煤矿主井提升及定量装卸载综合自动控制系统

为了提高煤矿主井提升效率,主井提升运行无人值守的自动化控制一直是追求的目标,为此采用全数字控制技术、计算机技术、电力电子技术、核子检测技术等先进技术,在解决提高全数字提升机电控系统的工作可靠性和安全可靠性以及定量装载控制和基于核子技术的卸载监视系统等诸多技术关键基础上,将全数字提升机电控系统和定量装卸载控制有机结合,构成了煤矿主井提升及装卸载综合自动化控制系统。该系统已成功应用于现场,基本实现了煤矿主井提升无人值守的自动化控制。

煤矿提升机自动控制系统的现状及改进

在解决提高全数字提升机电控系统的工作可靠性和安全可靠性以及自动控制中主要采用全数字控制、计算机、PLC控制、核子检测等先进技术的自动监视系统,将全数字提升机电控系统和自动控制系统有机结合,构成了煤矿主井提升综合自动化控制系统。

Real-Time PCR Technique and Its Application in Quantification of Plant Nucleic Acid Molecules

Real-time PCR is a closed DNA amplification system that skillfully integrates biochemical, photoelectric and computer techniques. Fluorescence data acquired once per cycle provides rapid absolute quantification of initial template copy numbers as PCR products are generated. This technique significantly simplifies and accelerates the process of producing reproducible quantification of nucleic acid molecules. It not only is a sensitive, accurate and rapid quantitative method, but it also provides an easier way to calculate the absolute starting copy number of nucleic acid molecules to be tested. Together with molecular bio-techniques, like microarray, real-time PCR will play a very important role in many aspects of molecular life science such as functional gene analysis and disease molecular diagnostics. This review introduces the detailed principles and application of the real-time PCR technique, describes a recently developed system for exact quantification of AUX/IAA genes In Arabidopsis, and discusses the problems with the real-time PCR process.

Down-regulation of STAT3 expression by vector-based small interfering RNA inhibits pancreatic cancer growth

AIM:To evaluate the effect of RNA interference (RNAi) mediated silence of signal transduction and activation of transcription (STAT)3 on the growth of human pancreatic cancer cells both in vitro and in vivo.METHODS:STAT3 specific shRNA was used to silence the expression of STAT3 in pancreatic cancer cell line SW1990.The anti-growth effects of RNAi against STAT3 were studied in vitro and in experimental cancer xenografts in nude mice.The potential pathways involved in STAT3 signaling were detected using reverse transcription polymerase chain reaction and western blotting.RESULTS:The expression of the STAT3 was inhibited using RNAi in SW1990 cells.RNAi against STAT3 inhibited cell proliferation,induced cell apoptosis and significantly reduced the levels of CyclinD1 and Bcl-xL when compared with parental and control vector-transfected cells.In vivo experiments showed that RNAi against STAT3 inhibited the tumorigenicity of SW1990 cells and significantly suppressed tumor growth when it was directly injected into tumors.CONCLUSION:STAT3 signaling pathway plays an important role in the progression of pancreatic cancer,and silence of STAT3 gene using RNAi technique may be a novel therapeutic option for treatment of pancreatic cancer.

A compound spike model for formation of nuclear tracks in solids

Formation of nuclear tracks in solids has been described as a thermal spike as well as a Coulomb explo- sion spike.Here,formation of nuclear tracks is described as a compound spike including partial roles of both thermal and Coulomb explosion spikes in track formation.Fractional roles of both spikes depend on atomic and electronic structure of a track detector and deposited energy density in the track detector by the incident charged particle.Be- havior of the cylindrical zone along the path of the incident particle is described mathematically in terms of bulk and individual atomic flow or movement.Defect structure of the latent nuclear tracks is described and conditions of con- tinuity and discontinuity of latent tracks are evaluated and discussed.This paper includes mathematical description, analysis and evaluation of the nuclear track formation issue in the light of published experimental and theoretical re- sults,which are useful for users of nuclear track detection technique and researchers involved in ion beam induced materials modification and ions implantation in semiconductors.

BaF_2 TIME DIFFERENTIAL PERTURBED ANGULAR DISTRIBUTION SPECTROMETER

A BaF2 time differential perturbed angular distribution spectrometer has been established at the HI-13 tandem accelerator in CIAE. The time resolution of the spectrometer is 195 ps and the nonlinearity is less than 2 %. The spectrometer works very stably and no time drift is found over a period of experimelltal ruffs. This spectrometer has been successfully used in the g-factor measurement of 43 Sc (19/2-,3.1232 MeV).

Tumor Molecular Imaging with Nanoparticles

Molecular imaging(MI)can provide not only structural images using traditional imaging techniques but also functional and molecular information using many newly emerging imaging techniques.Over the past decade,the utilization of nanotechnology in MI has exhibited many significant advantages and provided new opportunities for the imaging of living subjects.It is expected that multimodality nanoparticles(NPs)can lead to precise assessment of tumor biology and the tumor microenvironment.This review addresses topics related to engineered NPs and summarizes the recent applications of these nanoconstructs in cancer optical imaging,ultrasound,photoacoustic imaging,magnetic resonance imaging(MRI),and radionuclide imaging.Key challenges involved in the translation of NPs to the clinic are discussed.

Effects of Trapped Electrons on Off-axis Lower Hybrid Current Drive

The effects of trapped electrons on off-axis lower hybrid current drive （LHCD） in tokamaks are studied. The influence of the resonance regime on the current drive efficiency as well as the influence of trapped particle fraction on the current drive efficiency are emphasized.

Cytogenetic Diagnosis and Analysis of the Clinical Profile of Individuals with Non-down Syndrome Intellectual Disability

Chromosomal alterations are the main causes of genetic diseases. One of the characteristics of certain genetic syndromes is ID （intellectual disability） presented by the individual in varying degrees. The study of the ID, its etiology, association or not with chromosomal abnormalities and a clinical diagnosis associated with the examination of karyotype are important aspects to consider when providing genetic counseling for families. Due to the lack of similar studies and of easy access to cytogenetic services for the Amazonian population, this study aimed to contribute to the advancement of this line of study in the state, analyzing the karyotype of individuals with ID, not Down Syndrome treated at the APAE-Manaus and identifying the main types of chromosomal alterations in the individuals analyzed. Analyzes were performed of the clinical diagnosis through investigation of the data from the interview and medical records as well as analysis of the karyotype of 31 patients with non-Down syndrome ID, attended in the APAE-Manaus. Of these subjects, 20 were female and 11 male. The results showed only 2 cases of chromosome abnormalities are detectable by classical cytogenetics, one of mosaic Turner syndrome and one a heterochromatic variant. It is therefore necessary to complement the study with the addition of molecular techniques for the investigation of microdeletions and/or other alterations not detectable through the banding technique, mainly for individuals whose dysmorphisms indicate a suspected syndrome.