The total synthesis of a hydrated aurone derivative, 2-benzyl-4-methoxy-2,6-dihydroxybenzofuran-3（2H）-one, has been achieved for the first time with 2.4% overall yield. Using phloroglucinol as the starting material,...The total synthesis of a hydrated aurone derivative, 2-benzyl-4-methoxy-2,6-dihydroxybenzofuran-3（2H）-one, has been achieved for the first time with 2.4% overall yield. Using phloroglucinol as the starting material, the key steps included Friedel-Crafts acylation, Williamson synthesis, hydrogenolysis, aldol condensation, enolization and Rubottom oxidation.展开更多
Two total synthetic routes for the preparation of myricetin were designed and explored.It was validated that route B presented an efficient approach to synthesizing myricetin,starting from commercially available and i...Two total synthetic routes for the preparation of myricetin were designed and explored.It was validated that route B presented an efficient approach to synthesizing myricetin,starting from commercially available and inexpensive phloroglucinol.Myricetin was synthesized with an overall yield of 60%across three steps without the need of column chromatography separation.The successful preparation of myricetin on a 25-g scale underscored the potential of this approach.展开更多
文摘The total synthesis of a hydrated aurone derivative, 2-benzyl-4-methoxy-2,6-dihydroxybenzofuran-3（2H）-one, has been achieved for the first time with 2.4% overall yield. Using phloroglucinol as the starting material, the key steps included Friedel-Crafts acylation, Williamson synthesis, hydrogenolysis, aldol condensation, enolization and Rubottom oxidation.
基金The Clinical Medicine Special Project of Nantong University for financial support(Grant No.2022JQ011)。
文摘Two total synthetic routes for the preparation of myricetin were designed and explored.It was validated that route B presented an efficient approach to synthesizing myricetin,starting from commercially available and inexpensive phloroglucinol.Myricetin was synthesized with an overall yield of 60%across three steps without the need of column chromatography separation.The successful preparation of myricetin on a 25-g scale underscored the potential of this approach.
