The Second Tibetan Plateau Scientific Expedition and Research Program tasked a research team with the“Investigation of the water vapor channel of the Yarlung Zsangbo Grand Canyon(INVC)”in the southeastern Tibetan Pl...The Second Tibetan Plateau Scientific Expedition and Research Program tasked a research team with the“Investigation of the water vapor channel of the Yarlung Zsangbo Grand Canyon(INVC)”in the southeastern Tibetan Plateau(TP).This paper summarizes the scientific achievements obtained from the data collected by the INVC observation network and highlights the progress in investigating the development of heavy rainfall events associated with water vapor changes.The rain gauge network of the INVC can represent the impacts of the Yarlung Zsangbo Grand Canyon(YGC)topography on precipitation at the hourly scale.The microphysical characteristics of the precipitation in the YGC are different than those in the lowland area.The GPM-IMERG(Integrated MultisatellitE Retrievals for Global Precipitation Measurement)satellite precipitation data for the YGC region should be calibrated before they are used.The meridional water vapor flux through the YGC is more important than the zonal flux for the precipitation over the southeastern TP.The decreased precipitation around the YGC region is partly due to the decreased meridional water vapor flux passing through the YGC.High-resolution numerical models can benefit precipitation forecasting in this region by using a combination of specific schemes that capture the valley wind and water vapor flux along the valley floor.展开更多
目的探讨极体测序技术在Van der Woude综合征患者胚胎植入前单基因遗传病检测中的应用价值。方法对1例因IRF6基因新发变异导致的Van der Woude综合征女性患者,应用极体测序技术进行胚胎植入前遗传学检测。6枚卵经卵胞质内单精子注射(int...目的探讨极体测序技术在Van der Woude综合征患者胚胎植入前单基因遗传病检测中的应用价值。方法对1例因IRF6基因新发变异导致的Van der Woude综合征女性患者,应用极体测序技术进行胚胎植入前遗传学检测。6枚卵经卵胞质内单精子注射(intracytoplasmic sperm injection,ICSI)受精后,分别顺序活检第一极体、第二极体和囊胚滋养外胚层细胞。活检细胞经全基因组扩增后,利用PCR联合Sanger测序的方法检测极体和胚胎的致病变异携带状态,推断对应胚胎的致病性。为预防因囊胚培养失败造成无可移植胚胎的情况,在囊胚形成前对1枚致病性低的优质胚胎进行玻璃化冷冻。此外,通过在夫妇双方以及特定基因型的极体和胚胎样本中对变异位点及其上下游1M区域内的175个单核苷酸多态性(single nucleotide polymorphism,SNP)位点进行靶向捕获高通量测序,连锁分析构建单体型。选择致病性低的胚胎移植,成功妊娠后进行产前诊断以及跟踪随访。结果成功获得第一极体和第二极体各6枚,其中11枚极体的变异位点检测成功。6枚胚胎中,1枚预测致病性低的胚胎在患者知情同意后于第4日(day 4,D4)玻璃化冷冻;1枚胚胎成功发育至囊胚,但致病性高;4枚胚胎囊胚培养失败。连锁分析成功构建出与致病变异紧密连锁的SNP单体型,胚胎单体型分析与Sanger测序结果吻合。移植致病性低的D4期冷冻胚胎,成功妊娠后,患者夫妇拒绝有创产前诊断。出生后新生儿随访未发现唇腭裂,脐血基因检测不携带致病变异。结论本研究利用卵母细胞极体测序的检测方法,为1例因IRF6基因新发变异导致的Van der Woude综合征女性患者进行胚胎植入前单基因遗传病检测,成功阻断了该病向子代传递。展开更多
A new three-dimensional laterolog array sonde（3D-LS） is presented. The 3DLS is based on existing high-resolution laterolog array and azimuthal resistivity imaging sondes with radial, longitudinal, and circumferentia...A new three-dimensional laterolog array sonde（3D-LS） is presented. The 3DLS is based on existing high-resolution laterolog array and azimuthal resistivity imaging sondes with radial, longitudinal, and circumferential detection abilities. Six investigation modes are designed using the 3D finite-element method and different investigation depths are simulated based on the pseudo-geometrical factor of the six modes. The invasion profile is described using multi-array radial logs. From the analysis of the pseudo-geometrical factor, the investigation depth of the 3D-LS is about 1.5 m for conductive invasion, which is close to that of the dual laterolog tool but greater than that of the highly integrated azimuthal laterolog sonde. The vertical and azimuthal resolution is also analyzed with the same method. The 3DLS can detect low-resistivity anomalies of 0.5 m thickness and 15？ around the borehole for infinitely thick formations. This study lays the foundation for more work on 3D laterolog array sonde for evaluating low-resistivity anomalies.展开更多
The shadows similar to the vehicle and the spots caused by vehicle lamps need to be accurately detected in the vehicle segmentation involved in the video-based traffic parameter measurement. Generally, the road surfac...The shadows similar to the vehicle and the spots caused by vehicle lamps need to be accurately detected in the vehicle segmentation involved in the video-based traffic parameter measurement. Generally, the road surface is different from the vehicle surface in the gray-level architecture. An invariant gray-level architecture-the extremum image in the changing illumination environment is derived and a novel algorithm is presented for detecting shadows and spots. The gray-level structure that is not sensitive to the illumination is employed in the algorithm and the road surface mistaken as vehicles can be removed.展开更多
A theoretical prediction on forming limit diagram（FLD） of AZ31 magnesium alloy sheet was developed at warm temperatures based on the M-K theory. Two different yield criteria of von Mises and Hill＇48 were applied in...A theoretical prediction on forming limit diagram（FLD） of AZ31 magnesium alloy sheet was developed at warm temperatures based on the M-K theory. Two different yield criteria of von Mises and Hill＇48 were applied in this model. Mechanical properties of AZ31 magnesium alloy used in the prediction were obtained by uniaxial tensile tests and the Fields-Backofen equation was incorporated in the analysis. In addition, experimental FLDs of AZ31 were acquired by conducting rigid die swell test at different temperatures to verify the prediction. It is demonstrated from a comparison between the predicted and the experimental FLDs at 473 K and 523 K that the predicted results are influenced by the type of yield criterion used in the calculation, especially at lower temperatures. Furthermore, a better agreement between the predicted results and experimental data for AZ31 magnesium alloy sheet at warm temperatures was obtained when Hill＇48 yield criterion was applied.展开更多
Significant progress has been made in the development of non-precious metal electrocatalysts （NPMEs） during the past decade. Correspondingly, there is an urgent demand for an appropriate measurement method to be est...Significant progress has been made in the development of non-precious metal electrocatalysts （NPMEs） during the past decade. Correspondingly, there is an urgent demand for an appropriate measurement method to be established for the reliable evaluation of NPMEs. In this study, platinum and graphite counter electrodes were used to investigate the impact of counter electrode material on the accelerated durability testing （ADT） of NPMEs in acidic medium. Platinum used as the coun- ter electrode in a traditional three-electrode electrochemical cell was found to dissolve in acidic medium and re-deposit on NPME coated on the working electrode during ADT. Such re-deposition causes the oxygen reduction reaction （ORR） performance of NPMEs to remarkably improve, and thus will seriously mislead our judgment of NPMEs if we are unaware of it. The phenomenon can be avoided using a graphite counter electrode.展开更多
This paper presents a method for searching the weak story by using the ultimate shear force coefficient on the multi-story brick buildings with two frame-shear-wall-supported stories. The method of seismic damage pred...This paper presents a method for searching the weak story by using the ultimate shear force coefficient on the multi-story brick buildings with two frame-shear-wall-supported stories. The method of seismic damage prediction is discussed according to different weak stories. When the first story is t theweak one,the damage state of the building can be determined by the displacement ratio. The prediction method is also used in a practical engineering project.展开更多
基金funded by the Second Tibetan Plateau Scientific Expedition and Research Program[grant numbers 2019QZKK0105 and 2019QZKK0103]the National Natural Science Foundation of China[grant number 41975009].
文摘The Second Tibetan Plateau Scientific Expedition and Research Program tasked a research team with the“Investigation of the water vapor channel of the Yarlung Zsangbo Grand Canyon(INVC)”in the southeastern Tibetan Plateau(TP).This paper summarizes the scientific achievements obtained from the data collected by the INVC observation network and highlights the progress in investigating the development of heavy rainfall events associated with water vapor changes.The rain gauge network of the INVC can represent the impacts of the Yarlung Zsangbo Grand Canyon(YGC)topography on precipitation at the hourly scale.The microphysical characteristics of the precipitation in the YGC are different than those in the lowland area.The GPM-IMERG(Integrated MultisatellitE Retrievals for Global Precipitation Measurement)satellite precipitation data for the YGC region should be calibrated before they are used.The meridional water vapor flux through the YGC is more important than the zonal flux for the precipitation over the southeastern TP.The decreased precipitation around the YGC region is partly due to the decreased meridional water vapor flux passing through the YGC.High-resolution numerical models can benefit precipitation forecasting in this region by using a combination of specific schemes that capture the valley wind and water vapor flux along the valley floor.
文摘目的探讨极体测序技术在Van der Woude综合征患者胚胎植入前单基因遗传病检测中的应用价值。方法对1例因IRF6基因新发变异导致的Van der Woude综合征女性患者,应用极体测序技术进行胚胎植入前遗传学检测。6枚卵经卵胞质内单精子注射(intracytoplasmic sperm injection,ICSI)受精后,分别顺序活检第一极体、第二极体和囊胚滋养外胚层细胞。活检细胞经全基因组扩增后,利用PCR联合Sanger测序的方法检测极体和胚胎的致病变异携带状态,推断对应胚胎的致病性。为预防因囊胚培养失败造成无可移植胚胎的情况,在囊胚形成前对1枚致病性低的优质胚胎进行玻璃化冷冻。此外,通过在夫妇双方以及特定基因型的极体和胚胎样本中对变异位点及其上下游1M区域内的175个单核苷酸多态性(single nucleotide polymorphism,SNP)位点进行靶向捕获高通量测序,连锁分析构建单体型。选择致病性低的胚胎移植,成功妊娠后进行产前诊断以及跟踪随访。结果成功获得第一极体和第二极体各6枚,其中11枚极体的变异位点检测成功。6枚胚胎中,1枚预测致病性低的胚胎在患者知情同意后于第4日(day 4,D4)玻璃化冷冻;1枚胚胎成功发育至囊胚,但致病性高;4枚胚胎囊胚培养失败。连锁分析成功构建出与致病变异紧密连锁的SNP单体型,胚胎单体型分析与Sanger测序结果吻合。移植致病性低的D4期冷冻胚胎,成功妊娠后,患者夫妇拒绝有创产前诊断。出生后新生儿随访未发现唇腭裂,脐血基因检测不携带致病变异。结论本研究利用卵母细胞极体测序的检测方法,为1例因IRF6基因新发变异导致的Van der Woude综合征女性患者进行胚胎植入前单基因遗传病检测,成功阻断了该病向子代传递。
基金sponsored by the National Oil and Gas Major Projects(No.2011ZX05020-009)
文摘A new three-dimensional laterolog array sonde（3D-LS） is presented. The 3DLS is based on existing high-resolution laterolog array and azimuthal resistivity imaging sondes with radial, longitudinal, and circumferential detection abilities. Six investigation modes are designed using the 3D finite-element method and different investigation depths are simulated based on the pseudo-geometrical factor of the six modes. The invasion profile is described using multi-array radial logs. From the analysis of the pseudo-geometrical factor, the investigation depth of the 3D-LS is about 1.5 m for conductive invasion, which is close to that of the dual laterolog tool but greater than that of the highly integrated azimuthal laterolog sonde. The vertical and azimuthal resolution is also analyzed with the same method. The 3DLS can detect low-resistivity anomalies of 0.5 m thickness and 15？ around the borehole for infinitely thick formations. This study lays the foundation for more work on 3D laterolog array sonde for evaluating low-resistivity anomalies.
文摘The shadows similar to the vehicle and the spots caused by vehicle lamps need to be accurately detected in the vehicle segmentation involved in the video-based traffic parameter measurement. Generally, the road surface is different from the vehicle surface in the gray-level architecture. An invariant gray-level architecture-the extremum image in the changing illumination environment is derived and a novel algorithm is presented for detecting shadows and spots. The gray-level structure that is not sensitive to the illumination is employed in the algorithm and the road surface mistaken as vehicles can be removed.
基金Project(51375328)supported by the National Natural Science Foundation of ChinaProject(20143009)supported by Graduates Innovation Project of Shanxi Province,ChinaProject(2015-036)supported by Shanxi Scholarship Council of China
文摘A theoretical prediction on forming limit diagram（FLD） of AZ31 magnesium alloy sheet was developed at warm temperatures based on the M-K theory. Two different yield criteria of von Mises and Hill＇48 were applied in this model. Mechanical properties of AZ31 magnesium alloy used in the prediction were obtained by uniaxial tensile tests and the Fields-Backofen equation was incorporated in the analysis. In addition, experimental FLDs of AZ31 were acquired by conducting rigid die swell test at different temperatures to verify the prediction. It is demonstrated from a comparison between the predicted and the experimental FLDs at 473 K and 523 K that the predicted results are influenced by the type of yield criterion used in the calculation, especially at lower temperatures. Furthermore, a better agreement between the predicted results and experimental data for AZ31 magnesium alloy sheet at warm temperatures was obtained when Hill＇48 yield criterion was applied.
基金supported by the Fundamental Research Funds for the Central Universities(DUT15RC(3)001,DUT15ZD225)the Program for Liao-ning Excellent Talents in University(LR2015014)+1 种基金the Liaoning BaiQianWan Talents Program(201519)Dalian Excellent Young Scientific and Technological Talents(2015R006)
文摘Significant progress has been made in the development of non-precious metal electrocatalysts （NPMEs） during the past decade. Correspondingly, there is an urgent demand for an appropriate measurement method to be established for the reliable evaluation of NPMEs. In this study, platinum and graphite counter electrodes were used to investigate the impact of counter electrode material on the accelerated durability testing （ADT） of NPMEs in acidic medium. Platinum used as the coun- ter electrode in a traditional three-electrode electrochemical cell was found to dissolve in acidic medium and re-deposit on NPME coated on the working electrode during ADT. Such re-deposition causes the oxygen reduction reaction （ORR） performance of NPMEs to remarkably improve, and thus will seriously mislead our judgment of NPMEs if we are unaware of it. The phenomenon can be avoided using a graphite counter electrode.
文摘This paper presents a method for searching the weak story by using the ultimate shear force coefficient on the multi-story brick buildings with two frame-shear-wall-supported stories. The method of seismic damage prediction is discussed according to different weak stories. When the first story is t theweak one,the damage state of the building can be determined by the displacement ratio. The prediction method is also used in a practical engineering project.
