中药心安宁胶囊治疗冠心病心绞痛随机对照研究

目的 :观察心安宁胶囊治疗冠心病、心绞痛的疗效及安全性。方法 :随机选 41例冠心病心绞痛患者 ,接受心安宁胶囊治疗 (治疗组 ) 2 0例 ,心安宁片剂治疗 (对照组 ) 2 1例 ,治疗 6周 ,均为每日 3次、每次 3粒口服 ,观察治疗前后疗效及安全性。结果 :心安宁胶囊组治疗 6周与治疗前比较 ,显效率 35 % ,总有效率 90 % ,心电图疗效显效率 15 % ,总有效率 30 % ,与对照组相比均无统计学意义。用药 6周后 ,两组均未见明显不良反应 ,在心率、血压等指标方面均无明显变化 ,实验室指标正、异常改变方面两组比较无统计学意义。结论 :心安宁胶囊在治疗冠心病、心绞痛方面有一定的疗效 ,能改善冠心病、心绞痛患者的症状与心电图表现 ,但与心安宁片相比较 ,无明显疗效差异。

菖菊穹麻饮治疗风痰上扰老年性高血压随机平行对照研究

[目的]观察菖菊穹麻饮治疗风痰上扰老年性高血压疗效。[方法]使用随机平行对照方法,将72例门诊及住院患者按就诊顺序编号简单随机分为两组。对照组36例常规降压治疗,根据就诊前服用的降压药的种类和用量,分别以钙拮抗剂、血管紧张素转换酶抑制剂、β受体阻滞剂、利尿剂等单独或两种药物联合治疗。治疗组36例菖菊穹麻饮(石菖蒲12g,菊花30g,川芎15g,蔓荆子12g,白芷、藁本各10g,辛夷12g,半夏、钩藤、天麻各10g,白蒺藜、茯苓各12g,川牛膝15g,炙甘草6g;夜尿频数,腰膝软明显加女贞子、川杜仲10g,桑寄生12g;痰浊重加薤白、瓜蒌15g;纳呆食少者加白蔻仁、砂仁各5g;气虚明显加黄芪15g;尿少、足肿、面部浮肿加车前子10g,薏苡仁15),1剂/d,水煎200m L,早晚温服。连续治疗7d为1疗程。观测临床症状、血压、不良反应。连续治疗4疗程,判定疗效。[结果]治疗组显效29例,有效4例,无效3例,总有效率91.67%。对照组显效20例,有效9例,无效7例,总有效率80.56%。治疗组疗效优于对照组(P<0.05)。[结论]菖菊穹麻饮治疗老风痰上扰年性高血压疗效显著,无严重不良反应,值得推广。

健脾补肾方联合西药治疗1～2期慢性肾脏病脾肾气虚蛋白尿多中心随机平行对照研究

[目的]观察健脾补肾方辨治1~2期慢性肾脏病脾肾气虚蛋白尿疗效。[方法]使用多中心随机平行对照方法,将236例门诊患者按随机数字表法随机分两组;注意休息,避免重体力劳动,清淡饮食等。对照组108例缬沙坦,80mg/d,口服。治疗组128例健脾补肾方(黄芪30g,党参、白术各20g,茯苓、猪苓、黄柏、山茱萸各15g,山药、淫羊藿各20g,菟丝子、丹参、川芎各15g,益母草、牡丹皮各12g,甘草9g;贫血加当归、阿胶各15g;水肿加薏苡仁30g,泽泻15g;血尿加茜草、大小蓟各12g;湿热盛加车前草、通草各15g),1剂/d,水煎400mL,早晚口服。连续治疗3个月为1疗程。观测临床症状、24h尿蛋白定量、eGFR、不良反应。治疗1疗程,判定疗效。[结果]治疗组临床控制47例,显效35例,有效26例,无效20例,总有效率84.40%;对照组临床控制24例,显效19例,有效22例,无效43例,总有效率60.20%;治疗组疗效优于对照组(P<0.05)。中医证候疗效治疗组优于对照组(P<0.05)。24h尿蛋白水平、eGFR治疗组降低优于对照组(P<0.01)。[结论]健脾补肾方辨治1~2期慢性肾脏病脾肾气虚蛋白尿,疗效满意,无严重不良反应,值得推广。

电针联合温针灸治疗增生性膝关节炎随机平行对照研究

[目的]观察电针联合温针灸治疗增生性膝关节炎疗效。[方法]使用随机平行对照方法,将120例门诊患者按诊顺序单双号简单随机分为两组。对照组60例温针灸(内膝眼、犊鼻、血海、梁丘、阴陵泉、阳陵泉),患者仰卧位,常规消毒,血海、梁丘、阴陵泉、阳陵泉直刺1.2寸;犊鼻、内膝眼针尖朝向膝关节方向斜刺1.2寸,平补平泻,局部有酸、麻、胀感为得气,针尾处插艾条进行温灸,留针30min,清理艾柱,拔针,1次/d。治疗组60例针刺同对照组,得气针柄与6805-Ⅱ型电针仪连接,患者承受能力设置疏密波强度,留针期间取2.5cm艾柱,分别套在针尾上,艾柱燃尽后关闭电针机,清理,拔针,1次/d。连续治疗7d为1疗程。观测临床症状、膝关节疼痛评分、晨僵评分、活动度评分、不良反应。连续治疗3疗程(21d),判定疗效。[结果]治疗组显效39例,有效17例,无效4例,总有效率93.33%;对照组显效26例,有效18例,无效16例,总有效率73.33%;治疗组疗效优于对照组(P<0.01)。膝关节疼痛评分、晨僵评分、活动度评分两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]电针联合温针灸治疗增生性膝关节炎,疗效满意,无严重不良反应,值得推广。

加味参芪汤联合TP化疗方案治疗老年肺癌化疗并发症随机平行对照研究

[目的]观察加味参芪汤联合TP化疗方案治疗老年肺癌化疗并发症疗效。[方法]使用随机平行对照方法,将120例住院患者按随机数字表方法简单随机分为两组。对照组60例TP化疗方案,第1d,紫杉醇175mg/m^2,静滴;第1~3d,顺铂25mg/m^2,静滴。治疗组60例加味参芪汤(党参、黄芪各30g,白术、茯苓各15g,灵芝6g,山萸肉10g,五味子6g,清半夏10g,陈皮6g,桔梗10g,川贝3g,杏仁10g,阴虚火旺酌加麦冬、生地黄、丹皮、瓜蒌、知母等;气滞血瘀酌加当归、丹参、赤芍、苡仁、莪术等;痰热阻肺酌加瓜蒌、黄芩、鱼腥草、半枝莲、白花蛇舌草等;咳血酌加三七粉、大蓟、仙鹤草、茜草、白茅根等),水煎400mL,1剂/d,早晚温服,忌食生冷、海鲜、发物;西药治疗同对照组。连续治疗21d为1疗程。观测临床症状、毒副反应、睡眠质量(PSQI)、生活质量、不良反应。连续治疗3疗程,判定疗效。[结果]Ⅲ级以上严重毒副反应发生率治疗组低于对照组(P<0.05),睡眠、生存质量改善治疗组优于对照组(P<0.05)。[结论]加味参芪汤联合TP化疗方案治疗老年肺癌化疗并发症,可降低严重毒副反应发生率,提高睡眠和生存质量,值得推广。

Multicenter Clinical Randomized Controlled Trial and Network Pharmacology Analysis of Zhenzhu Qingyuan Granules for the Treatment of Gastroesophageal Reflux Disease

Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network pharmacology.Methods Patients with gastroesophageal reflux disease(GERD)of liver–stomach stagnant heat pattern who met the inclusion and exclusion criteria were randomly divided into the control group and the observation group.The control group received oral rabeprazole,whereas the observation group were given Zhenzhu Qingyuan Granules in addition to the rabeprazole.The treatment duration was 8 weeks.Clinical efficacy was observed in both groups after 8 weeks.Network pharmacology was used to analyze the action targets of ZhenzhuQingyuanGranules and the genes related to GERD,and core targets were inferred.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to explore the potential mechanisms of this formula.Results The clinical research results showed that the total effective rate in the treatment group was 92.68%,compared with 70.00%in the control group,with a statistically significant difference(p<0.05).After treatment,both Chinese medicine syndrome score and endoscopic score improved in both groups compared with before treatment(p<0.05),and the treatment group showed greater improvement than the control group(p<0.05).Network pharmacology identified effective components of Zhenzhu Qingyuan Granules for treating GERD,including quercetin,luteolin,andβ-sitosterol,with potential action targets such as tumor protein 53(TP53),protein kinase B(AKT1),and tumor necrosis factor.Conclusion Zhenzhu Qingyuan Granules can significantly improve clinical symptoms in patients with GERD of liver–stomach stagnated heat pattern,enhance clinical efficacy,and have high safety.This formula may exert therapeutic effects through multiple targets and pathways.

Management of liver cirrhosis between primary care and specialists

This article discusses a practical, evidence-based approach to the diagnosis and management of liver cirrhosis by focusing on etiology, severity, presence of complications, and potential home-managed treatments. Relevant literature from 1985 to 2010 (PubMed) was reviewed. The search criteria were peer-reviewed full papers published in English using the following MESH headings alone or in combination: "ascites", "liver fibrosis", "cirrhosis", "chronic hepatitis", "chronic liver disease", "decompensated cirrhosis", "hepatic encephalopathy", "hypertransaminasemia", "liver transplantation" and "portal hypertension". Forty-nine papers were selected based on the highest quality of evidence for each section and type (original, randomized controlled trial, guideline, and review article), with respect to specialist setting (Gastroenterology, Hepatology, and Internal Medicine) and primary care. Liver cirrhosis from any cause represents an emerging health issue due to the increasing prevalence of the disease and its complications worldwide. Primary care physicians play a key role in early identification of risk factors, in the management of patients for improving quality and length of life, and for preventing complications. Specialists, by contrast, should guide specific treatments, especially in the case of complications and for selecting patient candidates for liver transplantation. An integrated approach between specialists and primary care physicians is essential for providing better outcomes and appropriate home care for patients with liver cirrhosis.

Current situation on the reporting quality of randomized controlled trials in 5 leading Chinese medical journals

Objective:The Consolidated Standards for Reporting of Trials(CONSORT) statement has already proved to be an efficient standard for reporting quality of randomized controlled trials(RCTs).However,most of the Chinese medical journals have not endorsed the CONSORT statement.The current situation about the reporting quality of RCTs in Chinese medical journals is still unclear.The purpose of the study was to evaluate the reporting quality of RCTs on papers published in 5 leading Chinese medical journals.Methods:We evaluated 232 original RCT papers using a reporting quality scale based on CONSORT statement from 2001 to 2006 in 5 Chinese medical journals(Journal type 1) without adoption of CONSORT and Chinese Journal of Evidence-based Medicine(Journal type 2) which adopted CONSORT in 2004.We measured the inclusion of 26 items for the reporting quality scale and 6 core items of each RCT report,gave score to each item and calculated the total score obtained in each report and the proportion of reports including individual items.The reporting quality of RCT trials from 2001 to 2003(pre-adoption period) was compared with that from 2004 to 2006(post-adoption period).Results:The average reporting quality of RCTs was moderate(mean score,15.18),and the mean score of the 6 core items was low(mean score,1.09) in 5 leading journals.The difference in the total score and the score of the 6 core items between pre-adoption period(2001-2003) and post-adoption period(2004-2006) was statistically significant(P=0.003;P=0.000).Interaction between journal type and period was not significant(F=0.76;P=0.383).We concluded that the change tendency of reporting quality between Journal type 1 and 2 was not different.But as to the core items of sequence concealment and intention-to-treat analysis,the increases were greater for Journal type 2 when evaluated against Journal type 1(P=0.038;P=0.016).Conclusion:The reporting quality of RCT trials in 5 leading Chinese medical journals is improving.However,the lack of important items in RCT trials remains a serious problem.We recommend the endorsement of the Consolidated Standards for Reporting of Trials statement in Chinese medical journals and the continuing education on evidence-based medicine in China.

Efficacy of perioperative parecoxib injection on postoperative pain relief after laparoscopic cholecystectomy:A prospective,randomized study

AIM:To determine the efficacy of perioperative parecoxib injection on postoperative pain relief after laparoscopic cholecystectomy.METHODS: A prospective, double-blind, randomized, placebo-controlled study was conducted on 70 patients who underwent elective laparoscopic cholecystectomy under general anesthesia at Siriraj Hospital, Bangkok, from January 2006 to December 2007. Patients were randomized to receive either 20 mg parecoxib infusion 30 min before induction of anesthesia and at 12 h after the first dose (treatment group), or normal saline infusion, in the same schedule, as a placebo (control group). The degree of the postoperative pain was assessed every 3 h in the first 24 h after surgery, and then every 12 h the following day, using a visual analog scale. The consumption of analgesics was also recorded.RESULTS:There were 40 patients in the treatment group, and 30 patients in the control group. The pain scores at each time point, and analgesic consumption did not differ between the two groups. However,there were fewer patients in the treatment group than placebo group who required opioid infusion within the first 24 h (60% vs 37%, P=0.053).CONCLUSION: Perioperative administration of parecoxib provided no significant effect on postoperative pain relief after laparoscopic cholecystectomy. However, preoperative infusion 20 mg parecoxib could significantly reduce the postoperative opioid consumption.

Status of Clinical Application of Yufeng Ningxin Preparations and the Meta-Analysis of Its Efficacy and Safety in the Treatment of Cardiovascular and Cerebrovascular Diseases

Objective The objective of this study was to analyze the status of the clinical application of Yufeng Ningxin(YFNX)preparations and systematically evaluate their efficacy and safety in the treatment of cardiovascular and cerebrovascular diseases.Methods Through searching databases of China National Knowledge Infrastructure,Wanfang,SinoMed,VIP,PubMed,Embase,and the Cochrane Library,the literature of clinical research on YFNX preparations in treating malignant tumors of cardiovascular and cerebrovascular diseases from the establishment of the databases to February 2021 was collected.The clinical randomized controlled trials and case-control studies of cardiovascular and cerebrovascular diseases treated with these preparations were analyzed.Two reviewers independently screened literature,extracted data,and assessed the risk of bias in the included studies,and meta analysis was performed by using ReMan 5.3 software to analyze the eficacy and safety of YFNX preparations in the treatment of cardiovascular and cerebrovascular diseases.Results A total of 29 clinical studies were finally included.The dosage forms were dropping plls,tablets,capsules,and granules.The preparations were used for the treatment of coronary heart disease,hypertension,neuropathic headache,etc.This study systematically evaluated the efficacy and safety of YFNX preparations in the treatment of coronary heart disease,hypertension,and nervous headache.A total of 1,162 cases were included in 13 studies,582 cases of the YFNX preparation group and 580 cases of the Western medicine group.The results of meta-analysis showed that the clinical efficacy of YFNX preparations combined with the Western medicine group in the treatment of coronary heart disease and hypertension,improving electrocardiogram and reducing the frequency and duration of angina attacks,was better than that of the simple Western medicine group,and the difference was statistically significant.Conclusion YFNX preparations are effective for coronary heart disease,hypertension,and neuropathic headache,and the adverse reactions are few.

Acupuncture combined with speech rehabilitation training for post-stroke spasmodic dysphonia:a multicenter randomized controlled trial

Objective To observe the clinical efficacy of acupuncture combined with speech rehabilitation training for post-stroke spasmodic dysphonia and compare the differences in efficacy among the therapy of acupuncture combined with speech rehabilitation training and the monotherapy.Methods Two hundred and seventy cases of patients with post-stroke spasmodic dysarthria were randomly divided into three groups with the ratio of 1：1：1.Group A：acupuncture combined with speech rehabilitation training group（90 cases）,group B：acupuncture group（90 cases）,group C：speech rehabilitation training group（90 cases）.In the group B,acupuncture treatment was given at Baihui（百会 GV 20）,JTnjin（金津 EX-HN 12） and Yuye（玉液 EX-HN13） as well as tongue-three needles.In the group C,the treatment of speech rehabilitation training was provided.The two treatments mentioned above were combined in the group A.Patients were treated once a day for a month with improved Frenchay dysarthria rating scale as the indices of therapeutic effect evaluation.Results ① Group A：the cured and markedly effective rate was 88.7%,and total effective rate was 94.3%;group B：the cured and markedly effective rate was 44.2%and total effective rate was 81.4%;group C：the cured and markedly effective rate was 23.5%and total effective rate was 61.2%.Both the cured and markedly effective rate and the total effective rate in the group A were significantly higher than those in the group B or group C（all P0.05）;both the cured and markedly effective rate and the total effective rate in the group B were higher than those of group C（both P0.05）;② In comparison of functional recovery of tongue in accordance with the Frenchay dysarthria rating scale,the recovery rate of the tongue-stationary state was 71.74%in the group A,18.87%in the group B and 4.44%in the group C;the recovery rate of tongue lolling out was 66.23%in the group A,27.63%in the group B and 1.59%in the group C;the recovery rate of tongue up and down motion was 44.19%in the group A,4.94%in the group B and 1.35%in the group C;the recovery rate of lateral motion was 40.24%in the group A,7.59%in the group B and 0.00%in the group C;the recovery rate of alternating motion was 29.07%in the group A,7.14%in the group B and 1.23%in the group C;the recovery rate of speech was 29.07%in the group A,5.88%in the group B and 1.22%in the group C.In the three groups,the recovery rates of stationary state and tongue lolling out were superior to those of up and down movement,lateral movement,alternating movement and speech（all P0.05）.Conclusion The clinical efficacy of acupuncture combined with speech rehabilitation training for patients with post-stroke spasmodic dysarthria is significant,and the efficacy of acupuncture is superior to that of speech rehabilitation training;as for functional recovery of tongue like stationary state and tongue out,the therapy of acupuncture combined with speech rehabilitation training is effective.

The effect of meridian massage on BM,BMI,WC and HC in simple obesity patients:a randomized controlled trial

Objec ve To observe the eff ects of meridian massage on body weight（BW）. body mass index（BMI）,waist circumference（WC） and hip circumference（HC） in pa ents of simple obesity. Methods Fi y-four obesity pa ents were randomized into a massage group（28 patients） and a control group（26 patients） with SAS（statistical analysis software）. The patients in the control group were subjected to diet control and exercise program,while the pa ents in the massage group were subjected to diet control and massage program in combina on with meridian massage. Stomach meridian,spleen meridian,bladder meridian,Guānyuán（关元 CV 4）,Qihǎi（气海 CV 6）,Zhōngwǎn（中脘 CV 12）,Dàhéng（大横 SP 15,both sides）,Tiānshū（天枢 ST 25,both sides）,Zúsānl？（足三里 ST 36,both sides）,Fēnglóng（丰隆 ST 40,both sides） and Ashi points（at positions of fat accumulation） were selected,and the massages were mainly rolling manipulation,acupressure and pressing manipulation. The treatment was carried out 3 times a week for totally 24 times. Clinical therapeutic efficacy,BW,BMI,WC and HC of the patients in the two groups before and after treatment were evaluated. Results The difference in the comparison of therapeutic efficacy after treatment between the two groups was sta s cally significant,and the therapeu c effi cacy in the massage group was be er than that in the control group（P？？0.05）; BW,BWI,WC and HC in the massage group were significantly improved a er treatment in comparison to those before treatment and those in the control group after treatment（P？？0.05）. Conclusion Meridian massage can significantly improve body mass and other related indices of pa ents,improve their life quality,and thus may reduce the morbidity of obesity related diseases.

Study of remote efficacy and safety of acupuncture on cerebral infarction at recovery phase:multi-central randomized comparison trial

Objective To explore the remote efficacy and safety of consciousness-restoring resuscitation （Xingnao Kaiqiao, short for XNKQ） acupuncture on cerebral infarction at recovery phase. Methods Two hundred and thirty-four cases of cerebral infarction at recovery phase were randomized into XNKQ group and routine acupuncture group （routine group） in light of SAS code. One hundred and sixteen cases in the XNKQ group were treated with XNKQ acupuncture （once a day, totally 4 weeks） and routine treatment with western medicine. One hundred and eighteen cases in the routine group received routine acupuncture and routine treatment with western medicine. Follow-up lasted 6 months. Primary indexes： the situations of survival, treatment and recurrence at the end of follow-up. Secondary indexes： assessment of nerve functions at the end of follow-up and rate of adverse events during acupunc- ture. Results In 6 months follow-up, the mortality was 0.86% and rate of continuous treatment was 36.21% in the XNKQ group and they were 1.69% and 36.44% respectively in the routine group. The differences did not present statistical significance between the two groups （X^2 = 0.29, P=0.59; X^2 = 0.32, P = 0.57）. Concerning to the decrease of recurrence rate and improvement of nerve functions, the out-comes in the XNKQ group were superior to those in the routine group （P〈0.01）. Severe adverse events did not happen in the two groups. Conclusion XNKQ acupuncture is safe therapy and its remote efficacy is superior to that of routine acupuncture in the decrease of recurrence rate and improvement of nerve functions.

Meta-analysis of gemcitabine at 30 min standard-dose infusion versus prolonged low-dose infusion for advanced non-small cell lung cancer

To evaluate the efficacy and safety of gemcitabine （GEM） at 30 min standard-dose infusion （30 min-SDI） compared with prolonged low-dose infusion （P-LDI） in patients with advanced non-small-cell lung cancer （NSCLC）. Electronic databases including Pubmed, EMbase, Cochrane Library, CNKI, CBM, and VIP were searched using keywords ＂GEM＂, ＂P-LDI＂, and ＂NSCLC＂. Review Manager 5.3 was used to perform the recta-analysis. Primary endpoints were overall response rate （ORR） and 1-year survival rate （1-year SR）. Secondary endpoints were grade 3/4 hematotoxicity and nausea/vomiting. Six randomized controlled trials （RCTs） with a total of 637 patients were included. The results showed that P-LDI was superior in ORR （OR = 1.50, 95% CI： 1.08-2.10, P = 0.02）, but had an equal 1-year SR （OR = 1.27, 95 % CI： 0.90-1.79, P = 0.18） as compared with 30 min-SDl. For grade 3/4 adverse events, there was no significant difference in anemia （OR = 1.84, 95% CI： 0.61-5.57, P = 0.28） and nausea/vomiting （OR = 1.15, 95% CI： 0.63-2.12, P = 0.64） between the two treatments. However, patients with P-LDI experienced less leukopenia （OR = 0.64, 95% CI： 0.43-0.97, P = 0.04） and thrombocytopenia （OR = 0.37, 95% CI： 0.17-0.80, P = 0.01）. P-LDI was superior in terms of ORR, experienced less grade 3/4 thrombocytopenia and leukopenia compared with 30 min-SDI, and could be a viable treatment option for advanced NSCLC.

Effect of Acupuncture and Rehabilitation Training on Barthel Index in Early-stage of Stroke Cases

Objective： To study the effect of combined acupuncture and rehabilitation training on early-stage Barthel index of ischemic stroke cases. Method： Fifty ischemic stroke cases were randomized into a treatment group of 24 cases and control group of 26 cases. In addition to routine internal treatment methods, rehabilitation training was applied to cases in the control group, and combined acupuncture and rehabilitation training were applied to cases in the treatment group. Warming and reinforcing manipulations were applied to Jianyu （LI 15）, Quchi （LI 11）, Hegu （LI 4）, Yanglingquan （GB 34）, Yinlingquan （SP 9）, Zusanli （ST 36）, and Sanyinjiao （SP 6）, 20 rain of needle retaining for each point in one treatment. Then the scores of clinical neurological impairment and Barthel index of stroke cases were evaluated before the treatment and 3 weeks after respectively. Results： The significant progress and progress cases in the treatment group were 14 and 12 respectively, whereas that in the control group were 6 and 11 respectively, coupled with 7 cases of no progress. The therapeutic effect in the treatment is substantially better than the control group （P〈0.05）. There was no significant difference （P〉0.05） in neurological impairment and scores of Barthel index of the two groups before the treatment, whereas significant difference （P〈0.05） after the treatment. The scores of neurological impairment in the treatment group were significantly reduced after the treatment （P〈0.05）, and the scores of Barthel index were significantly increased （P〈0.05）. Conclusion： Combined acupuncture and rehabilitation training can produce significantly better effect on early neurological impairment and Barthel index of stroke cases than rehabilitation training alone.

Acupuncture on back-shu points of five zang for chronic fatigue syndrome:A randomized control trial

Objective: To observe the clinical efficacy of acupuncture on back-shu points of five zang in treating chronic fatigue syndrome(CFS).Methods: Sixty patients were randomized into treatment group and control group. In treatment group,the back-shu points of five zang organs were adopted for acupuncture. Shènshū(肾俞 BL23) was perpendicularly needled 15-30 mm in depth. The rest of the selected points were inserted obliquely 15-30 mm in the direction of the spine with even method of lifting-thrusting and twisting-twirling, 10 s for each acupoint. In control group, the acupoints were approximately 1.5-2 cm away outward from the back-shu points of five zang organs(about on the middle of the two sidelines of the bladder meridian of foottaiyang) and the points from the bladder meridian of foot-taiyang were excluded. Acupoints were needled6-9 mm in depth, and deqi was not required, without any manipulation. The treatments were carried out twice a week for twenty minutes each time, a total of eight treatments were given. The clinical efficacy of acupuncture treatment for CFS was evaluated through the Fatigue Scale-14(FS-14) and the Symptom Check-List 90(SCL-90) after treatment.Results: The total effective rate was 86.67% in the treatment group and 53.33% in the control group(P<0.01). In treatment group, FS-14 total scores, somatic fatigue scores, and mental fatigue scores were significantly reduced than before treatment(all P<0.01). In control group, FS-14 total scores and somatic fatigue scores were significantly reduced(both P<0.01). The improvement of FS-14 total scores, somatic fatigue scores, and mental fatigue scores in the treatment group were better than those in the control group(P<0.01, P<0.05). After treatment, SCL-90 total scores and somatization, compulsion, interpersonal sensitivity, depression, anxiety, hostility, psychoticism, and other factors scores were significantly reduced in the treatment group compared with before treatment(P<0.01). In control group, the SCL-90 total scores and the scores of somatization, compulsion, hostility, and other factors after treatment were lower than those before treatment(P< 0.01). The total scores of SCL-90 and somatization, compulsion, interpersonal sensitivity, depression, anxiety, psychoticism, and other factors in the treatment group were significantly lower than those in the control group(P< 0.01, P< 0.05).Conclusions: Acupuncture on back-shu points of five zang can significantly improve the somatic fatigue and mental fatigue of the patients, and at the same time improve their psychological status. Significant therapeutic effect was found on CFS. Compared with the control group, the acupuncture treatment can significantly improve the patient’s somatic fatigue, mental fatigue and psychological status.

Electroacupuncture at Qiuxu (GB 40) for Treatment of Migraine——A Clinical Multicentral Random Controlled Study

Objective： To observe the therapeutic effects of electroacupuncture （EA） at Qiuxu （GB 40） for treatment of migraine so as to provide clinical evidence for compilation of the Acupoints＇ Dictionary of the People＇s Republic of China. Methods： 275 migraine patients admitted in 3 hospitals were randomly divided into a treatment group treated by EA at Qiuxu （GB 40）, and a control group treated by EA at Tianshu （ST 25）. The indexes of the migraine symptoms and the 5-HT level were observed in both the groups before and after treatment. Results： There was an significant difference in VAS score between the two groups of the 3 clinical centers （P〈0.01）. The therapeutic effects of a 4-week treatment were much better in the treatment group than that of the control group. The 3-month follow-up survey showed that the long-term effects were in favor of the treatment group of the first and third clinical centers, though no significant difference was found in the treatment group of the second clinical center as compared with the control group. The results from the 6-month follow-up survey showed better effects in the treatment group of all the 3 clinical centers. Conclusion： EA at Oiuxu （GB 40） may show effect for migraine.

Rheumatoid arthritis treated with the triple strong-stimulation technique of acupuncture and moxibustion at specific acupoints:A randomized controlled trial

Objective: To explore the clinical therapeutic effects and the mechanism on rheumatic arthritis(RA)treated with the combination of the instruments and techniques of acupuncture and moxibusiton.Methods: A total of 60 RA patients were randomized into an observation group and a control group,30 cases in each one. In the control group, diclofenac sodium sustained release tablets were prescribed for oral administration, 0.3 g each time, twice a day, methotrexate tablets(MTX) for oral administration,10 mg each time, once a week and folic acid tablets for oral administration, 5 mg each time, once a week. In the observation group, besides the treatment with western medicines, simultaneously, the specific acupoints were selected and stimulated with the triple strong-stimulation therapy, in which, the strong bloodletting technique, the strong cupping technique and the strong moxibustion technique were combined together, with different instruments of acupuncture and moxibustion adopted. The treatment was given once every 3 days, consecutively for 10 times. In 30 days of treatment, the therapeutic effects were observed in the two groups. Separately, before and after treatment, the rheumatoid factors(RF),hypersensitive-C reactive protein(hs-CRP) and erythrocyte sedimentation rate(ESR), the scores of joint symptoms and physical signs as well as the disease activity score(DAS-28) were observed in the two groups.Results: Regarding RF, there were statistical significant differences before and after treatment in the observation group and the control group(the observation group 248.01 ± 79.81 vs 31.17 ± 29.01,the control group 254.11 ± 72.16 vs 66.42 ± 37.07, both P < 0.05). The result in the observation group was lower significantly than the control group after treatment(P < 0.05). Regarding hs-CRP, there were statistical significant differences before and after treatment in the observation group and the control group(the observation group 26.12 ± 9.22 vs 8.98 ± 7.66, the control group 23.18 ± 7.18 vs 16.01 ± 5.02, both P < 0.05). The result in the observation group was lower significantly than the control group after treatment(P < 0.05). Regarding ESR, there were statistical significant differences before and after treatment in the observation group and the control group(the observation group 30.56 ± 11.38 vs 12.58 ± 5.91,the control group 35.52 ± 9.67 vs 21.47 ± 6.91, both P < 0.05). The result in the observation group was lower significantly than the control group after treatment(P < 0.05). Regarding DAS-28, there were statistical significant differences before and after treatment in the observation group and the control group(the observation group 8.89 ± 2.01 vs 3.01 ± 0.74, the control group 8.14 ± 1.38 vs 4.12 ± 0.96, both P < 0.05). The result in the observation group was lower significantly than the control group after treatment(P < 0.05). Regarding the quantitative grading score of symptom, there were statistical significant differences before and after treatment in the observation group and the control group(the observation group 7.87 士 1.69 vs 3.82 ±1.96, the control group 7.77 ± 1.68 vs 5.01 ± 11.23, both P < 0.05). The result in the observation group was lower significantly than the control group after treatment(P < 0.05).The total effective rate was 96.67%(29/30) in the observation group and was 80.0%(24/30) in the control group, indicating the statistical significant difference between the two groups(P < 0.01).Conclusion: Based on western medications, the triple strong-stimulation therapy of acupuncture and moxibustion at specific acupoints significantly relieves the joint symptoms, reduces the inflammatory reaction indicators and improves the clinical therapeutic effects on RA in the patients.

The Needle-Rolling Therapy for Treatment of Non-organic Chronic Insomnia in 90 Cases

Objective: To evaluate the therapeutic effects of needle-rolling therapy for chronic insomnia. Methods: In the present multi-central randomly controlled clinical study, 180 cases of chronic insomnia were randomly divided into the following two groups, a treatment group (90 cases) treated by the needle-rolling therapy and a control group (90 cases) treated with clonopin. The treatment course for both the two groups was 4 weeks. The therapeutic effects were evaluated based on improvement of the TCM symptoms and the Pittsburgs's sleep-quality index (PSQI). Results: After treatment, there were significant differences between the two groups in the effective rate (P<0.05), and in the total score of PSQI and in the scores of the 4 sub-items, i.e. sleep-quality, sleep-efficiency, hypnotic and daytime function (P<0.05). Although there was no significant difference between the two groups in the effective rate after a 3-month follow-up period, significant differences still existed in the 3 sub-items of sleep-efficiency, hypnotic, and daytime function of the PSQI (P<0.05). Conclusion: As compared with hypnotics of the second generation, the needle-rolling therapy may show better therapeutic effects for chronic insomnia patients.