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蛛丝蛋白复合材料小直径血管支架的体内降解及体外生物相容性的研究 被引量:3
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作者 赵亮 陈红丽 +5 位作者 王勉 解丽芹 徐艳丽 何孟 冯志伟 李敏 《中国生物医学工程学报》 CAS CSCD 北大核心 2016年第1期88-95,共8页
探讨蛛丝蛋白复合材料小直径血管支架的体内降解性能和生物相容性,为其临床应用奠定基础。通过静电纺丝仪,将RGD-重组蛛丝蛋白(p NSR16)、聚己内酯(PCL)、明胶(Gt)、壳聚糖(CS)共混形成的纺丝液进行电纺,制得(p NSR16/PCL/CS)/(p NSR16/... 探讨蛛丝蛋白复合材料小直径血管支架的体内降解性能和生物相容性,为其临床应用奠定基础。通过静电纺丝仪,将RGD-重组蛛丝蛋白(p NSR16)、聚己内酯(PCL)、明胶(Gt)、壳聚糖(CS)共混形成的纺丝液进行电纺,制得(p NSR16/PCL/CS)/(p NSR16/PCL/Gt)支架,并将其植入SD大鼠腿部肌肉中,通过肉眼外观观察、组织切片HE染色评价等方法,评价蛛丝蛋白复合材料小直径血管支架的体内降解情况。分析支架浸提液对间充质干细胞集落形成、细胞分裂指数、台盼蓝拒染率、细胞毒性和细胞周期的影响,评价血管支架的生物相容性。血管支架在整个植入期内不断降解,(p NSR16/PCL/CS)/(p NSR16/PCL/Gt)支架降解程度更深,纤维断裂严重,12周时失重率为20.3%,其降解速度明显快于(PCL/CS)/(PCL/Gt)支架,后者在12周时仅降解了13.2%。在(p NSR16/PCL/CS)/(p NSR16/PCL/Gt)支架浸提液培养条件下的大鼠骨髓MSC集落生成率、平均集落面积和分裂指数都显著高于(PCL/CS)/(PCL/Gt)支架组。血管支架毒性等级均低于1级,无细胞毒性。与血管支架浸提液复合培养的MSC生长状态良好,台盼蓝拒染率高于95%,复合培养48 h后,细胞G0/1期比例降低,S、G2/M期比例均升高。蛛丝蛋白复合材料小直径血管支架的体内降解和生物相容性良好,应用于临床具有一定的可行性。 展开更多
关键词 组织工程血管 蛛丝蛋白复合材料直径血管支架 体内降解 体外生物相容性
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高温作用后GFRP/BFRP筋拉伸性能试验研究及强度折减计算 被引量:4
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作者 陆春华 平安 +1 位作者 延永东 张菊连 《哈尔滨工程大学学报》 EI CAS CSCD 北大核心 2023年第3期443-449,共7页
为探讨高温作用后2类纤维增强复合材料(FRP筋材)的拉伸性能退化情况,本文对高温作用后的玻璃/玄武岩纤维增强复合材料(GFRP/BFRP)筋材进行了拉伸试验,并将宏观与微观结合进行分析。试验结果表明:高温超过220℃后,筋材表面部分纤维开始脱... 为探讨高温作用后2类纤维增强复合材料(FRP筋材)的拉伸性能退化情况,本文对高温作用后的玻璃/玄武岩纤维增强复合材料(GFRP/BFRP)筋材进行了拉伸试验,并将宏观与微观结合进行分析。试验结果表明:高温超过220℃后,筋材表面部分纤维开始脱落,整体性逐渐遭到破坏,已不再适合进行拉伸试验;经220℃以内温度作用后,2类FRP筋材抗拉强度均随作用温度升高呈阶段性下降的趋势;而弹性模量总体变化幅度很小;高温作用后,直径16 mm的GFRP筋抗拉强度下降速率比12 mm的2种FRP筋更快;结合试验结果与扫描电镜微观结构分析,可认为高温作用后2类FRP筋抗拉强度退化的主要原因是树脂和纤维界面黏结性能的退化。结合本文和已有相关试验结果,提出了20~220℃温度范围内G/BFRP筋抗拉强度的折减计算模型,并给出了关键温度节点对应的强度保留率ηt建议值。 展开更多
关键词 火灾 高温作用 纤维增强复合材料直径 玻璃纤维增强复合材料 玄武岩纤维增强复合材料 微观分析 拉伸性能 强度计算
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内窥镜蛇骨节冲压回弹影响因素研究
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作者 胡聪慧 金晓怡 +1 位作者 何志坤 奚鹰 《农业装备与车辆工程》 2023年第11期76-80,共5页
内窥镜蛇骨节固定孔是为了放置0.15 mm的钢丝绳而设计,固定孔由冲压工艺获得,冲压完成后会发生回弹,从而影响钢丝绳的放置。针对此问题,首先分析冲压成形的特点以及冲压之后回弹的原因,并基于此建立回弹量表征——曲率半径变化量和Z轴... 内窥镜蛇骨节固定孔是为了放置0.15 mm的钢丝绳而设计,固定孔由冲压工艺获得,冲压完成后会发生回弹,从而影响钢丝绳的放置。针对此问题,首先分析冲压成形的特点以及冲压之后回弹的原因,并基于此建立回弹量表征——曲率半径变化量和Z轴方向的回弹量;其次,将三维软件建立的蛇骨节模型导入AutoForm软件,设置3道工序对蛇骨节固定孔冲压进行仿真模拟,分别从材料厚度、材料直径以及摩擦系数这3个方面研究对回弹量的影响。结果表明,随着材料厚度、材料直径以及摩擦系数的不断增加,Z轴方向的回弹量呈逐渐减小趋势。该结论可为之后企业设计蛇骨节提供参考。 展开更多
关键词 蛇骨节 回弹 材料厚度 材料直径 摩擦系数
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Parametric study on the axial performance of a fully grouted cable bolt with a new pull-out test 被引量:7
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作者 Chen Jianhang Hagan Paul C. Saydam Serkan 《International Journal of Mining Science and Technology》 SCIE EI CSCD 2016年第1期53-58,共6页
Modified cable bolts are commonly used in underground mines due to their superior performance in preventing bed separation when compared with plain strands. To better test the axial performance of a wide range of cabl... Modified cable bolts are commonly used in underground mines due to their superior performance in preventing bed separation when compared with plain strands. To better test the axial performance of a wide range of cable bolts,a new laboratory short encapsulation pull test(LSEPT) facility was developed. The facility simulates the interaction between cable bolts and surrounding rock mass,using artificial rock cylinders with a diameter of 300 mm in which the cable bolt is grouted. Furthermore,the joint where the load is applied is left unconstrained to allow shear slippage at the cable/grout or grout/rock interface.Based on this apparatus,a series of pull tests were undertaken using the MW9 modified bulb cable bolt.Various parameters including embedment length,test material strength and borehole size were evaluated. It was found that within a limited range of 360 mm,there is a linear relationship between the maximum bearing capacity of the cable bolt and embedment length. Beyond 360 mm,the peak capacity continues to rise but with a much lower slope. When the MW9 cable bolt was grouted in a weak test material,failure always took place along the grout/rock interface. Interestingly,increasing the borehole diameter from 42 to 52 m in weak test material altered the failure mode from grout/rock interface to cable/grout interface and improved the performance in terms of both peak and residual capacity. 展开更多
关键词 Modified cable boltsLoad transfer performanceShear slippageCable/grout interfaceEmbedment length
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Ultra-Thin Double-Walled Carbon Nanotubes: A Novel Nanocontainer for Preparing Atomic Wires 被引量:5
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作者 Lei Shi Leimei Sheng +3 位作者 Liming Yu Kang An Yoshinori Ando Xinluo Zhao 《Nano Research》 SCIE EI CAS CSCD 2011年第8期759-766,共8页
Double-walled carbon nanotubes (DWCNTs) with high graphitization have been synthesized by hydrogen arc discharge. The obtained DWCNTs have a narrow distribution of diameters of both the inner and outer tubes, and mo... Double-walled carbon nanotubes (DWCNTs) with high graphitization have been synthesized by hydrogen arc discharge. The obtained DWCNTs have a narrow distribution of diameters of both the inner and outer tubes, and more than half of the DWCNTs have inner diameters in the range 0.6-1.0 nm. Field electron emission from a DWCNT cathode to an anode has been measured, and the emission current density of DWCNTs reached 1 A/cm2 at an applied field of about 4.3 V/~tm. After high-temperature treatment of DWCNTs, long linear carbon chains (C-chains) can be grown inside the ultra-thin DWCNTs to form a novel C-chain@DWCNT nanostructure, showing that these ultra-thin DWCNTs are an appropriate nanocontainer for preparing truly one-dimensional nanostructures with one-atom-diameter. 展开更多
关键词 Arc discharge carbon chains double-walled carbon nanotubes field electron emission NANOCONTAINER NANOWIRES
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Geometric optimization of electrostatic fields for stable levitation of metallic materials 被引量:4
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作者 HU Liang WANG HaiPeng +1 位作者 LI LiuHui WEI BingBo 《Science China(Technological Sciences)》 SCIE EI CAS 2013年第1期53-59,共7页
Experimental and computational methods are used to optimize the electrostatic field for levitating metallic materials.The calculated launch voltage increases linearly with the distance between top and bottom electrode... Experimental and computational methods are used to optimize the electrostatic field for levitating metallic materials.The calculated launch voltage increases linearly with the distance between top and bottom electrodes.The combination of a larger top electrode diameter with a smaller bottom diameter may enhance the levitation ability because the electric field intensity near the levitated sample is strengthened.Top convex and bottom concave electrodes can guarantee good levitation stability but decrease the levitation force.The design of bottom electrode is crucial to attain not only a stable levitation state but also a higher levitation capability.As a measure characterizing the intrinsic levitation ability of various materials,the product of density and diameter of levitated samples can be used to determine the launch voltage for counteracting gravity according to a power relationship. 展开更多
关键词 electrostatic levitation containerless processing capacitive induction space science
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Huge metastable axial strain in ultrathin heteroepitaxial vertically aligned nanowires
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作者 Vivien Schuler Francisco Javier Bonilia +10 位作者 Dominique Demaille Alessandro Coati Alina Vlad Yves Garreau Michele Sauvage-Simkin Anastasiia Novikova Emiliano Fonda Sarah Hidki Victor Etgens Franck Vidal Yunlin Zheng 《Nano Research》 SCIE EI CAS CSCD 2015年第6期1964-1974,共11页
Strain engineering is a powerful tool to tailor the physical properties of materials coherently stacked in an epitaxial heterostructure. Such an approach, applied to the mature field of planar heteroepitaxy, has yield... Strain engineering is a powerful tool to tailor the physical properties of materials coherently stacked in an epitaxial heterostructure. Such an approach, applied to the mature field of planar heteroepitaxy, has yielded a variety of new phenomena and devices. Recently, heteroepitaxial vertically aligned nanocomposites have emerged as alternatives to planar structures. Owing to the peculiar geometry of such nanoarchitectures, efficient strain control can be achieved, opening the way to novel functionalities. In this paper, we report a very large tensile axial strain in epitaxial transition metal nanowires embedded in an oxide matrix. We show that axial strains in excess of 1.5% can be sustained over a large thickness (a few hundred nanometers) in epitaxial nanowires having ultrasmall diameters (-3-6 nm). The axial strain depends on the diameter of the nanowires, reflecting its epitaxial nature and the balance of interface and elastic energies. Furthermore, it is experimentally shown that such strain is metastable, in agreement with the calculations performed in the framework of the Frenkel-Kontorova model. The diameter dependence and metastability provide effective ways to control the strain, an appealing feature for the design of functional nanoarchitectures. 展开更多
关键词 SELF-ASSEMBLY HETEROEPITAXY NANOWIRES strain
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