弥散加权成像阴性脑梗死患者大血管狭窄或闭塞发生率的研究

目的阐明弥散加权成像(DWI)阴性脑梗死患者大血管狭窄或闭塞发生率。方法选择在该院神经内科住院的DWI阴性脑梗死患者(DWI阴性组,46例);DWI阳性脑梗死患者(DWI阳性组,357例)。记录两组患者的临床资料和血液学检验结果、头颅磁共振血管成像(MRA)检查结果。结果与DWI阳性组患者相比,DWI阴性组患者表现为偏身运动障碍的比例高,高级皮质功能障碍的比例高,失语的比例低,差异均有统计学意义(P<0.05)。DWI阴性组和DWI阳性组D、D、D的美国国立卫生研究院卒中量表(NIHSS)评分和改良Rankin量表(mRS)评分比较,差异无统计学意义(P>0.05)。DWI阴性组的甘油三酯和叶酸水平低于DWI阳性组,差异均有统计学意义(P<0.05)。DWI阴性组的大脑前动脉、颈内动脉(C~C段)、大脑后动脉狭窄或闭塞的比例低于DWI阳性组脑梗死患者,差异均有统计学意义(P<0.05)。DWI阴性组颅内狭窄或闭塞的动脉总数与DWI阳性组患者相比,差异无统计学意义(P>0.05)。DWI阴性组颈总动脉+颈内动脉(C段)、椎动脉(V~V段)、颅外狭窄或闭塞的血管总数与DWI阳性组患者相比,差异均无统计学意义(P>0.05)。结论DWI阴性脑梗死患者发生颅内、颅外大血管狭窄或者闭塞的概率可能并不低于DWI阳性脑梗死患者。

内皮素和降钙素基因相关肽与梗阻性黄疸大鼠门脉压力的关系

目的 通过测定梗阻性黄疸大鼠门静脉血中内皮素和降钙素基因相关肽浓度 ,探讨内皮素和降钙素基因相关肽在梗阻性黄疸鼠门脉压力升高中的作用 .方法 建立大鼠梗阻性黄疸模型 ,采用放射免疫法测定门静脉血中内皮素和降钙素基因相关肽的浓度 .结果 内皮素在胆道结扎后各时相均明显升高 (P<0 .0 5 ) ,3d达峰值 (186 .99± 36 .0 3ng·L- 1 ) ,降钙素基因相关肽在胆道结扎后第 1日无明显变化[(2 13.11± 35 .38) ng·L- 1 vs(180 .14± 30 .6 6 ) ng· L- 1 ],3d后明显升高 ,并与对照组相差明显 (P<0 .0 5 ) .梗阻性黄疸组大鼠门脉压力在各时相组均比对照组明显升高 (P<0 .0 5 )但未形成门脉高压 .内皮素抗血清治疗可降低内皮素浓度和升高的门静脉压力 .结论 梗阻性黄疸时内皮素和降钙素基因相关肽浓度均升高 。

Study on the Treatment of Acute Cerebral Infarction by Xuanzhong(GB 39)Toward Sanyinjiao(SP 6)Acupuncture as Main Therapy

Objective： To investigate the effects of acupuncture therapy on acute cerebral infarction. Methods： Eighty patients with acute cerebral infarction were randomly divided into a treatment group of 40 cases and a control group of 40 cases. Xuanzhong（GB 39）-throughSanyinjiao（SP 6） acupuncture was performed as a main treatment. The curative effects were compared between the two groups and the sizes of cerebral infarct, between pretreatment and posttreatment after one course of treatment. Results. The total recovery rate was 88.5% in the treatment group and 57.5% in the control group after one course of treatment. There was a significant difference between the two（P〈 0.05）. The rate of change in the infarct for the better was significantly higher in the treatment group than in the control group. There was also a significant difference（P〈 0.05）, Conclusion： This treatment is an effective method for lowering the rate of apoplectic disability and raising the cure rate,