The matrix metalloproteinase (MMP) stromelysin-3 (ST3) has long been implicated to play an important role in extracellular matrix (ECM) remodeling and cell fate determination during normal and pathological processes. ...The matrix metalloproteinase (MMP) stromelysin-3 (ST3) has long been implicated to play an important role in extracellular matrix (ECM) remodeling and cell fate determination during normal and pathological processes. However like other MMPs, the molecular basis of ST3 function in vivo remains unclear due to the lack of information on its physiological substrates. Furthermore, ST3 has only weak activities toward all tested ECM proteins. Using thyroid hormone-dependent Xenopus laevis metamorphosis as a model, we demonstrated previously that ST3 is important for apoptosis and tissue morphogenesis during intestinal remodeling. Here, we used yeast two-hybrid screen with mRNAs from metamorphosing tadpoles to identify potential substrate of ST3 during development. We thus isolated the 37 kd laminin receptor precursor (LR). We showed that LR binds to ST3 in vitro and can be cleaved by ST3 at two sites distinct from where other MMPs cleave. Through peptide sequencing, we determined that the two cleavage sites are in the extracellular domain between the transmembrane domain and laminin binding sequence. Furthermore, we demon strated that these cleavage sites are conserved in human LR. These results together with high levels of human LR and ST3 expression in carcinomas suggest that LR is a likely in vivo substrate of ST3 and that its cleavage by ST3 may alter cell-extracellular matrix interaction, thus, playing a role in mediating the effects of ST3 on cell fate and behavior ob- served during development and pathogenesis.展开更多
The water abundance of mine floor limestone needs to be solved urgently as the average depth of coal mining in China has increased gradually. A method is presented to discuss water abundance with the numerical and phy...The water abundance of mine floor limestone needs to be solved urgently as the average depth of coal mining in China has increased gradually. A method is presented to discuss water abundance with the numerical and physical layered geoelectrical model being established in the half-space, full-space and full-space with tunnel, respectively. The parameters of water abundance are changed in this study, which includes water quantity, water content and volume of abnormity of water-containing abnormity. Results indicate that the different work fields have different macroscopic influences on the apparent resistivity,and the water abundance parameters of water-containing abnormity have quantitative relationship with the apparent resistivity mean in abnormal regions(three-dimensional space region). The quantitative relationships are shown as following: firstly, the amount of water injection has negative linear correlation with the apparent resistivity mean; secondly, when abnormity is unsaturated, there is a negative power function relationship between water content and apparent resistivity mean; thirdly, the volume of abnormity and apparent resistivity mean behave as a decreasing power function law.展开更多
On the basis of panel data from 29 provinces and cities throughout the country in 2006-2010, a research is made on factors influencing regional industrial solid waste comprehensive utilization ability through a regres...On the basis of panel data from 29 provinces and cities throughout the country in 2006-2010, a research is made on factors influencing regional industrial solid waste comprehensive utilization ability through a regression analysis method. Research result shows that a positive influence will generate on the comprehensive utilization ability of the industrial solid waste by three factors： regional industrial soldi waste treatment earning level, regional industrial soldi waste treatment investment level and regional industrial pollution treatment subsidy strength. And this thesis will propose suggestions from improving earning ability, enhartcing treatment investment and increasing government subsidy depending on result of empirical analysis.展开更多
Economic clusters have been a central focus of current urban and regional research, policies and practices. However, a methodology to identify and analyze policy-relevant economic cluster dynamics is still not well de...Economic clusters have been a central focus of current urban and regional research, policies and practices. However, a methodology to identify and analyze policy-relevant economic cluster dynamics is still not well developed. Based on input-output(I-O) data of 1987, 1992, 1997, 2002 and 2007 of Beijing, this article presents an adapted principle component analysis for identifying the evolution of local economic cluster patterns. This research addresses the changes of economic interaction of industries with complementary and common activities over time. The identified clusters provide an insight into the reality of economic development in a diversifying urban economy: the increasing importance of services and the growing interaction between service and manufacturing industries. Our method therefore provides the analysts with a better understanding of the emergence, disappearance and development of economic clusters citywide. The results could be used to assist monitoring urban economic development and designing more practical urban economic strategies.展开更多
From the measurement of liquid flow field on a large plate by a hot-film anemometer, three different regions on the large plate were presented, including a liquid circulation area near the inlet down-comer, a region w...From the measurement of liquid flow field on a large plate by a hot-film anemometer, three different regions on the large plate were presented, including a liquid circulation area near the inlet down-comer, a region with very slow moving or stagnant liquid on the side of the tray and an active flow region at the center of the plate. According to the contribution of the three regions, the tray efficiency for large plates was proposed. The prediction plate efficiency by the present model are compared with the experimental data in the literature and those calculated by other models. It is shown that the present model is more accurate for prediction of efficiency of large plates, and the calculation is simpler.展开更多
Based on the 16 central cities＇ Panel Data in Yangtze River Delta, location quotient index is used in this paper to measure and analyze the current cluster situation of producer services in Yangtze River Delta, fixed...Based on the 16 central cities＇ Panel Data in Yangtze River Delta, location quotient index is used in this paper to measure and analyze the current cluster situation of producer services in Yangtze River Delta, fixed effects model of Panel Data model is also used in this paper, and the industrial structure is taken as the dependent variable, while the core explanatory variables is the degree of producer services＇ cluster development, which is calculated by location quotient, moreover, three control variables introduced in this paper and they are technology advantage, education level and R＆D spending, and the mentioned above is to empirically study the impacts of producer services＇ cluster development to the regional industrial structure. As a result, producer services＇ cluster development has a significant positive role in promoting the regional industrial structure optimization and upgrading, though the extent is not yet a big push and is still to be further strengthened. In this paper, it has provided a strong evidence that under China＇ s new normal economy, producer services is badly needed to promote regional industrial structure, and finally it makes specific suggestions based on the current cluster situation of producer services in Yangtze River Delta.展开更多
Resulting from the collision of the Eurasian and Indian plates, the Qinghai-Tibetan Plateau is commonly known as the ＇roof of the world＇. Collectively the Yarlung Tsangpo, Nu, Laneang, Yangtze, Yalong, and Yellow Ri...Resulting from the collision of the Eurasian and Indian plates, the Qinghai-Tibetan Plateau is commonly known as the ＇roof of the world＇. Collectively the Yarlung Tsangpo, Nu, Laneang, Yangtze, Yalong, and Yellow River basins drain the eastern margin of the plateau. In this paper, we utilize Shuttle Radar Topography Mission elevation data to examine morphometric and relief attributes of these basins to reveal insights rates of incision. A robust into tectonic activity and technique using Maflab is proposed to alleviate errors associated with SRTM data in the derivation of river longitudinal profiles. Convex longitudinal profiles are interpreted to be a product of uplift rates that exceed rates of channel incision along the entire margin of the Qinghai- Tibetan Plateau. Highest relief towards the south reflects extensive fluvial incision. High relief is also prominent along major active faults. Erosion patterns are related to distance from knickpoints. Highest rates of erosion and incision are evident towards the south, with decreasing values towards the north, suggesting a link between tectonic activity and erosion.展开更多
As a pivotal element within the modern service industry,tourism possesses the capacity to reconfigure regional economic dynamics,alter resource flow patterns,and notably influence urban green development.By establishi...As a pivotal element within the modern service industry,tourism possesses the capacity to reconfigure regional economic dynamics,alter resource flow patterns,and notably influence urban green development.By establishing an evaluation index system for urban green development across 60 prefecture-level cities within the Yellow River Basin from 2006 to 2021,this study employs the spatial Durbin model to delve into the nonlinear relationship between the tourism economy and urban green development.Furthermore,it investigates the heterogeneous impact of the tourism economy on green development across varying levels of urbanization.This study reveals several key findings:(1)Both tourism economy and urban green development exhibit significant spatial clustering,with tourism economy showing“midstream>downstream>upstream”and urban green development showing“downstream>midstream>upstream”.(2)The tourism economy exerts a non-linear positive influence on the green development of cities,characterized by a non-linear inverted“S”shape in its direct impact and a nonlinear“S”shape in its indirect impact.(3)As urbanization rate level escalate,the positive influence of the tourism economy on urban green development follows a non-linear trajectory,initially declining before ascending.Specifically,when the urbanization rate level is below the first threshold value,the tourism economy notably promotes urban green development.However,between the first and second threshold values,this positive impact diminishes,only to rebound beyond the second threshold value.展开更多
The wavelet finite element methods （WFEMs） own higher calculation accuracy and efficiency for structure analysis. Unfortunately, the existing WFEMs are still limited in low-frequency domain when capturing dynamic ch...The wavelet finite element methods （WFEMs） own higher calculation accuracy and efficiency for structure analysis. Unfortunately, the existing WFEMs are still limited in low-frequency domain when capturing dynamic characteristics of thin plate. This paper proposes the wavelet multi-elements method based on C1 type B-spline Kirchhoff plate （CIBKP） element to break up this limitation. The validity, numerical stability and convergence respectively are investigated systematically in numerical study. The corresponding results show that the calculation accuracy and numerical stability are very excellent when predicting the high-order natural frequency. The maximum relative errors can be rapidly reduced to 0.4% within the first 1000 modes of thin plate under simply supported. Besides, the method is suitable for predicting the dynamic characteristics of thin plate under various boundary conditions.展开更多
文摘The matrix metalloproteinase (MMP) stromelysin-3 (ST3) has long been implicated to play an important role in extracellular matrix (ECM) remodeling and cell fate determination during normal and pathological processes. However like other MMPs, the molecular basis of ST3 function in vivo remains unclear due to the lack of information on its physiological substrates. Furthermore, ST3 has only weak activities toward all tested ECM proteins. Using thyroid hormone-dependent Xenopus laevis metamorphosis as a model, we demonstrated previously that ST3 is important for apoptosis and tissue morphogenesis during intestinal remodeling. Here, we used yeast two-hybrid screen with mRNAs from metamorphosing tadpoles to identify potential substrate of ST3 during development. We thus isolated the 37 kd laminin receptor precursor (LR). We showed that LR binds to ST3 in vitro and can be cleaved by ST3 at two sites distinct from where other MMPs cleave. Through peptide sequencing, we determined that the two cleavage sites are in the extracellular domain between the transmembrane domain and laminin binding sequence. Furthermore, we demon strated that these cleavage sites are conserved in human LR. These results together with high levels of human LR and ST3 expression in carcinomas suggest that LR is a likely in vivo substrate of ST3 and that its cleavage by ST3 may alter cell-extracellular matrix interaction, thus, playing a role in mediating the effects of ST3 on cell fate and behavior ob- served during development and pathogenesis.
文摘The water abundance of mine floor limestone needs to be solved urgently as the average depth of coal mining in China has increased gradually. A method is presented to discuss water abundance with the numerical and physical layered geoelectrical model being established in the half-space, full-space and full-space with tunnel, respectively. The parameters of water abundance are changed in this study, which includes water quantity, water content and volume of abnormity of water-containing abnormity. Results indicate that the different work fields have different macroscopic influences on the apparent resistivity,and the water abundance parameters of water-containing abnormity have quantitative relationship with the apparent resistivity mean in abnormal regions(three-dimensional space region). The quantitative relationships are shown as following: firstly, the amount of water injection has negative linear correlation with the apparent resistivity mean; secondly, when abnormity is unsaturated, there is a negative power function relationship between water content and apparent resistivity mean; thirdly, the volume of abnormity and apparent resistivity mean behave as a decreasing power function law.
文摘On the basis of panel data from 29 provinces and cities throughout the country in 2006-2010, a research is made on factors influencing regional industrial solid waste comprehensive utilization ability through a regression analysis method. Research result shows that a positive influence will generate on the comprehensive utilization ability of the industrial solid waste by three factors： regional industrial soldi waste treatment earning level, regional industrial soldi waste treatment investment level and regional industrial pollution treatment subsidy strength. And this thesis will propose suggestions from improving earning ability, enhartcing treatment investment and increasing government subsidy depending on result of empirical analysis.
基金Under the auspices of National Natural Science Foundation of China(No.41371008)
文摘Economic clusters have been a central focus of current urban and regional research, policies and practices. However, a methodology to identify and analyze policy-relevant economic cluster dynamics is still not well developed. Based on input-output(I-O) data of 1987, 1992, 1997, 2002 and 2007 of Beijing, this article presents an adapted principle component analysis for identifying the evolution of local economic cluster patterns. This research addresses the changes of economic interaction of industries with complementary and common activities over time. The identified clusters provide an insight into the reality of economic development in a diversifying urban economy: the increasing importance of services and the growing interaction between service and manufacturing industries. Our method therefore provides the analysts with a better understanding of the emergence, disappearance and development of economic clusters citywide. The results could be used to assist monitoring urban economic development and designing more practical urban economic strategies.
基金Supported by the National Natural Science Foundation of China(No. 20176037)
文摘From the measurement of liquid flow field on a large plate by a hot-film anemometer, three different regions on the large plate were presented, including a liquid circulation area near the inlet down-comer, a region with very slow moving or stagnant liquid on the side of the tray and an active flow region at the center of the plate. According to the contribution of the three regions, the tray efficiency for large plates was proposed. The prediction plate efficiency by the present model are compared with the experimental data in the literature and those calculated by other models. It is shown that the present model is more accurate for prediction of efficiency of large plates, and the calculation is simpler.
文摘Based on the 16 central cities＇ Panel Data in Yangtze River Delta, location quotient index is used in this paper to measure and analyze the current cluster situation of producer services in Yangtze River Delta, fixed effects model of Panel Data model is also used in this paper, and the industrial structure is taken as the dependent variable, while the core explanatory variables is the degree of producer services＇ cluster development, which is calculated by location quotient, moreover, three control variables introduced in this paper and they are technology advantage, education level and R＆D spending, and the mentioned above is to empirically study the impacts of producer services＇ cluster development to the regional industrial structure. As a result, producer services＇ cluster development has a significant positive role in promoting the regional industrial structure optimization and upgrading, though the extent is not yet a big push and is still to be further strengthened. In this paper, it has provided a strong evidence that under China＇ s new normal economy, producer services is badly needed to promote regional industrial structure, and finally it makes specific suggestions based on the current cluster situation of producer services in Yangtze River Delta.
基金Funding was provided by International Science&Technology Cooperation Program of China(Grant Nos.2011DFG93160,2011DFA20820)
文摘Resulting from the collision of the Eurasian and Indian plates, the Qinghai-Tibetan Plateau is commonly known as the ＇roof of the world＇. Collectively the Yarlung Tsangpo, Nu, Laneang, Yangtze, Yalong, and Yellow River basins drain the eastern margin of the plateau. In this paper, we utilize Shuttle Radar Topography Mission elevation data to examine morphometric and relief attributes of these basins to reveal insights rates of incision. A robust into tectonic activity and technique using Maflab is proposed to alleviate errors associated with SRTM data in the derivation of river longitudinal profiles. Convex longitudinal profiles are interpreted to be a product of uplift rates that exceed rates of channel incision along the entire margin of the Qinghai- Tibetan Plateau. Highest relief towards the south reflects extensive fluvial incision. High relief is also prominent along major active faults. Erosion patterns are related to distance from knickpoints. Highest rates of erosion and incision are evident towards the south, with decreasing values towards the north, suggesting a link between tectonic activity and erosion.
基金The National Social Science Foundation of China(20BJL103,23BTJ001)The National Natural Science Foundation of China(71934001)+1 种基金The Philosophy and Social Science Foundation of Anhui Province(AHSKZ2022D16)The Project of Graduate Student Research InnovationFund of Anhui University of Finance and Economics(ACYC2022155).
文摘As a pivotal element within the modern service industry,tourism possesses the capacity to reconfigure regional economic dynamics,alter resource flow patterns,and notably influence urban green development.By establishing an evaluation index system for urban green development across 60 prefecture-level cities within the Yellow River Basin from 2006 to 2021,this study employs the spatial Durbin model to delve into the nonlinear relationship between the tourism economy and urban green development.Furthermore,it investigates the heterogeneous impact of the tourism economy on green development across varying levels of urbanization.This study reveals several key findings:(1)Both tourism economy and urban green development exhibit significant spatial clustering,with tourism economy showing“midstream>downstream>upstream”and urban green development showing“downstream>midstream>upstream”.(2)The tourism economy exerts a non-linear positive influence on the green development of cities,characterized by a non-linear inverted“S”shape in its direct impact and a nonlinear“S”shape in its indirect impact.(3)As urbanization rate level escalate,the positive influence of the tourism economy on urban green development follows a non-linear trajectory,initially declining before ascending.Specifically,when the urbanization rate level is below the first threshold value,the tourism economy notably promotes urban green development.However,between the first and second threshold values,this positive impact diminishes,only to rebound beyond the second threshold value.
基金supported by the National Natural Science Foundation of China(Nos.51405370&51225501)the National Basic Research Program of China(Grant No.2015CB057400)the Project Funded by China Postdoctoral Science Foundation(Grant No.2016T90908)
文摘The wavelet finite element methods （WFEMs） own higher calculation accuracy and efficiency for structure analysis. Unfortunately, the existing WFEMs are still limited in low-frequency domain when capturing dynamic characteristics of thin plate. This paper proposes the wavelet multi-elements method based on C1 type B-spline Kirchhoff plate （CIBKP） element to break up this limitation. The validity, numerical stability and convergence respectively are investigated systematically in numerical study. The corresponding results show that the calculation accuracy and numerical stability are very excellent when predicting the high-order natural frequency. The maximum relative errors can be rapidly reduced to 0.4% within the first 1000 modes of thin plate under simply supported. Besides, the method is suitable for predicting the dynamic characteristics of thin plate under various boundary conditions.
