Birgisson等对322例结直肠癌患者进行了术前血中组织源性金属蛋白酶～1抑制物（tissue inhibitor of metalloproteinases—1，TIMP-1）和癌胚抗原（earcino-embryonic antigen，CEA）水平检测。单变量分析结果发现，高TIMP-1和高CEA水...Birgisson等对322例结直肠癌患者进行了术前血中组织源性金属蛋白酶～1抑制物（tissue inhibitor of metalloproteinases—1，TIMP-1）和癌胚抗原（earcino-embryonic antigen，CEA）水平检测。单变量分析结果发现，高TIMP-1和高CEA水平患者的总生存期（TIMP-1：风险比2．1，95％可信区间1．6-2．7：CEA：风险比1．2．95％可信区间1．1～1．3）、展开更多
AIM:To compare creatinine clearance(Ccr) with estimated glomerular filtration rate(eGFR) in preoperative renal function tests in patients undergoing hepatectomy.METHODS:The records of 197 patients undergoing hepatecto...AIM:To compare creatinine clearance(Ccr) with estimated glomerular filtration rate(eGFR) in preoperative renal function tests in patients undergoing hepatectomy.METHODS:The records of 197 patients undergoing hepatectomy between August 2006 and August 2008 were studied,and preoperative Ccr,a three-variable equation for eGFR(eGFR3) and a five-variable equation for eGFR(eGFR5) were calculated.Abnormal values were defined as Ccr < 50 mL/min,eGFR3 and eGFR5 < 60 mL/min per 1.73 m2.The maximum increases in the postoperative serum creatinine(post Cr) level and postoperative rate of increase in the serum Cr level(post Cr rate) were compared.RESULTS:There were 37 patients(18.8%) with abnormal Ccr,31(15.7%) with abnormal eGFR3,and 40(20.3%) with abnormal eGFR5.Although there were no significant differences in the post Cr rate between patients with normal and abnormal Ccr,eGFR3 and eGFR5 values,the post Cr level was significantly higher in patients with eGFR3 and eGFR5 abnormality than in normal patients(P < 0.0001).Post Cr level tended to be higher in patients with Ccr abnormality(P = 0.0936 and P = 0.0875,respectively).CONCLUSION:eGFR5 and the simpler eGFR3,rather than Ccr,are recommended as a preoperative renal function test in patients undergoing hepatectomy.展开更多
文摘Birgisson等对322例结直肠癌患者进行了术前血中组织源性金属蛋白酶～1抑制物（tissue inhibitor of metalloproteinases—1，TIMP-1）和癌胚抗原（earcino-embryonic antigen，CEA）水平检测。单变量分析结果发现，高TIMP-1和高CEA水平患者的总生存期（TIMP-1：风险比2．1，95％可信区间1．6-2．7：CEA：风险比1．2．95％可信区间1．1～1．3）、
文摘AIM:To compare creatinine clearance(Ccr) with estimated glomerular filtration rate(eGFR) in preoperative renal function tests in patients undergoing hepatectomy.METHODS:The records of 197 patients undergoing hepatectomy between August 2006 and August 2008 were studied,and preoperative Ccr,a three-variable equation for eGFR(eGFR3) and a five-variable equation for eGFR(eGFR5) were calculated.Abnormal values were defined as Ccr < 50 mL/min,eGFR3 and eGFR5 < 60 mL/min per 1.73 m2.The maximum increases in the postoperative serum creatinine(post Cr) level and postoperative rate of increase in the serum Cr level(post Cr rate) were compared.RESULTS:There were 37 patients(18.8%) with abnormal Ccr,31(15.7%) with abnormal eGFR3,and 40(20.3%) with abnormal eGFR5.Although there were no significant differences in the post Cr rate between patients with normal and abnormal Ccr,eGFR3 and eGFR5 values,the post Cr level was significantly higher in patients with eGFR3 and eGFR5 abnormality than in normal patients(P < 0.0001).Post Cr level tended to be higher in patients with Ccr abnormality(P = 0.0936 and P = 0.0875,respectively).CONCLUSION:eGFR5 and the simpler eGFR3,rather than Ccr,are recommended as a preoperative renal function test in patients undergoing hepatectomy.
