手术中输注悬浮红细胞的病例,其中按照POTTS输血方案患者78例（P组,根据患者术中心功能、呼吸、体温及既往心绞痛病史个体化评分确定患者术中最低Hb）,按照限制性输血方案患者192例[R组,Hb（70-100）g/L由临床医师评估是否需要输血],比较2组患者低血红蛋白输血、生命体征相关输血指征、急性失血及合并症发生率,输血前估计失血量及Hb,术后30 d死亡率及并发症发生率。结果 P组与R组比较,低血红蛋白相关输血及生命体征相关输血发生率（%）分别87.18 vs 52.08,59.90 vs 83.33（P〈0.05）;输血前低血压发生率为74.4%vs 51.6%（P〈0.05）;P组输血前Hb（g/L）68 vs 78（P〈0.05）;术后30 d死亡率及术后并发症发生率（%）分别为3.85 vs 2.08,11.5vs 8.9（P〉0.05）。结论在非心脏择期手术中,POTTS方案较限制性输血方案更严格,但同样安全。展开更多
目的探讨围手术期输血指征评分(POTTS)在指导临床外科手术患者输血中的应用价值,并分析其有效性。方法选择2017年9月—2020年2月作者在张家港第五人民医院轮岗期间该院收治的50例外科围手术期患者作为研究对象,按输血方式不同将患者分...目的探讨围手术期输血指征评分(POTTS)在指导临床外科手术患者输血中的应用价值,并分析其有效性。方法选择2017年9月—2020年2月作者在张家港第五人民医院轮岗期间该院收治的50例外科围手术期患者作为研究对象,按输血方式不同将患者分为常规输血组和POTTS输血组,每组25例。常规输血组采用常规输血方式,根据《临床输血技术规范(2000年版)》结合患者病情,严格按照实践经验对患者进行输血;POTTS输血组采用POTTS指导输血。比较两组患者的临床指标〔术后引流量、住院时间、术后拆线时间、术后24 h血红蛋白(Hb)〕、血液输注量和输注率以及并发症发生率。结果POTTS输血组术后引流量明显少于常规输血组(mL:116.7±12.7比130.5±14.7,P<0.05),住院时间和术后拆线时间明显短于常规输血组(d:14.5±12.5比31.5±30.5,13.5±1.5比15.7±1.7,均P<0.05),术后24 h Hb水平明显低于常规输血组(g/L:80.6±5.4比99.8±9.7,P<0.05);POTTS输血组血液输注量(U:3±1比7±3)、输注率〔36.0%(9/25)比72.0%(18/25)〕、并发症发生率〔8.0%(2/25)比28.0%(7/25)〕均明显低于常规输血组(均P<0.05)。结论POTTS指导外科手术患者输血疗效良好,安全性高,能改善临床症状,减少血液输注量,降低并发症发生率。展开更多
The classification of infrasound events has considerable importance in improving the capability to identify the types of natural disasters.The traditional infrasound classification mainly relies on machine learning al...The classification of infrasound events has considerable importance in improving the capability to identify the types of natural disasters.The traditional infrasound classification mainly relies on machine learning algorithms after artificial feature extraction.However,guaranteeing the effectiveness of the extracted features is difficult.The current trend focuses on using a convolution neural network to automatically extract features for classification.This method can be used to extract signal spatial features automatically through a convolution kernel;however,infrasound signals contain not only spatial information but also temporal information when used as a time series.These extracted temporal features are also crucial.If only a convolution neural network is used,then the time dependence of the infrasound sequence will be missed.Using long short-term memory networks can compensate for the missing time-series features but induces spatial feature information loss of the infrasound signal.A multiscale squeeze excitation–convolution neural network–bidirectional long short-term memory network infrasound event classification fusion model is proposed in this study to address these problems.This model automatically extracted temporal and spatial features,adaptively selected features,and also realized the fusion of the two types of features.Experimental results showed that the classification accuracy of the model was more than 98%,thus verifying the effectiveness and superiority of the proposed model.展开更多
To introduce the advances of experimental research on acupuncture and moxibustion for treatment of Women＇s Climacteric Syndrome.The recent years experimental research literature of acupuncture and moxibustion for tre...To introduce the advances of experimental research on acupuncture and moxibustion for treatment of Women＇s Climacteric Syndrome.The recent years experimental research literature of acupuncture and moxibustion for treatment of Women＇s Climacteric Syndrome were reviewed.The research literatures on acupuncture treatment were major,focusing on the field of acupuncture and moxibustion regulating hypothalamic-pituitary-gonad axis and nerval-endocritic-immune net.Acupuncture and moxibustion could regulate the endocrine environment of menopausal women.Taking advantage of combination biomedicine with multi-sciences,to improve the acupuncture and moxibustion curative effct and probe the mechanism of menopausal pathology and acupuncture and moxibustion function to Women＇s Climacteric Syndrome,is the research direction afterward.展开更多
In the clinical reports, the E1784K mutation in SCN5A is recognized as a phenotypic overlap between the long QT syndrome （LQT3） and the Brugada syndrome （BrS） in the characteristics of electrocardiograms （ECGs） ...In the clinical reports, the E1784K mutation in SCN5A is recognized as a phenotypic overlap between the long QT syndrome （LQT3） and the Brugada syndrome （BrS） in the characteristics of electrocardiograms （ECGs） since the mutation can influence sodium channel functions. However it is still unclear if the E1784K mutation-induced sodium ionic channel alterations account for the overlap at tissue level. Thsu, a detailed computational model is developed to underpin the functional impacts of the E1784K mutation on the action potential （AP）, the effective refractory period （ERP） and the abnormal ECG. Simulation results stlggest＇that the E1784K mutation-induced sodium channel alterations are insufficient to produce the phenotypic overlap between LQT3 and BrS, and the overlap may arise from the complicated effects of the E1784K mutation-induced changes in sodium channel currents with an increase of the transient outward current ITo or a decrease of the L-type calcium current ICaL .展开更多
Based on the 1961-2010 weather data from 65 meteorological stations in Heilongjiang Province, using the statistic software and GIS, the change characteristics of water budget, including the precipitation, reference ev...Based on the 1961-2010 weather data from 65 meteorological stations in Heilongjiang Province, using the statistic software and GIS, the change characteristics of water budget, including the precipitation, reference evapotranspiration and water budget in the whole year and the temperature-defined growing season, were analyzed. The results indicated that the both the precipitation during the whole year and that of during the temperature-defined growing season from 1961 to 2010 all decreased, while the annual reference evapotranspiration decreased, but the reference evapotranspiration during the temperature-defined growing season presented an increasing trend. The water resources were generally characterized by water deficit, especially in the beginning of 21 st .展开更多
文摘目的评估围术期输血指征（POTTS）方案应用于非心脏择期手术的安全性。方法从2012年—2016年按照华西医院提出的《POTTS安全性与有效性试验方案》共纳入1 213名患者的多中心试验中,提取270例非心脏择期手术中输注悬浮红细胞的病例,其中按照POTTS输血方案患者78例（P组,根据患者术中心功能、呼吸、体温及既往心绞痛病史个体化评分确定患者术中最低Hb）,按照限制性输血方案患者192例[R组,Hb（70-100）g/L由临床医师评估是否需要输血],比较2组患者低血红蛋白输血、生命体征相关输血指征、急性失血及合并症发生率,输血前估计失血量及Hb,术后30 d死亡率及并发症发生率。结果 P组与R组比较,低血红蛋白相关输血及生命体征相关输血发生率（%）分别87.18 vs 52.08,59.90 vs 83.33（P〈0.05）;输血前低血压发生率为74.4%vs 51.6%（P〈0.05）;P组输血前Hb（g/L）68 vs 78（P〈0.05）;术后30 d死亡率及术后并发症发生率（%）分别为3.85 vs 2.08,11.5vs 8.9（P〉0.05）。结论在非心脏择期手术中,POTTS方案较限制性输血方案更严格,但同样安全。
文摘目的探讨围手术期输血指征评分(POTTS)在指导临床外科手术患者输血中的应用价值,并分析其有效性。方法选择2017年9月—2020年2月作者在张家港第五人民医院轮岗期间该院收治的50例外科围手术期患者作为研究对象,按输血方式不同将患者分为常规输血组和POTTS输血组,每组25例。常规输血组采用常规输血方式,根据《临床输血技术规范(2000年版)》结合患者病情,严格按照实践经验对患者进行输血;POTTS输血组采用POTTS指导输血。比较两组患者的临床指标〔术后引流量、住院时间、术后拆线时间、术后24 h血红蛋白(Hb)〕、血液输注量和输注率以及并发症发生率。结果POTTS输血组术后引流量明显少于常规输血组(mL:116.7±12.7比130.5±14.7,P<0.05),住院时间和术后拆线时间明显短于常规输血组(d:14.5±12.5比31.5±30.5,13.5±1.5比15.7±1.7,均P<0.05),术后24 h Hb水平明显低于常规输血组(g/L:80.6±5.4比99.8±9.7,P<0.05);POTTS输血组血液输注量(U:3±1比7±3)、输注率〔36.0%(9/25)比72.0%(18/25)〕、并发症发生率〔8.0%(2/25)比28.0%(7/25)〕均明显低于常规输血组(均P<0.05)。结论POTTS指导外科手术患者输血疗效良好,安全性高,能改善临床症状,减少血液输注量,降低并发症发生率。
基金supported by the Shaanxi Province Natural Science Basic Research Plan Project(2023-JC-YB-244).
文摘The classification of infrasound events has considerable importance in improving the capability to identify the types of natural disasters.The traditional infrasound classification mainly relies on machine learning algorithms after artificial feature extraction.However,guaranteeing the effectiveness of the extracted features is difficult.The current trend focuses on using a convolution neural network to automatically extract features for classification.This method can be used to extract signal spatial features automatically through a convolution kernel;however,infrasound signals contain not only spatial information but also temporal information when used as a time series.These extracted temporal features are also crucial.If only a convolution neural network is used,then the time dependence of the infrasound sequence will be missed.Using long short-term memory networks can compensate for the missing time-series features but induces spatial feature information loss of the infrasound signal.A multiscale squeeze excitation–convolution neural network–bidirectional long short-term memory network infrasound event classification fusion model is proposed in this study to address these problems.This model automatically extracted temporal and spatial features,adaptively selected features,and also realized the fusion of the two types of features.Experimental results showed that the classification accuracy of the model was more than 98%,thus verifying the effectiveness and superiority of the proposed model.
文摘To introduce the advances of experimental research on acupuncture and moxibustion for treatment of Women＇s Climacteric Syndrome.The recent years experimental research literature of acupuncture and moxibustion for treatment of Women＇s Climacteric Syndrome were reviewed.The research literatures on acupuncture treatment were major,focusing on the field of acupuncture and moxibustion regulating hypothalamic-pituitary-gonad axis and nerval-endocritic-immune net.Acupuncture and moxibustion could regulate the endocrine environment of menopausal women.Taking advantage of combination biomedicine with multi-sciences,to improve the acupuncture and moxibustion curative effct and probe the mechanism of menopausal pathology and acupuncture and moxibustion function to Women＇s Climacteric Syndrome,is the research direction afterward.
基金Supported by the National Natural Science Foundation of China(61001167,61172149)~~
文摘In the clinical reports, the E1784K mutation in SCN5A is recognized as a phenotypic overlap between the long QT syndrome （LQT3） and the Brugada syndrome （BrS） in the characteristics of electrocardiograms （ECGs） since the mutation can influence sodium channel functions. However it is still unclear if the E1784K mutation-induced sodium ionic channel alterations account for the overlap at tissue level. Thsu, a detailed computational model is developed to underpin the functional impacts of the E1784K mutation on the action potential （AP）, the effective refractory period （ERP） and the abnormal ECG. Simulation results stlggest＇that the E1784K mutation-induced sodium channel alterations are insufficient to produce the phenotypic overlap between LQT3 and BrS, and the overlap may arise from the complicated effects of the E1784K mutation-induced changes in sodium channel currents with an increase of the transient outward current ITo or a decrease of the L-type calcium current ICaL .
基金Supported by the Special Fund for Meteorological-Scientific Research in the Public Interest(GYHY201106026,GYHY200906021,GYHY200706030)the Special Fund for Climate Changes of China Meteorological Administration(CCSF-09-13)~~
文摘Based on the 1961-2010 weather data from 65 meteorological stations in Heilongjiang Province, using the statistic software and GIS, the change characteristics of water budget, including the precipitation, reference evapotranspiration and water budget in the whole year and the temperature-defined growing season, were analyzed. The results indicated that the both the precipitation during the whole year and that of during the temperature-defined growing season from 1961 to 2010 all decreased, while the annual reference evapotranspiration decreased, but the reference evapotranspiration during the temperature-defined growing season presented an increasing trend. The water resources were generally characterized by water deficit, especially in the beginning of 21 st .
