目的探讨阑尾杯状细胞腺癌(goblet cell adenocarcinoma of the appendix,GCA)的规范诊断与治疗。方法查阅国内外相关文献,对1例GCA患者的临床诊治进行回顾性分析。结果患者男,64岁,当地医院行腹腔镜下阑尾切除术,术后病理诊断为GCA后,...目的探讨阑尾杯状细胞腺癌(goblet cell adenocarcinoma of the appendix,GCA)的规范诊断与治疗。方法查阅国内外相关文献,对1例GCA患者的临床诊治进行回顾性分析。结果患者男,64岁,当地医院行腹腔镜下阑尾切除术,术后病理诊断为GCA后,于南昌大学第一附属医院行腹腔镜下右半结肠根治性切除术,术后恢复可,无严重并发症,术后9 d出院,现已行2次奥沙利铂+左亚叶酸钙+氟尿嘧啶化疗方案以及6次奥沙利铂+卡培他滨规律化疗,术后随访19个月,未见明确肿瘤复发或转移。结论阑尾肿瘤诊断缺乏特异性,若阑尾切除患者年龄较大、术前肿瘤标志物升高、阑尾管壁增厚、质硬或触及肿块时,应考虑阑尾肿瘤的可能性,必要时行术中冰冻切片送检,以达到一期根治的目的。展开更多
阑尾杯状细胞腺癌(GCA)是一种罕见的阑尾恶性肿瘤,其临床上缺乏特异性症状和阳性体征,通常主要表现为急性阑尾炎、慢性腹痛或完全无症状,所以误诊及漏诊率极高。肿瘤通常发生在阑尾的远端,由于阑尾位置变异,可能出现在腹腔不同部位,表...阑尾杯状细胞腺癌(GCA)是一种罕见的阑尾恶性肿瘤,其临床上缺乏特异性症状和阳性体征,通常主要表现为急性阑尾炎、慢性腹痛或完全无症状,所以误诊及漏诊率极高。肿瘤通常发生在阑尾的远端,由于阑尾位置变异,可能出现在腹腔不同部位,表现为管壁增厚或肿块,但有时在CT上可能仅表现为阑尾近端的软组织密度,远端肿大和积液。其确诊主要依赖术中所见及术后病理检查。手术切除是其主要治疗手段,CT能够清楚地显示肿瘤的大小、部位及浸润程度等,因此对术前准确诊断具有极其重要的指导意义。本文通过回顾性分析本院一例经术后病理诊断的阑尾杯状细胞腺癌资料,并对国内外相关文献回顾复习、探讨其影像学表现特征,以提高阑尾癌的术前影像诊断水平,减少其诊断的误诊率。Appendiceal goblet cell adenocarcinoma (GCA) is a rare malignant tumor of the appendix, which clinically lacks specific symptoms and positive signs, and is usually manifested as acute appendicitis, chronic abdominal pain, or completely asymptomatic, hence the rate of misdiagnosis and missed diagnosis is extremely high. The tumor usually occurs in the distal part of the appendix, and due to the variation in the location of the appendix, it may appear in different parts of the abdominal cavity, presenting as thickening of the wall or a mass, but sometimes on CT it may only appear as soft tissue density in the proximal part of the appendix, with distention and fluid accumulation in the distal part. The diagnosis mainly depends on intraoperative findings and postoperative pathological examination. Surgical resection is the main treatment method, and the resection mainly depends on the size, location, and degree of infiltration of the tumor, so preoperative accurate diagnosis has very important guiding significance. This article reviews the data of one case of appendiceal goblet cell adenocarcinoma diagnosed by postoperative pathology in our hospital, and reviews and discusses the imaging characteristics of related literature at home and abroad, in order to improve the preoperative imaging diagnosis level of appendiceal cancer and reduce the misdiagnosis rate.展开更多
阑尾杯状细胞腺癌(goblet cell adenocarcinoma of the appendix,GCA)是一种罕见的具有双重分泌性的肿瘤,因其发病隐匿,在临床特征、病理学及分子遗传学上具有独特的表现,现报道4例,以期加深对该病的认识。1临床资料1.1一般资料收集杭...阑尾杯状细胞腺癌(goblet cell adenocarcinoma of the appendix,GCA)是一种罕见的具有双重分泌性的肿瘤,因其发病隐匿,在临床特征、病理学及分子遗传学上具有独特的表现,现报道4例,以期加深对该病的认识。1临床资料1.1一般资料收集杭州市临平区第一人民医院2020年1月至2022年12月诊断的4例GCA,其中男3例,女1例,年龄42~83岁。展开更多
文摘目的探讨阑尾杯状细胞腺癌(goblet cell adenocarcinoma of the appendix,GCA)的规范诊断与治疗。方法查阅国内外相关文献,对1例GCA患者的临床诊治进行回顾性分析。结果患者男,64岁,当地医院行腹腔镜下阑尾切除术,术后病理诊断为GCA后,于南昌大学第一附属医院行腹腔镜下右半结肠根治性切除术,术后恢复可,无严重并发症,术后9 d出院,现已行2次奥沙利铂+左亚叶酸钙+氟尿嘧啶化疗方案以及6次奥沙利铂+卡培他滨规律化疗,术后随访19个月,未见明确肿瘤复发或转移。结论阑尾肿瘤诊断缺乏特异性,若阑尾切除患者年龄较大、术前肿瘤标志物升高、阑尾管壁增厚、质硬或触及肿块时,应考虑阑尾肿瘤的可能性,必要时行术中冰冻切片送检,以达到一期根治的目的。
文摘阑尾杯状细胞腺癌(GCA)是一种罕见的阑尾恶性肿瘤,其临床上缺乏特异性症状和阳性体征,通常主要表现为急性阑尾炎、慢性腹痛或完全无症状,所以误诊及漏诊率极高。肿瘤通常发生在阑尾的远端,由于阑尾位置变异,可能出现在腹腔不同部位,表现为管壁增厚或肿块,但有时在CT上可能仅表现为阑尾近端的软组织密度,远端肿大和积液。其确诊主要依赖术中所见及术后病理检查。手术切除是其主要治疗手段,CT能够清楚地显示肿瘤的大小、部位及浸润程度等,因此对术前准确诊断具有极其重要的指导意义。本文通过回顾性分析本院一例经术后病理诊断的阑尾杯状细胞腺癌资料,并对国内外相关文献回顾复习、探讨其影像学表现特征,以提高阑尾癌的术前影像诊断水平,减少其诊断的误诊率。Appendiceal goblet cell adenocarcinoma (GCA) is a rare malignant tumor of the appendix, which clinically lacks specific symptoms and positive signs, and is usually manifested as acute appendicitis, chronic abdominal pain, or completely asymptomatic, hence the rate of misdiagnosis and missed diagnosis is extremely high. The tumor usually occurs in the distal part of the appendix, and due to the variation in the location of the appendix, it may appear in different parts of the abdominal cavity, presenting as thickening of the wall or a mass, but sometimes on CT it may only appear as soft tissue density in the proximal part of the appendix, with distention and fluid accumulation in the distal part. The diagnosis mainly depends on intraoperative findings and postoperative pathological examination. Surgical resection is the main treatment method, and the resection mainly depends on the size, location, and degree of infiltration of the tumor, so preoperative accurate diagnosis has very important guiding significance. This article reviews the data of one case of appendiceal goblet cell adenocarcinoma diagnosed by postoperative pathology in our hospital, and reviews and discusses the imaging characteristics of related literature at home and abroad, in order to improve the preoperative imaging diagnosis level of appendiceal cancer and reduce the misdiagnosis rate.
文摘阑尾杯状细胞腺癌(goblet cell adenocarcinoma of the appendix,GCA)是一种罕见的具有双重分泌性的肿瘤,因其发病隐匿,在临床特征、病理学及分子遗传学上具有独特的表现,现报道4例,以期加深对该病的认识。1临床资料1.1一般资料收集杭州市临平区第一人民医院2020年1月至2022年12月诊断的4例GCA,其中男3例,女1例,年龄42~83岁。
