北美洲巨大的淡水湖群烟波浩淼,彼此靠近,又互相连接。南缘环绕密歇根湖、北面和东面濒临休伦湖、安大略湖及伊利湖、因湖得名的密歇根州,住东南隅边陲湖滨有座名城底特律,与加拿大重镇温莎隔河毗邻,有河底隧道和高高架起的美丽铁桥相...北美洲巨大的淡水湖群烟波浩淼,彼此靠近,又互相连接。南缘环绕密歇根湖、北面和东面濒临休伦湖、安大略湖及伊利湖、因湖得名的密歇根州,住东南隅边陲湖滨有座名城底特律,与加拿大重镇温莎隔河毗邻,有河底隧道和高高架起的美丽铁桥相通。这里是世界最大的汽车装配基地,城中最高建筑(47层)即为通用汽车公司总部的GM大厦。在人们心目中,底特律几乎成了汽车的同义词,以致没有机会提起底特律艺术馆(Detroit Institute of Arts)。展开更多
Biomarkers are very important indicators of normal and abnormal biological processes. Specific changes in pathologies, biochemistries and genetics can give us comprehensive information regarding the nature of any part...Biomarkers are very important indicators of normal and abnormal biological processes. Specific changes in pathologies, biochemistries and genetics can give us comprehensive information regarding the nature of any particular disease. A good biomarker should be precise and reliable, distinguishable between normal and interested disease, and differential between different diseases. It is believed that biomarkers have great potential in predicting chances for diseases, aiding in early diagnosis, and setting standards for the development of new remedies to treat diseases. New technologies have enabled scientists to identify biomarkers of several different neurodegenerative diseases. The followings, for instance, are only a few of the many new biomarkers that have been recently identified: the phosphorylated tau protein and aggregated β-amyloid peptide for Alzheimer’s disease (AD), α-synuclein contained Lewy bodies and altered dopamine transporter (DAT) imaging for Parkinson’s disease (PD), SOD mutations for familial amyotrophic lateral sclerosis (ALS), and CAG repeats resulted from Huntington’s gene mutations in Huntington’s disease (HD). This article will focus on the most-recent findings of biomarkers belonging to the four mentioned neurodegenerative diseases.展开更多
文摘北美洲巨大的淡水湖群烟波浩淼,彼此靠近,又互相连接。南缘环绕密歇根湖、北面和东面濒临休伦湖、安大略湖及伊利湖、因湖得名的密歇根州,住东南隅边陲湖滨有座名城底特律,与加拿大重镇温莎隔河毗邻,有河底隧道和高高架起的美丽铁桥相通。这里是世界最大的汽车装配基地,城中最高建筑(47层)即为通用汽车公司总部的GM大厦。在人们心目中,底特律几乎成了汽车的同义词,以致没有机会提起底特律艺术馆(Detroit Institute of Arts)。
文摘Biomarkers are very important indicators of normal and abnormal biological processes. Specific changes in pathologies, biochemistries and genetics can give us comprehensive information regarding the nature of any particular disease. A good biomarker should be precise and reliable, distinguishable between normal and interested disease, and differential between different diseases. It is believed that biomarkers have great potential in predicting chances for diseases, aiding in early diagnosis, and setting standards for the development of new remedies to treat diseases. New technologies have enabled scientists to identify biomarkers of several different neurodegenerative diseases. The followings, for instance, are only a few of the many new biomarkers that have been recently identified: the phosphorylated tau protein and aggregated β-amyloid peptide for Alzheimer’s disease (AD), α-synuclein contained Lewy bodies and altered dopamine transporter (DAT) imaging for Parkinson’s disease (PD), SOD mutations for familial amyotrophic lateral sclerosis (ALS), and CAG repeats resulted from Huntington’s gene mutations in Huntington’s disease (HD). This article will focus on the most-recent findings of biomarkers belonging to the four mentioned neurodegenerative diseases.
