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地西他滨联合预激方案治疗首程标准诱导化疗未缓解初诊AML患者的效果观察
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作者 侯丽敏 高瑛 +1 位作者 高秋英 牛奔 《中国实验血液学杂志》 CAS CSCD 北大核心 2024年第3期679-684,共6页
目的:探讨地西他滨联合预激方案治疗首程标准诱导化疗未缓解初诊急性髓系白血病(AML)患者的疗效及对调节性T淋巴细胞(Treg)相对含量的影响。方法:收集2013年3月-2019年3月陕西省人民医院收治的102例初诊经首程标准诱导化疗未缓解的AML患... 目的:探讨地西他滨联合预激方案治疗首程标准诱导化疗未缓解初诊急性髓系白血病(AML)患者的疗效及对调节性T淋巴细胞(Treg)相对含量的影响。方法:收集2013年3月-2019年3月陕西省人民医院收治的102例初诊经首程标准诱导化疗未缓解的AML患者(除急性早幼粒细胞白血病)的临床资料进行回顾性分析,根据治疗方案不同对患者进行分组,51例采用预激方案治疗为常规组,51例采用地西他滨联合预激方案治疗为联合组。比较两组疗效、毒副反应发生率、治疗前后生活质量核心量表(QLQ-C30)评分、T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、Treg)及3年总生存率。结果:联合组治疗总有效率为80.39%,显著高于常规组的62.75%(P<0.05);治疗后联合组QLQ-C30评分为60.27±6.96,较常规组65.73±7.96低(P<0.001);两组毒副反应发生率比较,差异无统计学意义(P>0.05);治疗后联合组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平较常规组高(均P<0.001),而Treg水平较常规组低(P<0.001);联合组3年总生存率为72.55%,高于常规组的52.94%(P<0.001)。结论:地西他滨联合预激方案治疗初诊首程标准诱导化疗未缓解AML患者效果显著,可通过调节Treg相对含量减少抗肿瘤免疫抑制,增强机体免疫功能,从而延长患者生存时间,提高生存质量,且未增加不良反应。 展开更多
关键词 地西他滨 标准诱导化疗 调节性T淋巴细胞 预激方案 急性髓系白血病
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地西他滨联合标准诱导方案治疗急性髓系白血病的疗效
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作者 冯安超 《黑龙江医药科学》 2023年第3期92-93,共2页
目的:探讨地西他滨联合标准诱导方案治疗急性髓系白血病(AML)患者的效果。方法:选取2017-06~2020-07驻马店市第一人民医院治疗的60例AML患者,按随机数字表法分为两组。对照组30例采用标准诱导方案治疗,观察组30例采用地西他滨联合标准... 目的:探讨地西他滨联合标准诱导方案治疗急性髓系白血病(AML)患者的效果。方法:选取2017-06~2020-07驻马店市第一人民医院治疗的60例AML患者,按随机数字表法分为两组。对照组30例采用标准诱导方案治疗,观察组30例采用地西他滨联合标准化诱导方案治疗,两组连续治疗3个周期。比较两组治疗3个周期后临床疗效,比较两组治疗期间毒副反应(包括骨髓抑制、肺部感染、软组织感染、粒细胞缺乏等)发生情况。结果:治疗3个周期后,观察组总有效率为76.67%,高于对照组50.00%(P<0.05);两组毒副反应比较,差异无统计学意义(P>0.05)。结论:地西他滨联合标准诱导方案可提高初治疗AML患者临床疗效,且未增加治疗毒性反应发生率,联合用药安全性较高。 展开更多
关键词 急性髓系白血病 地西他滨 标准诱导方案 毒副反应
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论可裂G_2的缠结算子(I)
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作者 陈仲沪 谭作文 《数学年刊(A辑)》 CSCD 北大核心 2001年第1期35-42,共8页
设G为线性连通单李群可裂G2.本文得到了G的缠结算子作用于G的标准诱导表示的某些子空间的公式.利用这些公式可给出C的不可约酉表示的精确极限.
关键词 线性连通单李群 不可约酉表示 可裂G2 缠结算子 标准诱导 精确极限
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“积极诱导规则”——从Grokster案看P2P侵权的新标准
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作者 杨晖 马宁 《知识产权法研究》 2006年第1期116-123,共8页
2005年6月27日,美国最高法院对争论已久的MGM Studios Inc v.Grokster Ltd案作出了判决,确立了判断版权侵权的新标准——积极诱导标准。鉴于目前P2P软件在我国也被广泛使用,本文即对这一判决进行分析,希望国内相关各方能有所借鉴。
关键词 版权侵权 积极诱导标准 通用物原则
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自体骨髓移植治疗复发/难治的急性白血病3例疗效观察
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作者 陈艳才 成功 +15 位作者 张普生 颜红芳 廖艳 何君 马跃成 卢昌友 沈郭琼 张琼 邓敏 陈宗万 冯运会 谢建强 肖振圭 杨科 贾敏 刘庆华 《攀枝花医药》 2003年第2期1-3,共3页
目的 探讨自体骨髓移植对复发/难治急性白血病的治疗效果。方法 选取3例患者作为研究对象,3例患者中,急性淋巴细胞白血病1例,急性髓细胞白血病2例,初治时均以标准诱导化疗方案化疗1疗程未达到完全缓解(CR),第2疗程重复诱导化疗方... 目的 探讨自体骨髓移植对复发/难治急性白血病的治疗效果。方法 选取3例患者作为研究对象,3例患者中,急性淋巴细胞白血病1例,急性髓细胞白血病2例,初治时均以标准诱导化疗方案化疗1疗程未达到完全缓解(CR),第2疗程重复诱导化疗方案后达到完全缓解,巩固化疗过程中,患者于第6-8疗程复发(中位数第7疗程),CR2至ABMT的中位时间为5月,预处理方案为CBV(即BCNU+CTX+VP-16),采集骨髓悬液约250-880ml,中位数590ml,含单个核细胞数为1.54-2.3×10^8/kg,中位数1.94X10^8/kg,采集后4℃冰箱保存60小时。结果 患者通过0细胞期,白细胞升至0.5×10^9/L的中位数时间为27天,血小板计数上升至20×10^9/L的中位数时间为36天,骨髓恢复正常造血的中位数时间为33天。结论 自体骨髓移植是一种有价值的治疗方法。 展开更多
关键词 自体骨髓移植 急性白血病 标准诱导化疗方案 造血干细胞移植 手术治疗
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Gradient principle of horizontal stress inducing rock burst in coal mine 被引量:6
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作者 何江 窦林名 《Journal of Central South University》 SCIE EI CAS 2012年第10期2926-2932,共7页
Based on the stress distribution characteristics of rock burst multiple sites, the criterion of horizontal stress inducing layer dislocation rock burst was established. Accordingly, the influencing factors were analyz... Based on the stress distribution characteristics of rock burst multiple sites, the criterion of horizontal stress inducing layer dislocation rock burst was established. Accordingly, the influencing factors were analyzed. The analysis results indicate that the stress condition, edge of etastic zone depth, supporting strength, and the friction angle and cohesion among coal stratum, roof and floor are sensitive factors. By introducing double-couple model, the layer dislocation rock burst was explained and the energy radiation characteristics were analyzed. The SOS micro-seismic monitoring system was applied to observe the rock burst hazards about a mining face. The results show that P- and S-wave energy radiations produced by rock burst have directional characteristics. The energy radiation characteristics of the 22 rock bursts occurring on 79Z6 long-wall face are basically the same as theoretical results, that is, the ratio of S-wave energy of sensor 4 to 6 is about 1.5 and that of P-wave is smaller than 0.5. The consistency of the monitored characteristics of the energy radiation theoretically increases with the total energy increasing. 展开更多
关键词 horizontal stress rock burst gradient principle micro-seismic monitoring directional characteristic energy radiation
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从MP3.com到Grokster——析网络服务商版权侵权责任的发展 被引量:2
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作者 廖春燕 《科技与法律》 2006年第4期106-112,共7页
网络服务商(ISP)是网上信息传输的中介,但由于网络版权侵权的广泛性和侵权者的隐蔽性,ISP被拉入了网络版权侵权纠纷的漩涡中。本文分析了美国从MP3.com案到Napster案再到Grokster案中对ISP责任认定的发展:即从直接侵权责任到间接侵权... 网络服务商(ISP)是网上信息传输的中介,但由于网络版权侵权的广泛性和侵权者的隐蔽性,ISP被拉入了网络版权侵权纠纷的漩涡中。本文分析了美国从MP3.com案到Napster案再到Grokster案中对ISP责任认定的发展:即从直接侵权责任到间接侵权责任再到积极诱导标准的发展。从中我们也可以看出一条科技发展与版权法律保护的博弈之路。文章最后分析了我国立法与司法实践中对ISP责任认定的现状。 展开更多
关键词 网络服务商 间接侵权责任 辅助侵权责任 替代侵权责任 积极诱导标准
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Photon-Induced Production of Mirror Quarks from LHT Model at LHC
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作者 YUE Chong-Xing LIU Jin-Yan DING Li LIU Wei MA Wei 《Communications in Theoretical Physics》 SCIE CAS CSCD 2009年第12期1041-1048,共8页
The photon-induced processes at the LHC provide clean experimental conditions due to absence of theproton remnants,which might produce complementary and interesting results for tests of the standard model and forsearc... The photon-induced processes at the LHC provide clean experimental conditions due to absence of theproton remnants,which might produce complementary and interesting results for tests of the standard model and forsearching of new physics.In the context of the littlest Higgs model with T-parity,we consider the photon-inducedproduction of the mirror quarks at the LHC.The cross sections for various production channels are calculated and asimply phenomenological analysis is performed by assuming leptonic decays. 展开更多
关键词 the mirror fermions the LHT model the LHC
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Study of the Pavement Settlement Standard Induced by Tunnel to Under-traverse Highway in Close Quarter
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作者 Zhang Peng Tan Zhongsheng Liu Heng Zhang Yuchuan 《Engineering Sciences》 EI 2008年第1期70-73,共4页
Now the surface settlement induced by shallow buried tunnel to under-traverse highway,mostly adopt the empirical value,3 cm,acquired from Beijing or Shenzhen metro,which is regarded as the controlling standard.But to ... Now the surface settlement induced by shallow buried tunnel to under-traverse highway,mostly adopt the empirical value,3 cm,acquired from Beijing or Shenzhen metro,which is regarded as the controlling standard.But to more project,tunnel under-traverse highway,we must decide the controlling standard flexibly,which should base on the pavement service function and the pavement condition.The thesis,based on the pavement evenness and running comfort ability in the view of completing the pavement service function,supposes the longitudinal pavement settlement cross section as a quadratic parabola,and gets the maximal settlement value in the range of longitudinal pavement influence when the tunnel is under-traverse highway perpendicularly.Then the controlling standard is decided.As Wenxiang Tunnel under-traverse Lianhuo Freeway on Zhengzhou-Xi'an Passenger Dedicated Railway Line for an example,the settlement controlling standard is acquired,and we hope it has an direction and reference value to similar tunnel construction. 展开更多
关键词 shallow buried tunnel pavement settlement EVENNESS comfort ability controlling standard
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Gemcitabine plus carboplatin used as induction regimen for elderly patients with locally advanced unresectable non-small cell lung cancer
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作者 Zhihua Sun Hongmin Zheng Linyun Zhang 《The Chinese-German Journal of Clinical Oncology》 CAS 2011年第2期85-87,共3页
Objective:The purpose of this study was to evaluate the efficacy and safety of gemcitabine(GEM) and carboplatin(CBP) used as induction regimen in the treatment of elderly patients with locally advanced unresectable no... Objective:The purpose of this study was to evaluate the efficacy and safety of gemcitabine(GEM) and carboplatin(CBP) used as induction regimen in the treatment of elderly patients with locally advanced unresectable non-small cell lung cancer(NSCLC).Methods:Seventy-eight cases of elderly patients have been cytologically and pathologically confirmed with locally advanced unresectable NSCLC,the age of the patients ranged from 65 to 75 years.The patients were treated with the combined regimen of gemcitabine and cisplatin.GEM 1000 mg/m2 intravenously injected by drip on the 1st,8th day and the dosage of CBP was AUC 4 that was used on the 1st day,21 days apart to each cycle,most patients received 2 cycles.Treatment response was evaluated according to the criteria of RECIST(Response Evaluation Criteria in Solid Tumor),the side effect of the regimen was judged based on WHO criteria.Results:Seventy-eight patients were evaluated and received a total of 156 cycles chemotherapy.There were no complete regression that could be observed,but 32 cases had partial regression(PR),37 cases with no change(NC) and 9 cases with progression disease(PD).The overall response rate was 41.0%.The main side effects were hematological toxicity.Conclusion:The GC regimen could be used as induction treatment for elderly patients with locally advanced unresectable NSCLC,and the regimen could be well tolerated and is safe in terms of side effects. 展开更多
关键词 elderly patient non-small cell lung cancer GEMCITABINE CARBOPLATIN induction chemotherapy
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