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特异性免疫治疗对桦树花粉过敏小鼠Th17细胞的影响 被引量:4
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作者 谢枝隽 尹佳 周俊雄 《中华临床免疫和变态反应杂志》 2019年第2期130-136,共7页
目的检测特异性免疫治疗前后,桦树花粉诱导的哮喘小鼠脾Th17细胞数量和其转录因子Rorc表达变化。方法小鼠采用颈后皮下注射(桦树花粉和佐剂)致敏和雾化激发的方法造模。通过检测哮喘相关指标评价动物模型和特异性免疫治疗疗效,检测指标... 目的检测特异性免疫治疗前后,桦树花粉诱导的哮喘小鼠脾Th17细胞数量和其转录因子Rorc表达变化。方法小鼠采用颈后皮下注射(桦树花粉和佐剂)致敏和雾化激发的方法造模。通过检测哮喘相关指标评价动物模型和特异性免疫治疗疗效,检测指标包括气道高反应,肺组织病理和血清免疫球蛋白水平(sIgE、sIgG1、sIgG2a)等。流式细胞术检测Th17细胞;RT-qPCR检测Rorc mRNA表达;高通量多因子检测平台Luminex 200TM检测血清细胞因子IL-4和IL-17A水平。结果与对照组比较,桦树花粉致敏和激发的哮喘小鼠具有气道高反应;血清桦树花粉特异性sIgE,sIgG1,sIgG2a水平升高;支气管周围有炎症细胞浸润,支气管内有大量黏液分泌;血清细胞因子IL-4和IL-17A水平明显升高。经特异性免疫治疗后,以上各项指标均明显下降。哮喘组小鼠脾Th17细胞数量(0.37±0.16)较对照组小鼠脾Th17细胞数量(0.18±0.86)明显增高(P<0.05);而特异性免疫治疗组,Th17细胞数量(0.16±0.16)较哮喘组显著降低(P<0.01)。哮喘组小鼠脾Th17细胞转录因子Rorc的表达量(3.99±1.39)较对照组(1.79±1.19)显著升高(P<0.01);经特异性免疫治疗后,Th17细胞转录因子Rorc的表达量(0.65±0.23)较哮喘组明显降低(P<0.01),差异有统计学意义。结论桦树花粉特异性免疫治疗能部分抑制Th17细胞的数量和功能,有助于进一步了解特异性免疫治疗的机制。 展开更多
关键词 桦树花粉过敏 特异性免疫治疗 TH17细胞 动物模型
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Stallergenes公司宣布:包含桦树花粉重组过敏原(rBet v1)的免疫治疗药片Ⅱb/Ⅲ期临床试验获肯定结果
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《国外药讯》 2009年第10期16-16,共1页
Stallergenes SA公司宣布了含桦树花粉重组过敏原(rBetv1)(Ⅰ)的舌下片的Ⅱb/Ⅲ期临床试验的首项结果,此试验主要在由桦树花粉引起的过敏性鼻炎患者中进行并观察此种使用(Ⅰ)舌下片的免疫疗法的进展。
关键词 Ⅲ期临床试验 重组过敏原 桦树花粉 免疫治疗 宣布 药片 过敏性鼻炎 免疫疗法
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北京地区桦树花粉过敏原致敏蛋白组分研究
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作者 王晓艳 丁佳琪 +2 位作者 陈力嘉 王洪田 王学艳 《临床耳鼻咽喉头颈外科杂志》 CAS CSCD 北大核心 2024年第3期195-199,共5页
目的研究北京地区桦树花粉过敏的主要致敏蛋白组分及其临床意义。方法采用横断面研究的方法将58例桦树花粉过敏的患者纳入研究。根据临床表现分为变应性鼻炎(allergic rhinitis,AR)和过敏性哮喘(allergic asthma,AA)组。采用ImmunoCAP... 目的研究北京地区桦树花粉过敏的主要致敏蛋白组分及其临床意义。方法采用横断面研究的方法将58例桦树花粉过敏的患者纳入研究。根据临床表现分为变应性鼻炎(allergic rhinitis,AR)和过敏性哮喘(allergic asthma,AA)组。采用ImmunoCAP荧光酶联免疫法检测患者血清桦树花粉sIgE浓度,以及桦树花粉主要致敏蛋白组分Bet v 1,Bet v 2,Bet v 4,Bet v 6 sIgE浓度并分级。分析桦树花粉和各组分蛋白sIgE在AR和AA中的差异。结果入组患者中,AR为44例(75.9%),AA为14例(24.1%)。单独春季花粉过敏的18例患者全部为AR患者,无AA患者。春秋季花粉过敏的患者共计40例,其中AR为26例(65%);AA为14例(35%)。58例纳入研究的患者均为桦树花粉sIgE 2级及以上阳性。4种桦树花粉的致敏蛋白组分中,对任意一种桦树花粉蛋白组分阳性占94.8%。单一组分致敏占77.6%;2种组分致敏占17.2%。Bet v 1和(或)Bet v 2阳性率为93.1%。4种蛋白组分的阳性率依次为:Bet v 1(82.8%)、Bet v 2(29.3%)、Bet v 6(1.7%)、Bet v 4(0)。桦树花粉sIgE和Bet v 1的sIgE级别呈显著正相关性(r=0.898,P<0.001)。Bet v 2的sIgE浓度在AA组显著高于AR组[(4.34±14.35)kUA/L vs(1.56±3.26)kUA/L,P<0.05],其他组分无显著性差异。结论北京地区桦树花粉的主要致敏蛋白组分为Bet v 1,桦树花粉组分蛋白以单一致敏为主,Bet v 1联合Bet v 2检测可诊断90%以上的桦树花粉过敏患者。 展开更多
关键词 花粉过敏 桦树花粉 致敏组分蛋白 Bet v 1 Bet v 2
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桦树花粉相关的食物过敏综合征一例 被引量:8
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作者 邵洁 罗海燕 APurohit G Pauli 《中华儿科杂志》 CAS CSCD 北大核心 2005年第2期149-150,共2页
关键词 桦树花粉 食物过敏综合征 免疫学特征 实验室检查
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烤制的榛子对某些桦树花粉过敏的病人是不安全的 被引量:1
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作者 耿江 《中华医学信息导报》 2003年第14期10-10,共1页
欧洲研究人员指出,烤制的榛子可以降低患有与桦树花粉相关的食物过敏病人的变态反应性,但坚果仍然不能认为对所有榛子过敏的病人是安全的。
关键词 烤制的榛子 桦树花粉过敏 不安全 变态反应性
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丹麦用桦树花粉提取物有效治疗严重花粉过敏性鼻炎
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《国外医药(植物药分册)》 2002年第5期228-228,共1页
关键词 丹麦 桦树花粉 提取物 治疗 花粉过敏性鼻炎
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Specific probiotics alleviate allergic rhinitis during the birch pollen season 被引量:19
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作者 Arthur C Ouwehand Merja Nermes +3 位作者 Maria Carmen Collado Nina Rautonen Seppo Salminen Erika Isolauri 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第26期3261-3268,共8页
AIM: To investigate whether birch pollen allergy symptoms are linked with gut microbiota changes and whether probiotics have an effect on these. METHODS: Forty seven children with confirmed birch pollen allergy were... AIM: To investigate whether birch pollen allergy symptoms are linked with gut microbiota changes and whether probiotics have an effect on these. METHODS: Forty seven children with confirmed birch pollen allergy were randomized to receive either a probiotic combination of Lactobacillus acidophilus (L. acidophilus) NCFM^TM (ATCC 700396) and Bifidobacterium lactis (B. lactis) BI-04 (ATCC SD5219) or placebo in a double-blind manner for 4 mo, starting prior to onset of the birch pollen season. Symptoms were recorded in a diary. Blood samples were taken for analysis of cytokines and eosinophils. Fecal samples were analysed for microbiota components, calprotectin and IgA. Nasal swabs were taken for analysis of eosinophils.RESULTS: The pollen season induced a reduction in Bifldobacterium , Clostridium and Bacteroides which could not be prevented by the probiotic intervention. During the intervention, significantly higher numbers ofB. lactis 11.2 × 10^7 ± 4.2 ×10^7 vs 0.1 × 10^7 ± 0.1 × 10^7 bacteria/g feces (P 〈 0.0001) and L. acidophilus NCFMTM 3.5 × 10^6 ± 1.3 × 10^6 vs 0.2 × 10^6 ±0.1 × 10^6 bacteria/g feces (P 〈 0.0001) were observed in the probiotic group compared to the placebo group.During May, there was a tendency for fewer subjects, (76.2% vs 95.2%, P = 0.078) to report runny nose, while during June, fewer subjects, 11.1% vs 33.3%, reported nasal blocking in the probiotics group (P = 0.101). Concomitantly, fewer subjects in the probiotic group had infiltration of eosinophils in the nasal mucosa compared to the placebo group, 57.1% vs 95% (P = 0.013). Eye symptoms tended to be slightly more frequent in the probiotic group, 12.5 d [interquartile range (IQR) 6-18] vs 7.5 d (IQR 0-11.5) (P = 0.066) during May. Fecal IgA was increased in the placebo group during the pollen season; this increase was prevented by the probiotics (P = 0.028). CONCLUSION: Birch pollen allergy was shown to be associated with changes in fecal microbiota composition. The specific combination of probiotics used was shown to prevent the pollen-induced infiltration of eosinophils into the nasal mucosa, and indicated a trend for reduced nasal symptoms. 展开更多
关键词 PROBIOTICS Pollen allergy INTESTINES Microbiology Immunity EOSINOPHILIA Lactobacillus acidoph/lus Bil^dobacterium lactis
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鼻科学
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《中国医学文摘(耳鼻咽喉科学)》 2015年第4期230-230,共1页
背景:toll样受体(TLR)对于机体稳态很重要,但它们对气传过敏的作用尚不完全清楚。目的:评价变应性鼻炎鼻腔上皮组织TLR蛋白质在基线和变应原激发时的表达。方法:研究对象为19名非吸烟的健康志愿者包括对桦树花粉过敏者和非过敏对... 背景:toll样受体(TLR)对于机体稳态很重要,但它们对气传过敏的作用尚不完全清楚。目的:评价变应性鼻炎鼻腔上皮组织TLR蛋白质在基线和变应原激发时的表达。方法:研究对象为19名非吸烟的健康志愿者包括对桦树花粉过敏者和非过敏对照者。于非过敏季节,在用桦树花粉或稀释剂进行鼻内激发前后进行鼻腔活检。 展开更多
关键词 鼻科学 TOLL样受体 桦树花粉 鼻腔活检 变应性鼻炎 健康志愿者 过敏者 机体稳态
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High correlation of specific IgE sensitization between birch pollen, soy and apple allergens indicates pollen-food allergy syndrome among birch pollen allergic patients in northern China 被引量:9
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作者 Guo-dong HAO Yi-wu ZHENG +4 位作者 Zhi-xiang WANG Xing-ai KONG Zhi-jing SONG Xu-xin LAI Michael D.SPANGFORT 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2016年第5期399-404,共6页
Background: Birch pollen sensitization and associated pollen-food syndrome among Chinese allergic patients have not been investigated. Methods: Sera from 203 allergic patients from the northern part of China and col... Background: Birch pollen sensitization and associated pollen-food syndrome among Chinese allergic patients have not been investigated. Methods: Sera from 203 allergic patients from the northern part of China and collected during February to July 2014 were investigated. Specific immunoglobulin E (IgE) against birch pollen extract Bet v and major birch pollen allergen Bet v 1 were measured using the ADVIA Centaur. The presence of major apple allergen Mal d 1 and soy bean allergen Gly m 4 specific IgE was measured by ImmunoCAP 100. Results: Among the 203 sere, 34 sera (16.7%) had specific IgE to Bet v and of these, 28 sere (82.4%) contained Bet v 1-specific IgE. Among the 28 sera with Bet v 1-specific IgE, 27 sera (96.4%) contained Mal d 1-specific IgE and 22 sera (78.6%) contained Gly m 4-specific igE. Of the 34 Bet v-positive sera, 6 sera (17.6%) contained no specific IgE for Bet v 1, Mal d 1, or Gly m 4. Almost all Bet v-positive sera were donated during the birch pollen season. Conclusions: The prevalence of birch allergy among patients visiting health care during pollen season can be as high as 16.7% in Tangshan City. The majority of Chinese birch allergic patients are IgE-sensitized to the major birch pollen allergen Bet v 1 as well as to the major apple allergen Mal d 1 and soy bean allergen Gly m 4. A relatively high number of patients (17.6%) are IgE-sensitized to birch pollen allergen(s) other than Bet v 1. The high prevalence of specific IgE to Mal d 1 and Gly m 4 among Bet v 1-sensitized patients indicates that pollen-food allergy syndrome could be of clinical relevance in China. 展开更多
关键词 APPLE Birch CROSS-REACTION Pollen-food allergy SOY Specific immunoglobulin E (IgE)
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