In mammalian embryos, primordial germ cells （PGCs） are induced in proximal epiblast by BMP signals expressed in extraembryonic tissues , and one of the most important downstream key players is Blimpl . Blimpl is kno...In mammalian embryos, primordial germ cells （PGCs） are induced in proximal epiblast by BMP signals expressed in extraembryonic tissues , and one of the most important downstream key players is Blimpl . Blimpl is known to act as a sup- pressor of somatic genes＇ expression in PGC specification process. It is assumed that there are still many unidentified molecules involved in PGC development. However, to analyze gene functions in mammalian embryos by generating knockout animals is labor-intensive, and a more concise way to efficiently identify genes regulating PGC development is desirable.展开更多
文摘In mammalian embryos, primordial germ cells （PGCs） are induced in proximal epiblast by BMP signals expressed in extraembryonic tissues , and one of the most important downstream key players is Blimpl . Blimpl is known to act as a sup- pressor of somatic genes＇ expression in PGC specification process. It is assumed that there are still many unidentified molecules involved in PGC development. However, to analyze gene functions in mammalian embryos by generating knockout animals is labor-intensive, and a more concise way to efficiently identify genes regulating PGC development is desirable.
