Objective: To provide theoretical basis for effect and mechanism of percutaneous lumbar discectomy in clinic. Methods: A total of 180 patients with lumbar intervertebral disc herniation were evaluated by CT on the fif...Objective: To provide theoretical basis for effect and mechanism of percutaneous lumbar discectomy in clinic. Methods: A total of 180 patients with lumbar intervertebral disc herniation were evaluated by CT on the fifth day before and after operation. Meanwhile, CT value was measured in the determined level and region. Results: After operation, CT value of the central and posterior determined point of herniated intervertebral disc was lower significantly than that before operation ( P<0.01 ), but CT value of the anterior determined point was different insignificantly. The excellent and good results of the patients together were 83% postoperatively. Conclusions: The curative effect of percutaneous lumbar discectomy is achieved through reduction of lumbar intradiscal pressure.展开更多
Objective： To investigate the material properties of normal and degenerated intervertebral discs （IVDs） and examine the effect of degenerative changes on IVD pathology. Methods： A computer-based online search was...Objective： To investigate the material properties of normal and degenerated intervertebral discs （IVDs） and examine the effect of degenerative changes on IVD pathology. Methods： A computer-based online search was undertaken to identify English articles about material properties of IVDs published from January 1950 to 2011 in PubMed database. The retrieved keywords included material properties, intervertebral disc and degeneration. Based on the principles of reliability, advancement and efficiency, the obtained data were primarily examined, and the original source was retrieved to read the full-text. Repetitive articles were excluded. The data of material properties of normal and degenerated IVDs were summarized and analyzed by meta-analysis. Results： The data of Young＇s modulus, Poisson＇s ratio, shear modulus, hydraulic permeability and intradiscal pres- sure of normal and degenerated 1VDs were obtained. Com- pared with normal IVDs, the Young＇s modulus and shear modulus of annulus fibrosus and nucleus pulposus werehigher in degenerated IVDs, the Poisson＇s ratio was lower while the hydraulic permeability and intradiscal pressure were higher. Besides, the degeneration-related alterations in IVDs had an influence both on itself and other spinal structures, leading to diseases such as bulging disc, discogenic pain and spinal stenosis. Meanwhile, the heavy mechanical loading and injury indicated important pathways to IVD degeneration. Conclusions： To a certain extent, the degenerative changes of IVD influence its material properties. And the degeneration-related alterations of composition can cause structural failure oflVDs, leading to injuries and diseases.展开更多
文摘Objective: To provide theoretical basis for effect and mechanism of percutaneous lumbar discectomy in clinic. Methods: A total of 180 patients with lumbar intervertebral disc herniation were evaluated by CT on the fifth day before and after operation. Meanwhile, CT value was measured in the determined level and region. Results: After operation, CT value of the central and posterior determined point of herniated intervertebral disc was lower significantly than that before operation ( P<0.01 ), but CT value of the anterior determined point was different insignificantly. The excellent and good results of the patients together were 83% postoperatively. Conclusions: The curative effect of percutaneous lumbar discectomy is achieved through reduction of lumbar intradiscal pressure.
基金This work was supported by grants from the National Natural Science Foundation of China （No. 30928005）, the Chongqing Natural Science Foundation of China （No. CSTC2009BB5013）, the Third Military Medical University Research Foundation of China （No. 2009XHG16）, and the Graduate Student＇s Scientific Research Innovation Foundation of Chinese Government （No. CDJXS11121145）.
文摘Objective： To investigate the material properties of normal and degenerated intervertebral discs （IVDs） and examine the effect of degenerative changes on IVD pathology. Methods： A computer-based online search was undertaken to identify English articles about material properties of IVDs published from January 1950 to 2011 in PubMed database. The retrieved keywords included material properties, intervertebral disc and degeneration. Based on the principles of reliability, advancement and efficiency, the obtained data were primarily examined, and the original source was retrieved to read the full-text. Repetitive articles were excluded. The data of material properties of normal and degenerated IVDs were summarized and analyzed by meta-analysis. Results： The data of Young＇s modulus, Poisson＇s ratio, shear modulus, hydraulic permeability and intradiscal pres- sure of normal and degenerated 1VDs were obtained. Com- pared with normal IVDs, the Young＇s modulus and shear modulus of annulus fibrosus and nucleus pulposus werehigher in degenerated IVDs, the Poisson＇s ratio was lower while the hydraulic permeability and intradiscal pressure were higher. Besides, the degeneration-related alterations in IVDs had an influence both on itself and other spinal structures, leading to diseases such as bulging disc, discogenic pain and spinal stenosis. Meanwhile, the heavy mechanical loading and injury indicated important pathways to IVD degeneration. Conclusions： To a certain extent, the degenerative changes of IVD influence its material properties. And the degeneration-related alterations of composition can cause structural failure oflVDs, leading to injuries and diseases.
