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浅谈新世纪大学教师的基本素质 被引量:1
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作者 李敏 《哈尔滨学院学报》 2003年第8期15-16,共2页
在当今世界知识经济和高科技迅速发展的形势下 ,我国教育改革与发展的根本问题 ,是提高教育教学质量与水平 ,全面深化教育改革 ,大力推进素质教育。而深化教育改革 ,推进教育发展 。
关键词 思想政治素质 道德素质 文化知识结构 机体素质 能力素质 心理素质
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中老年与迪斯科舞
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作者 张亦华 《家庭医学(上半月)》 1996年第10期11-11,共1页
中老年健身迪斯科舞是在当前自身保健锻炼热中发展起来的一项高雅、健康的娱乐锻炼活动,它集体操、拳击、舞蹈三者的特点,融娱乐与健身为一体,倍受中老年人的欢迎。中老年人跳迪斯科时,全身大小关节、肌肉、骨骼、神经血管以及心肺等各... 中老年健身迪斯科舞是在当前自身保健锻炼热中发展起来的一项高雅、健康的娱乐锻炼活动,它集体操、拳击、舞蹈三者的特点,融娱乐与健身为一体,倍受中老年人的欢迎。中老年人跳迪斯科时,全身大小关节、肌肉、骨骼、神经血管以及心肺等各脏器都参与活动,使呼吸心跳加快,血液循环增速,新陈代谢旺盛,对人体健康的确有利。 但是,有些中老年人自跳迪斯科舞后,反而出现了头晕、头胀、疲惫、精神倦怠、失眠、腰痛、关节痛、胸口不适等症状,究其原因,常见有以下因素: 运动量过大,超过自身的承受能力 中老年人的机体素质逐渐下降,其承受能力不能与年轻力壮的青年人相比。有人曾对一些中老年迪斯科舞爱好者的三项糖代谢生化指标——血糖。 展开更多
关键词 中老年人 迪斯科舞 承受能力 生化指标 运动量 机体素质 人体健康 老年健身 心血管系统疾病 糖代谢
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小儿病毒性心肌炎
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作者 陈俊杰 《家庭医学(上半月)》 1994年第7期14-15,共2页
自1952年,首先在甫非发现了新生儿的柯萨奇病毒性心肌炎以来,目前已知二十多种病毒如麻疹、风疹、水痘、乙脑、流行性腮腺炎、传染性肝炎、小儿麻痹及流感等病的病毒,以及埃可病毒都可能侵犯心脏而引发心肌的炎症如心肌间质炎性改变、... 自1952年,首先在甫非发现了新生儿的柯萨奇病毒性心肌炎以来,目前已知二十多种病毒如麻疹、风疹、水痘、乙脑、流行性腮腺炎、传染性肝炎、小儿麻痹及流感等病的病毒,以及埃可病毒都可能侵犯心脏而引发心肌的炎症如心肌间质炎性改变、心肌变性、坏死。但是,绝大多数患儿受到病毒侵袭后是不会发生心肌炎的,仅有一少部分孩子的机体抵抗力下降或伴有发烧、伤风感冒、肠道感染、过度疲劳、缺氧、严重营养不良以及大量使用皮质激素等等因素,致使机体素质下降。 展开更多
关键词 病毒性心肌 流行性腮腺炎 急性心力衰竭 心动过速 毒性心肌炎 严重营养不良 皮质激素 埃可病毒 机体素质 上呼吸道感染
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Effects of repetitive transcranial magnetic stimulation on hypothalamic-pituitary-adrenal axis of patients with depression 被引量:2
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作者 He Mingli Gu Zhengtian +1 位作者 Wang Xinyi Tian Xiaoping 《Journal of Medical Colleges of PLA(China)》 CAS 2009年第6期337-345,共9页
Objective: To investigate the effects of sleep electroencephalogram-modulated repetitive transcranial magnetic stimulation (SEM-rTMS) and conventional rTMS (C-rTMS) on the activity of hypothalamic-pituitary-adren... Objective: To investigate the effects of sleep electroencephalogram-modulated repetitive transcranial magnetic stimulation (SEM-rTMS) and conventional rTMS (C-rTMS) on the activity of hypothalamic-pituitary-adrenal (HPA) axis in patients with depression. Methods: In a double-blind, randomized controlled trial, 164 patients diagnosed with depression were randomized to treatment with SEM-rTMS (n=57), C-rTMS (n=55) or sham rTMS (n=52) for 30 rain every day for 10 d. Before and after treatment plasma concentrations of adrenocorticotropic hormone (ACTH) and cortisol (CORT) were measured, and the 24-item Hamilton Depression Rating Scale (HAMD-24) was used for assessment. Results: The HAMD-24 scores and plasma ACTH and CORT concentrations of these depressive patients before treatment were significantly different from those of the normal control group (P〈0.05). The HAMD-24 scores and plasma ACTH and CORT concentrations in the SEM-rTMS group and conventional rTMS group were decreased significantly (P〈0.05). There was a significant positive correlation between the HAMD-24 scores and plasma ACTH (n=240, r=0.105, P=0.048) and CORT concentrations (n-240, r=0.126, P=0.023) in the patients with depression before and after treatment. Conclusion: The antidepressant effect of rTMS, including SEM-rTMS, may be related to its decreasing HPA axis activity. (This trail was registered. No: ChiCTR-TRC-00000465) 展开更多
关键词 DEPRESSION Transcranial magnetic stimulation Hypothalamic-pituitary-adrenal axis
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Molecular mechMolecular mechanism of glucocorticoid resistance in inflammatory bowel disease 被引量:14
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作者 Sara De Iudicibus Raffaella Franca +2 位作者 Stefano Martelossi Alessandro Ventura Giuliana Decorti 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第9期1095-1108,共14页
Natural and synthetic glucocorticoids (GCs) are widely employed in a number of inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain the first-line treatment for in... Natural and synthetic glucocorticoids (GCs) are widely employed in a number of inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain the first-line treatment for inducing remission in moderate to severe active Crohn’s disease and ulcerative colitis. Despite their extensive therapeutic use and the proven effectiveness, considerable clinical evidence of wide inter-individual differences in GC efficacy among patients has been reported, in particular when these agents are used in inflammatory diseases. In recent years, a detailed knowledge of the GC mechanism of action and of the genetic variants affecting GC activity at the molecular level has arisen from several studies. GCs interact with their cytoplasmic receptor, and are able to repress inflammatory gene expression through several distinct mechanisms. The glucocorticoid receptor (GR) is therefore crucial for the effects of these agents: mutations in the GR gene (NR3C1, nuclear receptor subfamily 3, group C, member 1) are the primary cause of a rare, inherited form of GC resistance; in addition, several polymorphisms of this gene have been described and associated with GC response and toxicity.However, the GR is not self-standing in the cell and the receptor-mediated functions are the result of a complex interplay of GR and many other cellular partners. The latter comprise several chaperonins of the large cooperative hetero-oligomeric complex that binds the hormonefree GR in the cytosol, and several factors involved in the transcriptional machinery and chromatin remodeling, that are critical for the hormonal control of target genes transcription in the nucleus. Furthermore, variants in the principal effectors of GCs (e.g. cytokines and their regulators) have also to be taken into account for a comprehensive evaluation of the variability in GC response. Polymorphisms in genes involved in the transport and/or metabolism of these hormones have also been suggested as other possible candidates of interest that could play a role in the observed inter-individual differences in efficacy and toxicity. The best-characterized example is the drug efflux pump P-glycoprotein, a membrane transporter that extrudes GCs from cells, thereby lowering their intracellular concentration. This protein is encoded by the ABCB1/ MDR1 gene; this gene presents different known polymorphic sites that can influence its expression and function. This editorial reviews the current knowledge on this topic and underlines the role of genetics in predicting GC clinical response. The ambitious goal of pharmacogenomic studies is to adapt therapies to a patient’s specific genetic background, thus improving on efficacy and safety rates. 展开更多
关键词 GLUCOCORTICOIDS Inflammatory bowel disease PHARMACOGENOMICS
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Impact of Deficient Nutrition on Health Condition of Persons with Dementia
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作者 Velija Katica Nadzida Mlaco +1 位作者 Amela Katica Jasmin Katica 《Journal of Environmental Science and Engineering(B)》 2017年第11期582-588,共7页
Dementia is a loss of mental ability (ability to think, remember and make logical conclusions) which, in principle affects normal everyday life of a person. Dementia is not a disease but a group of symptoms that may... Dementia is a loss of mental ability (ability to think, remember and make logical conclusions) which, in principle affects normal everyday life of a person. Dementia is not a disease but a group of symptoms that may cause different diseases. Symptoms include change of behaviour, character and unexpected changes in the mood. Poor quality of nutrition affects significantly the intensity of dementia. Balanced diet that meets healthy safety standards and requirements will satisfy the needs of an organism for vitamins and minerals and special attention should be given to intake of folic acid, vitamin B12 and minerals zinc and selenium. Intake of omega3 fatty acids is a source of fuel for blood vessels, particularly for the ones of the nervous tissues. 展开更多
关键词 Dementio NUTRITION war period.
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Evaluation of Ecosystem Services Provided by 10 Typical Rice Paddies in China 被引量:8
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作者 肖玉 安凯 +1 位作者 谢高地 鲁春霞 《Journal of Resources and Ecology》 CSCD 2011年第4期328-337,共10页
Based on reference review, this study investigated ecosystem services supported by 10 typical rice paddies in six rice planting regions of China. The services were primary production, gas regulation, nitrogen transfor... Based on reference review, this study investigated ecosystem services supported by 10 typical rice paddies in six rice planting regions of China. The services were primary production, gas regulation, nitrogen transformation, soil organic matter accumulation, and water regulation and flood control. The results indicated that grain production of the 10 rice paddies was between 4.71 and 12.18 t ha^-1 y^-1; straw production was 4.65 to 9.79 t ha^-1 y^-1; gas regulation was calculated to emit O2 ranging from 8.27 to 19.69 t ha^-1 y^-1 and to assimilate greenhouse gases ranging from -2.13 to 19.24 t ha^-1 y^-1 (in CO2 equivalent); nitrogen transformation was estimated as nitrogen input ranging from 209.70 to 513.93 kg N ha^-1 y^-1 and nitrogen output of 112.87 to 332.69 kg N ha^-1 y^-1; soil organic matter accumulation was calculated to be between 0.69 and 4.88 t C ha^-1 y^-1; water regulation was estimated to consume water resources of 19875 m3 ha^-1 y^-1 and to support water resources of 6430 m3 ha^-1 y^-1; and flood control of several of the rice paddies was calculated to be 1500 m3 ha^-1 y^-1. The integrated economic value of ecosystem services of these rice paddies was estimated at USD 8605–21 405 ha^-1 y^-1, of which 74%–89% of the value can be ascribed to ecosystem services outside primary production. The results also indicated that the integrated economic value of the ecosystem services of the 10 rice paddies was higher when nitrogen fertilizer was applied in the range of 275 to 297 kg N ha^-1. Until now, the economic value of the rice paddy ecosystem has been underestimated as only the economic value of grain and straw production was previously calculated. As more and more forest land and grassland is lost to urban and industrial use, cropland and especially rice paddies, will become more ecologically important to society. The economic value of ecosystem services supplied by rice paddies, outside primary production, are worthy of increased research attention. 展开更多
关键词 rice paddy ecosystem services gas regulation soil organic matter accumulation nitrogen transformation
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Regulatory mechanism of hormones of the pituitary-target gland axes in kidney-Yang deficiency based on a support vector machine model 被引量:8
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作者 Wang Xiufeng Zhang Lei +4 位作者 Huang Rongbo Wu Qinghua Min Jianxin Ma Na Luo Laicheng 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2015年第2期238-243,共6页
OBJECTIVE:To study the development mechanism of kidney-Yang deficiency through the establishment of support vector machine models of relevant hormones of the pituitary-target gland axes in rats with kidney-Yang defici... OBJECTIVE:To study the development mechanism of kidney-Yang deficiency through the establishment of support vector machine models of relevant hormones of the pituitary-target gland axes in rats with kidney-Yang deficiency syndrome.METHODS:The kidney-Yang deficiency rat model was created by intramuscular injection of hydrocortisone,and contents of the hormones of the pituita- ry-thyroid axis:thyroid stimulating hormone(TSH),3,3',5-triiodothyronine(T_3) and thyroxine(T_4);hormones of the pituitary-adrenal gland axis:adrenocorticotropic hormone(ACTH) and Cortisol(CORT);and hormones of the pituitary-gonadal axis:luteinizing hormone(LH),follicle-stimulating hormone(FSH),and testosterone(T),were determined in the early,middle,and advanced stages.Ten support vector regression(SVR) models of the hormones were established to analyze the mutual relationships among the hormones of the three axes.RESULTS:The feedback control action of the pituitary-adrenal axis began to lose efficacy from the middle stage of kidney-Kong deficiency.The contents all hormones of the three pituitary-target gland axes decreased in the advanced stage.Relative errors of the jackknife test of the SVR models all were less than 10%.CONCLUSION:Imbalances in mutual regulation among the hormones of the pituitary-target gland axes,especially loss of effectiveness of the pituitary-adrenal axis,is one pathogenesis of kidney-Yang deficiency.The SVR model can accurately reflect the complicated non-linear relationships among pituitary-target gland axes in rats with of kidney-Yang deficiency. 展开更多
关键词 Kidney Yang deficiency Support vector regression machine Pituitary-thyroid axis Pituitary-adrenal axis Pituitary-gonadal axis
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