i Bag是一款智能背包,其设计初衷是为青少年提供一种兼具时尚、科技和健康保障元素的全新背负体验。本作品集成了MEMS陀螺、灵敏应变片组、GPS芯片、SIM卡通信模块、蓝牙模块、LED显示屏以及微控制器,开发了基于Android、i OS和Web的软...i Bag是一款智能背包,其设计初衷是为青少年提供一种兼具时尚、科技和健康保障元素的全新背负体验。本作品集成了MEMS陀螺、灵敏应变片组、GPS芯片、SIM卡通信模块、蓝牙模块、LED显示屏以及微控制器,开发了基于Android、i OS和Web的软硬件通信系统,实现了个性图案显示、实时安全定位和超重检测提示三大功能,并突破了传统背包的局限性,不仅可使用户成为产品个性化的参与者,还可以与背包进行实时人机交互,这一创新点为背包的个性化设计、青少年脊柱保护和出行安全提供了有趣的解决方案。展开更多
OBJECTIVE: We sought to estimate the rate of spontaneous resolution of asymptomatic Chlamydia trachomatis in pregnancy and to evaluate factors associated with its resolution. METHODS: A cohort of women enrolled in a l...OBJECTIVE: We sought to estimate the rate of spontaneous resolution of asymptomatic Chlamydia trachomatis in pregnancy and to evaluate factors associated with its resolution. METHODS: A cohort of women enrolled in a large multicenter randomized bacterial vaginosis antibiotic trial (metronidazole versus placebo) that, when randomly allocated, had asymptomatic C trachomatis diagnosed by urine ligase chain reaction (from frozen archival specimens) between 160/7 and 236/7 weeks were included. The urine ligase chain reaction is a highly accurate predictor of genital tract chlamydial infection. A follow- up ligase chain reaction was performed between 240/7 and 296/7 weeks. RESULTS: A total of 1,953 women were enrolled in the original antibiotic trial; 1,547 (79% ) had ligase chain reaction performed both at randomization and follow- up. Women receiving antibiotics effective against Chlamydia between randomization and follow- up or having symptomatic Chlamydia infection were excluded (26 women). Of the 140 women (9% ) who were diagnosed as positive via the initial ligase chain reaction assay, 61 (44% ) had spontaneous resolution of Chlamydia by the follow- up ligase chain reaction assay. Factors associated with spontaneous resolution included older age (P = .02), more than 5 weeks from randomization to follow- up (P = .02), and a greater number of lifetime sexual partners (P = .02). Using a logistic regression model, maternal age and a greater- than- 5- week follow- up interval remained significant; for every 5- year increase in maternal age, the odds of a positive result on the ligase chain reaction test at follow- up decreased by 40% (odds ratio 0.6; 95% confidence interval 0.4- 0.9). Race, substance abuse, parity, and treatment with metronidazole were not associated with spontaneous resolution. Gram stain score and vaginal pH at randomization and follow- up also were not associated. CONCLUSION: The prevalence of asymptomatic C trachomatis in pregnancy was 9% ; infection resolved spontaneously in almost half of these women. The association of older age and increasing time interval to spontaneous resolution of Chlamydia is consistent with a host immune- response mechanism.展开更多
Background: To demonstrate the efficacy of positron emission tomography (PET) for examining multiple sclerosis (MS) patients with hemianopia. Case: A 20- year-old man visited us with a complaint of left homonymous hem...Background: To demonstrate the efficacy of positron emission tomography (PET) for examining multiple sclerosis (MS) patients with hemianopia. Case: A 20- year-old man visited us with a complaint of left homonymous hemianopia and headache. Observations: The patient’ s visual acuity was 1.2 (n.c.) OD and 0.9 (1.0) OS. Magnetic resonance imaging (MRI) showed a mass in the temporoparietal lobe. A pathological diagnosis of MS was made by brain biopsy. Low glucose metabolism in the lesion and visual cortex was observed by PET with 18F-fluorodeoxy glucose. PET with 11C-flumazenyl revealed a reduction of 11C-uptake in the demyelinated optic radiation, and only a slight reduction of 11C-uptake in the primary visual cortex. The results of 11C-flumazenyl PET suggested a slight reduction of neuronal density. In 2 years, the visual field recovered to the normal state. Conclusion: PET can be a useful tool for estimating the visual outcome of patients with hemianopia in MS.展开更多
文摘OBJECTIVE: We sought to estimate the rate of spontaneous resolution of asymptomatic Chlamydia trachomatis in pregnancy and to evaluate factors associated with its resolution. METHODS: A cohort of women enrolled in a large multicenter randomized bacterial vaginosis antibiotic trial (metronidazole versus placebo) that, when randomly allocated, had asymptomatic C trachomatis diagnosed by urine ligase chain reaction (from frozen archival specimens) between 160/7 and 236/7 weeks were included. The urine ligase chain reaction is a highly accurate predictor of genital tract chlamydial infection. A follow- up ligase chain reaction was performed between 240/7 and 296/7 weeks. RESULTS: A total of 1,953 women were enrolled in the original antibiotic trial; 1,547 (79% ) had ligase chain reaction performed both at randomization and follow- up. Women receiving antibiotics effective against Chlamydia between randomization and follow- up or having symptomatic Chlamydia infection were excluded (26 women). Of the 140 women (9% ) who were diagnosed as positive via the initial ligase chain reaction assay, 61 (44% ) had spontaneous resolution of Chlamydia by the follow- up ligase chain reaction assay. Factors associated with spontaneous resolution included older age (P = .02), more than 5 weeks from randomization to follow- up (P = .02), and a greater number of lifetime sexual partners (P = .02). Using a logistic regression model, maternal age and a greater- than- 5- week follow- up interval remained significant; for every 5- year increase in maternal age, the odds of a positive result on the ligase chain reaction test at follow- up decreased by 40% (odds ratio 0.6; 95% confidence interval 0.4- 0.9). Race, substance abuse, parity, and treatment with metronidazole were not associated with spontaneous resolution. Gram stain score and vaginal pH at randomization and follow- up also were not associated. CONCLUSION: The prevalence of asymptomatic C trachomatis in pregnancy was 9% ; infection resolved spontaneously in almost half of these women. The association of older age and increasing time interval to spontaneous resolution of Chlamydia is consistent with a host immune- response mechanism.
文摘Background: To demonstrate the efficacy of positron emission tomography (PET) for examining multiple sclerosis (MS) patients with hemianopia. Case: A 20- year-old man visited us with a complaint of left homonymous hemianopia and headache. Observations: The patient’ s visual acuity was 1.2 (n.c.) OD and 0.9 (1.0) OS. Magnetic resonance imaging (MRI) showed a mass in the temporoparietal lobe. A pathological diagnosis of MS was made by brain biopsy. Low glucose metabolism in the lesion and visual cortex was observed by PET with 18F-fluorodeoxy glucose. PET with 11C-flumazenyl revealed a reduction of 11C-uptake in the demyelinated optic radiation, and only a slight reduction of 11C-uptake in the primary visual cortex. The results of 11C-flumazenyl PET suggested a slight reduction of neuronal density. In 2 years, the visual field recovered to the normal state. Conclusion: PET can be a useful tool for estimating the visual outcome of patients with hemianopia in MS.
