Objective: To observe the effectiveness of highly active antiret-rovirus therapy (HAART) on HIV/AIDS patients. Methods: Using HIV-1 quantitative methods and immu-nological function inspection, we monitored 4 HIV/AIDS ...Objective: To observe the effectiveness of highly active antiret-rovirus therapy (HAART) on HIV/AIDS patients. Methods: Using HIV-1 quantitative methods and immu-nological function inspection, we monitored 4 HIV/AIDS pa-tients who were suffering from immunological deficiency andwere treated with HAART Results: The reproduction of HIV in all 4 patients was effi-ciently controlled at the 4th week of the treatment. The averageviral load decreased by 1.99 Log/ml (0.73-2.46 Log/ml). Thenumber of CD^+_4 and CD^+_8 showed a steady continuous increase4 to 12 weeks after the treatment, with an increase of 67.2%and 103.0% respectively. Correlative study among differentvariables after the treatment revealed that positive correlationexisted between the number of CD^+_4 and CD^+_3 as well as CD^+_8,while negative correlation existed between the number of CD^+_4and plasma viral load. Conclusion: HIV-1 quantitative method (plasma viral load)and the number of CD^+_4 in peripheral blood can be used asimportant reference indicators in evaluating HAART.展开更多
Here we report a novel twin polarization angle （TPA） approach in the quantitative chirality detection with the surface sum-frequency generation vibrational spectroscopy （SFG-VS）. Generally, the achiral contributio...Here we report a novel twin polarization angle （TPA） approach in the quantitative chirality detection with the surface sum-frequency generation vibrational spectroscopy （SFG-VS）. Generally, the achiral contribution dominates the surface SFG-VS signal, and the pure chiral signal is usually two or three orders of magnitude smaller. Therefore, it has been difficult to make quantitative detection and analysis of the chiral contributions to the surface SFG- VS signal. In the TPA method, by varying together the polarization angles of the incoming visible light and the sum frequency signal at fixed s or p polarization of the incoming infrared beam, the polarization dependent SFG signal can give not only direct signature of the chiral contribution in the total SFG-VS signal, but also the accurate measurement of the chiral and achiral components in the surface SFG signal. The general description of the TPA method is presented and the experiment test of the TPA approach is also presented for the SFG-VS from the S- and R-limonene chiral liquid surfaces. The most accurate degree of chiral excess values thus obtained for the 2878 cm^-1 spectral peak of the S- and R-limonene liquid surfaces are （23.7±0.4）% and （-25.4±1.3）%, respectively.展开更多
文摘Objective: To observe the effectiveness of highly active antiret-rovirus therapy (HAART) on HIV/AIDS patients. Methods: Using HIV-1 quantitative methods and immu-nological function inspection, we monitored 4 HIV/AIDS pa-tients who were suffering from immunological deficiency andwere treated with HAART Results: The reproduction of HIV in all 4 patients was effi-ciently controlled at the 4th week of the treatment. The averageviral load decreased by 1.99 Log/ml (0.73-2.46 Log/ml). Thenumber of CD^+_4 and CD^+_8 showed a steady continuous increase4 to 12 weeks after the treatment, with an increase of 67.2%and 103.0% respectively. Correlative study among differentvariables after the treatment revealed that positive correlationexisted between the number of CD^+_4 and CD^+_3 as well as CD^+_8,while negative correlation existed between the number of CD^+_4and plasma viral load. Conclusion: HIV-1 quantitative method (plasma viral load)and the number of CD^+_4 in peripheral blood can be used asimportant reference indicators in evaluating HAART.
文摘Here we report a novel twin polarization angle （TPA） approach in the quantitative chirality detection with the surface sum-frequency generation vibrational spectroscopy （SFG-VS）. Generally, the achiral contribution dominates the surface SFG-VS signal, and the pure chiral signal is usually two or three orders of magnitude smaller. Therefore, it has been difficult to make quantitative detection and analysis of the chiral contributions to the surface SFG- VS signal. In the TPA method, by varying together the polarization angles of the incoming visible light and the sum frequency signal at fixed s or p polarization of the incoming infrared beam, the polarization dependent SFG signal can give not only direct signature of the chiral contribution in the total SFG-VS signal, but also the accurate measurement of the chiral and achiral components in the surface SFG signal. The general description of the TPA method is presented and the experiment test of the TPA approach is also presented for the SFG-VS from the S- and R-limonene chiral liquid surfaces. The most accurate degree of chiral excess values thus obtained for the 2878 cm^-1 spectral peak of the S- and R-limonene liquid surfaces are （23.7±0.4）% and （-25.4±1.3）%, respectively.
