毛冬青中木质素苷类化学成分的研究

目的:研究毛冬青的化学成分。方法:溶剂法和色谱法分离化合物,波谱法鉴定其结构。结果:分离得到6个木质素苷类化合物,其结构鉴定为(7S,8R)-dihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside(1),(-)-olivil-4′-O-β-D-glucopyranoside(2),(7S,8R)dehydrodiconiferyl alcohol 4-O-β-D-glucopyranosid(3),(+)-cyclo-olivil 6-O-β-D-glucopyranoside(4),(+)-medioresinol di-O-β-D-glucopyranoside(5),(+)-pinoresinol-4,4′-O-bisgluco-pyranoside(6)。结论:以上化合物均为首次从该属植物中分离得到。

蝉翼藤根中木质素苷及蔗糖酯成分研究

运用硅胶、MPLC和制备HPLC等柱色谱方法对蝉翼藤根的化学成分进行分离,并通过理化性质和MS、NMR波谱数据进行结构鉴定。从蝉翼藤根的95%乙醇提取物中分离鉴定了9个化合物,包括5个木质素苷acernikol-4″-O-β-D-glucopyranoside(1),(7R,8S)-dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucopyranoside(2),(7R,8S)-dihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside(3),(7R,8S)-dihydrodehydrodiconiferyl alcohol 9'-O-β-D-glucopyranoside(4),(7R,8S)-5-methoxydihydrodehy drodiconiferyl alcohol 4-O-β-D-glucopyranoside(5);3个蔗糖酯3,6'-O-diferuloylsucrose(6),3-O-feruloyl-6'-Osinapoylsucrose(7),sibricose A5(8);1个有机酸酯mehyl ferulate(9)。化合物1~5,8,9为首次从蝉翼藤属中分离得到。采用MTT法测定了化合物对肺癌细胞株A549、宫颈癌细胞株Hela和乳腺癌细胞株MCF-7的细胞毒活性。结果表明化合物2,3和7对所测试的人源肿瘤细胞具有较弱的抑制活性。

白珠树属5种药用植物木脂素苷含量的比较

<Abstrcat> The contents of lignans glycosides in five species of \%Gaultheria \%Kalm ex L. were measured by HPLC. The resultes proved that 5 plants collected from same place all contain lignans glycosides (LD). The contents of LD in the roots of different plants shows: \%G. fragrantissima>G. leucocarpa \%var. \%yunnanensis>G. leucocarpa \%var. \%cumingiana>G. tetramera>G. griffithiana, \%and these of the above\|ground parts indicate \%G. fragrantissima>G. leucocarpa \%var. \%yunnanensis\%. The contents of LD in the leaves of \%G. fragrantissima \%and \%G. leucocarpa \%var. \%cumingiana \%are higher than those in the stems, and that in stem of \%G. griffithiana \%higher than that in its leaf and root.