近日,休斯敦卫理公会研究所（Houston Methodist Research Institute）的研究人员通过研究表示,一种实验性药物或可促进小鼠脂肪和体质量下降。相关研究在圣地亚哥举办的第97届美国内分泌学会年会（ENDO2015）上发表。这种药物名为GC-1...近日,休斯敦卫理公会研究所（Houston Methodist Research Institute）的研究人员通过研究表示,一种实验性药物或可促进小鼠脂肪和体质量下降。相关研究在圣地亚哥举办的第97届美国内分泌学会年会（ENDO2015）上发表。这种药物名为GC-1,其可以加速机体脂肪细胞代谢燃烧脂肪。展开更多
Background: Correct staging of puberty is essential in order to differentiate different pathologies, as various components of the endocrine system influence b reast, pubic, and axillary hair development. Aims: To dete...Background: Correct staging of puberty is essential in order to differentiate different pathologies, as various components of the endocrine system influence b reast, pubic, and axillary hair development. Aims: To determine the current timi ng of adrenarche and breast deve lopment in Lithuanian preadolescent schoolgirls . Methods: Cross-sectional study of 1231 schoolgirls aged 7.0-11.6 years. Pube rty was staged according to the method of Tanner. Mean age at entry into each pu bertal stage was calculated by probit analysis. Results: Of the 255 girls aged 7 years, two had premature adrenarche (0.8%) and one premature thelarche (0.4%) . Mean age of onset of pubic/ axillary hair development was 11.0 years, and for breast development (Stage 2) 10.2 years. Breast Stage 3 development was attained at 11.3 years and Stage 4 at 13.9 years. Mean BMI, height, weight, and systolic blood pressure SD scores were higher in pubertal than in prepubertal girls. Ski nfold thickness was also significantly higher in girls with isolated adrenarche than in prepubertal girls. The increase in BMI and weight resulted from an incre ase in body fat as evidenced by measures of subscapular and triceps skinfold thi ckness. Girls with only signs of adrenarche or thelarche did not differ from eac h other from the anthropometric standpoint. Conclusions: Premature thelarche and premature adrenarche were relatively uncommon in this population. Pubertal onse t was slightly earlier than the UK Tanner standards and tended to occur in girls with a higher BMI.展开更多
通过对28例小于胎龄儿(SGA)和34例适于胎龄儿(AGA)的足月儿的血清脂质结合素水平的检测,来了解胎儿的生长与脂质结合素水平有何种关系。生后第1 个24 h内采集测定脂质结合素的血液样本。以上新生儿(SGA和AGA)的血清脂质结合素水平显著...通过对28例小于胎龄儿(SGA)和34例适于胎龄儿(AGA)的足月儿的血清脂质结合素水平的检测,来了解胎儿的生长与脂质结合素水平有何种关系。生后第1 个24 h内采集测定脂质结合素的血液样本。以上新生儿(SGA和AGA)的血清脂质结合素水平显著高于正常孩子(28.7±17.0 mg/L t vs 9.3±6.1 mg/L,P【 0.01)。在SGA和AGA之间,脂质结合素水平也有显著性差异(23.2±14.8 mg/L vs 33.2±17.5 mg/L,P =0.02)。所有新生儿的血清脂质结合素水平与出生体重和头围呈正相关,分别为(r=0.27,P【0.05)和(r=0.30,P【0.05)。血清脂质结合素水平与胎龄、出生身长、血糖水平、生后采集血液样本的时间无关。所有新生儿脂质结合素水平在男婴和女婴的浓度分别为30.0±19.7 mg/L vs 28.0±15.5 mg/L,无性别差异。结果表明:血清脂质结合素水平与出生体重的正相关关系和高脂血症不能仅凭机体脂肪的低百分数解释。SGA比AGA的脂质结合素水平更低,并不表示宫内发育迟缓的婴儿在生后早期有胰岛素抵抗,但可能成为将来发展成胰岛素抵抗或者2型糖尿病的因素。展开更多
TO THE EDITOR Bitter gourd （Momordica charantia）, has received widespread attention in the scientific community due to its beneficial effects, including anti-diabetic, anti-cancer and anti- inflammatory effects in l...TO THE EDITOR Bitter gourd （Momordica charantia）, has received widespread attention in the scientific community due to its beneficial effects, including anti-diabetic, anti-cancer and anti- inflammatory effects in laboratory studies. However, a well-defined mechanism by which this important plant food exerts its beneficial effects has not been elucidated. We present some of the latest findings on the plant＇s effects against colon cancer.展开更多
文摘近日,休斯敦卫理公会研究所（Houston Methodist Research Institute）的研究人员通过研究表示,一种实验性药物或可促进小鼠脂肪和体质量下降。相关研究在圣地亚哥举办的第97届美国内分泌学会年会（ENDO2015）上发表。这种药物名为GC-1,其可以加速机体脂肪细胞代谢燃烧脂肪。
文摘Background: Correct staging of puberty is essential in order to differentiate different pathologies, as various components of the endocrine system influence b reast, pubic, and axillary hair development. Aims: To determine the current timi ng of adrenarche and breast deve lopment in Lithuanian preadolescent schoolgirls . Methods: Cross-sectional study of 1231 schoolgirls aged 7.0-11.6 years. Pube rty was staged according to the method of Tanner. Mean age at entry into each pu bertal stage was calculated by probit analysis. Results: Of the 255 girls aged 7 years, two had premature adrenarche (0.8%) and one premature thelarche (0.4%) . Mean age of onset of pubic/ axillary hair development was 11.0 years, and for breast development (Stage 2) 10.2 years. Breast Stage 3 development was attained at 11.3 years and Stage 4 at 13.9 years. Mean BMI, height, weight, and systolic blood pressure SD scores were higher in pubertal than in prepubertal girls. Ski nfold thickness was also significantly higher in girls with isolated adrenarche than in prepubertal girls. The increase in BMI and weight resulted from an incre ase in body fat as evidenced by measures of subscapular and triceps skinfold thi ckness. Girls with only signs of adrenarche or thelarche did not differ from eac h other from the anthropometric standpoint. Conclusions: Premature thelarche and premature adrenarche were relatively uncommon in this population. Pubertal onse t was slightly earlier than the UK Tanner standards and tended to occur in girls with a higher BMI.
文摘通过对28例小于胎龄儿(SGA)和34例适于胎龄儿(AGA)的足月儿的血清脂质结合素水平的检测,来了解胎儿的生长与脂质结合素水平有何种关系。生后第1 个24 h内采集测定脂质结合素的血液样本。以上新生儿(SGA和AGA)的血清脂质结合素水平显著高于正常孩子(28.7±17.0 mg/L t vs 9.3±6.1 mg/L,P【 0.01)。在SGA和AGA之间,脂质结合素水平也有显著性差异(23.2±14.8 mg/L vs 33.2±17.5 mg/L,P =0.02)。所有新生儿的血清脂质结合素水平与出生体重和头围呈正相关,分别为(r=0.27,P【0.05)和(r=0.30,P【0.05)。血清脂质结合素水平与胎龄、出生身长、血糖水平、生后采集血液样本的时间无关。所有新生儿脂质结合素水平在男婴和女婴的浓度分别为30.0±19.7 mg/L vs 28.0±15.5 mg/L,无性别差异。结果表明:血清脂质结合素水平与出生体重的正相关关系和高脂血症不能仅凭机体脂肪的低百分数解释。SGA比AGA的脂质结合素水平更低,并不表示宫内发育迟缓的婴儿在生后早期有胰岛素抵抗,但可能成为将来发展成胰岛素抵抗或者2型糖尿病的因素。
文摘TO THE EDITOR Bitter gourd （Momordica charantia）, has received widespread attention in the scientific community due to its beneficial effects, including anti-diabetic, anti-cancer and anti- inflammatory effects in laboratory studies. However, a well-defined mechanism by which this important plant food exerts its beneficial effects has not been elucidated. We present some of the latest findings on the plant＇s effects against colon cancer.
