Microcapsules of volatile oil containing Herba Schizonepetae(VOHS) were prepared by emulsion solvent diffusion method to improve the drug loading and reduce the amount of pharmaceutical excipients.Orthogonal assay was...Microcapsules of volatile oil containing Herba Schizonepetae(VOHS) were prepared by emulsion solvent diffusion method to improve the drug loading and reduce the amount of pharmaceutical excipients.Orthogonal assay was applied to optimize the preparation condition of microcapsulation,and the results illustrated that the ratio of ethyl cellulose(EC) to VOHS influenced the property of VOHS microcapsule significantly.GC-MS analysis indicated that some volatile components with low concentration in VOHS were lost after microencapsulation.The microcapsules prepared with optimum condition had good fluidity,and the holes on the surface of the microcapsules contributed to the release of VOHS.The particles of the microcapsule conformed to a normal distribution with the diameter of 45—220 μm.In the simulated intestinal fluid containing 0.2% sodium dodecyl sulfate,pulegone in VOHS microcapsule showed a certain degree of slow release.Compared with β-cyclodextrin method,the microencapsulation used in the present work could reduce the amount of excipients and increase the drug loading.It was beneficial to reduce the dose of Chinese medicines containing volatile oils.展开更多
The study aimed to determine, by using a statistical model, the effect of weather conditions on the incidence of Lophodermium yellow needle blight causing by new species for science- Lophodermium corconticum, in the m...The study aimed to determine, by using a statistical model, the effect of weather conditions on the incidence of Lophodermium yellow needle blight causing by new species for science- Lophodermium corconticum, in the mountain dwarf pine growing in the subalpine Karkonosze Mountains and the Izerskie Mountains(Poland). Needles showed symptoms of yellow spots, gradual discolouration and premature fall in July. The assessment of healthiness of infected mountain dwarf pine needles spanned three years(2011- 2013) and was conducted in several test sites in the Karkonosze and Izerskie Mountains. The results were analyzed by taking into account the meteorological conditions. Field observations seem to indicate that the highest infestation of mountain dwarf pine occurs in June and July, while September and October see a significantly lower disease index in the Karkonosze Mountains. The lower indices of the infestation of mountain dwarf pine are characteristic for the vegetation in the Hala Izerska high mountain pasture; whereas the environmental conditions prevailing in the Kocio? Ma?ego Stawu cirque and above the Samotnia hostel are conducive to the development of Lophodermium yellow needle blight.展开更多
基金Supported by the Plan Issue of Shanghai Science&Technology Committee(No.13401901100)
文摘Microcapsules of volatile oil containing Herba Schizonepetae(VOHS) were prepared by emulsion solvent diffusion method to improve the drug loading and reduce the amount of pharmaceutical excipients.Orthogonal assay was applied to optimize the preparation condition of microcapsulation,and the results illustrated that the ratio of ethyl cellulose(EC) to VOHS influenced the property of VOHS microcapsule significantly.GC-MS analysis indicated that some volatile components with low concentration in VOHS were lost after microencapsulation.The microcapsules prepared with optimum condition had good fluidity,and the holes on the surface of the microcapsules contributed to the release of VOHS.The particles of the microcapsule conformed to a normal distribution with the diameter of 45—220 μm.In the simulated intestinal fluid containing 0.2% sodium dodecyl sulfate,pulegone in VOHS microcapsule showed a certain degree of slow release.Compared with β-cyclodextrin method,the microencapsulation used in the present work could reduce the amount of excipients and increase the drug loading.It was beneficial to reduce the dose of Chinese medicines containing volatile oils.
基金financed by the National Science Centre of Poland(Grant number N304/069940)
文摘The study aimed to determine, by using a statistical model, the effect of weather conditions on the incidence of Lophodermium yellow needle blight causing by new species for science- Lophodermium corconticum, in the mountain dwarf pine growing in the subalpine Karkonosze Mountains and the Izerskie Mountains(Poland). Needles showed symptoms of yellow spots, gradual discolouration and premature fall in July. The assessment of healthiness of infected mountain dwarf pine needles spanned three years(2011- 2013) and was conducted in several test sites in the Karkonosze and Izerskie Mountains. The results were analyzed by taking into account the meteorological conditions. Field observations seem to indicate that the highest infestation of mountain dwarf pine occurs in June and July, while September and October see a significantly lower disease index in the Karkonosze Mountains. The lower indices of the infestation of mountain dwarf pine are characteristic for the vegetation in the Hala Izerska high mountain pasture; whereas the environmental conditions prevailing in the Kocio? Ma?ego Stawu cirque and above the Samotnia hostel are conducive to the development of Lophodermium yellow needle blight.
