Molecular Dynamics Simulation for the Effect of Chain Length of Spacer and Tail of Cationic Gemini Surfactant on the Complex with Anionic Polyelectrolyte

Interaction of anionic polyelectrolyte with cationic gemini surfactant has been investigated by coarse-grained molecular dynamics simulation.Polyelectrolyte facilitates the oppositely charged ionic surfactants to aggregate by suppressing the electrostatic repulsion between ionic head groups leading to the formation of micellar complex.With addition of surfactant,the conformation of polyion chain changes from stretched to random coiled to spherical,and at the same time more free micelles are formed by surfactants in mixtures.Increasing the length of spacer or tail chain in gemini surfactant will weaken its interaction with polyelectrolyte and simultaneously strengthen its tendency to self-assemble.The simulation results are consistent with experimental observations and reveal that the electrostatic interaction plays an important role in the interaction of polyelectrolyte with gemini sur- factant.

N-乙酰基转移酶10的功能研究进展

NAT10基因是位于11号染色体（11p13）的单拷贝基因,其序列跨度45kb,N-乙酰基转移酶10（N-acetyltransferase 10,NAT10）蛋白共包含1025个氨基酸,分子量116kD,存在三个保守结构域,包括N端乙酰化酶结构域（GNAT家族）,ATP/GTP结合模型,ATPase结构域。