With the continuous development of science and technology and constantly improve of the quality of life, most people are increasingly aware of the importance of the environment. According to the serious problem that r...With the continuous development of science and technology and constantly improve of the quality of life, most people are increasingly aware of the importance of the environment. According to the serious problem that resource consumption and environmental pollution caused by the traditional building materials, green building materials has been the support of the people. Because of its low consumption, less pollution, beneficial to human health, harmony with the environment and other excellent performance, the green building materials has a rapid development in recent years. This paper is based on the thinking of innovation, starting from the environment, energy saving point of view, analysis the advantages and shortcomings of green building materials, explore the developing trend and future of this new type of material.展开更多
Based on Biot's model for fluid-saturated media,which takes the inertial,fluid viscous,mechanical couplings,compressibility of grains and fluid into account,the dispersion equations of plane waves in non-homogeneo...Based on Biot's model for fluid-saturated media,which takes the inertial,fluid viscous,mechanical couplings,compressibility of grains and fluid into account,the dispersion equations of plane waves in non-homogeneously saturated soil are established by using reverberation ray matrix method(RRMM) with the aid of Helmholtz theorem.The non-homogeneity considered is a gradient variation in material properties with depth.The propagation characteristic of elastic waves in non-homogeneously saturated soil is analyzed by numerical example in this paper.The results show that the wave number and dissipation change little for two kinds of compression along the variation direction of the material properties,however,the non-homogeneity has significant effect on the wave number and dissipation of shear wave.展开更多
Cationic lipids have been applied to siRNA delivery for tumor therapeutics. However, the excess positive charges of these nanoplexes may lead to high cytotoxicity and nonnegligible immunogenicity both in vitro and in ...Cationic lipids have been applied to siRNA delivery for tumor therapeutics. However, the excess positive charges of these nanoplexes may lead to high cytotoxicity and nonnegligible immunogenicity both in vitro and in vivo, which limited the applications of gene drugs. We constructed multi-component lipoplex to delivery 3＇,3＂-bis-peptide-siRNA conjugate （pp-siRNA） by the treatment of melanoma. Based on the previous studies that the gemini lipid （CLD） encapsulated pp-siRNA, a novel neutral cytosin-l-yl- lipid （DNCA） was considered to replace a certain ration of CLD by hydrogen bonds and ~t-n stacking for reducing the cytotoxicity. It similarly retained in both the loading efficiency and targeted mRNA inhibition when DNCA was accounted for 40% in the lipoplex, with lower toxicity. Moreover, CLD/DNCA/pp-siRNA nanoplex could be uptake in A375 cells and internalized mainly by macropinocytosis and caveolin-mediated endocytosis. Besides, 90% CLD/DNCA/pp-siRNA nanoplexes presented the highest efficient knockdown for the mutant B-RAF mRNA （-80%）. All the results demonstrated that the mixed cationic and neutral lipids could efficiently realize the delivery of pp-siRNA and had potential application for cancer therapy.展开更多
We study a model of scalars which includes both the SM Higgs and a scalar singlet as composites of heavy vector-like fermions. The vector-like fermions are bounded by the super-strong four-fermion interactions. The sc...We study a model of scalars which includes both the SM Higgs and a scalar singlet as composites of heavy vector-like fermions. The vector-like fermions are bounded by the super-strong four-fermion interactions. The scalar singlet decays to SM vector bosons through loop of heavy vector-like fermions. We show that the surprisingly large production cross section of di-photon events at 750 GeV resonance and the odd decay properties can all be explained.This model serves as a good model for both SM Higgs and a scalar resonance at 750 GeV.展开更多
文摘With the continuous development of science and technology and constantly improve of the quality of life, most people are increasingly aware of the importance of the environment. According to the serious problem that resource consumption and environmental pollution caused by the traditional building materials, green building materials has been the support of the people. Because of its low consumption, less pollution, beneficial to human health, harmony with the environment and other excellent performance, the green building materials has a rapid development in recent years. This paper is based on the thinking of innovation, starting from the environment, energy saving point of view, analysis the advantages and shortcomings of green building materials, explore the developing trend and future of this new type of material.
基金supported by the National Natural Science Foundation of China (Grant No. 11162008)the Fund of Education Department of Gansu Province of China for Master's Tutor (1103-07)the Fundamental Research Funds for the Gansu Universities (Grant No. 1104ZTC140)
文摘Based on Biot's model for fluid-saturated media,which takes the inertial,fluid viscous,mechanical couplings,compressibility of grains and fluid into account,the dispersion equations of plane waves in non-homogeneously saturated soil are established by using reverberation ray matrix method(RRMM) with the aid of Helmholtz theorem.The non-homogeneity considered is a gradient variation in material properties with depth.The propagation characteristic of elastic waves in non-homogeneously saturated soil is analyzed by numerical example in this paper.The results show that the wave number and dissipation change little for two kinds of compression along the variation direction of the material properties,however,the non-homogeneity has significant effect on the wave number and dissipation of shear wave.
基金The National Natural Science Foundation of China(Grant No.21778006 and 20932001)the Ministry of Science and Technology of China(Grant No.2012AA022501)
文摘Cationic lipids have been applied to siRNA delivery for tumor therapeutics. However, the excess positive charges of these nanoplexes may lead to high cytotoxicity and nonnegligible immunogenicity both in vitro and in vivo, which limited the applications of gene drugs. We constructed multi-component lipoplex to delivery 3＇,3＂-bis-peptide-siRNA conjugate （pp-siRNA） by the treatment of melanoma. Based on the previous studies that the gemini lipid （CLD） encapsulated pp-siRNA, a novel neutral cytosin-l-yl- lipid （DNCA） was considered to replace a certain ration of CLD by hydrogen bonds and ~t-n stacking for reducing the cytotoxicity. It similarly retained in both the loading efficiency and targeted mRNA inhibition when DNCA was accounted for 40% in the lipoplex, with lower toxicity. Moreover, CLD/DNCA/pp-siRNA nanoplex could be uptake in A375 cells and internalized mainly by macropinocytosis and caveolin-mediated endocytosis. Besides, 90% CLD/DNCA/pp-siRNA nanoplexes presented the highest efficient knockdown for the mutant B-RAF mRNA （-80%）. All the results demonstrated that the mixed cationic and neutral lipids could efficiently realize the delivery of pp-siRNA and had potential application for cancer therapy.
基金Supported by National Natural Science Foundation of China(NSFC) under Grant Nos.11135009,11375065 and 10925522
文摘We study a model of scalars which includes both the SM Higgs and a scalar singlet as composites of heavy vector-like fermions. The vector-like fermions are bounded by the super-strong four-fermion interactions. The scalar singlet decays to SM vector bosons through loop of heavy vector-like fermions. We show that the surprisingly large production cross section of di-photon events at 750 GeV resonance and the odd decay properties can all be explained.This model serves as a good model for both SM Higgs and a scalar resonance at 750 GeV.
