During mitosis, the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation, a complex movements orchestrated by mitotic kinases and its effector proteins. Faithful...During mitosis, the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation, a complex movements orchestrated by mitotic kinases and its effector proteins. Faithful chromosome segregation and cytokinesis ensure that each daughter cell receives a full copy of genetic materials of parent cell. Defects in these processes can lead to aneuploidy or polyploidy. Aurora/Ipl1p family, a class of conserved serine/threonine kinases, plays key roles in chromosome segregation and cytokinesis. This article highlights the function and regulation of Aurora/Ipllp family in mitosis and provides potential links between aberrant regulation of Aurora/Ipllp kinases and pathogenesis of human cancer.展开更多
In order to inhibit Free Riding in Peer-toPeer(P2P) file-sharing systems,the Free Riding Inhibition Mechanism Based on User Behavior(IMBUB) is proposed.IMBUB considers the regularity of user behavior and models user b...In order to inhibit Free Riding in Peer-toPeer(P2P) file-sharing systems,the Free Riding Inhibition Mechanism Based on User Behavior(IMBUB) is proposed.IMBUB considers the regularity of user behavior and models user behavior by analyzing many definitions and formulas.In IMBUB,Bandwidth Allocated Ratio,Incentive Mechanism Based on User Online Time,Double Reward Mechanism,Incentive Mechanism of Sharing for Permission and Inhibition Mechanism of White-washing Behavior are put forward to inhibit Free Riding and encourage user sharing.A P2P file system BITShare is designed and realized under the conditions of a campus network environment.The test results show that BITShare's Query Hit Ratio has a significant increase from 22% to 99%,and the sharing process in BITShare is very optimistic.Most users opt to use online time to exchange service quality instead of white-washing behavior,and the real white-ishing ratio in BITShare is lower than 1%.We confirm that IMBUB can effectively inhibit Free Riding behavior in P2P file-sharing systems.展开更多
The center cutter of a hard rock tunnel boring machine(TBM) is installed on the cutterhead at a small radius and thus bears complex side force.Given this fact,the formation mechanism and change law of the side force s...The center cutter of a hard rock tunnel boring machine(TBM) is installed on the cutterhead at a small radius and thus bears complex side force.Given this fact,the formation mechanism and change law of the side force suffered by the center cutter were studied.Based on the rock shear failure criterion in combination with the lateral rolling width,a model for predicting the average side force was set up.Besides,a numerical analysis model of the rock fragmentation of the center cutter was established,and the instantaneous load changing features were investigated.Results shows that the inner side of the center cutter can form lateral rolling annulus in rock during the rotary cutting process.The smaller the installation radius is,the greater the cutter side force will be.In a working condition,the side force of the innermost center cutter is 11.66 k N,while it decreases sharply when installation radius increases.Variation tends to be gentle when installation radius is larger than 500 mm,and the side force of the outermost center cutter is reduced to 0.74 k N.展开更多
The movement principle of sidewalls and floor of extraction opening is analyzed, it is found that floor heave not only has something to do with the floor strata, but sidewalls. The effect of sidewall anchor and corner...The movement principle of sidewalls and floor of extraction opening is analyzed, it is found that floor heave not only has something to do with the floor strata, but sidewalls. The effect of sidewall anchor and corner anchor is studied, the mechanical principle of reinforcing sidewalls and corners is put forward and applied in engineering practice.展开更多
Outsourcing elderly home-based service reduces risk, improves service quality and efficiency while there are risks mainly for demand-side risk and supply-side risk. In order to prevent these risks, risk-management fra...Outsourcing elderly home-based service reduces risk, improves service quality and efficiency while there are risks mainly for demand-side risk and supply-side risk. In order to prevent these risks, risk-management framework should be constructed with risk preparedness, risk identification, risk analysis, risk assessment and risk disposal as a whole process. Finally, this paper puts forward some suggestions to strengthen the legal regulation, improve the supervision mechanism, strengthen the purchasing performance evaluation and improve the capability ofnonprofits to delivery the service and so on,展开更多
文摘During mitosis, the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation, a complex movements orchestrated by mitotic kinases and its effector proteins. Faithful chromosome segregation and cytokinesis ensure that each daughter cell receives a full copy of genetic materials of parent cell. Defects in these processes can lead to aneuploidy or polyploidy. Aurora/Ipl1p family, a class of conserved serine/threonine kinases, plays key roles in chromosome segregation and cytokinesis. This article highlights the function and regulation of Aurora/Ipllp family in mitosis and provides potential links between aberrant regulation of Aurora/Ipllp kinases and pathogenesis of human cancer.
基金This work was partly supported by 2012 Outstanding Talents Project of Beijing Organization Department under Grant No.2012D00501700005，Science and Technology Project of Beijing Municipal Education Commission under Grant No.KM201110016006，National Natural Science Foundation of China under Grant No.61100205
文摘In order to inhibit Free Riding in Peer-toPeer(P2P) file-sharing systems,the Free Riding Inhibition Mechanism Based on User Behavior(IMBUB) is proposed.IMBUB considers the regularity of user behavior and models user behavior by analyzing many definitions and formulas.In IMBUB,Bandwidth Allocated Ratio,Incentive Mechanism Based on User Online Time,Double Reward Mechanism,Incentive Mechanism of Sharing for Permission and Inhibition Mechanism of White-washing Behavior are put forward to inhibit Free Riding and encourage user sharing.A P2P file system BITShare is designed and realized under the conditions of a campus network environment.The test results show that BITShare's Query Hit Ratio has a significant increase from 22% to 99%,and the sharing process in BITShare is very optimistic.Most users opt to use online time to exchange service quality instead of white-washing behavior,and the real white-ishing ratio in BITShare is lower than 1%.We confirm that IMBUB can effectively inhibit Free Riding behavior in P2P file-sharing systems.
基金Project (2013CB035401) supported by the National Basic Research Program of ChinaProject (51475478) supported by the National Natural Science Foundation of ChinaProject (2012AA041803) supported by the High-Tech Research and Development Program of China
文摘The center cutter of a hard rock tunnel boring machine(TBM) is installed on the cutterhead at a small radius and thus bears complex side force.Given this fact,the formation mechanism and change law of the side force suffered by the center cutter were studied.Based on the rock shear failure criterion in combination with the lateral rolling width,a model for predicting the average side force was set up.Besides,a numerical analysis model of the rock fragmentation of the center cutter was established,and the instantaneous load changing features were investigated.Results shows that the inner side of the center cutter can form lateral rolling annulus in rock during the rotary cutting process.The smaller the installation radius is,the greater the cutter side force will be.In a working condition,the side force of the innermost center cutter is 11.66 k N,while it decreases sharply when installation radius increases.Variation tends to be gentle when installation radius is larger than 500 mm,and the side force of the outermost center cutter is reduced to 0.74 k N.
文摘The movement principle of sidewalls and floor of extraction opening is analyzed, it is found that floor heave not only has something to do with the floor strata, but sidewalls. The effect of sidewall anchor and corner anchor is studied, the mechanical principle of reinforcing sidewalls and corners is put forward and applied in engineering practice.
文摘Outsourcing elderly home-based service reduces risk, improves service quality and efficiency while there are risks mainly for demand-side risk and supply-side risk. In order to prevent these risks, risk-management framework should be constructed with risk preparedness, risk identification, risk analysis, risk assessment and risk disposal as a whole process. Finally, this paper puts forward some suggestions to strengthen the legal regulation, improve the supervision mechanism, strengthen the purchasing performance evaluation and improve the capability ofnonprofits to delivery the service and so on,
