According to the heating effect caused by interaction between matters,a series of experiments on the interaction between drugs and cells from human bodies,DNA and physiological saline have been carried out with a MS-8...According to the heating effect caused by interaction between matters,a series of experiments on the interaction between drugs and cells from human bodies,DNA and physiological saline have been carried out with a MS-80 standard Calvet microcalorimeter.The experiments include: (1) Thermokinetic studies of the effect of anticancer drugs [sodium norcantharidate (ASN),the bioac- tire materials (Sp.P and Sp.S) from algae etc.]on the cancer cells [Hela,human breast carcinoma (Bcap-37),human adenocarcinoma gastric cells (SGc-7901 and MCF-7) etc.] and the normal cells from human bodies [diploid fibroblasts from human fetal lung (2BS) etc.] at 310.15 K:(2) Studies of the in- tercalation binding of some alkaloidal drugs with the bioactivity to inhibit monoamine oxidase (harmalinc and harmine etc.) to call thymus DNA in neutral aqueous solution at 298.15 K:(3) Studies of the interaction between long acting drugs (long acting oral contraceptive-norgestrel etc.) and slow- releasing drug (Contac) and aqueous solution of 0.9% NaCI at 310.15 K.All the experimental results have given their characteristic thermograms and the interaction enthalpy changes.On the analysis of all the results,the authors put forward a method on application of microcalorimetric technique for screen- ing and examination of medicines.The principle of application and the experimental operation of this method have been expounded,and some results of the above experiments have been discussed.As one of the methods for screening and examining medicines,the microcalorimctric method has some distin- guished features and advantages over other methods.展开更多
AIM： To identity the factors influencing colorectal cancer （CRC） screening behavior and willingness among Chinese outpatients.METHODS： An outpatient-based face-to-face survey was conducted from August 18 to Septem...AIM： To identity the factors influencing colorectal cancer （CRC） screening behavior and willingness among Chinese outpatients.METHODS： An outpatient-based face-to-face survey was conducted from August 18 to September 7, 2010 in Changhai Hospital. A total of 1200 consecutive patients aged ≥ 18 years were recruited for interview. The patient＇s knowledge about CRC and screening was pre-measured as a predictor variable, and other pre- dictors included age, gender, educational level, month- ly household income and health insurance status. The relationship between these predictors and screening behavior, screening willingness and screening approach were examined using Pearson＇s 2 test and logistic regression analyses.RESULTS： Of these outpatients, 22.5% had undergone CRC screening prior to this study. Patients who had participated in the screening were more likely to have good knowledge about CRC and screening （OR： 5.299, 95% CI： 3.415-8.223）, have health insurance （OR： 1.996, 95% CI： 1.426-2.794） and older in age. Higher income, however, was found to be a barrier to the screening （OR： 0.633, 95% CI： 0.467-0.858）. An analysis of screening willingness showed that 37.5% of the patients would voluntarily participated in a screen at the recommended age, but 41.3% would do so under doctor＇s advice. Screening willingness was positively correlated with the patient＇s knowledge sta- tus. Patients with higher knowledge levels would like to participate in the screening （OR： 4.352, 95% CI： 3.008-6.298）, and they would select colonoscopy as a screening approach （OR： 3.513, 95% CI： 2.290-5.389）. However, higher income level was, again, a bar- rier to colonoscopic screening （OR： 0.667, 95% CI： 0.505-0.908）. CONCLUSION： Patient＇s level of knowledge and in-ome should be taken into consideration when conducting a feasible CRC screening.展开更多
The MultiCarrier Code Division Multiple Access (MC-CDMA) scheme is promising for relieving capacity limit problems of Direct Sequence (DS-) CDMA systems due to serious InterChip Interference (ICI) and MultiUser Interf...The MultiCarrier Code Division Multiple Access (MC-CDMA) scheme is promising for relieving capacity limit problems of Direct Sequence (DS-) CDMA systems due to serious InterChip Interference (ICI) and MultiUser Interference (MUI) in high-data-rate wireless communication systems. In this paper, the Uniform Linear Array (ULA) is applied to the base station of macrocellular MC-CDMA systems in a frequency-selective fading channel environment. A joint space-frequency multiuser symbol sequence detector is developed for all active users within one macrocell without space-frequency channel estimation. Simultaneously, Directions-Of-Arrivals (DOAs) of all active users can also be estimated. By dividing the ULA into two identical overlapping subarrays, a specific auxiliary matrix is constructed, which includes both symbol sequence and DOA information of all active users. Then, based on the subspace method, performing the eigen decomposition on such auxiliary matrix, the closed-form solution of symbol sequences and DOAs for all active users can be obtained. In comparison with schemes based on channel estimation, our algorithm need not explicitly estimate the space-frequency channel for each active user,so it has lower computation complexity. Extensive computer simulations demonstrate the overall performance of this novel scheme.展开更多
The development of damage detection techniques for offshore jacket structures is vital to prevent catastrophic events. This paper applies a frequency response based method for the purpose of structural health monitori...The development of damage detection techniques for offshore jacket structures is vital to prevent catastrophic events. This paper applies a frequency response based method for the purpose of structural health monitoring. In efforts to fulfill this task, concept of the minimum rank perturbation theory has been utilized. The present article introduces a promising methodology to select frequency points effectively. To achieve this goal, modal strain energy ratio of each member was evaluated at different natural frequencies of structure in order to identify the sensitive frequency domain for damage detection. The proposed methodology opens up the possibility of much greater detection efficiency. In addition, the performance of the proposed method was evaluated in relation to multiple damages. The aforementioned points are illustrated using the numerical study of a two dimensional jacket platform, and the results proved to be satisfactory utilizing the proposed methodology.展开更多
Objective: Papanicolou (Pap) smear screening has dramatically reduced the incidence of invasive cervical cancer worldwide. Pap smear screening is still not widely available in developing countries and therefore cannot...Objective: Papanicolou (Pap) smear screening has dramatically reduced the incidence of invasive cervical cancer worldwide. Pap smear screening is still not widely available in developing countries and therefore cannot be used as mass screening tool. This study was designed to establish the role of Pap smear as a routine investigation for females presented to gynecological department. Methods: It was a hospital based study. Patients attending with complaints including irregular vaginal bleeding, vagina discharge, dyspareunia, low backache or lower abdominal pain and primary or secondary infertility were included in the study. All these patients underwent pap smear. Results: Age of females was 25 to 60 years. Ninety females had dysplasia. Mild to moderate dysplasia was positive in 84 females. Six patients had severe dysplasia suspicious for squamous cell carcinoma (SCC) which was confirmed as invasive SCC on biopsy. All patients with mild to moderate dysplasia were regularly followed at 4 to 6 months. Thirty patients were lost during follow up. Forty had negative smear at 6 months, while fourteen having persistent dysplasia on repeated pap smears were referred for biopsies. Histopathology confirmed invasive SCC in five patients while chronic cervicitis was reported in nine patients. Only two of screened patients with high suspicion for cancer showed false negative results. Directed biopsies done in these confirmed invasive SCC. Conclusion: Pap smear is a useful, simple, non-invasive and reliable screening tool for cervical cancer. It may be practiced as a routine investigation in outpatients in developing countries, where mass screening is not available.展开更多
This study aimed to evaluate the atypical lymphocyte warnings of Sysmex XE-4000 in outpatient children. [Method] Randomly 280 specimens of outpatient children were selected to analyze atypical lymphocytes with Sysmex ...This study aimed to evaluate the atypical lymphocyte warnings of Sysmex XE-4000 in outpatient children. [Method] Randomly 280 specimens of outpatient children were selected to analyze atypical lymphocytes with Sysmex XE-4000 and artificial smear microscopy simultaneously. [Result] With artificial smear microscopy as the gold standard, the atypical lymphocyte warnings of Sysmex XE-4000 in outpatient children exhibited a sensitivity of 97.4%, specificity of 69.3%, positive predictive value （PPV） of 55%, and negative predictive value （NPV） of 98.5%. [Conclusion] Sysmex XE-4000 shows a high sensitivity in atypical lymphocyte warnings, which can reduce the number of blood smears, improve the specificity of microscopy, and decline the labor intensity of inspection personnel. However, there are stil certain false positives to be confirmed by artificial microscopy.展开更多
This paper proposes a night-time vehicle detection method using variable Haar-like feature.The specific features of front vehicle cannot be obtained in road image at night-time because of light reflection and ambient ...This paper proposes a night-time vehicle detection method using variable Haar-like feature.The specific features of front vehicle cannot be obtained in road image at night-time because of light reflection and ambient light,and it is also difficult to define optimal brightness and color of rear lamp according to road conditions.In comparison,the difference of vehicle region and road surface is more robust for road illumination environment.Thus,we select the candidates of vehicles by analysing the difference,and verify the candidates using those brightness and complexity to detect vehicle correctly.The feature of brightness difference is detected using variable horizontal Haar-like mask according to vehicle size in the location of image.And the region occurring rapid change is selected as the candidate.The proposed method is evaluated by testing on the various real road conditions.展开更多
文摘According to the heating effect caused by interaction between matters,a series of experiments on the interaction between drugs and cells from human bodies,DNA and physiological saline have been carried out with a MS-80 standard Calvet microcalorimeter.The experiments include: (1) Thermokinetic studies of the effect of anticancer drugs [sodium norcantharidate (ASN),the bioac- tire materials (Sp.P and Sp.S) from algae etc.]on the cancer cells [Hela,human breast carcinoma (Bcap-37),human adenocarcinoma gastric cells (SGc-7901 and MCF-7) etc.] and the normal cells from human bodies [diploid fibroblasts from human fetal lung (2BS) etc.] at 310.15 K:(2) Studies of the in- tercalation binding of some alkaloidal drugs with the bioactivity to inhibit monoamine oxidase (harmalinc and harmine etc.) to call thymus DNA in neutral aqueous solution at 298.15 K:(3) Studies of the interaction between long acting drugs (long acting oral contraceptive-norgestrel etc.) and slow- releasing drug (Contac) and aqueous solution of 0.9% NaCI at 310.15 K.All the experimental results have given their characteristic thermograms and the interaction enthalpy changes.On the analysis of all the results,the authors put forward a method on application of microcalorimetric technique for screen- ing and examination of medicines.The principle of application and the experimental operation of this method have been expounded,and some results of the above experiments have been discussed.As one of the methods for screening and examining medicines,the microcalorimctric method has some distin- guished features and advantages over other methods.
文摘AIM： To identity the factors influencing colorectal cancer （CRC） screening behavior and willingness among Chinese outpatients.METHODS： An outpatient-based face-to-face survey was conducted from August 18 to September 7, 2010 in Changhai Hospital. A total of 1200 consecutive patients aged ≥ 18 years were recruited for interview. The patient＇s knowledge about CRC and screening was pre-measured as a predictor variable, and other pre- dictors included age, gender, educational level, month- ly household income and health insurance status. The relationship between these predictors and screening behavior, screening willingness and screening approach were examined using Pearson＇s 2 test and logistic regression analyses.RESULTS： Of these outpatients, 22.5% had undergone CRC screening prior to this study. Patients who had participated in the screening were more likely to have good knowledge about CRC and screening （OR： 5.299, 95% CI： 3.415-8.223）, have health insurance （OR： 1.996, 95% CI： 1.426-2.794） and older in age. Higher income, however, was found to be a barrier to the screening （OR： 0.633, 95% CI： 0.467-0.858）. An analysis of screening willingness showed that 37.5% of the patients would voluntarily participated in a screen at the recommended age, but 41.3% would do so under doctor＇s advice. Screening willingness was positively correlated with the patient＇s knowledge sta- tus. Patients with higher knowledge levels would like to participate in the screening （OR： 4.352, 95% CI： 3.008-6.298）, and they would select colonoscopy as a screening approach （OR： 3.513, 95% CI： 2.290-5.389）. However, higher income level was, again, a bar- rier to colonoscopic screening （OR： 0.667, 95% CI： 0.505-0.908）. CONCLUSION： Patient＇s level of knowledge and in-ome should be taken into consideration when conducting a feasible CRC screening.
基金Partially supported by the National Natural Science Foundation(No.69872029)and the Research Fund for Doctoral Program of Higher Education(No.19990690808)of China
文摘The MultiCarrier Code Division Multiple Access (MC-CDMA) scheme is promising for relieving capacity limit problems of Direct Sequence (DS-) CDMA systems due to serious InterChip Interference (ICI) and MultiUser Interference (MUI) in high-data-rate wireless communication systems. In this paper, the Uniform Linear Array (ULA) is applied to the base station of macrocellular MC-CDMA systems in a frequency-selective fading channel environment. A joint space-frequency multiuser symbol sequence detector is developed for all active users within one macrocell without space-frequency channel estimation. Simultaneously, Directions-Of-Arrivals (DOAs) of all active users can also be estimated. By dividing the ULA into two identical overlapping subarrays, a specific auxiliary matrix is constructed, which includes both symbol sequence and DOA information of all active users. Then, based on the subspace method, performing the eigen decomposition on such auxiliary matrix, the closed-form solution of symbol sequences and DOAs for all active users can be obtained. In comparison with schemes based on channel estimation, our algorithm need not explicitly estimate the space-frequency channel for each active user,so it has lower computation complexity. Extensive computer simulations demonstrate the overall performance of this novel scheme.
基金Financial Support by the Pars Oil and Gas Company(Grant No. 88-065)
文摘The development of damage detection techniques for offshore jacket structures is vital to prevent catastrophic events. This paper applies a frequency response based method for the purpose of structural health monitoring. In efforts to fulfill this task, concept of the minimum rank perturbation theory has been utilized. The present article introduces a promising methodology to select frequency points effectively. To achieve this goal, modal strain energy ratio of each member was evaluated at different natural frequencies of structure in order to identify the sensitive frequency domain for damage detection. The proposed methodology opens up the possibility of much greater detection efficiency. In addition, the performance of the proposed method was evaluated in relation to multiple damages. The aforementioned points are illustrated using the numerical study of a two dimensional jacket platform, and the results proved to be satisfactory utilizing the proposed methodology.
文摘Objective: Papanicolou (Pap) smear screening has dramatically reduced the incidence of invasive cervical cancer worldwide. Pap smear screening is still not widely available in developing countries and therefore cannot be used as mass screening tool. This study was designed to establish the role of Pap smear as a routine investigation for females presented to gynecological department. Methods: It was a hospital based study. Patients attending with complaints including irregular vaginal bleeding, vagina discharge, dyspareunia, low backache or lower abdominal pain and primary or secondary infertility were included in the study. All these patients underwent pap smear. Results: Age of females was 25 to 60 years. Ninety females had dysplasia. Mild to moderate dysplasia was positive in 84 females. Six patients had severe dysplasia suspicious for squamous cell carcinoma (SCC) which was confirmed as invasive SCC on biopsy. All patients with mild to moderate dysplasia were regularly followed at 4 to 6 months. Thirty patients were lost during follow up. Forty had negative smear at 6 months, while fourteen having persistent dysplasia on repeated pap smears were referred for biopsies. Histopathology confirmed invasive SCC in five patients while chronic cervicitis was reported in nine patients. Only two of screened patients with high suspicion for cancer showed false negative results. Directed biopsies done in these confirmed invasive SCC. Conclusion: Pap smear is a useful, simple, non-invasive and reliable screening tool for cervical cancer. It may be practiced as a routine investigation in outpatients in developing countries, where mass screening is not available.
文摘This study aimed to evaluate the atypical lymphocyte warnings of Sysmex XE-4000 in outpatient children. [Method] Randomly 280 specimens of outpatient children were selected to analyze atypical lymphocytes with Sysmex XE-4000 and artificial smear microscopy simultaneously. [Result] With artificial smear microscopy as the gold standard, the atypical lymphocyte warnings of Sysmex XE-4000 in outpatient children exhibited a sensitivity of 97.4%, specificity of 69.3%, positive predictive value （PPV） of 55%, and negative predictive value （NPV） of 98.5%. [Conclusion] Sysmex XE-4000 shows a high sensitivity in atypical lymphocyte warnings, which can reduce the number of blood smears, improve the specificity of microscopy, and decline the labor intensity of inspection personnel. However, there are stil certain false positives to be confirmed by artificial microscopy.
基金supported by the MKE(The Ministry of Knowledge Economy),Korea,under the ITRC(Infor mation Technology Research Center)support program supervised by the NIPA(National IT Industry Promotion Agency)(NIPA-2011-C1090-1121-0010)by the Brain Korea 21 Project in2011
文摘This paper proposes a night-time vehicle detection method using variable Haar-like feature.The specific features of front vehicle cannot be obtained in road image at night-time because of light reflection and ambient light,and it is also difficult to define optimal brightness and color of rear lamp according to road conditions.In comparison,the difference of vehicle region and road surface is more robust for road illumination environment.Thus,we select the candidates of vehicles by analysing the difference,and verify the candidates using those brightness and complexity to detect vehicle correctly.The feature of brightness difference is detected using variable horizontal Haar-like mask according to vehicle size in the location of image.And the region occurring rapid change is selected as the candidate.The proposed method is evaluated by testing on the various real road conditions.
