AIM:To evaluate whether weekend or nighttime admission affects prognosis of peptic ulcer bleeding despite early endoscopy.METHODS:Retrospective data collection from four referral centers,all of which had a formal out-...AIM:To evaluate whether weekend or nighttime admission affects prognosis of peptic ulcer bleeding despite early endoscopy.METHODS:Retrospective data collection from four referral centers,all of which had a formal out-of-hours emergency endoscopy service,even at weekends.A total of 388 patients with bleeding peptic ulcers who were admitted via the emergency room between January 2007 and December 2009 were enrolled.Analyzed parameters included time from patients' arrival until endoscopy,mortality,rebleeding,need for surgery and length of hospital stay.RESULTS:The weekday and weekend admission groups comprised 326 and 62 patients,respectively.There were no significant differences in baseline characteristics between the two groups,except for younger age in the weekend group.Most patients (97%) had undergone early endoscopy,which resulted in a low mortality rate regardless of point of presentation (1.8% overall vs 1.6% on the weekend).The only outcome that was worse in the weekend group was a higher rate of rebleeding (12% vs 21%,P = 0.030).However,multivariate analysis revealed nighttime admission and a high Rockall score (≥ 6) as significant independent risk factors for rebleeding,rather than weekend admission.CONCLUSION:Early endoscopy for peptic ulcer bleeding can prevent the weekend effect,and nighttime admission was identified as a novel risk factor for rebleeding,namely the nighttime effect.展开更多
Based on the principle of the electric-magnetic check-measure, this paper puts forward a new technology and method that use the magnetic marks to check and measure the dynamic physical parameters such as angle speed, ...Based on the principle of the electric-magnetic check-measure, this paper puts forward a new technology and method that use the magnetic marks to check and measure the dynamic physical parameters such as angle speed, bending strain,stress and bending moment. The principles of the check-measure and the dealing and exchanging technology about signals have been demonstrated and the rotating components have been made up. The timely and quantitative check-measure of the dynamic physical parameters during the component in working has been realized by using computer control.展开更多
Horizontal winds in the mesosphere （80-100 km） were measured by meteor radar in Wuhan, China （30° N, 114° E） over a 45-month interval in 2002-2005 and the data examined to investigate the monthly mean be...Horizontal winds in the mesosphere （80-100 km） were measured by meteor radar in Wuhan, China （30° N, 114° E） over a 45-month interval in 2002-2005 and the data examined to investigate the monthly mean behavior of the Ol tide. A clear seasonal variation in amplitude of the O1 tide ranging from -0.3 m/s to 2.6 m/s was observed. In most months, the northward and eastward components differed by about 7 lunar hours with the eastward component leading. Comparison of the amplitudes of the M2 and O1 tides suggests the O1 tide is quite stronger over Wuhan, China. The amplitude ratio of the O1 tide to the M2 tide is quite stronger than that the gravitational potential being 0.41. The vertical wavelength of the O1 tide differs on a monthly basis. Height profiles of the O1 tide showed obvious height variation. The O1 tide is stronger in January and July. In different month, the vertical wavelength for the O1 tide changes considerably at the same height. The year＇s variation trend of the northward and eastward components is very similar in both phase and amplitude.展开更多
OBJECTIVE: To examine the acute toxicity of an aqueous extract of Aspidopterys obcordata(A. obcordata) in Sprague Dawley rats.METHODS: The rats were orally administered a dose of 5000 mg/kg body weight and observed co...OBJECTIVE: To examine the acute toxicity of an aqueous extract of Aspidopterys obcordata(A. obcordata) in Sprague Dawley rats.METHODS: The rats were orally administered a dose of 5000 mg/kg body weight and observed continuously for 6 h and then daily for 14 days. Control rats were administered distilled water. The effect of the extract on general behavior, body weight, and food and water intake were measured.After 14 days, the rats were sacrificed and their organs(liver, heart, spleen, lungs, kidney, adrenal glands, ovaries, and testes) were removed for macroscopic examination. The body and organ weights in addition to hematology(e.g., hemoglobin and white blood cell counts) and clinical blood biochemistry(e.g., albumin and bilirubin) were also examined.RESULTS: There were no deaths recorded, and the rats treated with A. obcordata showed no signs of toxicity. All measured parameters in rats treated with A. obcordata were unaffected when compared with those in control rats. The acute toxicity(LD_(50))was estimated to be > 5000 mg/kg body weight.CONCLUSION: Our results demonstrate the safety of an acute oral administration of an aqueous extract of A. obcordata in rats and indicate that future subacute and long-term toxicity testing of A. obcordata is warranted.展开更多
Objective： To investigate the material properties of normal and degenerated intervertebral discs （IVDs） and examine the effect of degenerative changes on IVD pathology. Methods： A computer-based online search was...Objective： To investigate the material properties of normal and degenerated intervertebral discs （IVDs） and examine the effect of degenerative changes on IVD pathology. Methods： A computer-based online search was undertaken to identify English articles about material properties of IVDs published from January 1950 to 2011 in PubMed database. The retrieved keywords included material properties, intervertebral disc and degeneration. Based on the principles of reliability, advancement and efficiency, the obtained data were primarily examined, and the original source was retrieved to read the full-text. Repetitive articles were excluded. The data of material properties of normal and degenerated IVDs were summarized and analyzed by meta-analysis. Results： The data of Young＇s modulus, Poisson＇s ratio, shear modulus, hydraulic permeability and intradiscal pres- sure of normal and degenerated 1VDs were obtained. Com- pared with normal IVDs, the Young＇s modulus and shear modulus of annulus fibrosus and nucleus pulposus werehigher in degenerated IVDs, the Poisson＇s ratio was lower while the hydraulic permeability and intradiscal pressure were higher. Besides, the degeneration-related alterations in IVDs had an influence both on itself and other spinal structures, leading to diseases such as bulging disc, discogenic pain and spinal stenosis. Meanwhile, the heavy mechanical loading and injury indicated important pathways to IVD degeneration. Conclusions： To a certain extent, the degenerative changes of IVD influence its material properties. And the degeneration-related alterations of composition can cause structural failure oflVDs, leading to injuries and diseases.展开更多
文摘AIM:To evaluate whether weekend or nighttime admission affects prognosis of peptic ulcer bleeding despite early endoscopy.METHODS:Retrospective data collection from four referral centers,all of which had a formal out-of-hours emergency endoscopy service,even at weekends.A total of 388 patients with bleeding peptic ulcers who were admitted via the emergency room between January 2007 and December 2009 were enrolled.Analyzed parameters included time from patients' arrival until endoscopy,mortality,rebleeding,need for surgery and length of hospital stay.RESULTS:The weekday and weekend admission groups comprised 326 and 62 patients,respectively.There were no significant differences in baseline characteristics between the two groups,except for younger age in the weekend group.Most patients (97%) had undergone early endoscopy,which resulted in a low mortality rate regardless of point of presentation (1.8% overall vs 1.6% on the weekend).The only outcome that was worse in the weekend group was a higher rate of rebleeding (12% vs 21%,P = 0.030).However,multivariate analysis revealed nighttime admission and a high Rockall score (≥ 6) as significant independent risk factors for rebleeding,rather than weekend admission.CONCLUSION:Early endoscopy for peptic ulcer bleeding can prevent the weekend effect,and nighttime admission was identified as a novel risk factor for rebleeding,namely the nighttime effect.
文摘Based on the principle of the electric-magnetic check-measure, this paper puts forward a new technology and method that use the magnetic marks to check and measure the dynamic physical parameters such as angle speed, bending strain,stress and bending moment. The principles of the check-measure and the dealing and exchanging technology about signals have been demonstrated and the rotating components have been made up. The timely and quantitative check-measure of the dynamic physical parameters during the component in working has been realized by using computer control.
基金Acknowledgements This research was supported by National Natural Science Foundation of China （41104095）
文摘Horizontal winds in the mesosphere （80-100 km） were measured by meteor radar in Wuhan, China （30° N, 114° E） over a 45-month interval in 2002-2005 and the data examined to investigate the monthly mean behavior of the Ol tide. A clear seasonal variation in amplitude of the O1 tide ranging from -0.3 m/s to 2.6 m/s was observed. In most months, the northward and eastward components differed by about 7 lunar hours with the eastward component leading. Comparison of the amplitudes of the M2 and O1 tides suggests the O1 tide is quite stronger over Wuhan, China. The amplitude ratio of the O1 tide to the M2 tide is quite stronger than that the gravitational potential being 0.41. The vertical wavelength of the O1 tide differs on a monthly basis. Height profiles of the O1 tide showed obvious height variation. The O1 tide is stronger in January and July. In different month, the vertical wavelength for the O1 tide changes considerably at the same height. The year＇s variation trend of the northward and eastward components is very similar in both phase and amplitude.
基金National Natural Science Foundation of China(Transport Characters and Mechanism Research of Multiplicity Ingredient TCM Utilizing Sensitive Bioactivity in Caco-2 Cell Model,No.81173645)Program for Innovative Research Team in IMPLAD(Discovery and foundation of new drug of TCM)+2 种基金a grant from the Basic Scientific Research Special of the Central Public Welfare Research Institutes of IMPLAD(Research on the Kidney Stone Activities and Preliminary Mechanisms of Aspidopterys Obcordata,No.YZYN-15-06)PUMC Youth Fund(Study of Anti-Tumor Activities of Pegylation Artemisinin Prodrugs Based on PK-PD Binding Model,No.33320140076)Beijing Municipal Natural Science Foundation(Preparation of Silica-Based Nanoparticles/PDMS Hybrid Membranes for Pervaporation of Ethanol/Water Mixtures,No.2132010)
文摘OBJECTIVE: To examine the acute toxicity of an aqueous extract of Aspidopterys obcordata(A. obcordata) in Sprague Dawley rats.METHODS: The rats were orally administered a dose of 5000 mg/kg body weight and observed continuously for 6 h and then daily for 14 days. Control rats were administered distilled water. The effect of the extract on general behavior, body weight, and food and water intake were measured.After 14 days, the rats were sacrificed and their organs(liver, heart, spleen, lungs, kidney, adrenal glands, ovaries, and testes) were removed for macroscopic examination. The body and organ weights in addition to hematology(e.g., hemoglobin and white blood cell counts) and clinical blood biochemistry(e.g., albumin and bilirubin) were also examined.RESULTS: There were no deaths recorded, and the rats treated with A. obcordata showed no signs of toxicity. All measured parameters in rats treated with A. obcordata were unaffected when compared with those in control rats. The acute toxicity(LD_(50))was estimated to be > 5000 mg/kg body weight.CONCLUSION: Our results demonstrate the safety of an acute oral administration of an aqueous extract of A. obcordata in rats and indicate that future subacute and long-term toxicity testing of A. obcordata is warranted.
基金This work was supported by grants from the National Natural Science Foundation of China （No. 30928005）, the Chongqing Natural Science Foundation of China （No. CSTC2009BB5013）, the Third Military Medical University Research Foundation of China （No. 2009XHG16）, and the Graduate Student＇s Scientific Research Innovation Foundation of Chinese Government （No. CDJXS11121145）.
文摘Objective： To investigate the material properties of normal and degenerated intervertebral discs （IVDs） and examine the effect of degenerative changes on IVD pathology. Methods： A computer-based online search was undertaken to identify English articles about material properties of IVDs published from January 1950 to 2011 in PubMed database. The retrieved keywords included material properties, intervertebral disc and degeneration. Based on the principles of reliability, advancement and efficiency, the obtained data were primarily examined, and the original source was retrieved to read the full-text. Repetitive articles were excluded. The data of material properties of normal and degenerated IVDs were summarized and analyzed by meta-analysis. Results： The data of Young＇s modulus, Poisson＇s ratio, shear modulus, hydraulic permeability and intradiscal pres- sure of normal and degenerated 1VDs were obtained. Com- pared with normal IVDs, the Young＇s modulus and shear modulus of annulus fibrosus and nucleus pulposus werehigher in degenerated IVDs, the Poisson＇s ratio was lower while the hydraulic permeability and intradiscal pressure were higher. Besides, the degeneration-related alterations in IVDs had an influence both on itself and other spinal structures, leading to diseases such as bulging disc, discogenic pain and spinal stenosis. Meanwhile, the heavy mechanical loading and injury indicated important pathways to IVD degeneration. Conclusions： To a certain extent, the degenerative changes of IVD influence its material properties. And the degeneration-related alterations of composition can cause structural failure oflVDs, leading to injuries and diseases.
