AIM To investigate the specific biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke(CRCIS).METHODS A retrospective study was conducted on CRCIS patients(colorectal cancer patients with i...AIM To investigate the specific biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke(CRCIS).METHODS A retrospective study was conducted on CRCIS patients(colorectal cancer patients with ischemic stroke without conventional stroke risk factors) registered at seven centers between January 2007 and December 2017. Clinical data and laboratory and imaging findings were compared with age-and sex-matched patients with colorectal cancer(CRC) without ischemic stroke that were admitted to the same hospital during the same period. Univariate and multivariate analyses were performed to analyze the independent risk factors for CRCIS. A receiver operator characteristic curve was configured to calculate the optimal cut-off value of the products of the independent risk factors for CRCIS. RESULTS A total of 114 CRCIS patients and 114 CRC patients were included. Multiple lesions in multiple vascular territories were common in CRCIS patients(71, 62.28%). The levels of plasma D-dimer, carcinoembryonic antigen(CEA), cancer antigen 125, and neutrophil count were significantly higher in CRCIS patients than in CRC patients. Multiple logistic regression analysis revealed that plasma D-dimer levels [odds ratio(OR) = 1.002, 95% confidence interval(CI): 1.001-1.003, P < 0.001], CEA levels(OR = 1.011, 95%CI: 1.006-1.015, P < 0.001), and neutrophil count levels(OR = 1.626, 95%CI: 1.268-2.087, P < 0.001) were independent risk factors for CRCIS. In addition, receiver operator characteristic curve revealed that the area under curve for the products of plasma D-dimer, CEA, and neutrophil count was 0.889 ± 0.022(95%CI: 0.847-0.932, P < 0.001), and the optimal cut-off value for the product was 252.06, which was called the CRCIS Index, with a sensitivity of 86.0% and specificity of 79.8%.CONCLUSION Hypercoagulability induced by elevated CEA and neutrophils may be an important cause of CRCIS. The CRCIS index, which serves as a biomarker of CRCIS, needs further study.展开更多
Nowadays,more and more Android developers prefer to seek help from Q&A website like Stack Overflow,despite the rich official documentation.Several researches have studied the limitations of the official applicatio...Nowadays,more and more Android developers prefer to seek help from Q&A website like Stack Overflow,despite the rich official documentation.Several researches have studied the limitations of the official application programming interface(API)documentations and proposed approaches to improve them.However,few of them digged into the requirements of the third-party developers to study this.In this work,we gain insight into this question from multidimensional perspectives of API developers and API users by a kind of cross-validation.We propose a hybrid approach,which combines manual inspection on artifacts and online survey on corresponding developers,to explore the different focus between these two types of stakeholders.In our work,we manually inspect 1000 posts and receive 319 questionnaires in total.Through the mutual verification of the inspection and survey process,we found that the users are more concerned with the usage of API,while the official documentation mainly provides functional description.Furthermore,we identified 9 flaws of the official documentation and summarized 12 aspects(from the content to the representation)for promotion to improve the official API documentations.展开更多
基金the Guangxi Natural Science Foundation,No.2015GXNSFAA139228 and No.2016GXNSFAA380281Guangxi Medical and Health and Appropriate Technology Development and Promotion Application Project,No.S201660+1 种基金Innovation Project of Guangxi Graduate Education,No.YCSW2018105National Key Research and Development Program,No.2018YFC1311300
文摘AIM To investigate the specific biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke(CRCIS).METHODS A retrospective study was conducted on CRCIS patients(colorectal cancer patients with ischemic stroke without conventional stroke risk factors) registered at seven centers between January 2007 and December 2017. Clinical data and laboratory and imaging findings were compared with age-and sex-matched patients with colorectal cancer(CRC) without ischemic stroke that were admitted to the same hospital during the same period. Univariate and multivariate analyses were performed to analyze the independent risk factors for CRCIS. A receiver operator characteristic curve was configured to calculate the optimal cut-off value of the products of the independent risk factors for CRCIS. RESULTS A total of 114 CRCIS patients and 114 CRC patients were included. Multiple lesions in multiple vascular territories were common in CRCIS patients(71, 62.28%). The levels of plasma D-dimer, carcinoembryonic antigen(CEA), cancer antigen 125, and neutrophil count were significantly higher in CRCIS patients than in CRC patients. Multiple logistic regression analysis revealed that plasma D-dimer levels [odds ratio(OR) = 1.002, 95% confidence interval(CI): 1.001-1.003, P < 0.001], CEA levels(OR = 1.011, 95%CI: 1.006-1.015, P < 0.001), and neutrophil count levels(OR = 1.626, 95%CI: 1.268-2.087, P < 0.001) were independent risk factors for CRCIS. In addition, receiver operator characteristic curve revealed that the area under curve for the products of plasma D-dimer, CEA, and neutrophil count was 0.889 ± 0.022(95%CI: 0.847-0.932, P < 0.001), and the optimal cut-off value for the product was 252.06, which was called the CRCIS Index, with a sensitivity of 86.0% and specificity of 79.8%.CONCLUSION Hypercoagulability induced by elevated CEA and neutrophils may be an important cause of CRCIS. The CRCIS index, which serves as a biomarker of CRCIS, needs further study.
基金Project(2018-YFB1004202)supported by the National Key R&D Program of ChinaProject(61702534)supported by the National Natural Science Foundation of China
文摘Nowadays,more and more Android developers prefer to seek help from Q&A website like Stack Overflow,despite the rich official documentation.Several researches have studied the limitations of the official application programming interface(API)documentations and proposed approaches to improve them.However,few of them digged into the requirements of the third-party developers to study this.In this work,we gain insight into this question from multidimensional perspectives of API developers and API users by a kind of cross-validation.We propose a hybrid approach,which combines manual inspection on artifacts and online survey on corresponding developers,to explore the different focus between these two types of stakeholders.In our work,we manually inspect 1000 posts and receive 319 questionnaires in total.Through the mutual verification of the inspection and survey process,we found that the users are more concerned with the usage of API,while the official documentation mainly provides functional description.Furthermore,we identified 9 flaws of the official documentation and summarized 12 aspects(from the content to the representation)for promotion to improve the official API documentations.
