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Meta分析中标准化均差效应量的计算 被引量:7
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作者 张红 王珍 《中国组织工程研究与临床康复》 CAS CSCD 北大核心 2011年第4期737-740,共4页
背景:大多数情况下,在进行两组比较研究的Meta分析时,纳入Meta分析的各研究文献结果变量的操作差异较大,不同的研究结果间不能进行直接的比较,给Meta分析带来挑战。目的:深入挖掘原始研究的信息方法,增强Meta分析结果的效能。方法:根据... 背景:大多数情况下,在进行两组比较研究的Meta分析时,纳入Meta分析的各研究文献结果变量的操作差异较大,不同的研究结果间不能进行直接的比较,给Meta分析带来挑战。目的:深入挖掘原始研究的信息方法,增强Meta分析结果的效能。方法:根据原始研究提供的结局变量最常见的近10种情形介绍了标准化均差效应量的计算方法。结果与结论:在进行两组比较研究Meta分析时需要综合分析各种可能情况,特别是当原始研究文献提供的信息与研究者已掌握的公式存在着距离时需要尽可能挖掘到所需要的信息,避免信息的流失。 展开更多
关键词 标准化均差 META分析 效应量 计算 变量
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血栓素A合成酶1在结直肠癌组织中的表达临床病理意义及潜在靶向药物预测
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作者 罗婕 唐宇星 +2 位作者 覃凯 何融泉 李建军 《中文科技期刊数据库(引文版)医药卫生》 2024年第5期0170-0176,共7页
探讨血栓素A合成酶1(thromboxane A synthase 1,TBXAS1)在结直肠癌(colorectal cancer, CRC)组织中的表达临床病理意义及预测其潜在靶向药物。方法 整合CRC相关多中心高通量数据,计算TBXAS1 mRNA表达水平标准化平均差(standardized mean... 探讨血栓素A合成酶1(thromboxane A synthase 1,TBXAS1)在结直肠癌(colorectal cancer, CRC)组织中的表达临床病理意义及预测其潜在靶向药物。方法 整合CRC相关多中心高通量数据,计算TBXAS1 mRNA表达水平标准化平均差(standardized mean difference,SMD),结合THPA数据库免疫组化染色结果以及CRISPR敲除筛选技术细胞生长结果,验证TBXAS1在CRC中的表达意义。用汇总受试者工作特征曲线,灵敏度,特异度,似然比等指标来评价TBXAS1的临床病理意义。筛选放疗敏感数据集纳入后续分析以评估TBXAS1在CRC中的治疗意义,最后通过Coremine Medical数据库和分子对接技术筛选特异性靶向TBXAS1的药物。结果 本研究共纳入18个平台45个CRC数据集,含2455例CRC样本,1350例非癌结直肠组织对照样本。TBXAS1表达在CRC中显著上调,其标准化平均差为0.88(95%CI:0.63~1.14),汇总受试者工作特征曲线下面积为0.84(95%CI:0.80~0.87),灵敏度为0.67(95%CI:0.57~0.76),特异度为0.82(95%CI:0.78~0.86),阳性似然比为3.73(95%CI:2.93~4.76)、阴性似然比为0.4(95%CI:0.3-0.54);35株CRC细胞系依赖于TBXAS1生长,TBXAS1 mRNA在CRC放疗敏感细胞中高表达,TBXAS1可能是喹夫拉朋,利阿唑,伊非曲班的潜在靶标。结论 TBXAS1能够促进CRC细胞生长,从而发挥促癌作用,有望成为CRC潜在的治疗靶点。 展开更多
关键词 血栓素A合成酶1 结直肠癌 标准化均差 汇总受试者工作特征曲线 CRISPR敲除筛选技术
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Projection of IPCC AR4 Coupled Climate Models for Multitimescale Temperature Variation in Yunnan: A Case Study on Southwest Yunnan from 1960 to 2050 被引量:3
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作者 李少娟 黄樱 屠拉 《Journal of Resources and Ecology》 CSCD 2012年第1期33-42,共10页
Based on daily mean temperature records from 1961 to 2007 at 20 meteorological sites in Southwest Yunnan, and the surface temperature simulated by IPCC AR4 Climate Models, a quantitative examination was undertaken int... Based on daily mean temperature records from 1961 to 2007 at 20 meteorological sites in Southwest Yunnan, and the surface temperature simulated by IPCC AR4 Climate Models, a quantitative examination was undertaken into the characteristics of multi-timescale temperature (AMT, DMT and WMT) variation in Southwest Yunnan. The simulation abilities of the models were also evaluated with the normalized root mean square error (NRMSE) and Mann-Kendal test statistic methods. Temperatures show remarkable increasing trend from 1961 to 2007, with the Mann-Kendall test statistic passing 95% confidence verification. The result of the NRMSE analysis shows that the simulated temperature anomaly variations are more similar to observed ones especially for AMT and DMT, and the projected result (anomalies) of IPCC AR4 climate models can be used for predicting the trends in multi-timescale temperature variation in Southwest Yunnan in the next 40 years under the three emission scenarios, which has better simulating effect on AMT and DMT than WMT. Over the next 40 years the temperature will continue to rise, with annual mean temperature showing a more remarkable rising trend than that of the dry and wet seasons. Temperature anomalies exhibit different increasing rates under different emission scenarios: During the 2020s the rising rates of multi-timescale temperature anomalies in a high greenhouse gases emissions scenario (SRESA2) are smaller than those under a low emission scenario (SRESB1). Except that, the rate of increase in temperature anomalies are the highest in the intermediate emissions scenario (SRESA1B), followed by those in SRESA2, and those in low emissions scenario (SRESB1) are the lowest. The reason of different simulating effects on WMT from AMT and DMT was also discussed. 展开更多
关键词 Southwest Yunnan multi-timescale temperature normalized root mean square error projection of IPCC AR4 Coupled Climate Models
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