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种鸡梭状菌感染症的诊断
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作者 张鹏程 高洪伟 毕秀纯 《中国畜禽传染病》 CSCD 1990年第1期21-21,共1页
1987~1988年在吉林省三个地、市及国营鸡场的8日龄雏鸡、30日龄幼龄鸡发生一种以呈现皮肤溃烂、肝有黄白色坏死灶、腹水症状的传染病,从病死鸡的肝脏及皮下水肿液中分离到梭状菌及金黄色葡萄球菌。现将结果报告如下。
关键词 种鸡 梭状菌 金黄葡萄球 传染病
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糖尿病合并非梭状菌皮肤软组织产气性感染二例临床诊疗分析
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作者 吴远 吕宏军 +1 位作者 姚孝礼 刘娟 《中国全科医学》 CAS 北大核心 2022年第3期363-367,共5页
非梭状菌可分解坏死组织中的糖等底物并产生皮下气肿,而非梭状菌皮肤软组织产气性感染常出现在血糖控制不佳的糖尿病患者中。非梭状菌与梭状菌引起产气性感染的鉴别诊断依赖病原学检查结果,但在未取得病原学证据之前早期、联合使用广谱... 非梭状菌可分解坏死组织中的糖等底物并产生皮下气肿,而非梭状菌皮肤软组织产气性感染常出现在血糖控制不佳的糖尿病患者中。非梭状菌与梭状菌引起产气性感染的鉴别诊断依赖病原学检查结果,但在未取得病原学证据之前早期、联合使用广谱抗生素和及时、有效地清创及必要的手术是救治糖尿病合并非梭状菌皮肤软组织产气性感染患者的关键。本文报道了2例糖尿病合并非梭状菌皮肤软组织产气性感染患者并进行了文献复习,以期提高临床医生对该病的认识。 展开更多
关键词 糖尿病 2型 感染 产气性感染 梭状菌 诊断 治疗
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窖泥中梭状菌的耐酸耐酒性能测试 被引量:2
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作者 邓林 《酿酒科技》 1993年第5期39-39,共1页
梭状菌是指浓香型大曲酒酿酒过程中具有特殊作用的生态群体,其代谢产物是浓香型大曲酒呈香呈味物质的重要来源,主要包括己酸菌、丁酸菌等生香功能菌。
关键词 浓香型 白酒 窖泥 梭状菌 性能
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粪汁管饲治疗艰难梭状菌感染的研究
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作者 黄寅 《黑龙江医药》 CAS 2017年第1期163-165,共3页
目的:为有效治疗艰难梭状菌感染所造成的相关腹泻症状,提高患者生活质量,临床探究粪汁管饲治疗用于疾病治疗的可行性、优越性。方法:选取我院2013年5月至2016年3月期间96例经诊断为艰难梭状菌感染患者,按单盲法随机分成两组包括对照组... 目的:为有效治疗艰难梭状菌感染所造成的相关腹泻症状,提高患者生活质量,临床探究粪汁管饲治疗用于疾病治疗的可行性、优越性。方法:选取我院2013年5月至2016年3月期间96例经诊断为艰难梭状菌感染患者,按单盲法随机分成两组包括对照组、治疗组,每组48例。对照组患者服药甲硝唑、万古霉素治疗,治疗组使用粪汁管饲治疗,观察患者症状改善效果并记录症状改善所有时间情况。结果:治疗组患者临床症状改善有效率为95.8%,对照组为83.3%,对照组较治疗组患者治疗后临床病症改善效果好,P<0.05;治疗组在体温正常、症状消失时间、总治疗时间较对照组患者症状改善所用时间短,P<0.05。结论:临床对艰难梭状菌感染患者采用粪汁管饲治疗,患者腹泻、发热、腹痛等症状改善效果好且患者恢复快。 展开更多
关键词 移植 疗效 艰难梭状菌 感染 腹泻 芽胞杆
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窖泥中梭状菌的耐酸耐酒性能测试
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作者 邓林 《江苏食品与发酵》 1993年第2期5-6,共2页
本文对窖泥中的梭状菌群的耐酸耐酒性能进行了测试。认为它们在PH2.5至7.5都能存活,PH4.5至6.5生长良好;在酒度2%—11%(V%)的范围内能存活,2%~5%范围内生长良好.结果对浓香型大曲酒的生产具有重要指导意义.
关键词 梭状菌 耐酸 耐酒 性能 测试
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梭状芽抱杆菌L—Ⅱ基质范围的代谢研究 被引量:5
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作者 吴水清 《酿酒科技》 1993年第4期9-12,共4页
对梭状芽孢杆菌L—Ⅱ的含碳基质范围的研究表明:该菌株能利用乙酸、丙酸、丁酸、乙醇和丙醇。以乙醇和乙酸为底物时,主要产物是丁酸和己酸。以乙醇和丙酸为底物时,主要产物是戊酸和庚酸。以乙酸和丙醇为底物时,主要产物是丙酸、戊... 对梭状芽孢杆菌L—Ⅱ的含碳基质范围的研究表明:该菌株能利用乙酸、丙酸、丁酸、乙醇和丙醇。以乙醇和乙酸为底物时,主要产物是丁酸和己酸。以乙醇和丙酸为底物时,主要产物是戊酸和庚酸。以乙酸和丙醇为底物时,主要产物是丙酸、戊酸、丁酸和己酸。该菌的丙酸生物合成途径与克氏梭菌基本一致,适用于科研和浓香型酒生产。(益平) 展开更多
关键词 浓香型酒 芽孢 基质 代谢
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婴儿人群及婴儿配方粉中梭状芽胞杆菌分离鉴定及污染状况
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作者 薛成玉 遇晓杰 +5 位作者 张剑峰 郑晓华 焦艳玲 杨良浩 安宏 白晶 《首都公共卫生》 2019年第6期289-292,共4页
目的对婴儿配方粉、婴儿生物样品中梭状芽孢杆菌鉴定分析,获得梭状芽胞杆菌的污染水平数据,对婴儿膳食及环境暴露重要梭状芽孢杆菌对其健康影响风险评估研究提供数据支持。方法通过分离菌株的生长特性、革兰染色、普通显微镜下形态特征... 目的对婴儿配方粉、婴儿生物样品中梭状芽孢杆菌鉴定分析,获得梭状芽胞杆菌的污染水平数据,对婴儿膳食及环境暴露重要梭状芽孢杆菌对其健康影响风险评估研究提供数据支持。方法通过分离菌株的生长特性、革兰染色、普通显微镜下形态特征等表现特征,结合生化鉴定结果、16S rRNA基因测序对分离菌株进行综合鉴定。结果 200份样品中,共检出34株梭状芽胞杆菌。其中120份婴儿粪便中检出12株生胞梭菌(10.00%)、5株第三梭菌(4.17.%)、5株丁酸梭菌(4.17%)、2株索氏梭菌(1.67%);60份婴儿日常食用配方粉中检出5株生胞梭菌(5/60)、3株丁酸梭菌(3/60);20份市售婴儿配方奶粉检出2株生胞梭菌(2/20)。结论人工喂养的婴儿粪便中分离得到梭状芽孢杆菌,而母乳喂养婴儿粪便未分离出梭菌,二者差异具有统计学意义(χ^2=30.00,P<0.05);市售婴儿配方粉存在梭状芽孢菌污染,母乳喂养为最佳方式,可降低婴儿体内梭状芽胞杆菌的污染风险。 展开更多
关键词 芽孢 婴儿粪便 配方粉 分离鉴定
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厌氧梭状芽胞菌计算机鉴定程序的编制与应用
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作者 苏明权 丁振若 +1 位作者 孙怡群 徐修礼 《陕西医学检验》 1993年第3期166-167,共2页
随着临床细菌学鉴定方法的不断改革以及计算机的日益普及,细菌鉴定向着微量化,快速化、系统化、自动化方向发展。在计算机的辅助下,大量的细菌鉴定数据进行自动分析统计,由于系列的鉴定生化试验所反应结果数值化按着一定的数学模型进行... 随着临床细菌学鉴定方法的不断改革以及计算机的日益普及,细菌鉴定向着微量化,快速化、系统化、自动化方向发展。在计算机的辅助下,大量的细菌鉴定数据进行自动分析统计,由于系列的鉴定生化试验所反应结果数值化按着一定的数学模型进行多元化分析,利用计箅机快速的运算和高度精确的记忆能力。 展开更多
关键词 芽胞 计算机 鉴定程序
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一株稻田土壤梭状芽孢杆菌的分离及其固氮产氢能力研究 被引量:4
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作者 吴志宇 周革非 +3 位作者 陈慧敏 汤佳 谢章彰 刘芳华 《环境科学研究》 CAS CSCD 北大核心 2022年第11期2588-2595,共8页
为研究水稻土壤中协同固氮产氢菌的固氮产氢特性,拓展协同固氮产氢菌菌种资源,利用厌氧微生物富集培养、亨盖特厌氧滚管等技术,从华南稻田土壤中筛选到一株同时具有产氢和固氮能力的菌株BZ-1.经形态学观察及16S rRNA基因序列系统发育分... 为研究水稻土壤中协同固氮产氢菌的固氮产氢特性,拓展协同固氮产氢菌菌种资源,利用厌氧微生物富集培养、亨盖特厌氧滚管等技术,从华南稻田土壤中筛选到一株同时具有产氢和固氮能力的菌株BZ-1.经形态学观察及16S rRNA基因序列系统发育分析,鉴定菌株BZ-1属于梭状芽孢杆菌属(Clostridium sp.).通过测定产氢量、生物量、发酵产物及固氮酶酶活等,对菌株BZ-1的产氢能力及协同固氮产氢特性进行分析.结果表明:菌株BZ-1发酵34.55 mmol/L葡萄糖可产生42.19 mmol/L H_(2),主要副产物为丁酸(15.96 mmol/L)、乙酸(7.14 mmol/L)和乳酸(5.09 mmol/L);菌株BZ-1具有固氮酶活性,能够以N_(2)为唯一氮源进行生长;菌株BZ-1固氮产氢时,相比于添加7 mmol/L氯化铵的试验组,产氢量提高了14.71%,最大生物量降低了33.33%,乙酸产量提升了61.49%.研究显示,菌株BZ-1在协同固氮产氢条件下固氮能力的提升、生物量的降低以及核心碳代谢途径的改变可能是其产氢量提升的原因.固氮产氢菌株BZ-1的获得将为提高土壤肥力以及缓解铅、镉等重金属对农作物的胁迫作用提供新的思路. 展开更多
关键词 水稻田 芽孢杆BZ-1 固氮 产氢 协同
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糖尿病合并下肢肺炎克雷伯菌气性坏疽1例 被引量:2
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作者 周俊 陶珍 李浩 《中国感染控制杂志》 CAS CSCD 北大核心 2019年第7期687-689,共3页
气性坏疽是指由产气细菌引起且进展迅速的软组织感染,在早期报道中其病原体通常被特指为产气荚膜梭菌。然而随着大量文献报道,非产气荚膜梭菌导致的产气感染逐渐得到重视。本例患者为糖尿病合并下肢肺炎克雷伯菌气性坏疽,在肺炎克雷伯... 气性坏疽是指由产气细菌引起且进展迅速的软组织感染,在早期报道中其病原体通常被特指为产气荚膜梭菌。然而随着大量文献报道,非产气荚膜梭菌导致的产气感染逐渐得到重视。本例患者为糖尿病合并下肢肺炎克雷伯菌气性坏疽,在肺炎克雷伯菌感染病例中相对少见。本文结合文献分析,以期提高对糖尿病合并非梭状菌气性坏疽的认识。 展开更多
关键词 糖尿病 梭状菌 肺炎克雷伯 气性坏疽
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泰泽病原体基因组DNA提取方法的建立 被引量:2
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作者 孙庆莉 李红 +1 位作者 张丽芳 刘星 《中国实验动物学报》 CAS CSCD 2003年第3期151-155,共5页
目的 提取泰泽病原体基因组DNA ,为建立该菌基因组文库奠定基础。方法 使用密度梯度离心结合酶解消化方法、酶解消化方法、本研究建立方法即过滤盐析离心法 ,从感染肝脏组织纯化泰泽病原体 ,并比较三种方法纯化泰泽病原体效果 ;采用... 目的 提取泰泽病原体基因组DNA ,为建立该菌基因组文库奠定基础。方法 使用密度梯度离心结合酶解消化方法、酶解消化方法、本研究建立方法即过滤盐析离心法 ,从感染肝脏组织纯化泰泽病原体 ,并比较三种方法纯化泰泽病原体效果 ;采用氯化苄法、试剂盒、酚法提取泰泽病原体基因组DNA ,并比较三种方法提取基因组DNA质量 ;鉴定酚法提取泰泽病原体基因组DNA特异性。结果 使用过滤盐析离心法从感染肝脏组织纯化泰泽病原体 ,采用酚法提取其基因组DNA ,所获得的基因组DNA特异性好、纯度高、DNA片段长度大于 5 0kb ,且均一性好 ,无降解。结论 本研究首次成功提取泰泽病原体基因组DNA 。 展开更多
关键词 泰泽病原体 基因组 DNA 提取方法 毛发 泰泽病
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Effect of Clostridium butyricum on fecal flora in Helicobacter pylori eradication therapy 被引量:19
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作者 Izumi Shimbo Taketo Yamaguchi +4 位作者 Takeo Odaka Kenichi Nakajima Akinori Koide Hidehiko Koyama Hiromitsu Saisho 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第47期7520-7524,共5页
AIM: To investigate the effect of probiotic bacterium, Clostridium butyricum MIYAIRI 588 strain (CBM) on the changes of the fecal flora in Helicobacter pylori (H pylon) treatment. METHODS: Thirty-five patients w... AIM: To investigate the effect of probiotic bacterium, Clostridium butyricum MIYAIRI 588 strain (CBM) on the changes of the fecal flora in Helicobacter pylori (H pylon) treatment. METHODS: Thirty-five patients with gastric or duodenal ulcers positive for H pylori were randomized either to 1 wk amoxicillin, clarithromycin, lansoprazole (Group 1) or to the same regimen supplemented with CBM 7 d ahead of the triple therapy (Group 2). Stool samples were collected before and 2, 4, 7, 15, and 22 d after the starting eradication therapy, and were examined intestinal flora. Patients were required to keep a diary record of their condition. RESULTS: Obligate anaerobes decreased significantly on d 2, 4, 8 and 15 in Group 1. On the other hand, they did not decrease significantly in Group 2. The Escherichia coli was dominant bacterium in Enterobacteriaceae, but that was replaced by other species such as Klebsiella and Enterobacter after eradication in Group 1. The change was suppressed in Group 2. Abdominal symptoms were less frequent in Group 2 than in Group 1. CONCLUSION: The combined use of CBM reduced the changes in the intestinal flora and decreased the incidence of gastrointestinal side effects. 展开更多
关键词 Clostridium butyricum Intestinal flora Helicobacter pylori ERADICATION
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鸡溃疡性肠炎油乳剂灭活苗的研制
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作者 贾世玉 刁有祥 +2 位作者 付兴伦 邢仁增 马凤龙 《中国兽药杂志》 北大核心 1999年第3期1-3,共3页
将大肠梭状芽胞杆菌接种于色氨酸磷酸液体培养基作厌氧培养,36h 后离心收集细菌,生理盐水稀释使菌体浓度达5×109 CFU/m l,经甲醛溶液灭活后,与油佐剂乳化制成鸡溃疡性肠炎灭活苗。经检测证明,该疫苗安全、可靠... 将大肠梭状芽胞杆菌接种于色氨酸磷酸液体培养基作厌氧培养,36h 后离心收集细菌,生理盐水稀释使菌体浓度达5×109 CFU/m l,经甲醛溶液灭活后,与油佐剂乳化制成鸡溃疡性肠炎灭活苗。经检测证明,该疫苗安全、可靠,无毒副作用。 展开更多
关键词 溃疡性肠炎 芽胞 油乳剂灭
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Clostridium perfringens bacteremia caused by choledocholithiasis in the absence of gallbladder stones 被引量:11
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作者 Antwan Atia Tejas Raiyani +2 位作者 Pranav Patel Robert Patton Mark Young 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第39期5632-5634,共3页
A 67-years-old male presented with periumbilical abdominal pain, fever and jaundice. His anaerobic blood culture was positive for clostridium perfringens. Computed tomogram scan of the abdomen and abdominal ultrasound... A 67-years-old male presented with periumbilical abdominal pain, fever and jaundice. His anaerobic blood culture was positive for clostridium perfringens. Computed tomogram scan of the abdomen and abdominal ultrasound showed normal gallbladder and common bile duct (CBD). Subsequently magnetic resonance cholangiopancreaticogram showed choledocholithiasis. Endoscopic retrograde cholangiopancreaticogram-with sphincterotomy and CBD stone extraction was performed. The patient progressively improved with antibiotic therapy Choledocholithiasis should be considered as a source of clostridium perfringens bacteremia especially in the setting of elevated liver enzymes with cholestatic pattern. 展开更多
关键词 CHOLEDOCHOLITHIASIS Clostridium perfrin-gens BACTEREMIA
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Comparison of bacterial quantities in left and right colon biopsies and faeces 被引量:2
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作者 Anna Lyra Sofia Forssten +7 位作者 Peter Rolny Yvonne Wettergren Sampo J Lahtinen Krista Salli Lennart Cedgrd Elisabeth Odin Bengt Gustavsson Arthur C Ouwehand 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第32期4404-4411,共8页
AIM:To compare quantities of predominant and pathogenic bacteria in mucosal and faecal samples.METHODS:Twenty patients undergoing diagnostic colonoscopy with endoscopically and histologically normal mucosa were recrui... AIM:To compare quantities of predominant and pathogenic bacteria in mucosal and faecal samples.METHODS:Twenty patients undergoing diagnostic colonoscopy with endoscopically and histologically normal mucosa were recruited to the study,14 subjects of which also supplied faecal(F) samples between 15 d to 105 d post colonoscopy.Mucosal biopsies were taken from each subject from the midportion of the ascending colon(right side samples,RM) and the sigmoid(left side samples,LM).Predominant intestinal and mucosal bacteria including clostridial 16S rRNA gene clusters Ⅳ and ⅩⅣab,Bacteroidetes,Enterobacteriaceae,Bifidobacterium spp.,Akkermansia muciniphila(A.muciniphila),Veillonella spp.,Collinsella spp.,Faecalibacterium prausnitzii(F.prausnitzii) and putative pathogens such asEscherichia coli(E.coli),Clostridium difficile(C.difficile),Helicobacter pylori(H.pylori) and Staphylococcus aureus(S.aureus) were analysed by quantitative polymerase chain reaction(qPCR).Host DNA was quantified from the mucosal samples with human glyceraldehyde 3-phosphate dehydrogenase gene targeting qPCR.Paired t tests and the Pearson correlation were applied for statistical analysis.RESULTS:The most prominent bacterial groups were clostridial groups Ⅳ and ⅩⅣa+b andBacteroidetes and bacterial species F.prausnitzii in both sample types.H.pylori and S.aureus were not detected and C.difficile was detected in only one mucosal sample and three faecal samples.E.coli was detected in less than half of the mucosal samples at both sites,but was present in all faecal samples.All detected bacteria,except Enterobacteriaceae,were present at higher levels in the faeces than in the mucosa,but the different locations in the colon presented comparable quantities(RM,LM and F followed byP 1 for RMvs F,P 2 for LMvs F andP 3 for RM vs LM:4.17 ± 0.60 log 10 /g,4.16 ± 0.56 log 10 /g,5.88 ± 1.92 log 10 /g,P 1 = 0.011,P 2 = 0.0069,P 3 = 0.9778 forA.muciniphila;6.25 ± 1.3 log 10 /g,6.09 ± 0.81 log 10 /g,8.84 ± 1.38 log 10 /g,P 1 < 0.0001,P 2 = 0.0002,P 3 = 0.6893 forBacteroidetes;5.27 ± 1.68 log 10 /g,5.38 ± 2.06 log 10 /g,8.20 ± 1.14 log 10 /g,P 1 < 0.0001,P 2 ≤ 0.0001,P 3 = 0.7535 forBifidobacterium spp.;6.44 ± 1.15 log 10 /g,6.07 ±1.45 log 10 /g,9.74 ±1.13 log 10 /g,P 1 < 0.0001,P 2 ≤ 0.0001,P 3 = 0.637 forClostridium cluster Ⅳ;6.65 ± 1.23 log 10 /g,6.57 ± 1.52 log 10 /g,9.13 ± 0.96 log 10 /g,P 1 < 0.0001,P 2 ≤ 0.0001,P 3 = 0.9317 forClostridium cluster ⅩⅣa;4.57 ± 1.44 log10/g,4.63 ± 1.34 log10/g,7.05 ± 2.48 log 10 /g,P 1 = 0.012,P 2 = 0.0357,P 3 = 0.7973 for Collinsella spp.;7.66 ± 1.50 log 10 /g,7.60 ± 1.05 log 10 /g,10.02 ± 2.02 log 10 /g,P 1 ≤ 0.0001,P 2 = 0.0013,P 3 = 0.9919 forF.prausnitzsii;6.17 ± 1.3 log 10 /g,5.85 ± 0.93 log 10 /g,7.25 ± 1.01 log 10 /g,P 1 = 0.0243,P 2 = 0.0319,P 3 = 0.6982 for Veillonella spp.;4.68 ± 1.21 log 10 /g,4.71 ± 0.83 log 10 /g,5.70 ± 2.00 log 10 /g,P 1 = 0.1927,P 2 = 0.0605,P 3 = 0.6476 forEnterobacteriaceae).TheBifidobacterium spp.counts correlated significantly between mucosal sites and mucosal and faecal samples(Pearson correlation coefficients 0.62,P = 0.040 and 0.81,P = 0.005 between the right mucosal sample and faeces and the left mucosal sample and faeces,respectively).CONCLUSION:Non-invasive faecal samples do not reflect bacterial counts on the mucosa at the individual level,except for bifidobacteria often analysed in probiotic intervention studies. 展开更多
关键词 Gastrointestinal microbiota Mucosa Faeces Real-time quantitative polymerase chain reaction Sampling
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Soluble Carbohydrates Repress the Cellulolytic Activity of Clostridium cellulovorans and Eubacterium cellulosolvens 被引量:1
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作者 Benjamin Gay Blair Kevin Lee Anderson 《Journal of Agricultural Science and Technology(A)》 2015年第1期15-24,共10页
Studies have provided indirect evidence that cellulolytic activity of some anaerobic bacteria is repressed by carbohydrates, such as glucose. This effect is known as carbon catabolite repression (CCR). Previous work... Studies have provided indirect evidence that cellulolytic activity of some anaerobic bacteria is repressed by carbohydrates, such as glucose. This effect is known as carbon catabolite repression (CCR). Previous work has found that cellulolytic activity of Clostridium cellulovorans and Eubacterium cellulosolvens are regulated. Many cellulolytic systems of these organisms are expressed only in the presence of cellulose or cellobiose (the disaccharide of cellulose). Some of these cellulose-induced systems also appear subject to CCR when more soluble substrates, such as glucose, are also available. To determine if such repression directly effects cellulolytic activity of C. cellulovorans and E. cellulosolvens, these organisms were cultivated in media containing a glucose analog. We then measured the ability of low levels of analog to inhibit growth of the organisms when cellobiose or cellulose were the energy substrates. Our results found that growth of both C. cellulovorans and E. cellulosolvens in cellobiose-containing medium are strongly inhibited by glucose analogs. In addition, both organisms exhibited delayed and slower growth in cellulose-containing medium when a glucose analog was added. These results provide direct demonstration that these cellulolytic bacteria are subject to CCR. This repression of cellulolysis may affect both of these organisms' ability to serve as industrial platforms for biomass degradation, and may interfere with the contribution of E. cellulosolvens toward animal digestion of cellulose. These results were also in sharp contrast to what has been reported regarding CCR activity in Clostridium cellulolyticum, which actively expresses cellulases in the presence of low levels of glucose. 展开更多
关键词 CELLULOLYTIC anaerobic bacteria catabolite repression cellulolysis cellulose degradation.
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Prophylactic antibiotics for variceal hemorrhage: Clostridium difficile infection still can be a risk 被引量:1
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作者 Naohiro Okano Kentaro Iwata 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第18期2356-2356,共1页
Bron et al presented a retrospective study regarding the prophylactic use of antibiotics for variceal hemorrhage. Antibiotics appeared to improve the survival rate of patients without increasing clostridium difficile ... Bron et al presented a retrospective study regarding the prophylactic use of antibiotics for variceal hemorrhage. Antibiotics appeared to improve the survival rate of patients without increasing clostridium difficile infection (CDI). We argue against the conclusion of the authors and consider that this result may be simply due to concurrent use of metronidazole, a therapeutic agent against CDI. 展开更多
关键词 Variceal hemorrhage Prophylactic antibiotics Clostridium difficile infection
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On the Role of Intestinal Microbiota in Patients with Cognitive Decline
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作者 Friedrich Leblhuber Barbara Strassert +3 位作者 Kostja Steiner Johanna Gostner Burkhard Schuetz Dietmar Fuchs 《Journal of Pharmacy and Pharmacology》 2017年第9期648-653,共6页
Objective: The association between gut microbiota composition and biomarkers of immune activation and inflammation was assessed in the elderly. Patients: Serum inflammation markers of fifty-five outpatients (29 fem... Objective: The association between gut microbiota composition and biomarkers of immune activation and inflammation was assessed in the elderly. Patients: Serum inflammation markers of fifty-five outpatients (29 females, 26 males, aged 78 + 8.5 years) were analyzed. Stool specimens and thus data on gut microbiota were available from a subgroup of 23 individuals (9 females and 14 males). Results: Global cerebral atrophy was found in all magnet resonance tomography scans. Mean mini-mental-score examination in Alzheimer's disease patients was 18.8 ± 7.1, in patients with mild cognitive impairment 27.8 ± 1.5. Serum neopterin concentrations correlated with concentrations of fecal S100A12 (p 〈 0.001) and cq-antitrypsin (p 〈 0.05). Faecalibacterium prausnitzii correlated with MMSE (p 〈 0.05), with Akkermansia muciniphila (p 〈 0.01) and with serum neopterin (p 〈 0.05). Fecal zonulin correlated inversely with Clostridium cluster I (p 〈 0.02). Conclusions: Our results underline earlier in vitro and animal studies that cognitive decline associates with age-related changes in the intestinal microbiota and neuroinflammation. However, only correlational evidence can be reported, and a causative relationship still has to be demonstrated. 展开更多
关键词 MICROBIOTA brain-gut axis PREVENTION cognitive decline.
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Tetanus in Cat: From Neglected Wound to Neuromuscular DisordermCase Report
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作者 Maksimovic Alan Filipovic Selma +1 位作者 Lutvikadic Ismar Sunje-Rizvan Amila 《Journal of Life Sciences》 2016年第4期182-184,共3页
Tetanus is caused by the bacterium, Clostridium tetanL and can infect both domestic animals and man. The disease is rarely diagnosed in cats, as a consequence of their increased resistance to the neurotoxin, tetanospa... Tetanus is caused by the bacterium, Clostridium tetanL and can infect both domestic animals and man. The disease is rarely diagnosed in cats, as a consequence of their increased resistance to the neurotoxin, tetanospasmin. Mortality in animals is generally high (80%). To date these authors have not been able to locate any reports of mortality rates specific to cats. Clinical diagnosis is based on clinical signs and a history of an untreated penetrating wound. This case report describes the development of moderate generalized tetanus in an approximately six month old female stray cat, found with an untreated wound on the side of its neck. This report describes clinical signs, treatment and recovery of the animal. 展开更多
关键词 FELINE neglected wound TETANUS therapy.
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In vivo detection of mucosal healing-involved histiocytes by confocal laser endomicroscopy
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作者 Gheorghe Hundorfean Abbas Agaimy +4 位作者 Mircea T Chiriac Walter GeiBdrfer Jochen Wacker Markus F Neurath Jonas Mudter 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第32期4447-4449,共3页
Histiocytes have a pivotal role in wound repair and intestinal epithelial recovery-the most important goal to sustain gut functionality.Yet,an in vivo description of colonic histiocytes by confocal laser endomicroscop... Histiocytes have a pivotal role in wound repair and intestinal epithelial recovery-the most important goal to sustain gut functionality.Yet,an in vivo description of colonic histiocytes by confocal laser endomicroscopy(CLE) is missing.Here,we report the case of a 45-yearsold male patient who was referred to our clinic with weight loss and a history of two consecutive Clostridium difficile colitis episodes,the latter cured 3 wk before present admission.Stool microbiology was negative.Conventional colonoscopy showed atrophy and a light mucosal oedema in the distal colon.During on-going endoscopy,we performed a fluorescein-aided CLE which revealed large polygonal(histiocytes-like) cells with copious cytoplasm and large nuclei in the lamina propria of the sigmoid colon as well as regenerative epithelial changes.Histopathological assessment of biopsies from the same areas confirmed the endomicroscopical findings:Periodic acid-Schiff-and CD68-positive foamy histiocytes in the colonic lamina propria and an advanced epithelial recovery.Since stool microbiology was repeatedly negative and polymerase chain reaction-analysis from colonic biopsies could not detect any mRNA for Thropheryma whippleii and common pathogens,we interpreted this particular setting as a mucosal healing process after consecutive Clostridium difficile infections.In conclusion,by describing these colonic histiocytes,we highlight the clinical usefulness of CLE in describing the entity of histiocytes in vivo and in real-time during the process of post-infectious mucosal healing in the colon. 展开更多
关键词 Endomicroscopy Mucosal healing Advanced colonic imaging Colonic histiocytes
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