The journal Truth, Beauty, and Goodness was the main field where ZENG Xu-bai published his literature works; in response to the miscellaneous ＂revolutionary literature＂ at that time, he put forward the idea that lit...The journal Truth, Beauty, and Goodness was the main field where ZENG Xu-bai published his literature works; in response to the miscellaneous ＂revolutionary literature＂ at that time, he put forward the idea that literature should be a combination of unity and artistry, and emphasized self-expression of literature on the basis of popularization of literature. With these literature views, his works also had shown his pursuit for the specialty and artistry of literature, as well as a transition from technique-oriented writing to a balance of emotion expression and technique usage. Anyway, during his translation of French literature and creative practice, the rich literature nutrition he received led to his unclear and complex thoughts which he neutralized with carefulness, and hence his unique literature views.展开更多
Objective: To understand the function of nicotinamide N-methyltransferase (NNMT) protein as tumor biomarker in renal carcinoma. Methods: Recombinant NNMT protein was used to prepare monoclonal antibodies by hybridoma ...Objective: To understand the function of nicotinamide N-methyltransferase (NNMT) protein as tumor biomarker in renal carcinoma. Methods: Recombinant NNMT protein was used to prepare monoclonal antibodies by hybridoma technique. The diagnostic and prognostic function of NNMT protein in renal carcinoma was evaluated by analyzing 74 renal cancer tissues through immunohistochemical staining for NNMT by using the prepared antibodies. Results: Two hybridomas named 2F8 and 1E7 stably secreting the monoclonal antibodies were isolated successfully, and characters such as isotypes and specificity were determined. NNMT protein was significantly up-regulated in renal cancer and significantly associated with tumor histology and ages. The univariate survival analysis demonstrated that the pT-status, high levels of NNMT, and distant metastasis were significant prognosticators. Conclusion: NNMT is over-expressed in a large proportion in renal cell cancers. High NNMT expression is significantly associated with unfavorable prognosis. However, the prognostic value of NNMT needs further verification in larger sample sizes.展开更多
文摘The journal Truth, Beauty, and Goodness was the main field where ZENG Xu-bai published his literature works; in response to the miscellaneous ＂revolutionary literature＂ at that time, he put forward the idea that literature should be a combination of unity and artistry, and emphasized self-expression of literature on the basis of popularization of literature. With these literature views, his works also had shown his pursuit for the specialty and artistry of literature, as well as a transition from technique-oriented writing to a balance of emotion expression and technique usage. Anyway, during his translation of French literature and creative practice, the rich literature nutrition he received led to his unclear and complex thoughts which he neutralized with carefulness, and hence his unique literature views.
基金Project supported by the Science Foundation of Health Bureau of Zhejiang Province (Nos. 2005A055 and 2008B114)the Science Foundation of Education Bureau of Zhejiang Province (No. 20061271), China
文摘Objective: To understand the function of nicotinamide N-methyltransferase (NNMT) protein as tumor biomarker in renal carcinoma. Methods: Recombinant NNMT protein was used to prepare monoclonal antibodies by hybridoma technique. The diagnostic and prognostic function of NNMT protein in renal carcinoma was evaluated by analyzing 74 renal cancer tissues through immunohistochemical staining for NNMT by using the prepared antibodies. Results: Two hybridomas named 2F8 and 1E7 stably secreting the monoclonal antibodies were isolated successfully, and characters such as isotypes and specificity were determined. NNMT protein was significantly up-regulated in renal cancer and significantly associated with tumor histology and ages. The univariate survival analysis demonstrated that the pT-status, high levels of NNMT, and distant metastasis were significant prognosticators. Conclusion: NNMT is over-expressed in a large proportion in renal cell cancers. High NNMT expression is significantly associated with unfavorable prognosis. However, the prognostic value of NNMT needs further verification in larger sample sizes.
