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抗血小板药物在冠状动脉内支架植入术前的应用
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作者 张莉莉 贾国良 《医学争鸣》 北大核心 2002年第S1期53-55,共3页
由冠脉阻塞所致的缺血型心脏病在临床上较为常见,经皮冠状动脉腔内成型术(PTCA)是冠心病的主要治疗手段之一,冠状动脉内支架植入术是在PTCA基础上发展起来的一个介入技术,其应用在很大程度上提高了介入技术对于血管病变的临床价值,但无... 由冠脉阻塞所致的缺血型心脏病在临床上较为常见,经皮冠状动脉腔内成型术(PTCA)是冠心病的主要治疗手段之一,冠状动脉内支架植入术是在PTCA基础上发展起来的一个介入技术,其应用在很大程度上提高了介入技术对于血管病变的临床价值,但无论是PTCA还是冠状动脉内支架植入术均面临着急性血管闭塞和再狭窄难题,特别是冠状动脉腔内治疗术能显著激活血小板而增加了急性期或亚急性期血栓形成的风险,目前主要预防措施是应用抗血小板和抗凝药物治疗,以减少血栓形成。本文主要针对抗血小板药物在药理学预防血栓形成的疗效以及副作用的研究现状做一综述。 展开更多
关键词 抗血小板 经皮冠状动脉腔内成型术 冠状动脉内支 架植入术 血栓开成再狭窄
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冠心病患者支架植入术后的自我管理
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作者 江娟 《家庭生活指南(下旬刊)》 2020年第1期125-125,共1页
冠心病是指冠状动脉发生粥样硬化引起管腔狭窄或闭塞,导致病人出现心肌缺血、缺氧或坏死,从而出现胸痛、胸闷等不适症状,在活动后更加严重。冠心病多发于 40 岁以上的成年人,男性的发病率要普遍高于女性,且冠心病的发病年龄逐渐呈现年... 冠心病是指冠状动脉发生粥样硬化引起管腔狭窄或闭塞,导致病人出现心肌缺血、缺氧或坏死,从而出现胸痛、胸闷等不适症状,在活动后更加严重。冠心病多发于 40 岁以上的成年人,男性的发病率要普遍高于女性,且冠心病的发病年龄逐渐呈现年轻化的趋势。冠心病的治疗方式主要包括改变生活方式、药物治疗和手术治疗。 展开更多
关键词 冠心病患者 架植入术 自我管理
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颈椎前路可吸收人工骨架植入术的护理体会
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作者 李燕辉 张秋玲 李爱华 《中国基层医药》 CAS 2002年第5期465-465,共1页
关键词 颈椎前路可吸收有架植入术 护理 颈椎前路手术 术前 术后
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神经外科一项实用技术—无头架硬通道植入技术
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作者 赵奇煌 《全科医学杂志》 2001年第2期124-125,共2页
关键词 颅内压增高 无头硬通道植入术 手术适应症
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Retrospective analysis of percutaneous transluminal coronary angioplasty and coronary stenting 被引量:1
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作者 陈纪林 高润霖 +5 位作者 蔡强军 杨跃进 乔树宾 秦学文 张峻 姚民 《Chinese Medical Journal》 SCIE CAS CSCD 2002年第4期483-486,共4页
Objective To examine long term efficacy of percutaneous transluminal coronary angioplasty (PTCA),coronary stenting and to assess the factors affecting its efficacy Methods A total of 790 patients who underwent su... Objective To examine long term efficacy of percutaneous transluminal coronary angioplasty (PTCA),coronary stenting and to assess the factors affecting its efficacy Methods A total of 790 patients who underwent successful PTCA and PTCA+stent in this hospital were followed by direct interview or letter The rate of follow up was 84 2% and the period of follow up was 0 9-12 7 (3 5±2 4) years Results During follow up, 4 (0 5%) patients died, 22 (2 8%) had nonfatal acute myocardial infarction, 10 (1 3%) had coronary artery bypass surgery, and 98 (12 4%) had repeat PTCA The rate of recurrent angina pectoris was 31 1% The cardiac event free survival rate calculated by the Kaplan Meier method was 88 2% at 1 year and 80 6% at 12 7 years Cox regression analysis showed that there was a positive correlation between AMI history, stent implantation and the risk of cardiac events, and there was a negative correlation between the number of diseased arteries and the risk of cardiac events Compared to the PTCA group, patients with PTCA+stent had significantly lower rates of total cardiac events Conclusion The long term efficacy of PTCA, especially PTCA + stent in Chinese patients was very satisfactory, suggesting that PTCA+stent therapy should be the major treatment for revascularization in patients with coronary heart disease 展开更多
关键词 percutaneous transluminal coronary angioplasty · coronary stenting · long term prognosis
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The effect of spironolactone on the levels of GATA4 protein and hypoxia inducible factor-1α in patients receiving coronary stent implantation
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作者 Yumei Lou Xiaoying Ge +6 位作者 Zhelan Zheng Linyuan Xie Jiangfang Lian Wenjun Shen Kenan Lou Wanying Hu Dexing Hu 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2022年第2期134-141,共8页
In the present study,we aimed to explore the protective effect of spironolactone on cardiac function in patients undergoing coronary stent implantation by determining the serum levels of GATA4 and hypoxia-inducible fa... In the present study,we aimed to explore the protective effect of spironolactone on cardiac function in patients undergoing coronary stent implantation by determining the serum levels of GATA4 and hypoxia-inducible factor-1α(HIF-1α)proteins before and after the coronary stent implantation.A total of 134 patients undergoing coronary stent implantation in our hospital from March 2019 to March 2020 were retrospectively selected using the propensity score matching(PSM)method.Of the 134 patients,67 patients taking spironolactone were used as a test group,and the other 67 patients without taking spironolactone were used as a control group.In all patients,the levels of serum GATA4,HIF-1α,and troponin I proteins were determined before as well as 24 h and 6 months after the coronary stent implantation.Left ventricular ejection fraction(LVEF)and left ventricular systolic global longitudinal strain(GLS)were determined before and 6 months after the coronary stent implantation.There were no significant differences in the HIF-1αlevel between the two groups before and 6 months after the operation,while the HIF-1αlevel was significantly lower in the test group compared with the control group at 24 h after the operation(P<0.01).There were no significant differences in the GATA4 protein level between the two groups before and 24 h after the operation,while the GATA4 protein level was significantly lower in the test group compared with the control group at 6 months after the operation(P<0.01).There was no significant difference in LVEF between the two groups before and 6 months after the operation.GLS was significantly improved at 6 months after the operation compared with that before the operation in both groups,while GLS was significantly better in the test group compared with the control group at 6 months after the operation(P<0.01).Collectively,spironolactone could protect cardiac function probably by improving myocardial hypoxia and inhibiting myocardial remodeling. 展开更多
关键词 Coronary stent implantation SPIRONOLACTONE Hypoxia-inducible factor-1α GATA4 protein Ischemic cardiomyopathy Global longitudinal strain
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