Heterochromatin is characteristically more compact than chromatin is mediated by special histone modifications, euchromatin in the eukaryotic genome. The establishment of hetero- recruitment and propagation of heteroc...Heterochromatin is characteristically more compact than chromatin is mediated by special histone modifications, euchromatin in the eukaryotic genome. The establishment of hetero- recruitment and propagation of heterochromatin specific proteins, as well as formation of special primary and high order structures of chromatin. Chromatin remodeling factors are ATPases that can alter the conformation and/or positioning of nucleosomes along DNA in an ATP-dependent manner. There is increasing evidence implicating chromatin remodeling activities in heterochromatin in various organisms ranging from yeasts to humans. Chromatin remodeling factors play roles in the establishment, maintenance and epigenetic inheritance of heterochromatin, but the underlying molecular mechanisms have just begun to be investigated.展开更多
基金supported by U.S. National Institutes of Health (Grant No. GM62484)
文摘Heterochromatin is characteristically more compact than chromatin is mediated by special histone modifications, euchromatin in the eukaryotic genome. The establishment of hetero- recruitment and propagation of heterochromatin specific proteins, as well as formation of special primary and high order structures of chromatin. Chromatin remodeling factors are ATPases that can alter the conformation and/or positioning of nucleosomes along DNA in an ATP-dependent manner. There is increasing evidence implicating chromatin remodeling activities in heterochromatin in various organisms ranging from yeasts to humans. Chromatin remodeling factors play roles in the establishment, maintenance and epigenetic inheritance of heterochromatin, but the underlying molecular mechanisms have just begun to be investigated.
