硒酵母治疗糖尿病伴桥本甲状炎的临床研究

目的探讨硒酵母治疗在糖尿病伴桥本甲状炎的治疗中所起到的临床效果。方法将62例患者分为研究组和对照组,两组均进行常规西医药物治疗,同时,研究组在治疗过程中还给予硒酵母片的药物治疗。治疗后观察两组患者的治疗效果,并对治疗前后症状的改善进行评价。结果在治疗后对两组患者的疗效进行判定,研究组患者的临床效果相较于对照组更优,研究组患者的甲状腺肿胀、甲状腺疼痛、腹胀及粘液性水肿等临床症状的治愈率情况更为显著,研究组的总有效率为96.8%,明显高于对照组的51.6%。结论在糖尿病伴桥本甲状炎的治疗中要尽可能的寻找适宜的治疗方式,结合患者的发病情况有针对性的进行治疗,硒酵母在治疗中的效果是显著的,在治疗过程中可以提高患者的治疗效果。

桥本甲状腺炎的超声诊断进展

桥本甲状腺炎(HT)是常见的自身免疫性甲状腺疾病之一,是造成甲状腺功能减退最常见的原因。随着超声显像仪的进步,超声新技术的发展,HT的超声诊断也在不断发展。本文对HT超声诊断研究进展进行综述。

T_3核受体各亚型mRNA在不同甲状腺功能患者外周血白细胞中的表达

目的 T3对细胞的代谢调节作用是通过甲状腺激素核受体 (T3R)介导的 ,细胞中T3R量与细胞对T3的反应性有关。本文探讨了T3R表达与人体不同甲功状态的关系。方法 应用半定量RT PCR法 ,研究了Graves 甲亢、桥本甲炎甲功正常、桥本甲炎甲减患者外周血白细胞中T3R各亚型mRNA表达量的变化 ,并与正常对照进行比较。结果 外周血白细胞中T3Rα1 、T3Rα2 、T3Rβ2 mRNA表达在Graves 甲亢患者降低 ,在桥本甲炎甲减患者升高 ,而桥本甲炎甲功正常者有升高倾向 ;T3Rβ1 mRNA在不同甲功状态中变化不大。结论 在外周血白细胞中 ,T3RmRNA各亚型表达与甲功状态密切相关 ,T3对其受体亚型mRNA表达水平有下调作用 ,但T3Rβ1 mRNA表达不受甲功状态影响。

自身免疫性甲状腺疾病实验室诊断

目的:采用TPOAb、TGb、FT3、FT4五项指标对自身免疫性甲状腺疾病(AITD)提供诊断和鉴别诊断的实验室依据。方法:采用放射免疫(受体)分析法测量165例AITD患者血清中TPOAb、TGAb、TRAb、FT3、FT4水平。结果:桥本甲状腺炎组TPOAb和TGAb升高与Graves病组、桥本甲亢组比较差异有显著性(P<0.001);TRAb、FT3、FT4正常与Graves病组、桥本甲亢组结果差异有显著性(P<0.001);Graves组和桥本甲亢组TRAb、FT3、FT4升高差异无显著性(P>0.05),而TPOAb和TGAb结果升高差异有显著性(P<0.001)。结论:上述五项实验室指标对AITD诊断、鉴别诊断及治疗原则、方法的选择具有重要意义。

Coeliac disease in Dutch patients with Hashimoto’s thyroiditis and vice versa

AIM: To define the association between Hashimoto’s thyroiditis and coeliac disease in Dutch patients. METHODS: A total of 104 consecutive patients with Hashimoto’s thyroiditis underwent coeliac serological tests (antigliadins, transglutaminase and endomysium antibodies) and HLA-DQ typing. Small intestinal biopsy was performed when any of coeliac serological tests was positive. On the other hand, 184 patients with coeliac disease were subjected to thyroid biochemical (thyroid stimulating hormone and free thyroxine) and thyroid serological tests (thyroglobulin and thyroid peroxidase antibodies). RESULTS: Of 104 patients with Hashimoto’s thyroiditis, sixteen (15%) were positive for coeliac serology and five patients with documented villous atrophy were diagnosed with coeliac disease (4.8%; 95% CI 0.7-8.9). HLA-DQ2 (and/or -DQ8) was present in all the five and 53 patients with Hashimoto’s thyroiditis (50%; 95% CI 43-62). Of 184 patients with coeliac disease, 39 (21%) were positive for thyroid serology. Based on thyroid biochemistry, the 39 patients were subclassified into euthyroidism in ten (5%; 95% CI 2-9), subclinicalhypothyroidism in seven (3.8%; 95% CI 1.8-7.6), and overt hypothyroidism (Hashimoto’s thyroiditis) in 22 (12%; 95% CI 8-16). Moreover, four patients with coeliac disease had Graves’ disease (2%; 95% CI 0.8-5) and one patient had post-partum thyroiditis. CONCLUSION: The data from a Dutch population confirm the association between Hashimoto’s thyroiditis and coeliac disease. Screening patients with Hashimoto’s thyroiditis for coeliac disease and vice versa is recom- mended.

Advances in the relationship between Hashimoto’s thyroiditis and thyroid cancer

In recent years,the incidence of Hashimoto’s thyroiditis and thyroid cancer has shown a rapid growth trend.These two diseases have severely affected the public health.Many epidemiological studies have shown that thyroid cancer is often associated with Hashimoto’s thyroiditis.Hashimoto’s thyroiditis may promote the occurrence of thyroid cancer,as well as affecting the progression of the tumor,lymph node metastasis,and even the prognosis of patients.In this paper,the relationship between Hashimoto’s thyroiditis and thyroid cancer and the pathogenesis of thyroid cancer are reviewed regarding molecular mechanism,clinical pathology,and serology.

Clinical Study on Combined Moxibustion and Medication for Hashimoto’s Thyroiditis

Objective： To observe the clinical effect of combined moxibustion and medication for Hashimoto’s thyroiditis. Methods： A total of 85 cases with Hashimoto’s thyroiditis who met the inclusion criteria were randomly allocated into an observation group and a control group. Forty-two cases in the observation group were treated with combined moxibustion with oral Levothyroxine Sodium tablets, whereas 43 cases in the control group were treated with oral Levothyroxine Sodium tablets alone. Then the scores of clinical symptoms and exophthalmos before and after treatment were compared. In addition, the time period for improvement of clinical symptoms in both groups were recorded and compared. Results： After one-month treatment, the scores of clinical symptoms and exophthalmos in the observation group were significantly improved than those in the control group （P0.05）; and it took less time for the cases in the observation group to get improvement compared with the control group. Conclusion： Combined moxibustion and oral Levothyroxine Sodium tablet is an efficient reliable therapy for Hashimoto’s thyroiditis.

Reflection and prospect on acupuncture-moxibustion in treating Hashimoto's thyroiditis

Objective： To categorize and summarize the clinical and mechanism studies of the past 30 years on the treatment of Hashimoto＇s thyroiditis（HT） with moxibustion, moxibustion plus medication, and acupuncture plus medication, etc., and to analyze the current problems. Methods： The clinical and laboratory studies related to the treatment of HT with acupuncture-moxibustion therapies published before June 2015 were retrieved from MEDLINE, Excerpta Medica Database（EMBASE）, China National Knowledge Infrastructure（CNKI）, Wanfang Academic Journal Full-text Database（Wanfang） and Chongqing VIP Database（CQVIP）. Results： Moxibustion, moxibustion plus medication, and acupuncture plus medication can produce certain therapeutic effects in treating HT. Conclusion： The research on the treatment of HT with acupuncture-moxibustion therapies is rather limited in the amount and content. In the future, standardization should be fortified, specific moxibustion research needs deepening, and the action mechanism of moxibustion should be emphasized.