Damage caused by the 2011 Tohoku Earthquake （Mw 9.0） to transmission and distribution pipelines in Sendai City is summarized. The locations of the pipeline repairs are discussed relative to earthquake intensity, geo...Damage caused by the 2011 Tohoku Earthquake （Mw 9.0） to transmission and distribution pipelines in Sendai City is summarized. The locations of the pipeline repairs are discussed relative to earthquake intensity, geomorphologic conditions and landform change in the developed areas of hilly land. Repair rate （repairs/km） is summarized according to pipe material and presence or absence of artificial landform change. The following findings were obtained： （1） More than 80% of the repairs took place in pipelines installed in higher lands such as hill and terrace areas consisting of hard soils; （2） Nearly all the pipe repairlocations in hill areas are where landform change was made through land development tor residential purposes over me past several decades; （3） The aforementioned repair rate was more than 3.6 times than that of other lowland areas where no landform change occurred. The heaviest concentrations of pipe repairs of vinyl chloride pipes and ductile iron pipes were observed within the boundary area between cutting and filling, having a thickness between -2.5 m and 2.5 m. Approximately 78% of the all pipe repairs occurred outside of areas where severe ground failures took place. A mechanism of pipe damage in the areas free of severe ground failure was discussed.展开更多
Alveologenesis is the final stage of lung development and is responsible for the formation of the principle gas exchange units called alveoli. The lung mesenchyme, in particular the alveolar myofibroblasts, are driver...Alveologenesis is the final stage of lung development and is responsible for the formation of the principle gas exchange units called alveoli. The lung mesenchyme, in particular the alveolar myofibroblasts, are drivers of alveolar development, however,few key regulators that govern the proper distribution and behavior of these cells in the distal lung during alveologenesis have been identified. While Hox5 triple mutants(Hox5 aabbcc) exhibit neonatal lethality, four-allele, compound mutant mice(Hox5 AabbCc) are born in Mendelian ratios and are phenotypically normal at birth. However, they exhibit defects in alveologenesis characterized by a BPD-like phenotype by early postnatal stages that becomes more pronounced at adult stages. Invasive pulmonary functional analyses demonstrate significant increases in total lung volume and compliance and a decrease in elastance in Hox5 compound mutants. SMA+ myofibroblasts in the distal lung are distributed abnormally during peak stages of alveologenesis and aggregate, resulting in the formation of a disrupted elastin network. Examination of other key components of the distal lung ECM, as well as other epithelial cells and lipofibroblasts reveal no differences in distribution. Collectively, these data indicate that Hox5 genes play a critical role in alveolar development by governing the proper cellular behavior of myofibroblasts during alveologenesis.展开更多
文摘Damage caused by the 2011 Tohoku Earthquake （Mw 9.0） to transmission and distribution pipelines in Sendai City is summarized. The locations of the pipeline repairs are discussed relative to earthquake intensity, geomorphologic conditions and landform change in the developed areas of hilly land. Repair rate （repairs/km） is summarized according to pipe material and presence or absence of artificial landform change. The following findings were obtained： （1） More than 80% of the repairs took place in pipelines installed in higher lands such as hill and terrace areas consisting of hard soils; （2） Nearly all the pipe repairlocations in hill areas are where landform change was made through land development tor residential purposes over me past several decades; （3） The aforementioned repair rate was more than 3.6 times than that of other lowland areas where no landform change occurred. The heaviest concentrations of pipe repairs of vinyl chloride pipes and ductile iron pipes were observed within the boundary area between cutting and filling, having a thickness between -2.5 m and 2.5 m. Approximately 78% of the all pipe repairs occurred outside of areas where severe ground failures took place. A mechanism of pipe damage in the areas free of severe ground failure was discussed.
基金supported by a Ruth L. Kirschstein National Research Service Award (NSRA) training Grant 5 T32 HL 7749-20 to S.M.Hsupported by MICHR PTSP UL1TR002240 to L.M.Sthe National Heart, Lung, and Blood Institute (NHLBI) R01-HL119215 to D.M.W
文摘Alveologenesis is the final stage of lung development and is responsible for the formation of the principle gas exchange units called alveoli. The lung mesenchyme, in particular the alveolar myofibroblasts, are drivers of alveolar development, however,few key regulators that govern the proper distribution and behavior of these cells in the distal lung during alveologenesis have been identified. While Hox5 triple mutants(Hox5 aabbcc) exhibit neonatal lethality, four-allele, compound mutant mice(Hox5 AabbCc) are born in Mendelian ratios and are phenotypically normal at birth. However, they exhibit defects in alveologenesis characterized by a BPD-like phenotype by early postnatal stages that becomes more pronounced at adult stages. Invasive pulmonary functional analyses demonstrate significant increases in total lung volume and compliance and a decrease in elastance in Hox5 compound mutants. SMA+ myofibroblasts in the distal lung are distributed abnormally during peak stages of alveologenesis and aggregate, resulting in the formation of a disrupted elastin network. Examination of other key components of the distal lung ECM, as well as other epithelial cells and lipofibroblasts reveal no differences in distribution. Collectively, these data indicate that Hox5 genes play a critical role in alveolar development by governing the proper cellular behavior of myofibroblasts during alveologenesis.
