Renal interstitial fibrosis （RIF） is a common pathological process of chronic kidney disease that progresses toend-stage renal failure. The degree of RIF is closely related to renal function. The study of the pathog...Renal interstitial fibrosis （RIF） is a common pathological process of chronic kidney disease that progresses toend-stage renal failure. The degree of RIF is closely related to renal function. The study of the pathogenesis of renalinterstitial fibrosis, exploration of effective prevention measures to delay the progress of end stage renal disease andprolong the life of patients is significant. The pathology of RIF has complicated extracellular and intercellularmechanisms, involving many cells and cytokines, resulting in an incomplete mechanistic understanding of thedisease. Finding effective herbs or herbal extracts for prevention and treatment of RIF is crucial because currentmedical approaches do not reliably slow or reverse RIF. The research progress of RIF in recent years issummarized as follows.展开更多
Granitic continental crust distinguishes the Earth from other planets in the Solar System. Consequently, for understanding terrestrial continent development, it is of great significance to investigate the formation an...Granitic continental crust distinguishes the Earth from other planets in the Solar System. Consequently, for understanding terrestrial continent development, it is of great significance to investigate the formation and evolution of granite.Crystal fractionation is one of principal magma evolution mechanisms. Nevertheless, it is controversial whether crystal fractionation can effectively proceed in felsic magma systems because of the high viscosity and non-Newtonian behavior associated with granitic magmas. In this paper, we focus on the physical processes and evaluate the role of crystal fractionation in the evolution of granitic magmas during non-transport processes, i.e., in magma chambers and after emplacement. Based on physical calculations and analyses, we suggest that general mineral particles can settle only at tiny speed(~10^(-9)–10^(-7) m s^(-1))in a granitic magma body due to high viscosity of the magma; however, the cumulating can be interrupted with convection in magma chambers, and the components of magma chambers will tend to be homogeneous. Magma convection ceases once the magma chamber develops into a mush(crystallinity, F>~40–50%). The interstitial melts can be extracted by hindered settling and compaction, accumulating gradually and forming a highly silicic melt layer. The high silica melts can further evolve into high-silica granite or high-silica rhyolite. At various crystallinities, multiple rejuvenation of the mush and the following magma intrusion may generate a granite complex with various components. While one special type of granites, represented by the South China lithium-and fluoride-rich granite, has lower viscosity and solidus relative to general granitic magmas, and may form vertical zonation in mineral-assemblage and composition through crystal fractionation. Similar fabrics in general intrusions that show various components on small lengthscales are not the result of gravitational settling. Rather, the flowage differentiation may play a key role. In general, granitic magma can undergo effective crystal fractionation; high-silica granite and volcanics with highly fractionated characteristics may be the products of crystal fractionation of felsic magmas, and many granitoids may be cumulates.展开更多
To deeply understand the emergence of cooperation in natural,social and economical systems,we present an improved fitness evaluation mechanism with memory in spatial prisoner's dilemma game on regular lattices.In ...To deeply understand the emergence of cooperation in natural,social and economical systems,we present an improved fitness evaluation mechanism with memory in spatial prisoner's dilemma game on regular lattices.In our model,the individual fitness is not only determined by the payoff in the current game round,but also by the payoffs in previous round bins.A tunable parameter,termed as the memory strength(μ),which lies between 0 and 1,is introduced into the model to regulate the ratio of payoffs of current and previous game rounds in the individual fitness calculation.When μ = 0,our model is reduced to the standard prisoner's dilemma game;while μ = 1 represents the case in which the payoff is totally determined by the initial strategies and thus it is far from the realistic ones.Extensive numerical simulations indicate that the memory effect can substantially promote the evolution of cooperation.For μ < 1,the stronger the memory effect,the higher the cooperation level,but μ = 1 leads to a pathological state of cooperation,but can partially enhance the cooperation in the very large temptation parameter.The current results are of great significance for us to account for the role of memory effect during the evolution of cooperation among selfish players.展开更多
基金This work was supported by the National Natural Science Foundation of China （8160150013）.
文摘Renal interstitial fibrosis （RIF） is a common pathological process of chronic kidney disease that progresses toend-stage renal failure. The degree of RIF is closely related to renal function. The study of the pathogenesis of renalinterstitial fibrosis, exploration of effective prevention measures to delay the progress of end stage renal disease andprolong the life of patients is significant. The pathology of RIF has complicated extracellular and intercellularmechanisms, involving many cells and cytokines, resulting in an incomplete mechanistic understanding of thedisease. Finding effective herbs or herbal extracts for prevention and treatment of RIF is crucial because currentmedical approaches do not reliably slow or reverse RIF. The research progress of RIF in recent years issummarized as follows.
基金supported by the National Key R&D Program of China (Grant Nos. 2016YFC0600204 & 2016YFC0600408)the National Natural Science Foundation of China (Grant Nos. 41421062 & 41372005)
文摘Granitic continental crust distinguishes the Earth from other planets in the Solar System. Consequently, for understanding terrestrial continent development, it is of great significance to investigate the formation and evolution of granite.Crystal fractionation is one of principal magma evolution mechanisms. Nevertheless, it is controversial whether crystal fractionation can effectively proceed in felsic magma systems because of the high viscosity and non-Newtonian behavior associated with granitic magmas. In this paper, we focus on the physical processes and evaluate the role of crystal fractionation in the evolution of granitic magmas during non-transport processes, i.e., in magma chambers and after emplacement. Based on physical calculations and analyses, we suggest that general mineral particles can settle only at tiny speed(~10^(-9)–10^(-7) m s^(-1))in a granitic magma body due to high viscosity of the magma; however, the cumulating can be interrupted with convection in magma chambers, and the components of magma chambers will tend to be homogeneous. Magma convection ceases once the magma chamber develops into a mush(crystallinity, F>~40–50%). The interstitial melts can be extracted by hindered settling and compaction, accumulating gradually and forming a highly silicic melt layer. The high silica melts can further evolve into high-silica granite or high-silica rhyolite. At various crystallinities, multiple rejuvenation of the mush and the following magma intrusion may generate a granite complex with various components. While one special type of granites, represented by the South China lithium-and fluoride-rich granite, has lower viscosity and solidus relative to general granitic magmas, and may form vertical zonation in mineral-assemblage and composition through crystal fractionation. Similar fabrics in general intrusions that show various components on small lengthscales are not the result of gravitational settling. Rather, the flowage differentiation may play a key role. In general, granitic magma can undergo effective crystal fractionation; high-silica granite and volcanics with highly fractionated characteristics may be the products of crystal fractionation of felsic magmas, and many granitoids may be cumulates.
基金Supported by the National Natural Science Foundation of China under Grant Nos. 61203138,60904063Innovation Fund for Technology Based Firms in Tianjin
文摘To deeply understand the emergence of cooperation in natural,social and economical systems,we present an improved fitness evaluation mechanism with memory in spatial prisoner's dilemma game on regular lattices.In our model,the individual fitness is not only determined by the payoff in the current game round,but also by the payoffs in previous round bins.A tunable parameter,termed as the memory strength(μ),which lies between 0 and 1,is introduced into the model to regulate the ratio of payoffs of current and previous game rounds in the individual fitness calculation.When μ = 0,our model is reduced to the standard prisoner's dilemma game;while μ = 1 represents the case in which the payoff is totally determined by the initial strategies and thus it is far from the realistic ones.Extensive numerical simulations indicate that the memory effect can substantially promote the evolution of cooperation.For μ < 1,the stronger the memory effect,the higher the cooperation level,but μ = 1 leads to a pathological state of cooperation,but can partially enhance the cooperation in the very large temptation parameter.The current results are of great significance for us to account for the role of memory effect during the evolution of cooperation among selfish players.
